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  1. Article ; Online: Neurobiology of social stress and age-related neurodegeneration.

    Wang, Jun / Russo, Scott J

    Neuroscience and biobehavioral reviews

    2023  Volume 156, Page(s) 105482

    MeSH term(s) Humans ; Alzheimer Disease ; Amyloid beta-Peptides
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-11-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105482
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  2. Article ; Online: Neurobiology and systems biology of stress resilience.

    Kalisch, Raffael / Russo, Scott J / Müller, Marianne B

    Physiological reviews

    2024  

    Abstract: Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts to unravel the factors and mechanisms that make ... ...

    Abstract Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts to unravel the factors and mechanisms that make resilience possible and to harness its insights for the development of preventative interventions in individuals at risk for acquiring stress-related dysfunctions. Biological resilience research has been lagging behind the psychological and social sciences, but has seen a massive surge in recent years. At the same time, progress in this field has been hampered by methodological challenges related to finding suitable operationalizations and study designs, replicating findings, and modeling resilience in animals. We embed a review of behavioral, neuroimaging, neurobiological, and systems-biological findings in adults in a critical methods discussion. We find preliminary evidence that hippocampal-based pattern separation and prefrontal-based cognitive control functions protect against the development of pathological fears in the aftermath of singular, event-type stressors (as found in fear-related disorders, including simpler forms of post-traumatic stress disorder, PTSD), by facilitating the perception of safety. Reward system-based pursuit and savoring of positive reinforcers appear to protect against the development of more generalized dysfunctions of the anxious-depressive spectrum resulting from more severe or longer-lasting stressors (as in depression, generalized or comorbid anxiety, or severe PTSD). Links between preserved functioning of these neural systems under stress and neuroplasticity, immunoregulation, gut microbiome composition, and integrity of the gut barrier and the blood-brain barrier are beginning to emerge. On this basis, avenues for biological interventions are pointed out.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00042.2023
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  3. Article ; Online: Early life stress and altered social behaviors: A perspective across species.

    Parise, Lyonna F / Joseph Burnett, C / Russo, Scott J

    Neuroscience research

    2023  

    Abstract: Childhood and adolescent affiliations guide how individuals engage in social relationships throughout their lifetime and adverse experiences can promote biological alterations that facilitate behavioral maladaptation. Indeed, childhood victims of abuse ... ...

    Abstract Childhood and adolescent affiliations guide how individuals engage in social relationships throughout their lifetime and adverse experiences can promote biological alterations that facilitate behavioral maladaptation. Indeed, childhood victims of abuse are more likely to be diagnosed with conduct or mood disorders which are both characterized by altered social engagement. A key domain particularly deserving of attention is aggressive behavior, a hallmark of many disorders characterized by deficits in reward processing. Animal models have been integral in identifying both the short- and long-term consequences of stress exposure and suggest that whether it is disruption to parental care or social isolation, chronic exposure to early life stress increases corticosterone, changes the expression of neurotransmitters and neuromodulators, and facilitates structural alterations to the hypothalamus, hippocampus, and amygdala, influencing how these brain regions communicate with other reward-related substrates. Herein, we describe how adverse early life experiences influence social behavioral outcomes across a wide range of species and highlight the long-term biological mechanisms that are most relevant to maladaptive aggressive behavior.
    Language English
    Publishing date 2023-11-20
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2023.11.005
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  4. Article ; Online: Central regulation of stress-evoked peripheral immune responses.

    Chan, Kenny L / Poller, Wolfram C / Swirski, Filip K / Russo, Scott J

    Nature reviews. Neuroscience

    2023  Volume 24, Issue 10, Page(s) 591–604

    Abstract: Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are associated with systemic inflammation. Recent studies have reported stress-induced alterations in haematopoiesis that result in monocytosis, neutrophilia, ... ...

    Abstract Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are associated with systemic inflammation. Recent studies have reported stress-induced alterations in haematopoiesis that result in monocytosis, neutrophilia, lymphocytopenia and, consequently, in the upregulation of pro-inflammatory processes in immunologically relevant peripheral tissues. There is now evidence that this peripheral inflammation contributes to the development of psychiatric symptoms as well as to common co-morbidities of psychiatric disorders such as metabolic syndrome and immunosuppression. Here, we review the specific brain and spinal regions, and the neuronal populations within them, that respond to stress and transmit signals to peripheral tissues via the autonomic nervous system or neuroendocrine pathways to influence immunological function. We comprehensively summarize studies that have employed retrograde tracing to define neurocircuits linking the brain to the bone marrow, spleen, gut, adipose tissue and liver. Moreover, we highlight studies that have used chemogenetic or optogenetic manipulation or intracerebroventricular administration of peptide hormones to control somatic immune responses. Collectively, this growing body of literature illustrates potential mechanisms through which stress signals are conveyed from the CNS to immune cells to regulate stress-relevant behaviours and comorbid pathophysiology.
    MeSH term(s) Humans ; Depressive Disorder, Major ; Adipose Tissue ; Anxiety ; Inflammation ; Immunity
    Language English
    Publishing date 2023-08-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-023-00729-2
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  5. Article ; Online: Brain-spleen connection aids antibody production.

