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  1. AU="Sánchez-Garcia, Joaquín"
  2. AU="Schaller, Benoit"
  3. AU="Hernandez, A"
  4. AU="Nguyen, Thien H"
  5. AU="Park, Jung Wan"
  6. AU="Mahajan, Aman"
  7. AU="Hao, Yanling"
  8. AU="Eing, Lorenz"
  9. AU="Geoffroy, Pierre A"
  10. AU="Chapuis, J"
  11. AU="Berta, László"
  12. AU="Barzilay, Regina"
  13. AU="Schmidt, Michael Rahbek"
  14. AU=Tack J
  15. AU="Oh, Hye Min"
  16. AU=Gaffen Sarah L AU=Gaffen Sarah L
  17. AU="Schmitt, Christine"
  18. AU="McKay, Jackie"
  19. AU="Bellissimo, Catherine A"
  20. AU="Desai, Urja"
  21. AU="Chini, Maria Giovanna"
  22. AU="Xiao, Difei"
  23. AU="Ryan, Chris"
  24. AU="Omar Bazighifan"
  25. AU="Corominas Galbany, Jordi"
  26. AU=Fox Norma E
  27. AU="Hamilton, Shelia M"
  28. AU="Nichols, J Wylie"
  29. AU="Pesce R."
  30. AU="Gambitta, P"
  31. AU="Imran, Aqeel"
  32. AU="Sharma, Yashoda"
  33. AU="Kosai, Jordyn"
  34. AU="Aroca Ferri, María"
  35. AU="Laba, Stephanie"
  36. AU="Kim, Ye-Sel"

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  1. Artikel ; Online: Identifying prognostic gene panels in acute myeloid leukemia.

    Sanchez-Garcia, Joaquin / Serrano, Josefina / Prados de La Torre, Esther / Serrano-López, Juana / Aparicio-Perez, Clara / Barragán, E / Montesinos, Pau

    Expert review of hematology

    2023  Band 16, Heft 4, Seite(n) 277–287

    Abstract: Introduction: Acute myeloid leukemia (AML) is a heterogeneous disease currently including 12 entities defined by genetic findings with remarkable differences in prognosis and targeted therapies availability. Therefore, identification of genetic ... ...

    Abstract Introduction: Acute myeloid leukemia (AML) is a heterogeneous disease currently including 12 entities defined by genetic findings with remarkable differences in prognosis and targeted therapies availability. Therefore, identification of genetic abnormalities by efficient techniques has become a necessary tool in routine clinical practice for AML patients.
    Areas covered: In the present review, we will focus on our current knowledge of relevant prognosis gene mutations in AML, as recently updated by European Leukemia Net Leukemia risk classification.
    Expert opinion: About 25% of newly diagnosed younger AML patients will be promptly classified as favorable prognosis by demonstrating the presence of
    Mesh-Begriff(e) Humans ; Prognosis ; Nucleophosmin ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Mutation ; Antineoplastic Combined Chemotherapy Protocols ; fms-Like Tyrosine Kinase 3/genetics
    Chemische Substanzen Nucleophosmin (117896-08-9) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
    Sprache Englisch
    Erscheinungsdatum 2023-03-29
    Erscheinungsland England
    Dokumenttyp Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2023.2193322
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  2. Artikel ; Online: 18

    Cordoba, Raul / Sánchez-García, Joaquín / Domingo-Domenech, Eva / López Jiménez, Javier / Martínez Pozo, Antonio / Carpio, Cecilia / Bendaña, Ángeles / González, Ana Julia / González de Villambrosia, Sonia / Gómez Codina, José / Navarro, Belén / Rodríguez, Guillermo / Naves, Andrea / Baeza, Lourdes / Martín García-Sancho, Alejandro

    Expert review of hematology

    2024  Band 17, Heft 1-3, Seite(n) 95–100

    Abstract: Background: An accurate assessment of tumor viability after first-line treatment is critical for predicting treatment failure in peripheral T-cell lymphomas (PTCLs). : Research design and methods: Retrospective observational study including 175 ... ...

    Abstract Background: An accurate assessment of tumor viability after first-line treatment is critical for predicting treatment failure in peripheral T-cell lymphomas (PTCLs).
    Research design and methods: Retrospective observational study including 175 patients diagnosed with PTCL between 2008 and 2013 in 13 Spanish sites.
    Results: Fifty patients were evaluated with
    Conclusions: 18
    Mesh-Begriff(e) Humans ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18/therapeutic use ; Prognosis ; Lymphoma, T-Cell, Peripheral/therapy ; Lymphoma, T-Cell, Peripheral/drug therapy ; Retrospective Studies
    Chemische Substanzen Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Sprache Englisch
    Erscheinungsdatum 2024-02-07
    Erscheinungsland England
    Dokumenttyp Observational Study ; Journal Article
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2024.2313457
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  3. Artikel: Evolving Risk Classifications in AML in a Real-Life Scenario: After Changes upon Changes, Is It More and More Adverse?

