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  1. Article ; Online: Overall survival in patients with re-excision of positive microscopic margins of limb and trunk wall soft tissue sarcoma operated outside of a reference center: a nationwide cohort analysis.

    Gouin, Francois / Stoeckle, Eberhard / Honoré, Charles / Ropars, Mickael / Jafari, Mehrdad / Mattei, Jean Camille / Rochwerger, Alexandre / Carrere, Sébastien / Waast, Denis / Ferron, Gwenaël / Machiavello, Jean-Christophe / Anract, Philippe / Marchal, Frédéric / Sirveaux, François / Marco, Oren / Guiramand, Jérôme / Paquette, Brice / Di Marco, Antonio / Causeret, Sylvain /
    Guilloit, Jean-Marc / Soibinet, Pauline / Tzanis, Dimitri / Gimbergues, Pierre / Fiorenza, Fabrice / Dujardin, Franck / Le Nail, Louis R / Ruzic, Jean-Christophe / Chemin-Airiau, Claire / Morelle, Magali / Meeus, Pierre / Karanian, Marie / Le Loarer, François / Vaz, Gualter / Blay, Jean-Yves

    BMC cancer

    2022  Volume 22, Issue 1, Page(s) 1034

    MeSH term(s) Cohort Studies ; Extremities/pathology ; Extremities/surgery ; Humans ; Margins of Excision ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Prospective Studies ; Retrospective Studies ; Sarcoma/pathology ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/surgery
    Language English
    Publishing date 2022-10-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-022-10121-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Management and outcomes of adolescent and young adult sarcoma patients: results from the French nationwide database NETSARC.

    Kubicek, Pierre / Cesne, Axel Le / Lervat, Cyril / Toulmonde, Maud / Chevreau, Christine / Duffaud, Florence / Le Nail, Louis-Romée / Morelle, Magali / Gaspar, Nathalie / Vérité, Cécile / Castex, Marie-Pierre / Penel, Nicolas / Saada, Esma / Causeret, Sylvain / Bertucci, François / Perrin, Christophe / Bompas, Emmanuelle / Orbach, Daniel / Laurence, Valérie /
    Piperno-Neumann, Sophie / Anract, Philippe / Rios, Maria / Gentet, Jean-Claude / Mascard, Éric / Pannier, Stéphanie / Blouin, Pascale / Carrère, Sébastien / Chaigneau, Loïc / Soibinet-Oudot, Pauline / Corradini, Nadège / Boudou-Rouquette, Pascaline / Ruzic, Jean-Christophe / Lebrun-Ly, Valérie / Dubray-Longeras, Pascale / Varatharajah, Sharmini / Lebbe, Céleste / Ropars, Mickaël / Kurtz, Jean-Emmanuel / Guillemet, Cécile / Lotz, Jean-Pierre / Berchoud, Juliane / Cherrier, Grégory / Ducimetière, Françoise / Chemin, Claire / Italiano, Antoine / Honoré, Charles / Desandes, Emmanuel / Blay, Jean-Yves / Gouin, François / Marec-Bérard, Perrine

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 69

    Abstract: Background: The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young ...

