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  1. Article ; Online: Hydration of LiOH and LiClNear-Infrared Spectroscopic Analysis

    Masato Takeuchi / Ryo Kurosawa / Junichi Ryu / Masaya Matsuoka

    ACS Omega, Vol 6, Iss 48, Pp 33075-

    2021  Volume 33084

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Effect of Lithium Compound Addition on the Dehydration and Hydration of Calcium Hydroxide as a Chemical Heat Storage Material

    Aya Maruyama / Ryo Kurosawa / Junichi Ryu

    ACS Omega, Vol 5, Iss 17, Pp 9820-

    2020  Volume 9829

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Comparison of the Effect of Coaddition of Li Compounds and Addition of a Single Li Compound on Reactivity and Structure of Magnesium Hydroxide

    Ryo Kurosawa / Masato Takeuchi / Junichi Ryu

    ACS Omega, Vol 4, Iss 18, Pp 17752-

    2019  Volume 17761

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Impact of spaceflight and artificial gravity on sulfur metabolism in mouse liver

    Ryo Kurosawa / Ryota Sugimoto / Hiroe Imai / Kohei Atsuji / Koji Yamada / Yusuke Kawano / Iwao Ohtsu / Kengo Suzuki

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    sulfur metabolomic and transcriptomic analysis

    2021  Volume 12

    Abstract: Abstract Spaceflight induces hepatic damage, partially owing to oxidative stress caused by the space environment such as microgravity and space radiation. We examined the roles of anti-oxidative sulfur-containing compounds on hepatic damage after ... ...

    Abstract Abstract Spaceflight induces hepatic damage, partially owing to oxidative stress caused by the space environment such as microgravity and space radiation. We examined the roles of anti-oxidative sulfur-containing compounds on hepatic damage after spaceflight. We analyzed the livers of mice on board the International Space Station for 30 days. During spaceflight, half of the mice were exposed to artificial earth gravity (1 g) using centrifugation cages. Sulfur-metabolomics of the livers of mice after spaceflight revealed a decrease in sulfur antioxidants (ergothioneine, glutathione, cysteine, taurine, thiamine, etc.) and their intermediates (cysteine sulfonic acid, hercynine, N-acethylserine, serine, etc.) compared to the controls on the ground. Furthermore, RNA-sequencing showed upregulation of gene sets related to oxidative stress and sulfur metabolism, and downregulation of gene sets related to glutathione reducibility in the livers of mice after spaceflight, compared to controls on the ground. These changes were partially mitigated by exposure to 1 g centrifugation. For the first time, we observed a decrease in sulfur antioxidants based on a comprehensive analysis of the livers of mice after spaceflight. Our data suggest that a decrease in sulfur-containing compounds owing to both microgravity and other spaceflight environments (radiation and stressors) contributes to liver damage after spaceflight.
    Keywords Medicine ; R ; Science ; Q
    Subject code 500
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia

    Masahiko Ajiro / Tomonari Awaya / Young Jin Kim / Kei Iida / Masatsugu Denawa / Nobuo Tanaka / Ryo Kurosawa / Shingo Matsushima / Saiko Shibata / Tetsunori Sakamoto / Rolenz Studer / Adrian R. Krainer / Masatoshi Hagiwara

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 12

    Abstract: Familial dysautonomia is caused by splicing mutation of IKBKAP gene, which induces skipping of exon 20 and subsequent functional loss. Here, the authors report that a synthetic splice modulator RECTAS ameliorates pathogenic exon 20 skipping and shows ... ...

    Abstract Familial dysautonomia is caused by splicing mutation of IKBKAP gene, which induces skipping of exon 20 and subsequent functional loss. Here, the authors report that a synthetic splice modulator RECTAS ameliorates pathogenic exon 20 skipping and shows therapeutic effects in cellular and animal models.
    Keywords Science ; Q
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Author Correction

    Masahiko Ajiro / Tomonari Awaya / Young Jin Kim / Kei Iida / Masatsugu Denawa / Nobuo Tanaka / Ryo Kurosawa / Shingo Matsushima / Saiko Shibata / Tetsunori Sakamoto / Lorenz Studer / Adrian R. Krainer / Masatoshi Hagiwara

    Nature Communications, Vol 12, Iss 1, Pp 1-

    Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia

    2021  Volume 1

    Keywords Science ; Q
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A randomized, double-blind, placebo-controlled pilot trial of low-intensity pulsed ultrasound therapy for refractory angina pectoris.

