Article ; Online: Biomarkers of Kidney Injury Among Nicaraguan Sugarcane Workers.
American journal of kidney diseases : the official journal of the National Kidney Foundation
2016 Volume 67, Issue 2, Page(s) 209–217
Abstract: Background: In Central America, an epidemic of chronic kidney disease of unknown cause disproportionately affects young male agricultural workers.: Study design: Longitudinal cohort study.: Setting & participants: 284 sugarcane workers in 7 jobs ... ...
| Abstract | Background: In Central America, an epidemic of chronic kidney disease of unknown cause disproportionately affects young male agricultural workers. Study design: Longitudinal cohort study. Setting & participants: 284 sugarcane workers in 7 jobs were recruited from one company in northwestern Nicaragua. Blood and urine samples were collected before and near the end of the 6-month harvest season. Predictors: Job category (cane cutter, seeder, seed cutter, agrichemical applicator, irrigator, driver, and factory worker); self-reported water and electrolyte solution intake. Outcomes & measurements: Changes in levels of urinary kidney injury biomarkers normalized to urine creatinine level, including neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18), N-acetyl-β-d-glucosaminidase (NAG), and albumin; serum creatinine-based estimated glomerular filtration rate (eGFR). Results: Mean eGFR was 113 mL/min/1.73 m(2) and <5% of workers had albuminuria. Field workers had increases in NGAL and IL-18 levels that were 1.49 (95% CI, 1.06 to 2.09) and 1.61 (95% CI, 1.12 to 2.31) times as high, respectively, as in non-field workers. Cane cutters and irrigators had the greatest increases in NGAL levels during the harvest, whereas cane cutters and seeders had the greatest increases in IL-18 levels. Electrolyte solution consumption was associated with lower mean NGAL and NAG levels among cane cutters and lower mean IL-18 and NAG levels among seed cutters; however, there was no overall effect of hydration among all workers. On average, workers with the largest increases in NGAL and NAG levels during the harvest had declines in eGFRs of 4.6 (95% CI, 1.0 to 8.2) and 3.1 (95% CI, -0.6 to 6.7) mL/min/1.73 m(2), respectively. Limitations: Surrogate exposure measure, loss to follow-up. Conclusions: Results are consistent with the hypothesis that occupational heat stress and volume depletion may be associated with the development of kidney disease, and future studies should directly measure these occupational factors. The presence of urine tubular injury markers supports a tubulointerstitial disease that could occur with repeated tubular injury. |
|---|---|
| MeSH term(s) | Adult ; Biomarkers/blood ; Biomarkers/urine ; Cohort Studies ; Dehydration/blood ; Dehydration/epidemiology ; Dehydration/urine ; Farmers ; Female ; Heat-Shock Response/physiology ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Nicaragua/epidemiology ; Occupational Exposure/adverse effects ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/urine ; Saccharum ; Young Adult |
| Chemical Substances | Biomarkers |
| Language | English |
| Publishing date | 2016-02 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 604539-x |
| ISSN | 1523-6838 ; 0272-6386 |
| ISSN (online) | 1523-6838 |
| ISSN | 0272-6386 |
| DOI | 10.1053/j.ajkd.2015.08.022 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1669: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.MO 468: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.