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  1. Article ; Online: Author Correction

    Ryo Imai / Hiroshi Makino / Takasumi Katoh / Tetsuro Kimura / Tadayoshi Kurita / Kazuya Hokamura / Kazuo Umemura / Yoshiki Nakajima

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia

    2021  Volume 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia

    Ryo Imai / Hiroshi Makino / Takasumi Katoh / Tetsuro Kimura / Tadayoshi Kurita / Kazuya Hokamura / Kazuo Umemura / Yoshiki Nakajima

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 9

    Abstract: Abstract Desflurane is one of the most frequently used inhalational anesthetics in clinical practice. A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this ... ...

    Abstract Abstract Desflurane is one of the most frequently used inhalational anesthetics in clinical practice. A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this effect with desflurane. In the present study, we examined the rest/activity rhythm of mice by counting the number of running wheel rotations, and we found that desflurane anesthesia caused a phase shift in the circadian rhythm that was dependent on the time of day of anesthesia. We also found that desflurane anesthesia altered the relative mRNA expression of four major clock genes (Per2, Bmal, Clock, and Cry1) in the suprachiasmatic nucleus (SCN). These results are important for elucidating the effects of desflurane on the SCN, which is the master clock for the mammalian circadian rhythm. Further studies on the relationship between anesthesia and circadian rhythm may lead to the prevention and treatment of postoperative complications related to circadian rhythms.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: Miocene to Pliocene Paleoceanography of the Western Equatorial Pacific Ocean Based on Calcareous Nannofossils, ODP Hole 805B

    Tokiyuki Sato / Ryo Imai / Meutia Farida

    Open Journal of Geology , Vol 02, Iss 02, Pp 72-

    2012  Volume 79

    Abstract: We describe in detail the Miocene to Quaternary paleoceanography of the western equatorial Pacific Ocean based on calcareous nannofossils of Hole 805B. The relative abundance of Discoaster which lived in the lower photic zone under the stable sea with ... ...

    Abstract We describe in detail the Miocene to Quaternary paleoceanography of the western equatorial Pacific Ocean based on calcareous nannofossils of Hole 805B. The relative abundance of Discoaster which lived in the lower photic zone under the stable sea with nutricline and thermocline, decreased step by step at NN5/NN6 and NN10/NN11 boundaries. Al- though the size of Reticulofenestra which is strongly influenced by nutrient, increased five times throughout the section, it drastically decreased in NN4-5 zone, NN10, NN12, and in NN15/NN16 boundary. On the basis of the relationship between Discoaster abundance and Reticulofenestra size change, collapse of the stability of the sea surface in the west- ern equatorial Pacific Ocean progressed step by step throughout the Miocene to Quaternary.
    Keywords Paleoceanography ; Calcareous Nannofossils ; Discoaster ; Reticulofenestra ; Nutricline ; Thermocline ; Geology ; QE1-996.5 ; Science ; Q ; DOAJ:Earth Sciences ; DOAJ:Earth and Environmental Sciences
    Subject code 551
    Language English
    Publishing date 2012-04-01T00:00:00Z
    Publisher Scientific Research Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice.

    Miho Kawakatsu / Yoshishige Urata / Ryo Imai / Shinji Goto / Yusuke Ono / Noriyuki Nishida / Tao-Sheng Li

    PLoS ONE, Vol 8, Iss 3, p e

    2013  Volume 60023

    Abstract: Nicaraven, a chemically synthesized hydroxyl radical-specific scavenger, has been demonstrated to protect against ischemia-reperfusion injury in various organs. We investigated whether nicaraven can attenuate radiation-induced injury in hematopoietic ... ...

    Abstract Nicaraven, a chemically synthesized hydroxyl radical-specific scavenger, has been demonstrated to protect against ischemia-reperfusion injury in various organs. We investigated whether nicaraven can attenuate radiation-induced injury in hematopoietic stem/progenitor cells, which is the conmen complication of radiotherapy and one of the major causes of death in sub-acute phase after accidental exposure to high dose radiation. C57BL/6 mice were exposed to 1 Gy γ-ray radiation daily for 5 days in succession (a total of 5 Gy), and given nicaraven or a placebo after each exposure. The mice were sacrificed 2 days after the last radiation treatment, and the protective effects and relevant mechanisms of nicaraven in hematopoietic stem/progenitor cells with radiation-induced damage were investigated by ex vivo examination. We found that post-radiation administration of nicaraven significantly increased the number, improved the colony-forming capacity, and decreased the DNA damage of hematopoietic stem/progenitor cells. The urinary levels of 8-oxo-2'-deoxyguanosine, a marker of DNA oxidation, were significantly lower in mice that were given nicaraven compared with those that received a placebo treatment, although the levels of intracellular and mitochondrial reactive oxygen species in the bone marrow cells did not differ significantly between the two groups. Interestingly, compared with the placebo treatment, the administration of nicaraven significantly decreased the levels of the inflammatory cytokines IL-6 and TNF-α in the plasma of mice. Our data suggest that nicaraven effectively diminished the effects of radiation-induced injury in hematopoietic stem/progenitor cells, which is likely associated with the anti-oxidative and anti-inflammatory properties of this compound.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Genetic diversity and recombination of enterovirus G strains in Japanese pigs

    Shinobu Tsuchiaka / Yuki Naoi / Ryo Imai / Tsuneyuki Masuda / Mika Ito / Masataka Akagami / Yoshinao Ouchi / Kazuo Ishii / Shoichi Sakaguchi / Tsutomu Omatsu / Yukie Katayama / Mami Oba / Junsuke Shirai / Yuki Satani / Yasuhiro Takashima / Yuji Taniguchi / Masaki Takasu / Hiroo Madarame / Fujiko Sunaga /
    Hiroshi Aoki / Shinji Makino / Tetsuya Mizutani / Makoto Nagai

    PLoS ONE, Vol 13, Iss 1, p e

    High prevalence of strains carrying a papain-like cysteine protease sequence in the enterovirus G population.

    2018  Volume 0190819

    Abstract: To study the genetic diversity of enterovirus G (EV-G) among Japanese pigs, metagenomics sequencing was performed on fecal samples from pigs with or without diarrhea, collected between 2014 and 2016. Fifty-nine EV-G sequences, which were >5,000 ... ...

    Abstract To study the genetic diversity of enterovirus G (EV-G) among Japanese pigs, metagenomics sequencing was performed on fecal samples from pigs with or without diarrhea, collected between 2014 and 2016. Fifty-nine EV-G sequences, which were >5,000 nucleotides long, were obtained. By complete VP1 sequence analysis, Japanese EV-G isolates were classified into G1 (17 strains), G2 (four strains), G3 (22 strains), G4 (two strains), G6 (two strains), G9 (six strains), G10 (five strains), and a new genotype (one strain). Remarkably, 16 G1 and one G2 strain identified in diarrheic (23.5%; four strains) or normal (76.5%; 13 strains) fecal samples possessed a papain-like cysteine protease (PL-CP) sequence, which was recently found in the USA and Belgium in the EV-G genome, at the 2C-3A junction site. This paper presents the first report of the high prevalence of viruses carrying PL-CP in the EV-G population. Furthermore, possible inter- and intragenotype recombination events were found among EV-G strains, including G1-PL-CP strains. Our findings may advance the understanding of the molecular epidemiology and genetic evolution of EV-Gs.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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