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Article ; Online: The Association Between Cervical Foraminal Stenosis and Adhesive Capsulitis: An Imaging-based Case-Control Study.

Russo, Salvatore / Sharma, Aadhar / Vardanyan, Robert / Thavarajasingam, Santhosh Gouthaman / Riew, K Daniel

2024

Abstract: Study design: Retrospective single-center imaging-based case-control study.: Objective: To determine the association between cervical foraminal stenosis and adhesive capsulitis.: Summary of background data: Patients with cervical spondylosis often ...

Abstract	Study design: Retrospective single-center imaging-based case-control study. Objective: To determine the association between cervical foraminal stenosis and adhesive capsulitis. Summary of background data: Patients with cervical spondylosis often exhibit shoulder symptoms. Cervical radiculopathies, particularly C5, can cause severe shoulder pain and reduced shoulder mobility, mimicking glenohumeral adhesive capsulitis (frozen shoulder), a common shoulder condition. This is the first study investigating the connection between adhesive capsulitis and cervical radiculopathy. Methods: 438 patients who underwent glenohumeral hydrodistension between 2012 and 2019 were reviewed. Included were individuals with unilateral frozen shoulder investigated using ultrasound and cervical spine MRI to investigate cervical spondylosis. Foraminal stenosis at C3/4, C4/5, C5/6 and C6/7 was graded in axial T2 MRI, ipsilateral and contralateral to the adhesive capsulitis. The presence of foraminal stenosis ipsilateral to the frozen shoulder (cases) was compared with the contralateral side (control). McNemar's exact test was used to assess the strength of a correlation. Results: Among 438 patients, 107 reported frozen shoulder and neck pain (24.5%), with 48 matching the study criteria. A significant association between ipsilateral frozen shoulder and C4/5 foraminal stenosis was observed (P=0.00000008636). Ipsilateral foraminal stenosis was observed in 57.3% of these cases, with bilateral stenosis in 29.1%. Additionally, 78% had neck pain on the same side as their frozen shoulder, and 44% had pain radiating to the shoulder. 48% patients underwent nerve-targeted interventions, with 44% addressing the C5 nerve (25% C5 steroid injection and 19% C4/5 anterior cervical discectomy and fusion). Conclusion: A substantial association between C5 foraminal stenosis and ipsilateral frozen shoulder was found. C5 radiculopathy could be a risk factor for "neurogenic frozen shoulder". Those diagnosing frozen shoulder and cervicobrachialgia should recognize that frozen shoulder and C5 radiculopathy may coexist. A multidisciplinary approach involving both shoulder and spine specialists is recommended for a definitive diagnosis.
Language	English
Publishing date	2024-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000005031
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Zs.A 1305: Show issues

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Article: Cost-Effectiveness Analysis for the Treatment of Diabetic Foot Ulcer in France: Platelet-Rich Plasma vs Standard of Care.

Russo, Salvatore / Landi, Stefano / Courric, Stephane

ClinicoEconomics and outcomes research : CEOR

2022 Volume 14, Page(s) 1–10

Abstract: Introduction: Diabetic chronic foot ulcers (DFU) lead to pain, reduced quality of life and represent a severe economic burden for patients and health systems. The clinical results of PRP effectiveness in the treatment of DFU are promising; on the other ... ...

Abstract	Introduction: Diabetic chronic foot ulcers (DFU) lead to pain, reduced quality of life and represent a severe economic burden for patients and health systems. The clinical results of PRP effectiveness in the treatment of DFU are promising; on the other hand, the costs associated with treating DFUs with PRP are higher than those using standard therapy. Therefore, this study aims to determine the cost-effectiveness of platelet-rich plasma (PRP) therapy compared to standard therapy from the French healthcare system perspective. Methods: A cost-effectiveness analysis (CEA) was performed using a decision Markov model with a cohort of patients with chronic DFU (duration of >3 weeks) with high orthopaedic risk and with ulcers graded 3A according to University of Texas classification. The effectiveness outcomes are reported in terms of quality adjusted life year (QALY). The costs are reported in euro (€) currency evaluated in 2019. A micro-costing approach alongside a clinical study was used to assess resource use. Deterministic sensibility analyses are reported to evaluate the robustness of the results. The analyses were carried out in the French setting. Results: The incremental cost-effectiveness ratio (ICER) of PRP treatment is -€613/ QALY, which, being lower than zero, indicates the dominance of the PRP therapy. Deterministic and probabilistic sensitivity analysis underlines the main parameter affecting CE results. Lowest number of standard of care weekly medications (from 5 to 3) leads to a €622/QALY while increasing PRP weekly medication (from 1 to 4) has an ICER of €732/QALY. Discussion: PRP is a cost-effective or even a cost-saving alternative in the French setting. PRP has higher cost for the complete medication, but, in the absence of wound complications, has the potential to involve lower consumption of resources in the form of routine medication over a 1-year time horizon.
Language	English
Publishing date	2022-01-03
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2520698-9
ISSN	1178-6981
ISSN	1178-6981
DOI	10.2147/CEOR.S327191
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Article: Comparative Structural Analysis of GFRP, Reinforced Concrete, and Steel Frames under Seismic Loads.

