Result 1 - 10 of total 171
für Hornquartett
(Exempla nova ; 597)
2014
| Title translation | Ruzicka |
|---|---|
| Author's details | Peter Ruzicka |
| Series title | Exempla nova ; 597 |
| Language | German |
| Size | 7 S |
| Edition | Partitur |
| Publisher | Sikorski |
| Publishing place | Hamburg |
| Document type | Book |
| Database | Former special subject collection: coastal and deep sea fishing |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Nachzeichnung für Klavier
(Exempla nova ; 586)
2014
| Author's details | Peter Ruzicka |
|---|---|
| Series title | Exempla nova ; 586 |
| Language | German |
| Size | 11 S |
| Publisher | Sikorski |
| Publishing place | Hamburg |
| Document type | Book |
| Database | Former special subject collection: coastal and deep sea fishing |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2024
Abstract: Imaging-based methods are widely used for studying the subcellular localization of proteins in living cells. While routine for individual proteins, global monitoring of protein dynamics following perturbation typically relies on arrayed panels of ... ...
| Abstract | Imaging-based methods are widely used for studying the subcellular localization of proteins in living cells. While routine for individual proteins, global monitoring of protein dynamics following perturbation typically relies on arrayed panels of fluorescently tagged cell lines, limiting throughput and scalability. Here, we describe a strategy that combines high-throughput microscopy, computer vision and machine learning to detect perturbation-induced changes in multicolour tagged visual proteomics cell (vpCell) pools. We use genome-wide and cancer-focused intron-targeting sgRNA libraries to generate vpCell pools and a large, arrayed collection of clones each expressing two different endogenously tagged fluorescent proteins. Individual clones can be identified in vpCell pools by image analysis using the localization patterns and expression level of the tagged proteins as visual barcodes, enabling simultaneous live-cell monitoring of large sets of proteins. To demonstrate broad applicability and scale, we test the effects of antiproliferative compounds on a pool with cancer-related proteins, on which we identify widespread protein localization changes and new inhibitors of the nuclear import/export machinery. The time-resolved characterization of changes in subcellular localization and abundance of proteins upon perturbation in a pooled format highlights the power of the vpCell approach for drug discovery and mechanism-of-action studies. |
|---|---|
| Language | English |
| Publishing date | 2024-04-19 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1474722-4 |
| ISSN | 1476-4679 ; 1465-7392 |
| ISSN (online) | 1476-4679 |
| ISSN | 1465-7392 |
| DOI | 10.1038/s41556-024-01407-w |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5169: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.MG 12: Show issues |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
(Zwoelf_essay : Denkheft ; 5)
2013
| Institution | Hochschule für Musik und Theater Hamburg |
|---|---|
| Author's details | Peter Ruzicka |
| Series title | Zwoelf_essay : Denkheft ; 5 |
| Language | German |
| Size | 4 S. |
| Publisher | Hochschule für Musik und Theater |
| Publishing place | Hamburg |
| Document type | Book |
| Database | Former special subject collection: coastal and deep sea fishing |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
späte Gedanken für Klavier
(Exempla nova ; 521)
2013
| Author's details | Peter Ruzicka |
|---|---|
| Series title | Exempla nova ; 521 |
| Language | German |
| Size | 15 S |
| Publisher | Sikorski |
| Publishing place | Hamburg |
| Document type | Book |
| Database | Former special subject collection: coastal and deep sea fishing |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Hommage für Kammerensemble : Partitur
(Exempla nova ; 504)
2012
| Author's details | score / Peter Ruzicka |
|---|---|
| Series title | Exempla nova ; 504 |
| Language | German |
| Size | 22 S. |
| Edition | Partitur |
| Publisher | Sikorski |
| Publishing place | Hamburg |
| Document type | Book |
| Note | Aufführungsdauer: ca. 11 Minuten |
| Database | Former special subject collection: coastal and deep sea fishing |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
(Exempla nova ; 524)
2012
| Title translation | Stücke, Klar, 2012 |
|---|---|
| Author's details | Peter Ruzicka |
| Series title | Exempla nova ; 524 |
| Language | German |
| Size | 9 S |
| Publisher | Sikorski |
| Publishing place | Hamburg |
| Document type | Book |
| Database | Former special subject collection: coastal and deep sea fishing |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Erinnerung für Orchester
(Exempla nova ; 505)
2011
| Title translation | Ruzicka : Peter |
|---|---|
| Title variant | Mahler-Bild |
| Author's details | Peter Ruzicka |
| Series title | Exempla nova ; 505 |
| Language | German ; Malay |
| Size | 22 S. |
| Edition | Partitur |
| Publisher | Sikorski |
| Publishing place | Hamburg |
| Document type | Book |
| Note | Als Ms. des Komp. gedr. |
| Database | Former special subject collection: coastal and deep sea fishing |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Musik für Oboe und Kammerorchester
(Exempla nova ; 501)
2011
| Title translation | Ruzicka : Peter |
|---|---|
| Title variant | Music for oboe and chamber orchestra |
| Author's details | Peter Ruzicka |
| Series title | Exempla nova ; 501 |
| Size | 39 S., 41 cm |
| Edition | Partitur |
| Publisher | Sikorski |
| Publishing place | Hamburg |
| Document type | Book |
| Database | Former special subject collection: coastal and deep sea fishing |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
(Exempla nova ; 454)
2010
| Title translation | Ruzicka : Peter |
|---|---|
| Title variant | 5 for piano |
| Author's details | Peter Ruzicka |
| Series title | Exempla nova ; 454 |
| Size | 16 S. |
| Publisher | Sikorski |
| Publishing place | Hamburg |
| Document type | Book |
| Note | Komponiert 2009 |
| Database | Former special subject collection: coastal and deep sea fishing |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.