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  1. Article ; Online: GABA

    Cook, Daniel C / Ryan, Timothy A

    eLife

    2023  Volume 12

    Abstract: Control of neurotransmission efficacy is central to theories of how the brain computes and stores information. Presynaptic G-protein coupled receptors (GPCRs) are critical in this problem as they locally influence synaptic strength and can operate on a ... ...

    Abstract Control of neurotransmission efficacy is central to theories of how the brain computes and stores information. Presynaptic G-protein coupled receptors (GPCRs) are critical in this problem as they locally influence synaptic strength and can operate on a wide range of time scales. Among the mechanisms by which GPCRs impact neurotransmission is by inhibiting voltage-gated calcium (Ca
    MeSH term(s) Synapses ; Presynaptic Terminals/physiology ; Synaptic Transmission/physiology ; Action Potentials/physiology ; gamma-Aminobutyric Acid ; Calcium
    Chemical Substances gamma-Aminobutyric Acid (56-12-2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.83530
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  2. Article ; Online: Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals.

    Pulido, Camila / Ryan, Timothy A

    Science advances

    2021  Volume 7, Issue 49, Page(s) eabi9027

    Abstract: The brain is a metabolically fragile organ as compromises in fuel availability rapidly degrade cognitive function. Nerve terminals are likely loci of this vulnerability as they do not store sufficient ATP molecules, needing to synthesize them during ... ...

    Abstract The brain is a metabolically fragile organ as compromises in fuel availability rapidly degrade cognitive function. Nerve terminals are likely loci of this vulnerability as they do not store sufficient ATP molecules, needing to synthesize them during activity or suffer acute degradation in performance. The ability of on-demand ATP synthesis to satisfy activity-driven ATP hydrolysis will depend additionally on the magnitude of local resting metabolic processes. We show here that synaptic vesicle (SV) pools are a major source of presynaptic basal energy consumption. This basal metabolic processes arises from SV-resident V-ATPases compensating for a hidden resting H
    Language English
    Publishing date 2021-12-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abi9027
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  3. Article: Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape for insights into Neurodegenerative Disorders.

    Kumar, Mukesh / Knapp, Justin A / Gupta, Kallol / Ryan, Timothy A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Recent advances have expanded the role of lipid droplets (LDs) beyond passive lipid storage, implicating their involvement in various metabolic processes across mammalian tissues. Neuronal LDs, long debated in existence, have been identified in several ... ...

    Abstract Recent advances have expanded the role of lipid droplets (LDs) beyond passive lipid storage, implicating their involvement in various metabolic processes across mammalian tissues. Neuronal LDs, long debated in existence, have been identified in several neural structures, raising questions about their contribution to neurodegenerative disorders. Elucidating the specific chemical makeup of these organelles within neurons is critical for understanding their implication in neural pathologies. This study outlines an improved methodology to stimulate and isolate mature LDs from cultured primary neurons, offering insights into their unique lipid-protein composition. Integrating this method with high-throughput techniques may unveil disease-specific alterations in lipid metabolism, providing avenues for potential therapeutic interventions.
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.13.571527
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  4. Article ; Online: Munc13 marks the spot.

    Ryan, Timothy A

    Nature neuroscience

    2017  Volume 21, Issue 1, Page(s) 5–6

    Language English
    Publishing date 2017-12-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-017-0042-8
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  5. Article ; Online: Local Sourcing of Secretory Proteins in Faraway Places.

    Farrell, Ryan J / Ryan, Timothy A

    Trends in neurosciences

    2020  Volume 43, Issue 9, Page(s) 649–650

    Abstract: A recent paper by Carter et al. identifies a novel organelle, the ribosome-associated vesicle (RAV), that might serve as a portable, local factory for producing proteins destined for the secretory pathway. The appearance of RAVs in dendrites suggests ... ...

    Abstract A recent paper by Carter et al. identifies a novel organelle, the ribosome-associated vesicle (RAV), that might serve as a portable, local factory for producing proteins destined for the secretory pathway. The appearance of RAVs in dendrites suggests they may serve to generate membrane and secreted proteins in distal processes.
    MeSH term(s) Endoplasmic Reticulum ; Proteins ; Ribosomes
    Chemical Substances Proteins
    Language English
    Publishing date 2020-06-13
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2020.06.004
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  6. Article: A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions.