    Aparicio-Pérez, Clara / Prados de la Torre, Esther / Sanchez-Garcia, Joaquin / Martín-Calvo, Carmen / Martínez-Losada, Carmen / Casaño-Sanchez, Javier / Serrano-López, Juana / Serrano, Josefina

    Cancers

    2023  Band 15, Heft 5

    Abstract: Acute myeloid leukemia (AML) is a heterogeneous disease classified into three risk categories (favorable, intermediate and adverse) with significant differences in outcomes. Definitions of risk categories evolve overtime, incorporating advances in ... ...

    Abstract Acute myeloid leukemia (AML) is a heterogeneous disease classified into three risk categories (favorable, intermediate and adverse) with significant differences in outcomes. Definitions of risk categories evolve overtime, incorporating advances in molecular knowledge of AML. In this study, we analyzed the impacts of evolving risk classifications in 130 consecutive AML patients in a single-center real-life experience. Complete cytogenetic and molecular data were collected using conventional qPCR and targeted Next Generation Sequencing (NGS). Five-year OS probabilities were consistent among all classification models (roughly 50-72%, 26-32% and 16-20% for favorable, intermediate and adverse risk groups, respectively). In the same way, the medians of survival months and prediction power were similar in all models. In each update, around 20% of patients were re-classified. The adverse category consistently increased over time (31% in MRC, 34% in ELN2010, 50% in ELN2017), reaching up to 56% in the recent ELN2022. Noteworthily, in multivariate models, only age and the presence of
    Sprache Englisch
    Erscheinungsdatum 2023-02-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15051425
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  4. Artikel ; Online: Peripheral T-cell lymphoma with a T follicular-helper phenotype: A different entity? Results of the Spanish Real-T study.

    Martín García-Sancho, Alejandro / Rodríguez-Pinilla, Socorro M / Domingo-Domenech, Eva / Climent, Fina / Sánchez-Garcia, Joaquín / López Jiménez, Javier / García-Cosío Piqueras, Mónica / Castellvi, Josep / González, Ana Julia / González de Villambrosia, Sonia / Gómez Codina, José / Navarro, Belén / Rodríguez, Guillermo / Borrero, Juan José / Fraga, Máximo / Naves, Andrea / Baeza, Lourdes / Córdoba, Raúl

    British journal of haematology

    2023  Band 203, Heft 2, Seite(n) 182–193

    Abstract: Nodal peripheral T-cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL-TFH) is a new type of PTCL. We aimed to define its clinical characteristics and prognosis compared to PTCL not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell ...

    Abstract Nodal peripheral T-cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL-TFH) is a new type of PTCL. We aimed to define its clinical characteristics and prognosis compared to PTCL not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL). This retrospective observational study included 175 patients diagnosed with PTCL between 2008 and 2013 in 13 Spanish sites. Patient diagnosis was centrally reviewed, and patients were reclassified according to the World Health Organization (WHO) 2016 criteria: 21 patients as PTCL-NOS, 55 as AITL and 23 as PTCL-TFH. Median follow-up was 56.07 months (95% CI 38.7-73.4). Progression-free survival (PFS) and overall survival (OS) were significantly higher in patients with PTCL-TFH than in those with PTCL-NOS and AITL (PFS, 24.6 months vs. 4.6 and 7.8 months, respectively, p = 0.002; OS, 52.6 months vs. 10.0 and 19.3 months, respectively, p < 0.001). Histological diagnosis maintained an independent influence on both PFS (hazard ratio [HR] 4.1 vs. PTCL-NOS, p = 0.008; HR 2.6 vs. AITL, p = 0.047) and OS (HR 5.7 vs. PTCL-NOS, p = 0.004; HR 2.6 vs. AITL, p = 0.096), regardless of the International Prognostic Index. These results suggest that PTCL-TFH could have more favourable features and prognosis than the other PTCL subtypes, although larger series are needed to corroborate these findings.
    Mesh-Begriff(e) Humans ; Lymphoma, T-Cell, Peripheral ; Immunoblastic Lymphadenopathy/genetics ; Prognosis ; Phenotype ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2023-06-30
    Erscheinungsland England
    Dokumenttyp Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18941
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: High-throughput RNA sequencing transcriptome analysis of ABC-DLBCL reveals several tumor evasion strategies.