Mincigrucci, Luca / Civera, Marco / Lenticchia, Erica / Ceravolo, Rosario / Rosano, Michele / Russo, Salvatore

Materials (Basel, Switzerland)

2023 Volume 16, Issue 14

Abstract: Fibre-reinforced polymer composites in general, and especially glass fibre-reinforced polymer (GFRP), have increasingly been used in recent decades in construction. The advantages of GFRP as an alternative construction material are its high strength-to- ... ...

Abstract	Fibre-reinforced polymer composites in general, and especially glass fibre-reinforced polymer (GFRP), have increasingly been used in recent decades in construction. The advantages of GFRP as an alternative construction material are its high strength-to-weight ratio, corrosive resistance, high durability, and ease of installation. The main purpose of this study is to evaluate the response of GFRP under dynamic conditions (more specifically, under seismic loads) and to compare the performance of this composite material with that of two traditional building materials: reinforced concrete and structural steel. To this aim, a finite element analysis is carried out on a two-dimensional frame modelled with steel, reinforced concrete (RC), or GFRP pultruded materials and subjected to a seismic input. The dynamic response of the structure is evaluated for the three building materials in terms of displacements, inter-storey drift, base shear, and stress. The results show a good performance of the GFRP frame, with stress distribution and displacements halfway between those of RC and steel. Most importantly, the GFRP frame outperforms the other materials in terms of reduced weight and, thus, base shear (-40% compared to steel and -88.5% compared to RC).
Language	English
Publishing date	2023-07-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16144908
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Article ; Online: Gastric leak closure after the misdeployment of a lumen-apposing metal stent.

Grande, Giuseppe / Gottin, Matteo / Carloni, Lorenzo / Cocca, Silvia / Russo, Salvatore / Conigliaro, Rita / Bertani, Helga

Endoscopy

2023 Volume 55, Issue S 01, Page(s) E1017–E1018

MeSH term(s)	Humans ; Stomach/surgery ; Stents ; Anastomotic Leak
Language	English
Publishing date	2023-08-30
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2155-5080
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A New Step-Up Dual Endoscopic Approach for Large-Size Infected Pancreatic Necrosis: Percutaneous Endoscopic Necrosectomy Followed by Transluminal Endoscopic Drainage/Necrosectomy.

Mangiafico, Santi / Bertani, Helga / Pigò, Flavia / Russo, Salvatore / Lupo, Marinella / Cocca, Silvia / Grande, Giuseppe / Germani, Ugo / Manta, Raffaele / Conigliaro, Rita

Surgical laparoscopy, endoscopy & percutaneous techniques

2024 Volume 34, Issue 2, Page(s) 156–162

Abstract: Background: Acute pancreatitis in 10% to 20% of cases can be associated with necrosis of the pancreatic gland, peripancreatic tissue, or both. We report a case series of a new endoscopic approach to treat infected pancreatic necrosis (IPN).: Patients ... ...

Abstract	Background: Acute pancreatitis in 10% to 20% of cases can be associated with necrosis of the pancreatic gland, peripancreatic tissue, or both. We report a case series of a new endoscopic approach to treat infected pancreatic necrosis (IPN). Patients and methods: Consecutive patients with IPN, extending from the perigastric area up to the paracolic gutters or into the pelvis, were prospectively studied from January 2017 to June 2022. The treatment protocol was radiologic percutaneous drainage as the first step, followed by fully covered metal stent placement (FC-SEMS) in the track of the catheter. Percutaneous endoscopic necrosectomy (PEN) was performed 2 to 4 days later using a flexible endoscope through the percutaneous tract. About 2 to 4 weeks later, when a matured sac was visible, EUS-guided endoscopic transluminal drainage (ETD) with lumen-apposing metal stents (LAMS) was performed. Control of sepsis with resolution of collection(s) was the primary outcome measure. Results: We included 18 patients, males in 50% of cases with age 60±12 years old. Most frequent cause of pancreatitis was biliary (7 cases) followed by alcoholic in 6 cases; in 3 cases pancreatitis was caused by hyperlipemia and in 2 cases was idiopathic. Mean size of WON was 18±2 cm. For PEN, SEMSs used were esophageal FC-SEMS. LAMS used for ETD were Hot Axios, Hot Spaxus and Nagistent. Mean time of endoscopic intervention for PEN and ETD was 18±3 and 37±4 days, respectively. In 5 cases adverse events occurred: 3 cases of overinflations resolved with introduction of Verres needles in abdomen. In 2 cases postprocedural GI bleeding required endoscopic intervention. In all cases control of sepsis was reached together with resolution of collections. No cases of deaths were observed. Conclusions: Step-up percutaneous and transluminal endoscopic necrosectomy therapy is an effective strategy for large-size IPN with combined central and peripheral necrosis.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Pancreatitis, Acute Necrotizing/surgery ; Acute Disease ; Treatment Outcome ; Stents/adverse effects ; Drainage/methods ; Sepsis ; Intraabdominal Infections ; Necrosis ; Retrospective Studies
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1475108-2
ISSN	1534-4908 ; 1530-4515 ; 1051-7200
ISSN (online)	1534-4908
ISSN	1530-4515 ; 1051-7200
DOI	10.1097/SLE.0000000000001271
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Zs.A 3200: Show issues