    Farrell, Ryan J / Bredvik, Kirsten G / Hoppa, Michael B / Hennigan, S Thomas / Brown, Timothy A / Ryan, Timothy A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The endoplasmic reticulum (ER) is an important regulator ... ...

    Abstract The endoplasmic reticulum (ER) is an important regulator of
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.15.580492
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  7. Article ; Online: The control of release probability at nerve terminals.

    Dittman, Jeremy S / Ryan, Timothy A

    Nature reviews. Neuroscience

    2019  Volume 20, Issue 3, Page(s) 177–186

    Abstract: Exocytosis is a fundamental membrane fusion process by which the soluble or membrane-associated cargoes of a secretory vesicle are delivered to the extracellular milieu or the cell surface. While essential for all organs, the brain relies on a ... ...

    Abstract Exocytosis is a fundamental membrane fusion process by which the soluble or membrane-associated cargoes of a secretory vesicle are delivered to the extracellular milieu or the cell surface. While essential for all organs, the brain relies on a specialized form of exocytosis to mediate information flow throughout its vast circuitry. Neurotransmitter-laden synaptic vesicles fuse with the plasma membrane on cue with astonishing speed in a probabilistic process that is both tightly regulated and capable of a fascinating array of plasticities. Here, we examine progress in the molecular understanding of synaptic vesicle fusion and its control.
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Exocytosis/physiology ; Membrane Fusion/physiology ; Neuronal Plasticity/physiology ; Neurons/physiology ; Presynaptic Terminals/physiology ; Synaptic Transmission/physiology ; Synaptic Vesicles/physiology
    Language English
    Publishing date 2019-01-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-018-0111-3
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  8. Article ; Online: Editorial overview: Molecular neuroscience.

    Ryan, Timothy A / Jin, Yishi

    Current opinion in neurobiology

    2019  Volume 57, Page(s) iii–vi

    MeSH term(s) Neurosciences
    Language English
    Publishing date 2019-06-30
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2019.06.002
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  9. Article ; Online: iATPSnFR2: A high-dynamic-range fluorescent sensor for monitoring intracellular ATP.

    Marvin, Jonathan S / Kokotos, Alexandros C / Kumar, Mukesh / Pulido, Camila / Tkachuk, Ariana N / Yao, Jocelyn Shuxin / Brown, Timothy A / Ryan, Timothy A

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 21, Page(s) e2314604121

    Abstract: We developed a significantly improved genetically encoded quantitative adenosine triphosphate (ATP) sensor to provide real-time dynamics of ATP levels in subcellular compartments. iATPSnFR2 is a variant of iATPSnFR1, a previously developed sensor that ... ...

    Abstract We developed a significantly improved genetically encoded quantitative adenosine triphosphate (ATP) sensor to provide real-time dynamics of ATP levels in subcellular compartments. iATPSnFR2 is a variant of iATPSnFR1, a previously developed sensor that has circularly permuted superfolder green fluorescent protein (GFP) inserted between the ATP-binding helices of the
    MeSH term(s) Adenosine Triphosphate/metabolism ; Green Fluorescent Proteins/metabolism ; Green Fluorescent Proteins/genetics ; Humans ; Biosensing Techniques/methods ; Animals ; Oxidative Phosphorylation ; Proton-Translocating ATPases/metabolism ; Proton-Translocating ATPases/genetics
    Language English
    Publishing date 2024-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2314604121
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  10. Article ; Online: A Path(way) to Keeping Your Synapses on an Even Keel.

    Ryan, Timothy A / Sleckman, Barry P

    Neuron

    2018  Volume 100, Issue 5, Page(s) 1013–1014

    Abstract: In this issue of Neuron, Harris et al. (2018) show that a signal transduction pathway normally exploited by the innate immune system in recognizing foreign agents plays a critical role in controlling a synapse's ability to maintain stability in the ... ...

    Abstract In this issue of Neuron, Harris et al. (2018) show that a signal transduction pathway normally exploited by the innate immune system in recognizing foreign agents plays a critical role in controlling a synapse's ability to maintain stability in the efficacy of synaptic transmission over both rapid and prolonged timescales.
    MeSH term(s) Immunity, Innate ; Neurons ; Synapses ; Synaptic Transmission ; Synaptic Vesicles
    Language English
    Publishing date 2018-12-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2018.11.033
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