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  1. Article ; Online: HPV16 conjunctival squamous cell carcinoma.

    Chiodi, Stefano / Romano, Nicola / Mosci, Carlo / Castaldi, Antonio / Rutigliani, Mariangela

    The American journal of the medical sciences

    2022  Volume 365, Issue 1, Page(s) e7–e8

    MeSH term(s) Humans ; Human papillomavirus 16 ; Carcinoma, Squamous Cell/pathology ; Papillomavirus Infections/complications ; Papillomavirus Infections/pathology
    Language English
    Publishing date 2022-09-19
    Publishing country United States
    Document type Letter
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2022.08.021
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  2. Article ; Online: Giant Granuloma Simulating Brain Tumor as Isolated Manifestation of Tuberculosis.

    Fischetti, Aldo / Romano, Nicola / Rutigliani, Mariangela / Feasi, Marcello / Castaldi, Antonio

    The American journal of the medical sciences

    2021  Volume 363, Issue 2, Page(s) e19–e20

    MeSH term(s) Brain Neoplasms/diagnostic imaging ; Granuloma/diagnostic imaging ; Humans ; Tuberculosis/complications ; Tuberculosis/diagnosis
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Letter
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2021.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Positive peritoneal swab in SARS-CoV-2 patients undergoing abdominal emergency surgery: effect or cause?

    Tartaglia, Dario / Barberis, Andrea / Coccolini, Federico / Pistello, Mauro / Rutigliani, Mariangela / Chiarugi, Massimo

    Infection

    2022  Volume 50, Issue 4, Page(s) 989–993

    Abstract: Purpose: The presence of the SARS-CoV-2 in the peritoneal fluid is a matter of debate in the COVID-19 literature. The study aimed to report the prevalence of SARS-CoV-2 in the peritoneal fluid of patients with nasopharyngeal swab tested positive for ... ...

    Abstract Purpose: The presence of the SARS-CoV-2 in the peritoneal fluid is a matter of debate in the COVID-19 literature. The study aimed to report the prevalence of SARS-CoV-2 in the peritoneal fluid of patients with nasopharyngeal swab tested positive for SARS-CoV-2 undergoing emergency surgery and review the literature.
    Methods: The present study was conducted between March 2020 and June 2021. Diagnosis of SARS-CoV-2 positivity was confirmed by preoperative real-time reverse transcriptase-polymerase chain reaction (RT-PCR).
    Results: Eighteen patients with positive nasopharyngeal swabs were operated in emergency in two third-level Italian hospitals. In 13 of these patients (72%), a peritoneal swab was analyzed: SARS-CoV-2 RNA was found in the abdominal fluid of two patients (15%). Neither of them had visceral perforation and one patient died. In ten patients with negative peritoneal swabs, visceral perforation and mortality rates were 30% and 20%, respectively.
    Conclusion: SARS-CoV-2 peritoneal positivity is rare. Abdominal surgery can, therefore, be safely performed in patients with COVID-19 using standard precautions. The correlation with a visceral perforation is not evaluable. The clinical outcomes seem uninfluenced by the viral colonization of the peritoneum. Assessment in large series to provide definitive answers about the involvement of the SARS-CoV-2 in the peritoneum will be challenging to coordinate.
    MeSH term(s) COVID-19/diagnosis ; COVID-19 Testing ; Humans ; RNA, Viral/genetics ; Real-Time Polymerase Chain Reaction ; SARS-CoV-2/genetics
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2022-03-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01785-z
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  4. Article: Catastrophic ACTH-secreting pheochromocytoma: an uncommon and challenging entity with multifaceted presentation.

    Foppiani, Luca / Poeta, Maria Gabriella / Rutigliani, Mariangela / Parodi, Simona / Catrambone, Ugo / Cavalleri, Lorenzo / Antonucci, Giancarlo / Del Monte, Patrizia / Piccardo, Arnoldo

    Endocrinology, diabetes & metabolism case reports

    2023  Volume 2023, Issue 2

    Abstract: Summary: Cushing's syndrome due to ectopic adrenocorticotropic hormone (ACTH) secretion (EAS) by a pheochromocytoma is a challenging condition. A woman with hypertension and an anamnestic report of a 'non-secreting' left adrenal mass developed ... ...

