Article ; Online: Are oral cancers effectively palliated with radiotherapy? Outcomes of treatment with a modified QUAD SHOT regimen.
2024
Abstract: Background: This study assessed a palliative radiotherapy regimen using daily radiation over 4 days for three courses in inoperable head and neck cancers, emphasizing oral primary cancers.: Methods: Retrospective data of 116 patients treated with a ... ...
| Abstract | Background: This study assessed a palliative radiotherapy regimen using daily radiation over 4 days for three courses in inoperable head and neck cancers, emphasizing oral primary cancers. Methods: Retrospective data of 116 patients treated with a daily dose of 3.6-3.7 Gy in four fractions over 4 days to a total of three courses, with a 2-week gap after every course, were analyzed for survival outcomes. A subgroup analysis was done for oral cancer. Results: Ninety-nine (85%) completed three courses. Overall subjective response rate was 77%. Median overall survival and progression-free survival were 12 months (95% confidence interval [CI]: 8-20) and 8 months (95% CI: 6-10), with numerically higher overall survival in oral cancer. The treatment was well tolerated, with no on-treatment hospitalization or grade 3-4 toxicities. Conclusion: The modified QUAD SHOT regimen is practical for palliation in head and neck cancers. |
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| Language | English | |||||
| Publishing date | 2024-03-25 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 645165-2 | |||||
| ISSN | 1097-0347 ; 0148-6403 ; 1043-3074 | |||||
| ISSN (online) | 1097-0347 | |||||
| ISSN | 0148-6403 ; 1043-3074 | |||||
| DOI | 10.1002/hed.27730 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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