    Tomohiko Shindo / Kenta Ito / Tsuyoshi Ogata / Ryo Kurosawa / Kumiko Eguchi / Yuta Kagaya / Kenichiro Hanawa / Yuhi Hasebe / Kensuke Nishimiya / Takashi Shiroto / Jun Takahashi / Yasuo Okumura / Teruo Noguchi / Yukio Ozaki / Hiroyuki Daida / Nobuhisa Hagiwara / Tohru Masuyama / Taishiro Chikamori / Yoshihiro Fukumoto /
    Kenichi Tsujita / Hiroshi Kanai / Satoshi Yasuda / Hiroaki Shimokawa

    PLoS ONE, Vol 18, Iss 6, p e

    2023  Volume 0287714

    Abstract: Background Despite the advances in the treatment of cardiovascular diseases, effective treatment remains to be established to improve the quality of life and prognosis of patients with chronic coronary syndromes. This study was aimed to evaluate the ... ...

    Abstract Background Despite the advances in the treatment of cardiovascular diseases, effective treatment remains to be established to improve the quality of life and prognosis of patients with chronic coronary syndromes. This study was aimed to evaluate the effectiveness and safety of the low-intensity pulsed ultrasound (LIPUS) therapy, which we have developed as a novel non-invasive angiogenic therapy through upregulation of endothelial nitric oxide synthase (eNOS). Methods and findings We conducted a randomized, double-blind, placebo-controlled (RCT) pilot trial of the LIPUS therapy for patients with refractory angina pectoris. The patients who received optimal medical therapy without indication of PCI or CABG due to the lack of graftability or complexity of coronary lesions were enrolled. They were randomly divided into the LIPUS treatment group (N = 31) and the placebo group (N = 25) in a 1:1 fashion. The LIPUS therapy was performed in a transthoracic manner for 20 min for 3 sections each (mitral, papillary muscle, and apex levels) under the conditions that we identified; frequency 1.875 MHz, intensity 0.25 MPa, and 32 cycles. The primary endpoint was weekly use of nitroglycerin. Secondary endpoints included stress myocardial perfusion imaging and others. The average weekly nitroglycerin use (times/week) was decreased from 5.50 to 2.44 in the LIPUS group and from 5.94 to 2.83 in the placebo group. The changes in the average weekly nitroglycerin use were comparable; -3.06 (95% CI: -4.481 to -1.648) in the LIPUS group (P<0.01) and -3.10 (95% CI: -4.848 to -1.356) in the placebo group (P<0.01). No adverse effects were noted. Conclusions In the present study, the LIPUS therapy did not further ameliorate chest pain as compared with optimal medications alone in patients with refractory angina pectoris. The present findings need to be confirmed in another trial with a large number of patients. (Registration ID: UMIN000012369).
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Identification of Novel Therapeutic Targets for Pulmonary Arterial Hypertension

    Kimio Satoh / Nobuhiro Kikuchi / Taijyu Satoh / Ryo Kurosawa / Shinichiro Sunamura / Mohammad Abdul Hai Siddique / Junichi Omura / Nobuhiro Yaoita / Hiroaki Shimokawa

    International Journal of Molecular Sciences, Vol 19, Iss 12, p

    2018  Volume 4081

    Abstract: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are fatal diseases; however, their pathogenesis still remains to be elucidated. We have recently screened novel pathogenic molecules and have performed drug ... ...