    Abstract Summary: Cushing's syndrome due to ectopic adrenocorticotropic hormone (ACTH) secretion (EAS) by a pheochromocytoma is a challenging condition. A woman with hypertension and an anamnestic report of a 'non-secreting' left adrenal mass developed uncontrolled blood pressure (BP), hyperglycaemia and severe hypokalaemia. ACTH-dependent severe hypercortisolism was ascertained in the absence of Cushingoid features, and a psycho-organic syndrome developed. Brain imaging revealed a splenial lesion of the corpus callosum and a pituitary microadenoma. The adrenal mass displayed high uptake on both 18F-FDG PET/CT and 68Ga-DOTATOC PET/CT; urinary metanephrine levels were greatly increased. The combination of antihypertensive drugs, high-dose potassium infusion, insulin and steroidogenesis inhibitor normalized BP, metabolic parameters and cortisol levels; laparoscopic left adrenalectomy under intravenous hydrocortisone infusion was performed. On combined histology and immunohistochemistry, an ACTH-secreting pheochromocytoma was diagnosed. The patient's clinical condition improved and remission of both hypercortisolism and catecholamine hypersecretion ensued. Brain magnetic resonance imaging showed a reduction of the splenial lesion. Off-therapy BP and metabolic parameters remained normal. The patient was discharged on cortisone replacement therapy for post-surgical hypocortisolism. EAS due to pheochromocytoma displays multifaceted clinical features and requires prompt diagnosis and multidisciplinary management in order to overcome the related severe clinical derangements.
    Learning points: A small but significant number of cases of adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome are caused by ectopic ACTH secretion by neuroendocrine tumours, which is usually associated with severe hypercortisolism causing severe clinical and metabolic derangements. Ectopic ACTH secretion by a pheochromocytoma is exceedingly rare but can be life-threatening, owing to the simultaneous excess of both cortisol and catecholamines. The combination of biochemical and hormonal testing and imaging procedures is mandatory for the diagnosis of ectopic ACTH secretion, and in the presence of an adrenal mass, the possibility of an ACTH-secreting pheochromocytoma should be taken into account. Immediate-acting steroidogenesis inhibitors are required for the treatment of hypercortisolism, and catecholamine excess should also be appropriately managed before surgical removal of the tumour. A multidisciplinary approach is required for the treatment of this challenging entity.
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2785530-2
    ISSN 2052-0573
    ISSN 2052-0573
    DOI 10.1530/EDM-22-0308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Gastric glomus tumor: Endoscopy, MD-CT and pathologic features.

    Rossi, Umberto G / Rutigliani, Mariangela / Paparo, Francesco / Filauro, Marco

    Gastroenterologia y hepatologia

    2020  Volume 44, Issue 1, Page(s) 35–36

    MeSH term(s) Gastroscopy ; Glomus Tumor/diagnostic imaging ; Glomus Tumor/pathology ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography ; Pyloric Antrum/diagnostic imaging ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/pathology
    Language Spanish
    Publishing date 2020-04-28
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2020.03.006
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    Zs.A 2044: Show issues Location:
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  6. Article ; Online: MRI appearance of anaplastic extraventricular ependymoma.

    Romano, Nicola / Fischetti, Aldo / Rutigliani, Mariangela / Marinaro, Eugenio Lucio / Castaldi, Antonio

    Acta neurologica Belgica

    2021  Volume 122, Issue 6, Page(s) 1591–1593

    MeSH term(s) Humans ; Ependymoma/diagnostic imaging ; Magnetic Resonance Imaging ; Brain Neoplasms/diagnostic imaging
    Language English
    Publishing date 2021-01-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-020-01586-x
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  7. Article: Hepatic and splenic sarcoidosis as multiple micro-nodular formations.

    Rossi, Umberto G / Rutigliani, Mariangela / Antonucci, Giancarlo / Rollandi, Gian Andrea

    Gastroenterologia y hepatologia

    2019  Volume 43, Issue 2, Page(s) 95–96

    MeSH term(s) Female ; Humans ; Liver Diseases/diagnostic imaging ; Liver Diseases/pathology ; Middle Aged ; Sarcoidosis/diagnostic imaging ; Sarcoidosis/pathology ; Splenic Diseases/diagnostic imaging ; Splenic Diseases/pathology
    Language Spanish
    Publishing date 2019-10-18
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2019.08.002
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  8. Article ; Online: Aromatase Inhibitors as Adjuvant Treatment for ER/PgR Positive Stage I Endometrial Carcinoma: A Retrospective Cohort Study.

    Paleari, Laura / Rutigliani, Mariangela / Siri, Giacomo / Provinciali, Nicoletta / Colombo, Nicoletta / Decensi, Andrea

    International journal of molecular sciences

    2020  Volume 21, Issue 6

    Abstract: Objective: Although endometrial cancer (EC) is a hormone dependent neoplasm, there are no recommendations for the determination of steroid hormone receptors in the tumor tissue and no hormone therapy has ever been assessed in the adjuvant setting. The ... ...