    Serrano López, Juana / Jiménez-Jiménez, Carla / Chutipongtanate, Somchai / Serrano, Josefina / Rodríguez-Moreno, Marta / Jiménez, Álvaro / Jiménez, Yesenia / G Pedrero, Sara / Laínez, Daniel / Alonso-Domínguez, Juan Manuel / Llamas Sillero, Pilar / Piris, Miguel Ángel / Sánchez-García, Joaquín

    Leukemia & lymphoma

    2022  Band 63, Heft 8, Seite(n) 1861–1870

    Abstract: Activated B-cell (ABC) lymphoma, a distinct molecular entity within diffuse large B-cell lymphoma (DLBCL), remains highly incurable, showing a worse response to standard immunochemotherapy. The discouraging results obtained in several clinical trials ... ...

    Abstract Activated B-cell (ABC) lymphoma, a distinct molecular entity within diffuse large B-cell lymphoma (DLBCL), remains highly incurable, showing a worse response to standard immunochemotherapy. The discouraging results obtained in several clinical trials using proteasome inhibitors, tyrosine kinase inhibitors, or immunomodulators, lead to an intense search for new, potentially druggable biomarkers in DLBCL. In this study, we designed an experimental strategy for DLBCL to discover high- and low-abundance RNA-seq-derived transcripts involved in the oncogenic phenotype in patients diagnosed with ABC-DLBCL. Based on the results of a comparative analysis, 79 DE genes and two enriched gene sets related to metabolism and immunity were selected. Genes related to drug resistance, anti-inflammatory response, and tumor-cell dissemination were found to be up-regulated, while tumor suppressor genes were down-regulated. Then, we searched for the perturbagens most suitable for gene expression profiling (GEP) by iLINCS-CMap. Herein, we present a novel experimental approach that connects the omics signature of DLBCL with potential drugs for more accurate treatments.
    Mesh-Begriff(e) Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; High-Throughput Nucleotide Sequencing ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Oncogenes ; Transcriptome
    Sprache Englisch
    Erscheinungsdatum 2022-04-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2022.2056173
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  6. Artikel ; Online: Factores pronósticos clínico-biológicos en pacientes con leucemia aguda mieloblástica en recaída.

    Yébenes-Ramírez, Manuel / Serrano, Josefina / Martínez-Losada, Carmen / Sánchez-García, Joaquín

    Medicina clinica

    2016  Band 147, Heft 5, Seite(n) 185–191

    Abstract: Background and objective: Acute myeloid leukemia (AML) is the most frequent type of acute leukemia in adults. Despite recent advances in the characterization of pathogenesis of AML, the cure rates are under 40%, being leukemia relapse the most common ... ...

    Titelübersetzung Clinical and biological prognostic factors in relapsed acute myeloid leukemia patients.
    Abstract Background and objective: Acute myeloid leukemia (AML) is the most frequent type of acute leukemia in adults. Despite recent advances in the characterization of pathogenesis of AML, the cure rates are under 40%, being leukemia relapse the most common cause of treatment failure. Leukaemia relapse occurs due to clonal evolution or clonal escape. In this study, we aimed to analyze the clinical and biological factors influencing outcomes in patients with AML relapse.
    Patients and methods: We included a total of 75 AML patients who experienced leukaemia relapse after achieving complete remission. We performed complete immunophenotyping and conventional karyotyping in bone marrow aspirates obtained at diagnosis and at leukemia relapse.
    Results: Overall survival (OS) of the series was 3.7%±2.3, leukaemia progression being the most common cause of death. Patients relapsing before 12 months and those with adverse cytogenetic-molecular risk had statistically significant worse outcomes. A percentage of 52.5 of patients showed phenotypic changes and 50% cytogenetic changes at relapse. We did not find significant clinical factors predicting clonal evolution. The presence of clonal evolution at relapse did not have a significant impact on outcome.
    Conclusions: Patients with relapsed AML have a dismal prognosis, especially those with early relapse and adverse cytogenetic-molecular risk. Clonal evolution with phenotypic and cytogenetic changes occurred in half of the patients without predictive clinical factors or impact on outcome.
    Sprache Spanisch
    Erscheinungsdatum 2016-09-02
    Erscheinungsland Spain
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2016.05.015
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  7. Artikel ; Online: Machine learning applied to gene expression analysis of T-lymphocytes in patients with cGVHD.

