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Artikel ; Online: In Response: Using Propensity Score Matching to Balance the Baseline Characteristics.

Ryan, Bríd M

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2021 Band 16, Heft 6, Seite(n) e46

Mesh-Begriff(e)	Humans ; Lung Neoplasms ; Propensity Score
Sprache	Englisch
Erscheinungsdatum	2021-05-25
Erscheinungsland	United States
Dokumenttyp	Letter ; Comment
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1016/j.jtho.2021.02.028
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: When a bad day at the golf course is a bad day at the office: occupational stressors, institutional supports, and the mental health of NCAA golf coaches.

Upenieks, Laura / Ryan, Brendan M / Carson, Howie J

Frontiers in sports and active living

2023 Band 5, Seite(n) 1286965

Abstract: This study examined the mental health of NCAA collegiate golf coaches. Utilizing the person-environment fit theory and previous literature on coaches' well-being, this study examined four outcomes among 48 participants, namely: depressive and anxiety ... ...

Abstract	This study examined the mental health of NCAA collegiate golf coaches. Utilizing the person-environment fit theory and previous literature on coaches' well-being, this study examined four outcomes among 48 participants, namely: depressive and anxiety symptoms, burnout, and job turnover intentions. Results suggested that coaching stressors (e.g., administrative tasks, practice plans, pressure to win) only associate with greater burnout. More consistent evidence showed that workplace stress (e.g., lack of control and autonomy, poor work-family balance) associated with higher levels of all outcomes. Finally, greater perceived organizational support had a beneficial association with each outcome. The findings of the current study suggest golf coaches are at risk of mental health problems because of the stressors of this job. Taken as a whole, athletic departments, coaches, and student-athletes must reconsider norms that overemphasize performance and underemphasize self-care and work-life balance.
Sprache	Englisch
Erscheinungsdatum	2023-11-30
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ISSN	2624-9367
ISSN (online)	2624-9367
DOI	10.3389/fspor.2023.1286965
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Lung cancer health disparities.

Ryan, Bríd M

Carcinogenesis

2018 Band 39, Heft 6, Seite(n) 741–751

Abstract: Compared with all other racial and ethnic groups in the United States, African Americans are disproportionally affected by lung cancer, both in terms of incidence and survival. It is likely that smoking, as the main etiological factor associated with ... ...

Abstract	Compared with all other racial and ethnic groups in the United States, African Americans are disproportionally affected by lung cancer, both in terms of incidence and survival. It is likely that smoking, as the main etiological factor associated with lung cancer, contributes to these disparities, but the precise mechanism is still unclear. This paper seeks to explore the history of lung cancer disparities and review to the literature regarding the various factors that contribute to them.
Mesh-Begriff(e)	African Americans ; Ethnic Groups ; Healthcare Disparities ; Humans ; Incidence ; Lung Neoplasms/etiology ; Smoking/adverse effects ; United States
Sprache	Englisch
Erscheinungsdatum	2018-03-13
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/bgy047
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Oral infliximab nanomedicines for targeted treatment of inflammatory bowel diseases.

Mohan, Lauren J / Daly, Jacqueline S / Ryan, Barbara M / Ramtoola, Zebunnissa

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2023 Band 183, Seite(n) 106379

Abstract: Background and aims: Anti-TNF biological therapies such as infliximab (INF) have revolutionised the treatment of inflammatory bowel diseases (IBD). However, serious adverse effects due to systemic administration can significantly impact patient quality ... ...