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Article ; Online: Does fracture-extension into the pars interarticularis alter outcomes in odontoid failure? a technical note on pars interarticularis osteotomy and atlantoaxial distraction arthrodesis.

Russo, Salvatore / Mobasheri, Reza / de Negreiros Nanni, Felipe / Lam, Khai

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2021 Volume 30, Issue 6, Page(s) 1556–1565

Abstract: Purpose: Odontoid process fractures can extend rostral into the C2 arch. We investigated the clinical impact of a concurrent fracture of the pars interarticularis on odontoid failure. To overcome the surgical challenges related to the morphology of ... ...

Abstract	Purpose: Odontoid process fractures can extend rostral into the C2 arch. We investigated the clinical impact of a concurrent fracture of the pars interarticularis on odontoid failure. To overcome the surgical challenges related to the morphology of these fractures, we describe a novel surgical strategy using atlantoaxial joint distraction arthrodesis. Methods: We conducted a single centre cohort study of 13 consecutive patients with odontoid fractures extending into the pars treated between June 2016 and June 2018. Criteria for a stable fibrous non-union were: Atlanto-Dens Interval (ADI) < 3 mm, Posterior Atlanto-Dens Interval (PADI) > 14 mm and lack of symptomatic motion at the fracture site. Atlantoaxial instability was defined as greater than 50% subluxation across the C1-C2 joint. Return to pre-injury performance status was considered a satisfactory clinical outcome. Results: The mean age of the patient population was 77.2 years (SD 11.9). The mean follow-up time was 15 months (SD 5.2). 69% had an associated atlantoaxial instability (P-value 0.0005). Cervical orthosis treatment was associated with a high non-union rate (70%) (P-value 0.04) although it did not affect the overall clinical outcome. 2 cases presented with cord compression were treated surgically with pars interarticularis osteotomy and atlantoaxial distraction arthrodesis. Conclusions: Odontoid fracture with extension into the pars interarticularis often present with atlantoaxial instability and may result in stable fibrous non-union if treated non-operatively. The C1-C2 segment can be stabilised with atlantoaxial distraction arthrodesis achieved through an osteotomy of the pars interarticularis.
MeSH term(s)	Aged ; Arthrodesis ; Atlanto-Axial Joint/diagnostic imaging ; Atlanto-Axial Joint/surgery ; Cohort Studies ; Humans ; Odontoid Process/diagnostic imaging ; Odontoid Process/surgery ; Osteotomy
Language	English
Publishing date	2021-03-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-021-06806-3
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Zs.A 3437: Show issues

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Article: Rheological, Thermal and Mechanical Characterization of Toughened Self-Healing Supramolecular Resins, Based on Hydrogen Bonding.

Guadagno, Liberata / Raimondo, Marialuigia / Naddeo, Carlo / Vertuccio, Luigi / Russo, Salvatore / Iannuzzo, Generoso / Calabrese, Elisa

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 23

Abstract: This paper proposes the design of toughened self-healing supramolecular resins able to fulfill functional and structural requirements for industrial applications. These new nanocomposites are based on compounds acting as promotors of reversible self- ... ...

Abstract	This paper proposes the design of toughened self-healing supramolecular resins able to fulfill functional and structural requirements for industrial applications. These new nanocomposites are based on compounds acting as promotors of reversible self-healing interactions. Electrically conductive carbon nanotubes, selected among those allowing to reach the electrical percolation threshold (EPT) with a very low amount of nanofiller, were dispersed in the self-healing polymeric matrix to contrast the electrical insulating properties of epoxy matrices, as required for many applications. The formulated supramolecular systems are thermally stable, up to 360 °C. Depending on the chemical formulation, the self-healing efficiency
Language	English
Publishing date	2022-12-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12234322
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Article ; Online: Extended Tromograph Surveys for a Full Experimental Characterisation of the San Giorgio Cathedral in Ragusa (Italy).

