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  1. Article: Young endurance training starting age in non-elite athletes is associated with higher proximal aortic distensibility.

    Ryffel, Christoph P / Eser, Prisca / Marcin, Thimo / Herrsche, Dario / Brugger, Nicolas / Trachsel, Lukas D / Wilhelm, Matthias

    Open heart

    2022  Volume 9, Issue 1

    Abstract: Objective: Decreased proximal aortic distensibility (AD) is known to significantly predict all-cause mortality and cardiovascular events among individuals without overt cardiovascular disease. This cross-sectional study investigated the association of ... ...

    Abstract Objective: Decreased proximal aortic distensibility (AD) is known to significantly predict all-cause mortality and cardiovascular events among individuals without overt cardiovascular disease. This cross-sectional study investigated the association of endurance training (ET) parameters, namely, ET starting age, ET years and yearly ET volume with AD in non-elite endurance athletes.
    Methods: Healthy, normotensive, male Caucasian participants of a 10-mile race were assessed with a 2D echocardiogram and comprehensive interview. Ascending aortic diameters were measured simultaneously with pulse pressure. Aortic strain, AD and aortic stiffness index were calculated. Predictors of AD were investigated among training parameters by linear regression models corrected for age, resting heart rate, stroke volume index and mean blood pressure.
    Results: Ninety-two of 121 athletes (aged 42±8 years) had sufficient echocardiogram quality and were used for analysis. ET starting age (range 6-52 years) and years of ET (range 2-46 years) were highly collinear and used in two separate models for AD. Significant factors for AD were ET starting age, 10-mile race time and resting heart rate in model I, and age, years of ET, 10-mile race time and heart rate in model II (all p<0.01).
    Conclusions: In our cohort of healthy, non-elite, middle-aged runners, AD was significantly higher in athletes with younger ET starting age or more years of ET (in the model adjusted for confounders). In the model with years of ET, age had a negative contribution to AD, suggesting that with older age, the benefit of more years of ET on AD decreased. Future studies assessing the effect of exercise training on arterial properties should include training starting age.
    MeSH term(s) Aorta/diagnostic imaging ; Aorta/physiology ; Athletes ; Child ; Cross-Sectional Studies ; Echocardiography ; Endurance Training ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2021-001771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Age at start of endurance training is associated with patterns of left ventricular hypertrophy in middle-aged runners.

    Ryffel, Christoph P / Eser, Prisca / Trachsel, Lukas D / Brugger, Nicolas / Wilhelm, Matthias

    International journal of cardiology

    2018  Volume 267, Page(s) 133–138

    Abstract: Background: Left ventricular hypertrophy (LVH) is a physiological adaptation to long-term endurance training. We investigated the impact of age at start of endurance training on LV geometry in a cohort of male, middle-aged, non-elite endurance athletes.! ...

    Abstract Background: Left ventricular hypertrophy (LVH) is a physiological adaptation to long-term endurance training. We investigated the impact of age at start of endurance training on LV geometry in a cohort of male, middle-aged, non-elite endurance athletes.
    Methods: A total of 121 healthy, normotensive, Caucasian participants of a 10-mile race were recruited and assessed with an echocardiogram and a comprehensive interview. Athletes were classified based on patterns of LVH.
    Results: Thirty-five athletes (31%) had LVH. Athletes with eccentric LVH (16%) were significantly younger at start of endurance training compared to athletes with concentric LVH (15%, 14 ± 5 years vs. 31 ± 8 years; P < 0.001). Although the yearly volume of endurance training was comparable between athletes with eccentric and concentric LVH, athletes with eccentric LVH had shorter race times. All athletes with an increased LV end diastolic volume index (LVEDVI; ≥74 ml/m
    Conclusions: In our cohort of non-elite middle-aged runners, eccentric LVH was found only in athletes with an early start of endurance training. In case of a mature starting age, endurance training may, contrary to what is commonly assumed, also lead to concentric LVH. The consideration of endurance training starting age may lead to a better understanding of morphological adaptations of the heart.
    MeSH term(s) Adolescent ; Adult ; Age of Onset ; Athletes ; Correlation of Data ; Echocardiography/methods ; Endurance Training/adverse effects ; Endurance Training/methods ; Heart Ventricles/diagnostic imaging ; Humans ; Hypertrophy, Left Ventricular/epidemiology ; Hypertrophy, Left Ventricular/etiology ; Hypertrophy, Left Ventricular/physiopathology ; Male ; Middle Aged ; Switzerland/epidemiology ; Ventricular Remodeling
    Language English
    Publishing date 2018-06-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2018.04.111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Exercise-induced cardiac remodeling in non-elite endurance athletes: Comparison of 2-tiered and 4-tiered classification of left ventricular hypertrophy.

    Trachsel, Lukas D / Ryffel, Christoph P / De Marchi, Stefano / Seiler, Christian / Brugger, Nicolas / Eser, Prisca / Wilhelm, Matthias

    PloS one

    2018  Volume 13, Issue 2, Page(s) e0193203

    Abstract: Background: Long-term endurance sport practice leads to eccentric left ventricular hypertrophy (LVH). We aimed to compare the new 4-tiered classification (4TC) for LVH with the established 2-tiered classification (2TC) in a cohort of normotensive non- ... ...

    Abstract Background: Long-term endurance sport practice leads to eccentric left ventricular hypertrophy (LVH). We aimed to compare the new 4-tiered classification (4TC) for LVH with the established 2-tiered classification (2TC) in a cohort of normotensive non-elite endurance athletes.
    Methods: Male participants of a 10-mile race were recruited and included when blood pressure (BP) was normal (<140/90 mmHg). Phenotypic characterization of LVH was based on relative wall thickness (2TC), and on LV concentricity2/3 (LV mass/end-diastolic volume [LVM/EDV]2/3) plus LVEDV index (4TC). Parameters of LV geometry, BP, cumulative training hours, and race time were compared between 2TC and 4TC by analysis of variance, and post-hoc analysis.
    Results: Of 198 athletes recruited, 174 were included. Mean age was 41.6±7.5 years. Forty-two (24%) athletes had LVH. Allocation in the 2TC was: 32 (76%) eccentric LVH and 10 (24%) concentric LVH. Using the 4TC 12 were reclassified to concentric LVH, and 2 to eccentric LVH, resulting in 22 (52%) eccentric LVH (7 non-dilated, 15 dilated), and 20 (48%) concentric LVH (all non-dilated). Based on the 2TC, markers of endurance training did not differ between eccentric and concentric LVH. Based on the 4TC, athletes with eccentric LVH had more cumulative training hours and faster race times, with highest values thereof in athletes with eccentric dilated LVH.
    Conclusions: In our cohort of normotensive endurance athletes, the new 4TC demonstrated a superior discrimination of exercise-induced LVH patterns, compared to the established 2TC, most likely because it takes three-dimensional information of the ventricular geometry into account.
    MeSH term(s) Adult ; Athletes ; Blood Pressure/physiology ; Exercise/physiology ; Female ; Heart Ventricles/physiopathology ; Humans ; Hypertrophy, Left Ventricular/physiopathology ; Male ; Middle Aged ; Physical Endurance/physiology ; Ventricular Remodeling/physiology
    Language English
    Publishing date 2018-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0193203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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