Abstract	Background and aims: Anti-TNF biological therapies such as infliximab (INF) have revolutionised the treatment of inflammatory bowel diseases (IBD). However, serious adverse effects due to systemic administration can significantly impact patient quality of life, limiting their success. Oral nanomedicines propose an innovative solution to provide local delivery to inflamed gastrointestinal tissues, thereby limiting systemic exposure and enhancing therapeutic efficacy. This study aimed to examine the potential of INF nanomedicines for IBD treatment with a focus on nanoparticle (NP) size to modulate the targeting of INF to the epithelial barrier. Methods: Healthy and inflamed in vitro models of the intestinal epithelial barrier were established to examine the cell interaction of PLGA-PEGNPs of varying particle sizes and polydispersities. INF-loaded NPs were prepared by electrostatic interaction of INF with NPs and examined for their therapeutic efficacy in the inflamed epithelial cell barrier model. Results: NP interaction was significantly enhanced in the inflamed cell barrier model, with increased transport observed for 130 - 300 nm NPs and accumulation of larger NPs (∼600 nm) at the barrier. Delivery of INF directly to the inflamed barrier by ∼600 nm NPs accelerated recovery of barrier integrity and reduced inflammatory cytokine secretion and cytotoxicity in comparison to treatment with INF alone. Conclusions: Results from this study show that NP particle size can be used to differentially target and treat the inflamed intestinal barrier. Oral INF nanomedicines of modulated size present a novel strategy for the local, targeted treatment of IBD.
Mesh-Begriff(e)	Humans ; Infliximab ; Nanomedicine ; Quality of Life ; Tumor Necrosis Factor Inhibitors ; Intestinal Mucosa ; Inflammatory Bowel Diseases ; Drug Carriers ; Nanoparticles
Chemische Substanzen	Infliximab (B72HH48FLU) ; Tumor Necrosis Factor Inhibitors ; Drug Carriers
Sprache	Englisch
Erscheinungsdatum	2023-01-13
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2023.106379
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: microRNAs in Cancer Susceptibility.

Ryan, Bríd M

Advances in cancer research

2017 Band 135, Seite(n) 151–171

Abstract: microRNAs (miRNAs) are a small RNA species without protein-coding potential. However, they are key modulators of protein translation. Many studies have linked miRNAs with cancer initiation, progression, diagnosis, and prognosis, and recent studies have ... ...

Abstract	microRNAs (miRNAs) are a small RNA species without protein-coding potential. However, they are key modulators of protein translation. Many studies have linked miRNAs with cancer initiation, progression, diagnosis, and prognosis, and recent studies have also linked them with cancer etiology and susceptibility, especially through single-nucleotide polymorphisms (SNPs). This review discusses some of the recent advances in miRNA-SNP literature-including SNPs in miRNA genes, miRNA target sites, and the processing machinery. In addition, we highlight some emerging areas of interest, including isomiRs and non-3'UTR focused miRNA-binding mechanisms that could provide further novel insight into the relationship between miR-SNPs and cancer. Finally, we note that additional epidemiological and experimental research is needed to close the gap in our understanding of the genotype-phenotype relationship between miRNA-SNPs and cancer.
Sprache	Englisch
Erscheinungsdatum	2017
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	127-2
ISSN	2162-5557 ; 0065-230X
ISSN (online)	2162-5557
ISSN	0065-230X
DOI	10.1016/bs.acr.2017.06.004
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Understanding the role of dopamine in cancer: past, present and future.

Grant, Christopher E / Flis, Amy L / Ryan, Bríd M

Carcinogenesis

2022 Band 43, Heft 6, Seite(n) 517–527

Abstract: Dopamine (DA, 3-hydroxytyramine) is a member of the catecholamine family and is classically characterized according to its role in the central nervous system as a neurotransmitter. In recent decades, many novel and intriguing discoveries have been made ... ...

Abstract	Dopamine (DA, 3-hydroxytyramine) is a member of the catecholamine family and is classically characterized according to its role in the central nervous system as a neurotransmitter. In recent decades, many novel and intriguing discoveries have been made about the peripheral expression of DA receptors (DRs) and the role of DA signaling in both normal and pathological processes. Drawing from decades of evidence suggesting a link between DA and cancer, the DA pathway has recently emerged as a potential target in antitumor therapies. Due to the onerous, expensive and frequently unsuccessful nature of drug development, the repurposing of dopaminergic drugs for cancer therapy has the potential to greatly benefit patients and drug developers alike. However, the lack of clear mechanistic data supporting the direct involvement of DRs and their downstream signaling components in cancer represents an ongoing challenge that has limited the translation of these drugs to the clinic. Despite this, the breadth of evidence linking DA to cancer and non-tumor cells in the tumor microenvironment justifies further inquiry into the potential applications of this treatment modality in cancer. Herein, we review the literature characterizing the interplay between the DA signaling axis and cancer, highlighting key findings, and then propose rational lines of investigation to follow.
Mesh-Begriff(e)	Dopamine/metabolism ; Humans ; Neoplasms/drug therapy ; Tumor Microenvironment
Chemische Substanzen	Dopamine (VTD58H1Z2X)
Sprache	Englisch
Erscheinungsdatum	2022-05-27
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/bgac045
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Differential eligibility of African American and European American lung cancer cases using LDCT screening guidelines.