    Abstract Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are fatal diseases; however, their pathogenesis still remains to be elucidated. We have recently screened novel pathogenic molecules and have performed drug discovery targeting those molecules. Pulmonary artery smooth muscle cells (PASMCs) in patients with PAH (PAH-PASMCs) have high proliferative properties like cancer cells, which leads to thickening and narrowing of distal pulmonary arteries. Thus, we conducted a comprehensive analysis of PAH-PASMCs and lung tissues to search for novel pathogenic proteins. We validated the pathogenic role of the selected proteins by using tissue-specific knockout mice. To confirm its clinical significance, we used patient-derived blood samples to evaluate the potential as a biomarker for diagnosis and prognosis. Finally, we conducted a high throughput screening and found inhibitors for the pathogenic proteins.
    Keywords pathogenesis ; pulmonary hypertension ; biomarker ; drug discovery ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Deep learning-based age estimation from chest X-rays indicates cardiovascular prognosis

    Hirotaka Ieki / Kaoru Ito / Mike Saji / Rei Kawakami / Yuji Nagatomo / Kaori Takada / Toshiya Kariyasu / Haruhiko Machida / Satoshi Koyama / Hiroki Yoshida / Ryo Kurosawa / Hiroshi Matsunaga / Kazuo Miyazawa / Kouichi Ozaki / Yoshihiro Onouchi / Susumu Katsushika / Ryo Matsuoka / Hiroki Shinohara / Toshihiro Yamaguchi /
    Satoshi Kodera / Yasutomi Higashikuni / Katsuhito Fujiu / Hiroshi Akazawa / Nobuo Iguchi / Mitsuaki Isobe / Tsutomu Yoshikawa / Issei Komuro

    Communications Medicine, Vol 2, Iss 1, Pp 1-

    2022  Volume 12

    Abstract: Ieki et al. train a deep learning model to estimate patients’ age from chest X-ray images. X-ray age is found to be an indicator of poor prognosis in patients with heart failure and patients admitted to the intensive care unit with cardiovascular disease. ...

    Abstract Ieki et al. train a deep learning model to estimate patients’ age from chest X-ray images. X-ray age is found to be an indicator of poor prognosis in patients with heart failure and patients admitted to the intensive care unit with cardiovascular disease.
    Keywords Medicine ; R
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates contractile dysfunction of pressure-overloaded heart in mice.

    Tsuyoshi Ogata / Kenta Ito / Tomohiko Shindo / Kazuaki Hatanaka / Kumiko Eguchi / Ryo Kurosawa / Yuta Kagaya / Yuto Monma / Sadamitsu Ichijo / Hirofumi Taki / Hiroshi Kanai / Hiroaki Shimokawa

    PLoS ONE, Vol 12, Iss 9, p e

    2017  Volume 0185555

    Abstract: Chronic left ventricular (LV) pressure overload causes relative ischemia with resultant LV dysfunction. We have recently demonstrated that low-intensity pulsed ultrasound (LIPUS) improves myocardial ischemia in a pig model of chronic myocardial ischemia ... ...

    Abstract Chronic left ventricular (LV) pressure overload causes relative ischemia with resultant LV dysfunction. We have recently demonstrated that low-intensity pulsed ultrasound (LIPUS) improves myocardial ischemia in a pig model of chronic myocardial ischemia through enhanced myocardial angiogenesis. In the present study, we thus examined whether LIPUS also ameliorates contractile dysfunction in LV pressure-overloaded hearts.Chronic LV pressure overload was induced with transverse aortic constriction (TAC) in mice. LIPUS was applied to the whole heart three times in the first week after TAC and was repeated once a week for 7 weeks thereafter (n = 22). Animals in the control groups received the sham treatment without LIPUS (n = 23). At 8 weeks after TAC, LV fractional shortening was depressed in the TAC-Control group, which was significantly ameliorated in the TAC-LIPUS group (30.4±0.5 vs. 36.2±3.8%, P<0.05). Capillary density was higher and perivascular fibrosis was less in the LV in the TAC-LIPUS group than in the TAC-Control group. Myocardial relative ischemia evaluated with hypoxyprobe was noted in the TAC-Control group, which was significantly attenuated in the TAC-LIPUS group. In the TAC-LIPUS group, as compared with the control group, mRNA expressions of BNP and collagen III were significantly lower (both P<0.05) and protein expressions of VEGF and eNOS were significantly up-regulated associated with Akt activation (all P<0.05). No adverse effect related to the LIPUS therapy was noted.These results indicate that the LIPUS therapy ameliorates contractile dysfunction in chronically pressure-overloaded hearts through enhanced myocardial angiogenesis and attenuated perivascular fibrosis. Thus, the LIPUS therapy may be a promising, non-invasive treatment for cardiac dysfunction due to chronic pressure overload.
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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