    Cathomas, Flurin / Russo, Scott J

    Nature

    2020  Volume 581, Issue 7807, Page(s) 142–143

    MeSH term(s) Antibody Formation ; Brain ; Immunity, Humoral ; Spleen
    Language English
    Publishing date 2020-05-13
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-01168-0
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  6. Article ; Online: Non-invasive chemogenetics.

    Menard, Caroline / Russo, Scott J

    Nature biomedical engineering

    2019  Volume 2, Issue 7, Page(s) 467–468

    MeSH term(s) Designer Drugs ; Neurons
    Chemical Substances Designer Drugs
    Language English
    Publishing date 2019-04-01
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2157-846X
    ISSN (online) 2157-846X
    DOI 10.1038/s41551-018-0269-z
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  7. Article ; Online: The Neurobiology of Resilience: Complexity and Hope.

    Murrough, James W / Russo, Scott J

    Biological psychiatry

    2019  Volume 86, Issue 6, Page(s) 406–409

    MeSH term(s) Adaptation, Psychological ; Humans ; Hypothalamo-Hypophyseal System/physiology ; Neurobiology ; Resilience, Psychological ; Stress, Psychological/physiopathology ; Stress, Psychological/psychology
    Language English
    Publishing date 2019-08-13
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2019.07.016
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  8. Article ; Online: Using social rank as the lens to focus on the neural circuitry driving stress coping styles.

    LeClair, Katherine B / Russo, Scott J

    Current opinion in neurobiology

    2021  Volume 68, Page(s) 167–180

    Abstract: Social hierarchy position in humans is negatively correlated with stress-related psychiatric disease risk. Animal models have largely corroborated human studies, showing that social rank can impact stress susceptibility and is considered to be a major ... ...

    Abstract Social hierarchy position in humans is negatively correlated with stress-related psychiatric disease risk. Animal models have largely corroborated human studies, showing that social rank can impact stress susceptibility and is considered to be a major risk factor in the development of psychiatric illness. Differences in stress coping style is one of several factors that mediate this relationship between social rank and stress susceptibility. Coping styles encompass correlated groupings of behaviors associated with differential physiological stress responses. Here, we discuss recent insights from animal models that highlight several neural circuits that can contribute to social rank-associated differences in coping style.
    MeSH term(s) Adaptation, Psychological ; Animals ; Humans ; Mental Disorders ; Stress, Psychological
    Language English
    Publishing date 2021-04-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2021.03.007
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    Zs.A 3260: Show issues Location:
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  9. Article ; Online: Neurovascular adaptations modulating cognition, mood, and stress responses.

    Dion-Albert, Laurence / Dudek, Katarzyna A / Russo, Scott J / Campbell, Matthew / Menard, Caroline

    Trends in neurosciences

    2023  Volume 46, Issue 4, Page(s) 276–292

    Abstract: The neurovascular unit (NVU) is a dynamic center for substance exchange between the blood and the brain, making it an essential gatekeeper for central nervous system (CNS) homeostasis. Recent evidence supports a role for the NVU in modulating brain ... ...

    Abstract The neurovascular unit (NVU) is a dynamic center for substance exchange between the blood and the brain, making it an essential gatekeeper for central nervous system (CNS) homeostasis. Recent evidence supports a role for the NVU in modulating brain function and cognition. In addition, alterations in NVU processes are observed in response to stress, although the mechanisms via which they can affect mood and cognitive functions remain elusive. Here, we summarize recent studies of neurovascular regulation of emotional processes and cognitive function, including under stressful conditions. We also highlight relevant RNA-sequencing (RNA-seq) databases aiming to profile the NVU along with innovative tools to study and manipulate NVU function that can be exploited in the context of cognition and stress research throughout development, aging, or brain disorders.
    MeSH term(s) Humans ; Brain ; Brain Diseases ; Cognition ; Emotions ; Aging ; Blood-Brain Barrier
    Language English
    Publishing date 2023-02-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2023.01.005
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  10. Article ; Online: Recent advances in the study of aggression.

    Flanigan, Meghan E / Russo, Scott J

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2018  Volume 44, Issue 2, Page(s) 241–244

    MeSH term(s) Aggression/physiology ; Aggression/psychology ; Animals ; Brain/physiology ; Humans
    Language English
    Publishing date 2018-09-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-018-0226-2
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