Ryan, Bríd M

BMJ open respiratory research

2016 Band 3, Heft 1, Seite(n) e000166

Abstract: Introduction: Lung cancer incidence and mortality is higher among African Americans compared with European Americans in the USA where screening guidelines are currently in place and based on age at diagnosis and smoking history. Given the different ... ...

Abstract	Introduction: Lung cancer incidence and mortality is higher among African Americans compared with European Americans in the USA where screening guidelines are currently in place and based on age at diagnosis and smoking history. Given the different smoking patterns observed in these populations and the earlier age at which African Americans are diagnosed, it is possible that African Americans will be disproportionally excluded from screening programmes. Methods: We assessed the capture of African American and EA lung cancer cases using the National Lung Screening Trial, US Preventive Services Task Force and Centers for Medicare and Medicaid Services eligibility guidelines in a population of lung cancer cases diagnosed between 1998 and 2014 in the Baltimore region of Maryland (n=1658). Results: We found an absolute increase of 3.8% (relative increase: 11.5%) of EA lung cancer cases that fell within the eligible screening guidelines when compared with African Americans. This difference in proportions was not statistically significant (p=0.134). However, differences were more pronounced among women, where an absolute and relative difference of 4.2% and 13.6%, respectively, was observed (p=0.083). As more EA are likely to successfully quit smoking compared with African Americans, the inclusion of the time since quitting variable decreased the relative differences in eligibility. Conclusions: Current screening guidelines are projected to capture a higher proportion of EA lung cancer cases than African American cases; however, the differences are not statistically significant. Further studies are needed, especially among high-risk populations, to determine if racial differences in eligibility criteria for lung screening will lead to a widening of cancer health disparities.
Sprache	Englisch
Erscheinungsdatum	2016
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2736454-9
ISSN	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2016-000166
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Prenatal smoke exposure, DNA methylation and a link between DRD1 and lung cancer.

Ryan, Bríd M / Robles, Ana I

International journal of epidemiology

2019 Band 48, Heft 4, Seite(n) 1377–1378

Mesh-Begriff(e)	Adult ; CpG Islands ; DNA Methylation ; Female ; Humans ; Lung Neoplasms ; Pregnancy ; Receptors, Dopamine D1 ; Smoke ; Tobacco Smoke Pollution
Chemische Substanzen	DRD1 protein, human ; Receptors, Dopamine D1 ; Smoke ; Tobacco Smoke Pollution
Sprache	Englisch
Erscheinungsdatum	2019-03-13
Erscheinungsland	England
Dokumenttyp	Letter ; Comment
ZDB-ID	187909-1
ISSN	1464-3685 ; 0300-5771
ISSN (online)	1464-3685
ISSN	0300-5771
DOI	10.1093/ije/dyz035
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: DRD1 suppresses cell proliferation and reduces EGFR activation and PD-L1 expression in NSCLC.

Grant, Christopher E / Flis, Amy L / Toulabi, Leila / Zingone, Adriana / Rossi, Emily / Aploks, Krist / Sheppard, Heather / Ryan, Bríd M

Molecular oncology

2024

Abstract: Dopamine (DA) acts in various key neurological and physiological processes as both a neurotransmitter and circulating hormone. Over the past several decades, the DA signaling network has been shown to regulate the progression of several types of solid ... ...

