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  1. Article ; Online: Promoting Holistic Care in Familial Hypercholesterolemia: The Case for Family-Centered Science.

    Ryan, Heather H / Martyn-Nemeth, Pamela / Hayman, Laura L

    The Journal of cardiovascular nursing

    2023  

    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639335-4
    ISSN 1550-5049 ; 0889-4655
    ISSN (online) 1550-5049
    ISSN 0889-4655
    DOI 10.1097/JCN.0000000000001004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2315: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Environmental Exposures and Pediatric Cardiology: A Scientific Statement From the American Heart Association.

    Zachariah, Justin P / Jone, Pei-Ni / Agbaje, Andrew O / Ryan, Heather H / Trasande, Leonardo / Perng, Wei / Farzan, Shohreh F

    Circulation

    2024  Volume 149, Issue 20, Page(s) e1165–e1175

    Abstract: Environmental toxicants and pollutants are causes of adverse health consequences, including well-established associations between environmental exposures and cardiovascular diseases. Environmental degradation is widely prevalent and has a long latency ... ...

    Abstract Environmental toxicants and pollutants are causes of adverse health consequences, including well-established associations between environmental exposures and cardiovascular diseases. Environmental degradation is widely prevalent and has a long latency period between exposure and health outcome, potentially placing a large number of individuals at risk of these health consequences. Emerging evidence suggests that environmental exposures in early life may be key risk factors for cardiovascular conditions across the life span. Children are a particularly sensitive population for the detrimental effects of environmental toxicants and pollutants given the long-term cumulative effects of early-life exposures on health outcomes, including congenital heart disease, acquired cardiac diseases, and accumulation of cardiovascular disease risk factors. This scientific statement highlights representative examples for each of these cardiovascular disease subtypes and their determinants, focusing specifically on the associations between climate change and congenital heart disease, airborne particulate matter and Kawasaki disease, blood lead levels and blood pressure, and endocrine-disrupting chemicals with cardiometabolic risk factors. Because children are particularly dependent on their caregivers to address their health concerns, this scientific statement highlights the need for clinicians, research scientists, and policymakers to focus more on the linkages of environmental exposures with cardiovascular conditions in children and adolescents.
    MeSH term(s) Humans ; Environmental Exposure/adverse effects ; United States/epidemiology ; Child ; American Heart Association ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/epidemiology ; Cardiology/standards ; Risk Factors ; Adolescent ; Environmental Pollutants/adverse effects
    Chemical Substances Environmental Pollutants
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIR.0000000000001234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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  3. Article ; Online: Hepatotoxicity of Statins as Determined by Serum Alanine Aminotransferase in a Pediatric Cohort With Dyslipidemia.

    Desai, Nirav K / Mendelson, Michael M / Baker, Annette / Ryan, Heather H / Griggs, Suzanne / Boghani, Meera / Yellen, Elizabeth / Buckley, Lucy / Gillman, Matthew W / Zachariah, Justin P / Graham, Dionne / Jonas, Maureen M / de Ferranti, Sarah D

    Journal of pediatric gastroenterology and nutrition

    2018  Volume 68, Issue 2, Page(s) 175–181

    Abstract: Objective: The aim of the study was to evaluate the hepatotoxicity of statins, as determined by serum alanine aminotransferase (ALT), in children and adolescents with dyslipidemia in real-world clinical practice.: Study design: Clinical and ... ...

    Abstract Objective: The aim of the study was to evaluate the hepatotoxicity of statins, as determined by serum alanine aminotransferase (ALT), in children and adolescents with dyslipidemia in real-world clinical practice.
    Study design: Clinical and laboratory data were prospectively collected between September 2010 and March 2014. We compared ALT levels between patients prescribed versus not prescribed 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins), and then compared ALT before and after initiation of statins.
    Results: Over the 3.5-year observation period, there were 2704 ALT measurements among 943 patients. The mean age was 14 years; 54% were boys, 47% obese, and 208 patients were treated with statins. Median follow-up after first ALT was 18 months. The mean (SD) ALT in statin and non-statin users was 23 (20) U/L and 28 (28) U/L, respectively. In models adjusted for age, sex, and race, ALT was 2.1 U/L (95% CI 0.1 to 4.4; P = 0.04) lower among statin users, which was attenuated after adjustment for weight category. Patients started on statins during the observation period did not demonstrate an increase in ALT over time (ALT 0.9 U/L [95% confidence interval -5.2 to 3.4] increase per year; P = 0.7).
    Conclusions: In our study population, we did not observe a higher burden of ALT elevations among pediatric patients on statins as compared to those with dyslipidemia who are not on statins, supporting the hepatic safety of statin use in childhood.
    MeSH term(s) Adolescent ; Alanine Transaminase/blood ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Dyslipidemias/blood ; Dyslipidemias/drug therapy ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Liver Function Tests ; Male ; Prospective Studies
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Alanine Transaminase (EC 2.6.1.2)
    Language English
    Publishing date 2018-10-17
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1097/MPG.0000000000002174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1728: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Statin-Associated Myopathy in a Pediatric Preventive Cardiology Practice.

    Johnson, Philip K / Mendelson, Michael M / Baker, Annette / Ryan, Heather H / Warren, Shira / Graham, Dionne / Griggs, Suzanne S / Desai, Nirav K / Yellen, Elizabeth / Buckley, Lucy / Zachariah, Justin P / de Ferranti, Sarah D

    The Journal of pediatrics

    2017  Volume 185, Page(s) 94–98.e1

    Abstract: Objectives: To describe muscle-related statin adverse effects in real-world pediatric practice.: Study design: Using prospectively collected quality improvement data from a pediatric preventive cardiology practice, we compared serum creatine kinase ( ... ...

    Abstract Objectives: To describe muscle-related statin adverse effects in real-world pediatric practice.
    Study design: Using prospectively collected quality improvement data from a pediatric preventive cardiology practice, we compared serum creatine kinase (CK) levels among patients prescribed and not prescribed statins, and pre-/poststatin initiation. Multivariable mixed-effect models were constructed accounting for repeated measures, examining the effect of statins on log-transformed CK (lnCK) levels adjusted for age, sex, weight, season, insurance type, and race/ethnicity.
    Results: Among 1501 patients seen over 3.5 years, 474 patients (14?±?4 years, 47% female) had at least 1 serum CK measured. Median (IQR) CK levels of patients prescribed (n?=?188 patients, 768 CK measurements) and not prescribed statins (n?=?351 patients, 682 CK measurements) were 107 (83) IU/L and 113 (81) IU/L, respectively. In multivariable-adjusted models, lnCK levels did not differ based on statin use (??=?0.02 [SE 0.05], P?=?.7). Among patients started on statins (n?=?86, 130 prestatin and 292 poststatin CK measurements), median CK levels did not differ in adjusted models (? for statin use on lnCK?=?.08 [SE .07], P?=?.2). There was a clinically insignificant increase in CK over time (??=?.08 [SE .04], P?=?.04 per year). No muscle symptoms or rhabdomyolysis were reported among patients with high CK levels.
    Conclusions: In a real-world practice, pediatric patients using statins did not experience higher CK levels, nor was there a meaningful CK increase with statin initiation. These data suggest the limited utility to checking CK in the absence of symptoms, supporting current guidelines.
    MeSH term(s) Adolescent ; Boston ; Creatine Kinase/blood ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Male ; Multivariate Analysis ; Muscular Diseases/blood ; Muscular Diseases/chemically induced ; Pediatrics
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Creatine Kinase (EC 2.7.3.2)
    Language English
    Publishing date 2017-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2017.02.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um IV Zs.116: Show issues Location:
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