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  1. Article ; Online: In Vivo

    Aldaba-Muruato, Liseth Rubi / Sánchez-Barbosa, Sandra / Rodríguez-Purata, Víctor Hugo / Cabrera-Cruz, Georgina / Rosales-Domínguez, Estefany / Martínez-Valentín, Daniela / Alarcón-López, Yoshio Aldo / Aguirre-Vidal, Pablo / Hernández-Serda, Manuel Alejandro / Cárdenas-Granados, Luis Alfonso / Vázquez-Valadez, Víctor Hugo / Angeles, Enrique / Macías-Pérez, José Roberto

    International journal of molecular sciences

    2023  Volume 25, Issue 1

    Abstract: ... ...

    Abstract Tert
    MeSH term(s) Animals ; Rats ; Rats, Wistar ; Kelch-Like ECH-Associated Protein 1 ; Molecular Docking Simulation ; NF-E2-Related Factor 2 ; Necrosis ; Hydroquinones
    Chemical Substances 2-tert-butylhydroquinone (C12674942B) ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Hydroquinones
    Language English
    Publishing date 2023-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Liposomes Bearing Non-Bilayer Phospholipid Arrangements Induce Specific IgG Anti-Lipid Antibodies by Activating NK1.1

    Landa-Saldívar, Carla / Reséndiz-Mora, Albany / Sánchez-Barbosa, Sandra / Sotelo-Rodríguez, Anahi / Barrera-Aveleida, Giovanna / Nevárez-Lechuga, Irene / Galarce-Sosa, Iván / Taniguchi-Ponciano, Keiko / Cruz-Guzmán, Oriana Del Rocío / Wong-Baeza, Isabel / Escobar-Gutiérrez, Alejandro / Baeza, Isabel / Wong-Baeza, Carlos

    Membranes

    2022  Volume 12, Issue 7

    Abstract: Liposomes are artificial models of cellular membranes that are used as delivery systems for genes, drugs and protein antigens. We have previously used them to study the antigenic properties of their phospholipids. Here, we used them to induce the ... ...

    Abstract Liposomes are artificial models of cellular membranes that are used as delivery systems for genes, drugs and protein antigens. We have previously used them to study the antigenic properties of their phospholipids. Here, we used them to induce the production of IgG anti-non-bilayer phospholipid arrangements (NPAs) antibodies in mice; these antibodies cause cell lysis and trigger a lupus-like disease in mice. We studied the mechanisms that lead to the production of these antibodies, and provide evidence that NK1.1
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes12070643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lupresan, a new drug that prevents or reverts the formation of nonbilayer phospholipid arrangements that trigger a murine lupus resembling human lupus.

    Reséndiz-Mora, Albany / Landa, Carla / Sánchez-Barbosa, Sandra / Meza-Toledo, Sergio / Santiago-Hernández, Juan Carlos / Wong, Carlos / Baeza, Isabel / Wong-Baeza, Carlos

    Biochemical and biophysical research communications

    2018  Volume 509, Issue 1, Page(s) 275–280

    Abstract: Non-bilayer phospholipid arrangements (NPA) are lipid associations different from the bilayer, formed by the interactions of conic anionic lipids and divalent cations that produce an inverted micelle which is inserted between the lipid layers, so the ... ...

    Abstract Non-bilayer phospholipid arrangements (NPA) are lipid associations different from the bilayer, formed by the interactions of conic anionic lipids and divalent cations that produce an inverted micelle which is inserted between the lipid layers, so the polar heads of the outer lipids spread and expose new antigens. Since these structures are transient, they are not immunogenic, but if they are stabilized by drugs, such as chlorpromazine, they become immunogenic and induce anti-NPA antibodies that trigger a lupus-like disease in mice. Chloroquine is a drug used for the treatment of lupus; chloroquine has a quinoline ring and two positive charges that interact with conic anionic lipids and prevent or revert the formation of NPA. However, the polyamine spermidine is more effective, since it has three positive charges and interacts with more lipids, but polyamines cannot be used as drugs, because they are highly toxic. Here we report the design and synthesis of Lupresan, an analogous of chloroquine with its quinoline ring but with three positive charges. Lupresan is more effective in preventing or reverting the formation of NPA than chloroquine or spermidine, and as a consequence, it decreased auto-antibody titers and healed the malar rash in mice with lupus to a greater extent than chloroquine. A drug as Lupresan could be used for the treatment of human lupus.
    MeSH term(s) Animals ; Antibodies, Antiphospholipid/immunology ; Antimalarials/therapeutic use ; Cell Line ; Chloroquine/therapeutic use ; Disease Models, Animal ; Drug Discovery ; Female ; HEK293 Cells ; Humans ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/immunology ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Phospholipids/immunology
    Chemical Substances Antibodies, Antiphospholipid ; Antimalarials ; Phospholipids ; Chloroquine (886U3H6UFF)
    Language English
    Publishing date 2018-12-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2018.12.119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
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  4. Article ; Online: Dysregulation of miR-155-5p and miR-200-3p and the Anti-Non-Bilayer Phospholipid Arrangement Antibodies Favor the Development of Lupus in Three Novel Murine Lupus Models.

    Zárate-Neira, Luz Ángela / Sánchez-Barbosa, Sandra / Pedroza-Torres, Abraham / Reséndiz-Mora, Albany / Wong, Carlos / Baeza, Isabel / Pérez-Plasencia, Carlos / Wong-Baeza, Carlos

    Journal of immunology research

    2017  Volume 2017, Page(s) 8751642

    Abstract: Systemic lupus erythematosus (SLE) is characterized by deregulated activation of T and B cells, autoantibody production, and consequent formation of immune complexes. Liposomes with nonbilayer phospholipid arrangements (NPA), induced by chlorpromazine, ... ...

    Abstract Systemic lupus erythematosus (SLE) is characterized by deregulated activation of T and B cells, autoantibody production, and consequent formation of immune complexes. Liposomes with nonbilayer phospholipid arrangements (NPA), induced by chlorpromazine, procainamide, or manganese, provoke a disease resembling human lupus when administered to mice. These mice produce anti-NPA IgM and IgG antibodies and exhibit an increased number of TLR-expressing spleen cells and a modified gene expression associated with
    MeSH term(s) Adaptor Proteins, Vesicular Transport/metabolism ; Animals ; Antibody Formation/genetics ; Chlorpromazine/chemistry ; Disease Models, Animal ; Female ; Humans ; Inflammation/genetics ; Interferon-alpha/metabolism ; Killer Cells, Natural/immunology ; Lupus Erythematosus, Systemic/genetics ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; MicroRNAs/genetics ; Phospholipids/chemistry ; Phospholipids/immunology ; Signal Transduction ; Toll-Like Receptor 4/metabolism
    Chemical Substances Adaptor Proteins, Vesicular Transport ; Ifna1 protein, mouse ; Ifna2 protein, mouse ; Interferon-alpha ; MicroRNAs ; Mirn155 microRNA, mouse ; Mirn200 microRNA, mouse ; Phospholipids ; TICAM-1 protein, mouse ; Tlr4 protein, mouse ; Toll-Like Receptor 4 ; Chlorpromazine (U42B7VYA4P)
    Language English
    Publishing date 2017-12-04
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-8861
    ISSN (online) 2314-7156
    ISSN 2314-8861
    DOI 10.1155/2017/8751642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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