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  1. Article ; Online: Privacy Preserving Fingerprint Authentication at the Cloud Server for eHealth Services

    S Rajarajan / R Kausik / M Charan / PLK. Priyadarsini

    EAI Endorsed Transactions on Pervasive Health and Technology, Vol 5, Iss

    2019  Volume 18

    Abstract: BACKGROUND: Restricting entry and access to highly sensitive systems like e-Health services is vital to protect the privacy and confidentiality of customers. User authentication is implemented predominantly done using Bio-metric schemes. But there is a ... ...

    Abstract BACKGROUND: Restricting entry and access to highly sensitive systems like e-Health services is vital to protect the privacy and confidentiality of customers. User authentication is implemented predominantly done using Bio-metric schemes. But there is a challenge in securely storing the fingerprint templates. Since fingerprints are permanent, fingerprints gettingstolen will be a serious issue.OBJECTIVE: The objective of this paper is to design a scheme to carry out the fingerprint match at the cloud server that will not compromise the fingerprints.METHODS: When users input their fingerprint, a unique key is generated and it is sent to the server for verification.RESULTS: We evaluated our proposed scheme and ascertained that it generates unique Fingerprint Identification Number for different fingerprints and the false rejection rate of our proposed scheme is within acceptable limit.CONCLUSION: The proposed scheme overcomes the security threats to the stored fingerprints of users.
    Keywords biometrics ; fingerprints ; privacy-preserving ; cancellable-biometrics ; cloud ; image feature extraction ; surf ; Medicine ; R ; Medical technology ; R855-855.5
    Subject code 303
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher European Alliance for Innovation (EAI)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A Study on in vitro antiviral activities of lyophilized extracts of Glycyrrhiza glabra on Hepatitis B Virus

    Sangeetha Vani / S. Rajarajan

    International Journal of Pharmacological Research, Vol 6, Iss 6, Pp 206-

    2016  Volume 209

    Abstract: The present study is to determine the effect of lyophilized extracts of different solvents of Glycyrrhiza glabra on Hepatitis B. The lyophilized plant extracts were collected and studied for its cytotoxicity in HepG2 cell line and in vitro antiviral ... ...

    Abstract The present study is to determine the effect of lyophilized extracts of different solvents of Glycyrrhiza glabra on Hepatitis B. The lyophilized plant extracts were collected and studied for its cytotoxicity in HepG2 cell line and in vitro antiviral activity of these extracts was investigated by HBs Ag binding Inhibition Assay, Hepatitis B Virus DNA Polymerase Inhibition Assay using fluorescent probes. The results from Glycyrrhiza glabra were promising in acting as a potent antiviral agent.
    Keywords Hepatitis B ; G.glabra ; HBs Ag Binding Assay ; HBV DNA polymerase. ; Medicine ; R ; Therapeutics. Pharmacology ; RM1-950
    Language English
    Publishing date 2016-06-01T00:00:00Z
    Publisher Bharati Biomedical and Advance Research Centre
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Spectral characterisation, antiviral activities, in silico ADMET and molecular docking of the compounds isolated from Tectona grandis to chikungunya virus.

    K, Sangeetha / Purushothaman, Indu / S, Rajarajan

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2017  Volume 87, Page(s) 302–310

    Abstract: Chikungunya infection is treated symptomatically with antipyretics and anti-inflammatory drugs without any specific antiviral drug till date. The lack of an approved antiviral drug and the emergence of virulent strains after 2006 epidemics emphasize the ... ...

    Abstract Chikungunya infection is treated symptomatically with antipyretics and anti-inflammatory drugs without any specific antiviral drug till date. The lack of an approved antiviral drug and the emergence of virulent strains after 2006 epidemics emphasize the need for the development of potential antiviral drugs to Chikungunya virus. Hence, we studied the antiviral activity of the extracts and compounds isolated from Tectona grandis leaves to both the Asian and East central South African strains of Chikungunya virus. Five compounds were isolated from the ethanolic extract of Tectona grandis by bioactivity guided fractionation followed by Spectral Characterisation through GC-MS and NMR spectroscopy and investigated for the antiviral activity. Also in silico ADMET and Molecular Docking of the characterised compounds against the structural and non structural proteins of Chikungunya virus were performed. The characterised compound Benzene-1-carboxylic acid hexadeconate was effective at IC 50 3.036μg/ml (7.5μM) and 76.46μg/ml (189.02μM) to Asian and ECSA strain of CHIKV respectively. The compound showed desirable pharmacokinetic properties and significant molecular interactions with the E1 protein of Chikungunya virus by in silico analysis. Thus Benzene-1-carboxylic acid-2-hexadeconate isolated from Tectona grandis was found to be a promising drug candidate to both the Asian and ECSA strains of Chikungunya virus with high selectivity indices in comparison to the reference RNA antiviral drug Ribavirin.
    MeSH term(s) Animals ; Antiviral Agents/isolation & purification ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Cercopithecus aethiops ; Chikungunya virus/drug effects ; Chikungunya virus/metabolism ; Computer Simulation ; Gas Chromatography-Mass Spectrometry/methods ; Humans ; Lamiaceae ; Magnetic Resonance Spectroscopy/methods ; Molecular Docking Simulation/methods ; Plant Extracts/isolation & purification ; Plant Extracts/metabolism ; Plant Extracts/pharmacology ; Vero Cells
    Chemical Substances Antiviral Agents ; Plant Extracts
    Language English
    Publishing date 2017-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2016.12.069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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