    Serrano-López, Juana / Fernández, José Luis / Lumbreras, Eva / Serrano, Josefina / Martínez-Losada, Carmen / Martín, Carmen / Hernández-Rivas, Jesús M / Sánchez-García, Joaquín

    Bone marrow transplantation

    2020  Band 55, Heft 8, Seite(n) 1668–1670

    Mesh-Begriff(e) CD4-Positive T-Lymphocytes ; Chronic Disease ; Gene Expression ; Graft vs Host Disease/genetics ; Humans ; Machine Learning
    Sprache Englisch
    Erscheinungsdatum 2020-03-10
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-020-0848-y
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  8. Artikel ; Online: Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.

    Serrano-Lopez, Juana / Hegde, Shailaja / Kumar, Sachin / Serrano, Josefina / Fang, Jing / Wellendorf, Ashley M / Roche, Paul A / Rangel, Yamileth / Carrington, Leolene J / Geiger, Hartmut / Grimes, H Leighton / Luther, Sanjiv / Maillard, Ivan / Sanchez-Garcia, Joaquin / Starczynowski, Daniel T / Cancelas, Jose A

    eLife

    2021  Band 10

    Abstract: Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emergent ... ...

    Abstract Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emergent activation of a previously unrecognized system of rapid migration of granulocyte-macrophage progenitors and committed macrophage-dendritic progenitors, but not other progenitors or stem cells, from bone marrow (BM) to regional lymphatic capillaries. The progenitor traffic to the systemic lymphatic circulation is mediated by Ccl19/Ccr7 and is NF-κB independent, Traf6/IκB-kinase/SNAP23 activation dependent, and is responsible for the secretion of pre-stored Ccl19 by a subpopulation of CD205
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Bone Marrow/immunology ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Cell Lineage ; Cell Movement ; Cells, Cultured ; Child ; Child, Preschool ; Disease Models, Animal ; Female ; Granulocyte-Macrophage Progenitor Cells/immunology ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Granulocyte-Macrophage Progenitor Cells/pathology ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Lymphadenopathy/immunology ; Lymphadenopathy/metabolism ; Lymphadenopathy/pathology ; Lymphatic System/immunology ; Lymphatic System/metabolism ; Lymphatic System/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Myeloid Progenitor Cells/immunology ; Myeloid Progenitor Cells/metabolism ; Myeloid Progenitor Cells/pathology ; Phenotype ; Signal Transduction ; Time Factors ; Young Adult ; Mice
    Chemische Substanzen Inflammation Mediators
    Sprache Englisch
    Erscheinungsdatum 2021-04-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.66190
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  9. Artikel: Characterization of the DNAM-1, TIGIT and TACTILE Axis on Circulating NK, NKT-Like and T Cell Subsets in Patients with Acute Myeloid Leukemia.

    Valhondo, Isabel / Hassouneh, Fakhri / Lopez-Sejas, Nelson / Pera, Alejandra / Sanchez-Correa, Beatriz / Guerrero, Beatriz / Bergua, Juan M / Arcos, Maria Jose / Bañas, Helena / Casas-Avilés, Ignacio / Sanchez-Garcia, Joaquin / Serrano, Josefina / Martin, Carmen / Duran, Esther / Alonso, Corona / Solana, Rafael / Tarazona, Raquel

    Cancers

    2020  Band 12, Heft 8

    Abstract: ... ...

    Abstract Background
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12082171
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  10. Artikel ; Online: A rare composite lymphoma: follicular and in situ mantle cell.

    Marí-Jimenez, Pilar / Martínez-Losada, Carmen / Centeno-Haro, Macarena / Rodríguez-García, Guillermo / Perez-Seoane, Carlos / Sánchez-García, Joaquín

    Annals of hematology

    2016  Band 95, Heft 8, Seite(n) 1351–1352

    Mesh-Begriff(e) Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bendamustine Hydrochloride/administration & dosage ; Composite Lymphoma/diagnosis ; Composite Lymphoma/drug therapy ; Female ; Humans ; Lymph Nodes/pathology ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/drug therapy ; Lymphoma, Mantle-Cell/diagnosis ; Lymphoma, Mantle-Cell/drug therapy ; Remission Induction ; Rituximab/administration & dosage ; Treatment Outcome
    Chemische Substanzen Rituximab (4F4X42SYQ6) ; Bendamustine Hydrochloride (981Y8SX18M)
    Sprache Englisch
    Erscheinungsdatum 2016-08
    Erscheinungsland Germany
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-016-2680-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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