Imposa, Giacomo / Grassi, Sabrina / Barontini, Alberto / Morreale, Gabriele / Russo, Salvatore / Lourenço, Paulo B / Imposa, Sebastiano

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 2

Abstract: Geophysical surveys are widely used to reconstruct subsoil seismo-stratigraphic structures with a non-invasive approach. In this study the geophysical surveys were carried out with the aim to characterise the San Giorgio Cathedral in Ragusa (Italy) and ... ...

Abstract	Geophysical surveys are widely used to reconstruct subsoil seismo-stratigraphic structures with a non-invasive approach. In this study the geophysical surveys were carried out with the aim to characterise the San Giorgio Cathedral in Ragusa (Italy) and the area on which it is built from a dynamic point of view. A 3D subsoil model was realised through the integration of two active (i.e., seismic tomography and multichannel analysis of surface waves) and one passive seismic technique (horizontal to vertical spatial ratio). The instrumentation used for the latter method consists of a tromograph (Tromino
MeSH term(s)	Italy ; Vibration ; Soil
Chemical Substances	Soil
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23020889
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Article: Small Bowel Cystic Lymphangioma: An Uncommon Finding During Single-Balloon Enteroscopy.

Cocca, Silvia / Pontillo, Giuseppina / Grande, Giuseppe / Mussetto, Alessandro / Russo, Salvatore / Bertani, Helga / Conigliaro, Rita Luisa

ACG case reports journal

2023 Volume 10, Issue 4, Page(s) e01029

Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2814825-3
ISSN	2326-3253
ISSN	2326-3253
DOI	10.14309/crj.0000000000001029
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Article ; Online: On-therapy impedance-pH monitoring can efficiently characterize PPI-refractory GERD and support treatment escalation.

Frazzoni, Marzio / Frazzoni, Leonardo / Ribolsi, Mentore / Russo, Salvatore / Conigliaro, Rita / De Bortoli, Nicola / Savarino, Edoardo

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

2023 Volume 35, Issue 5, Page(s) e14547

Abstract: Background: On-therapy impedance-pH monitoring is recommended in patients with documented GERD and PPI-refractory heartburn in order to establish whether the unremitting symptom is reflux-related or not.: Aims: To define on-PPI cut-offs of impedance- ... ...

Abstract	Background: On-therapy impedance-pH monitoring is recommended in patients with documented GERD and PPI-refractory heartburn in order to establish whether the unremitting symptom is reflux-related or not. Aims: To define on-PPI cut-offs of impedance-pH metrics allowing proper interpretation of on-therapy impedance-pH monitoring. Methods: Blinded expert review of impedance-pH tracings performed during double-dosage PPI, prospectively collected from 150 GERD patients with PPI-refractory heartburn and 45 GERD patients with PPI-responsive heartburn but persisting extra-esophageal symptoms. Acid exposure time (AET), number of total refluxes (TRs), post-reflux swallow-induced peristaltic wave (PSPW) index, and mean nocturnal baseline impedance (MNBI) were assessed. On-PPI cut-offs were defined and evaluated with ROC analysis and the area under curve (AUC). Results: All the four impedance-pH metrics significantly differed between PPI-refractory and PPI-responsive heartburn cases. At ROC analysis, AUC was 0.73 for AET, 0.75 for TRs, 0.81 for PSPW index, and 0.71 for MNBI; best cut-offs were ≥1.7% for AET, ≥45 for TRs, ≤36% for PSPW index, and ≤ 1847 Ω for MNBI; AUC of such cut-offs was 0.66, 0.71, 0.73, and 0.68, respectively. Analysis of PSPW index and MNBI added to assessment of AET and TRs significantly increased the yield of on-therapy impedance-pH monitoring in the PPI-refractory cohort (97% vs. 83%, p < 0.0001). Notably, suboptimal acid suppression as shown by AET ≥1.7% was detected in 43% of 150 PPI-refractory cases. Conclusions: We have defined on-PPI cut-offs of impedance-pH metrics by which comprehensive assessment of impedance-pH tracings, including analysis of PSPW index and MNBI can efficiently characterize PPI-refractory GERD and support treatment escalation.
MeSH term(s)	Humans ; Heartburn/diagnosis ; Esophageal pH Monitoring ; Electric Impedance ; Gastroesophageal Reflux/diagnosis ; Hydrogen-Ion Concentration ; Proton Pump Inhibitors/pharmacology
Chemical Substances	Proton Pump Inhibitors
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.14547
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