Abstract	Dopamine (DA) acts in various key neurological and physiological processes as both a neurotransmitter and circulating hormone. Over the past several decades, the DA signaling network has been shown to regulate the progression of several types of solid tumors, and considerable evidence has shown it is a druggable pathway in the cancer cell context. However, the specific activity and effect of these pathway components appears to be tissue-type and cell-context-dependent. In the present study, expression and methylation of dopamine receptor D1 (DRD1) were measured using RNA sequencing (RNAseq) and reverse transcription polymerase chain reaction (RT-PCR) in non-small cell lung cancer (NSCLC) samples, and validated using publicly available datasets, including The Cancer Genome Atlas (TCGA). In vitro and in vivo functional experiments were performed for cell proliferation and tumor growth, respectively. Mechanistic analyses of the transcriptome and kinome in DRD1-modulated cells informed further experiments, which characterized the effects on the epidermal growth factor receptor (EGFR) pathway and programmed cell death 1 ligand 1 (PD-L1) proteins. Through these experiments, we identified the DRD1 gene as a negative regulator of disease progression in NSCLC. We show that DRD1, as well as other DA pathway components, are expressed in normal human lung tissue, and that loss of DRD1 expression through promoter hypermethylation is a common feature in NSCLC patients and is associated with worse survival. At the cellular level, DRD1 affects proliferation by inhibiting the activation of EGFR and mitogen-activated protein kinase 1/2 (ERK1/2). Interestingly, we also found that DRD1 regulates the expression of PD-L1 in lung cancer cells. Taken together, these results suggest that DRD1 methylation may constitute a biomarker of poor prognosis in NSCLC patients while other components of this pathway could be targeted to improve response to EGFR- and PD-L1-targeted therapies.
Sprache	Englisch
Erscheinungsdatum	2024-04-04
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2415106-3
ISSN	1878-0261 ; 1574-7891
ISSN (online)	1878-0261
ISSN	1574-7891
DOI	10.1002/1878-0261.13608
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Racial Disparities in Cigarette Smoking Behaviors and Differences Stratified by Metropolitan Area of Residence.

Arauz, Rony F / Mayer, Margaret / Reyes-Guzman, Carolyn / Ryan, Bríd M

International journal of environmental research and public health

2022 Band 19, Heft 5

Abstract: Background: Black cigarette smokers experience a disproportionate burden of non-small cell lung cancer (NSCLC) compared to other racial and ethnic groups, despite starting to smoke later in life, smoking less frequently, and smoking fewer cigarettes per ...

Abstract	Background: Black cigarette smokers experience a disproportionate burden of non-small cell lung cancer (NSCLC) compared to other racial and ethnic groups, despite starting to smoke later in life, smoking less frequently, and smoking fewer cigarettes per day compared with White smokers. Research has shown that these disparities in NSCLC are wider in rural areas. Objective: To examine differences in smoking behaviors between Black and White individuals living in non-metropolitan areas and metropolitan areas. Methods: Using harmonized data from the Tobacco Use Supplement to the Current Population Survey (TUS-CPS) years 2010-2011, 2014-2015, and 2018-2019, we compared smoking behaviors between Black and White current and former smokers by metropolitan status (i.e., whether an individual lives in a densely populated area or not) and by both metropolitan status and sex. Results: Smoking prevalence was higher among White participants living in non-metropolitan versus Black participants. Further, in non-metropolitan areas, Black individuals reported smoking fewer cigarettes per day, fewer years of smoking, and a later age of initiation compared to White individuals. Additionally, Black individuals, especially men, were more likely than White individuals to be current non-daily smokers. Conclusions: Our findings show that Black individuals living in non-metropolitan areas do not, in aggregate, have more cigarette smoking exposure relative to White individuals. Additional research is needed to further understand smoking-related exposures and other factors that may contribute to lung cancer disparities, especially in non-metropolitan areas.
Mesh-Begriff(e)	Carcinoma, Non-Small-Cell Lung ; Cigarette Smoking/epidemiology ; Humans ; Lung Neoplasms/epidemiology ; Male ; Racial Groups ; Smokers
Sprache	Englisch
Erscheinungsdatum	2022-03-02
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19052910
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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