    Abstract Background: The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young adults (AYAs) patients with sarcoma at the national level.
    Patients and methods: NETSARC database gathers regularly monitored and updated data from patients with sarcoma. NETSARC was queried for patients (15-30 years) with sarcoma diagnosed from 2010 to 2017 for whom tumor resection had been performed. We reported management, locoregional recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) in AYA treated in French reference sarcoma centers (RSC) and outside RSC (non-RSC) and conducted multivariable survival analyses adjusted for classical prognostic factors.
    Results: Among 3,227 patients aged 15-30 years with sarcoma diagnosed between 2010 and 2017, the study included 2,227 patients with surgery data available, among whom 1,290 AYAs had been operated in RSC, and 937 AYAs in non-RSC. Significant differences in compliance to guidelines were observed including pre-treatment biopsy (RSC: 85.9%; non-RSC 48.1%), pre-treatment imaging (RSC: 86.8%; non-RSC: 56.5%) and R0 margins (RSC 57.6%; non-RSC: 20.2%) (p < 0.001). 3y-OS rates were 81.1% (95%CI 78.3-83.6) in AYA in RSC and 82.7% (95%CI 79.4-85.5) in AYA in non-RSC, respectively. Whereas no significant differences in OS was observed in AYAs treated in RSC and in non-RSC, LRFS and PFS were improved in AYAs treated in RSC compared to AYAs treated in non-RSC (Hazard Ratios (HR): 0.58 and 0.83, respectively).
    Conclusions: This study highlights the importance for AYA patients with sarcoma to be managed in national sarcoma reference centers involving multidisciplinary medical teams with paediatric and adult oncologists.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Child ; Prospective Studies ; Sarcoma/diagnosis ; Sarcoma/surgery ; Soft Tissue Neoplasms/surgery ; Databases, Factual ; Progression-Free Survival
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-10556-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: No Geographical Inequalities in Survival for Sarcoma Patients in France: A Reference Networks' Outcome?

    Fayet, Yohan / Chevreau, Christine / Decanter, Gauthier / Dalban, Cécile / Meeus, Pierre / Carrère, Sébastien / Haddag-Miliani, Leila / Le Loarer, François / Causeret, Sylvain / Orbach, Daniel / Kind, Michelle / Le Nail, Louis-Romée / Ferron, Gwenaël / Labrosse, Hélène / Chaigneau, Loïc / Bertucci, François / Ruzic, Jean-Christophe / Le Brun Ly, Valérie / Farsi, Fadila /
    Bompas, Emmanuelle / Noal, Sabine / Vozy, Aurore / Ducoulombier, Agnes / Bonnet, Clément / Chabaud, Sylvie / Ducimetière, Françoise / Tlemsani, Camille / Ropars, Mickaël / Collard, Olivier / Michelin, Paul / Gantzer, Justine / Dubray-Longeras, Pascale / Rios, Maria / Soibinet, Pauline / Le Cesne, Axel / Duffaud, Florence / Karanian, Marie / Gouin, François / Tétreau, Raphaël / Honoré, Charles / Coindre, Jean-Michel / Ray-Coquard, Isabelle / Bonvalot, Sylvie / Blay, Jean-Yves

    Cancers

    2022  Volume 14, Issue 11

    Abstract: The national reference network NETSARC+ provides remote access to specialized diagnosis and the Multidisciplinary Tumour Board (MTB) to improve the management and survival of sarcoma patients in France. The IGéAS research program aims to assess the ... ...

    Abstract The national reference network NETSARC+ provides remote access to specialized diagnosis and the Multidisciplinary Tumour Board (MTB) to improve the management and survival of sarcoma patients in France. The IGéAS research program aims to assess the potential of this innovative organization to address geographical inequalities in cancer management. Using the IGéAS cohort built from the nationwide NETSARC+ database, the individual, clinical, and geographical determinants of the 3-year overall survival of sarcoma patients in France were analyzed. The survival analysis was focused on patients diagnosed in 2013 (n = 2281) to ensure sufficient hindsight to collect patient follow-up. Our study included patients with bone (16.8%), soft-tissue (69%), and visceral (14.2%) sarcomas, with a median age of 61.8 years. The overall survival was not associated with geographical variables after adjustment for individual and clinical factors. The lower survival in precarious population districts [HR 1.23, 95% CI 1.02 to 1.48] in comparison to wealthy metropolitan areas (HR = 1) found in univariable analysis was due to the worst clinical presentation at diagnosis of patients. The place of residence had no impact on sarcoma patients' survival, in the context of the national organization driven by the reference network. Following previous findings, this suggests the ability of this organization to go through geographical barriers usually impeding the optimal management of cancer patients.
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14112620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Determinants of the access to remote specialised services provided by national sarcoma reference centres.