    Abstract Objective: Although endometrial cancer (EC) is a hormone dependent neoplasm, there are no recommendations for the determination of steroid hormone receptors in the tumor tissue and no hormone therapy has ever been assessed in the adjuvant setting. The purpose of this study was to explore the effect of adjuvant aromatase inhibitors (AIs) on progression-free survival (PFS) and overall survival (OS) in patients with early stage and steroid receptors-positive EC.
    Methods: We retrospectively analyzed clinical and pathological factors in 73 patients with high-risk (49.3%) or low-risk (50.7%) stage I (
    Results: Univariate and multivariate Cox proportional regression analyses, adjusted for age, grade, stage, depth of myometrial invasion, lymphovascular space invasion, BMI, ER, PgR and Ki-67 labeling index levels, showed that PFS and OS had a trend to be longer in patients receiving AI than in the reference group HR= 0.23 (95% CI; 0.04-1.27) for PFS and HR= 0.11 (95% CI; 0.01-1.36) for OS.
    Conclusion: Compared with no treatment, AI exhibited a trend toward a benefit on PFS and OS in patients with early stage hormone receptor-positive EC. Given the exploratory nature of our study, randomized clinical trials for ER/PgR positive EC patients are warranted to assess the clinical benefit of AI and the potential predictive role of steroid receptors and Ki-67.
    MeSH term(s) Aged ; Aged, 80 and over ; Antineoplastic Agents, Hormonal/administration & dosage ; Antineoplastic Agents, Hormonal/adverse effects ; Antineoplastic Agents, Hormonal/therapeutic use ; Aromatase Inhibitors/administration & dosage ; Aromatase Inhibitors/adverse effects ; Aromatase Inhibitors/therapeutic use ; Chemotherapy, Adjuvant ; Endometrial Neoplasms/drug therapy ; Endometrial Neoplasms/metabolism ; Endometrial Neoplasms/mortality ; Endometrial Neoplasms/pathology ; Female ; Humans ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Antineoplastic Agents, Hormonal ; Aromatase Inhibitors ; Receptors, Estrogen ; Receptors, Progesterone
    Language English
    Publishing date 2020-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21062227
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  9. Article ; Online: Collision Tumor Composed of an Inflammatory Myofibroblastic Tumor and Adenocarcinoma of the Colon: a Rare Entity.

    Cornacchia, Chiara / Rutigliani, Mariangela / Belli, Fiorenza / Romano, Nicola / Serventi, Alberto / Fiocca, Roberto / Filauro, Marco

    Journal of gastrointestinal and liver diseases : JGLD

    2020  Volume 29, Issue 3, Page(s) 461–463

    Abstract: This report presents the case of an 83-year old man with a collision tumor consisting of an inflammatory myofibroblastic tumor (IMT) and adenocarcinoma of the left colon. As the clinical and radiologic features of IMT are non-specific, only the accurate ... ...

    Abstract This report presents the case of an 83-year old man with a collision tumor consisting of an inflammatory myofibroblastic tumor (IMT) and adenocarcinoma of the left colon. As the clinical and radiologic features of IMT are non-specific, only the accurate histopathological examination from the left hemicolectomy specimen was diagnostic. Although the prognosis of a colorectal IMT seemed more favorable than in other sites, four months after surgery the patient developed a tumor relapse. Therefore, malignant behavior of IMT could not be totally excluded. Recent studies have demonstrated that a chromosomal rearrangement involving 2p23, the site of the anaplastic lymphoma kinase (ALK) gene, is present in a subset of these tumors. In our patient, tumor cells did not present ALK-1 perinuclear positivity and it could have indicated a less favorable prognosis. The collision of these different entities is extremely rare and this is the first case reported in literature. Further cases of collision tumors with clinical information including their treatment and prognosis are needed.
    MeSH term(s) Adenocarcinoma/chemistry ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Biopsy ; Colectomy ; Colonic Neoplasms/chemistry ; Colonic Neoplasms/pathology ; Colonic Neoplasms/surgery ; Fatal Outcome ; Granuloma, Plasma Cell/metabolism ; Granuloma, Plasma Cell/pathology ; Granuloma, Plasma Cell/surgery ; Humans ; Immunohistochemistry ; Male ; Neoplasms, Complex and Mixed/chemistry ; Neoplasms, Complex and Mixed/pathology ; Neoplasms, Complex and Mixed/surgery ; Treatment Outcome
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-09-09
    Publishing country Romania
    Document type Case Reports
    ZDB-ID 2427021-0
    ISSN 1842-1121 ; 1841-8724
    ISSN (online) 1842-1121
    ISSN 1841-8724
    DOI 10.15403/jgld-782
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    Zs.A 3825: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article: Facial Artery Arteriovenous Malformation Endovascular and Surgical Treatment: Liquid Embolic Device an Advantage for Both Technique.

    Rossi, Umberto G / Verrina, Giuseppe / Ieradi, Anna Maria / Rutigliani, Mariangela / Cariati, Maurizio

    Acta neurologica Taiwanica

    2020  Volume 292, Page(s) 54–58

    Abstract: Facial ArterioVenous Malformations (AVM) are rare lesions and present great difficulty in their diagnosis and treatment. We report a case of a 24-year-old male who has been diagnosed a right facial AVM that underwent endovascular embolization with a ... ...

    Abstract Facial ArterioVenous Malformations (AVM) are rare lesions and present great difficulty in their diagnosis and treatment. We report a case of a 24-year-old male who has been diagnosed a right facial AVM that underwent endovascular embolization with a liquid embolic device and consequently surgical resection. The type of liquid embolic device used has given advantage for both treatment techniques.
    MeSH term(s) Arteries ; Embolization, Therapeutic ; Humans ; Intracranial Arteriovenous Malformations ; Male ; Young Adult
    Language English
    Publishing date 2020-05-20
    Publishing country China (Republic : 1949- )
    Document type Case Reports ; Journal Article
    ZDB-ID 2192417-X
    ISSN 1028-768X ; 1019-6099
    ISSN 1028-768X ; 1019-6099
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