    Fayet, Yohan / Tétreau, Raphaël / Honoré, Charles / Le Nail, Louis-Romée / Dalban, Cécile / Gouin, François / Causeret, Sylvain / Piperno-Neumann, Sophie / Mathoulin-Pelissier, Simone / Karanian, Marie / Italiano, Antoine / Chaigneau, Loïc / Gantzer, Justine / Bertucci, François / Ropars, Mickael / Saada-Bouzid, Esma / Cordoba, Abel / Ruzic, Jean-Christophe / Varatharajah, Sharmini /
    Ducimetière, Françoise / Chabaud, Sylvie / Dubray-Longeras, Pascale / Fiorenza, Fabrice / De Percin, Sixtine / Lebbé, Céleste / Soibinet, Pauline / Michelin, Paul / Rios, Maria / Farsi, Fadila / Penel, Nicolas / Bompas, Emmanuelle / Duffaud, Florence / Chevreau, Christine / Le Cesne, Axel / Blay, Jean-Yves / Le Loarer, François / Ray-Coquard, Isabelle

    BMC cancer

    2021  Volume 21, Issue 1, Page(s) 631

    Abstract: Background: Spatial inequalities in cancer management have been evidenced by studies reporting lower quality of care or/and lower survival for patients living in remote or socially deprived areas. NETSARC+ is a national reference network implemented to ... ...

    Abstract Background: Spatial inequalities in cancer management have been evidenced by studies reporting lower quality of care or/and lower survival for patients living in remote or socially deprived areas. NETSARC+ is a national reference network implemented to improve the outcome of sarcoma patients in France since 2010, providing remote access to specialized diagnosis and Multidisciplinary Tumour Board (MTB). The IGéAS research program aims to assess the potential of this innovative organization, with remote management of cancers including rare tumours, to go through geographical barriers usually impeding the optimal management of cancer patients.
    Methods: Using the nationwide NETSARC+ databases, the individual, clinical and geographical determinants of the access to sarcoma-specialized diagnosis and MTB were analysed. The IGéAS cohort (n = 20,590) includes all patients living in France with first sarcoma diagnosis between 2011 and 2014. Early access was defined as specialised review performed before 30 days of sampling and as first sarcoma MTB discussion performed before the first surgery.
    Results: Some clinical populations are at highest risk of initial management without access to sarcoma specialized services, such as patients with non-GIST visceral sarcoma for diagnosis [OR 1.96, 95% CI 1.78 to 2.15] and MTB discussion [OR 3.56, 95% CI 3.16 to 4.01]. Social deprivation of the municipality is not associated with early access on NETSARC+ remote services. The quintile of patients furthest away from reference centres have lower chances of early access to specialized diagnosis [OR 1.18, 95% CI 1.06 to 1.31] and MTB discussion [OR 1.24, 95% CI 1.10 to 1.40] but this influence of the distance is slight in comparison with clinical factors and previous studies on the access to cancer-specialized facilities.
    Conclusions: In the context of national organization driven by reference network, distance to reference centres slightly alters the early access to sarcoma specialized services and social deprivation has no impact on it. The reference networks' organization, designed to improve the access to specialized services and the quality of cancer management, can be considered as an interesting device to reduce social and spatial inequalities in cancer management. The potential of this organization must be confirmed by further studies, including survival analysis.
    MeSH term(s) Adolescent ; Adult ; Aged ; Databases, Factual/statistics & numerical data ; Female ; France ; Health Services Accessibility/organization & administration ; Health Services Accessibility/statistics & numerical data ; Healthcare Disparities/organization & administration ; Healthcare Disparities/statistics & numerical data ; Humans ; Male ; Medical Oncology/organization & administration ; Medical Oncology/statistics & numerical data ; Middle Aged ; Patient Care Team/organization & administration ; Patient Care Team/statistics & numerical data ; Quality of Health Care ; Remote Consultation/organization & administration ; Remote Consultation/statistics & numerical data ; Sarcoma/diagnosis ; Sarcoma/therapy ; Young Adult
    Language English
    Publishing date 2021-05-29
    Publishing country England
    Document type Journal Article
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/s12885-021-08393-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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