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Article: The Present and Future of Neoadjuvant Endocrine Therapy for Breast Cancer Treatment.

Martí, Covadonga / Sánchez-Méndez, José Ignacio

2021 Volume 13, Issue 11

Abstract: Endocrine therapy (ET) has established itself as an efficacious treatment for estrogen receptor-positive (ER+) breast cancers, with a reduction in recurrence rates and increased survival rates. The pre-surgical approach with chemotherapy (NCT) has become ...

Abstract	Endocrine therapy (ET) has established itself as an efficacious treatment for estrogen receptor-positive (ER+) breast cancers, with a reduction in recurrence rates and increased survival rates. The pre-surgical approach with chemotherapy (NCT) has become a common form of management for large, locally advanced, or high-risk tumors. However, a good response to NCT is not usually expected in ER+ tumors. Good results with primary ET, mainly in elderly women, have encouraged studies in other stages of life, and nowadays neoadjuvant endocrine treatment (NET) has become a useful approach to many ER+ breast cancers. The aim of this review is to provide an update on the current state of art regarding the present and the future role of NET.
Language	English
Publishing date	2021-05-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13112538
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Article: Surgical Interest of an Accurate Real-World Prediction of Primary Systemic Therapy Response in HER2 Breast Cancers.

Sánchez-Méndez, Jose Ignacio / Horstmann, Mónica / Méndez, Nieves / Frías, Laura / Moreno, Elisa / Yébenes, Laura / Roca, Mᵃ José / Hernández, Alicia / Martí, Covadonga

Cancers

2023 Volume 15, Issue 10

Abstract: Human epidermal growth factor receptor 2 (HER2)-enriched breast cancers (BC) present the highest rates of pathological response to primary systemic therapy (PST), but they are also the ones that tend to be larger at diagnosis, with microcalcifications ... ...

Abstract	Human epidermal growth factor receptor 2 (HER2)-enriched breast cancers (BC) present the highest rates of pathological response to primary systemic therapy (PST), but they are also the ones that tend to be larger at diagnosis, with microcalcifications and, often, with axillary involvement. If we do not have a reliable method to predict the degree of response, we may not be able to transfer the benefits of PST to surgery. The post-PST surgery planning is guided by the findings in the magnetic resonance imaging (MRI), whose predictive capacity, although high, is far from optimal. Thus, it seems interesting to find other variables to improve it. A retrospective observational study including women with HER2 BC treated with PST and further surgery was conducted. Information regarding clinical, radiological, and histopathological variables was gathered from a total of 132 patients included. Radiological complete response (rCR) was achieved in 65.9% of the sample, and pathological complete response (pCR), according to Miller and Payne criteria, in 58.3% of cases. A higher Ki67 value, the absence of Hormonal Receptors expression, and an rCR was significantly related to a pCR finding. This information impacts directly in surgery planning, as it permits adjustment of the breast resection volume.
Language	English
Publishing date	2023-05-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15102757
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Article: Breast-Conserving Surgery Guided with Magnetic Seeds vs. Wires: A Single-Institution Experience.

Moreno-Palacios, Elisa / Martí, Covadonga / Frías, Laura / Meléndez, Marcos / Loayza, Adolfo / Roca, María José / Córdoba, Vicenta / Oliver, José María / Hernández, Alicia / Sánchez-Méndez, José Ignacio

Cancers

2024 Volume 16, Issue 3

Abstract: Purpose: The aim of this study is to describe our initial experience using magnetic seeds (Magseed: Methods: We performed a retrospective study including all breast-conserving surgeries for non-palpable breast lesions under 16 mm from June 2018 to ... ...

Abstract	Purpose: The aim of this study is to describe our initial experience using magnetic seeds (Magseed Methods: We performed a retrospective study including all breast-conserving surgeries for non-palpable breast lesions under 16 mm from June 2018 to May 2021. We compared breast-conserving surgeries guided with magnetic seeds (Magseed Results: Data from 225 cases were collected, including 149 cases guided by magnetic seeds and 76 cases guided by wires. The breast lesion was localized in every case. Both cohorts were similar regarding clinical and pathological characteristics. We found significant statistical differences ( Conclusion: In our experience, the use of magnetic seed (Magseed
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16030566
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Article ; Online: Impacto de la primera ola de la pandemia de COVID-19 en la atención a pacientes oncológicos en un hospital terciario.

Cruz-Castellanos, Patricia / Ortiz-Cruz, Eduardo / Sánchez-Méndez, Jose Ignacio / Tapia, Mar / Morera, Rosa / Redondo, Andrés

Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia

2022 Volume 55, Issue 2, Page(s) 77–84

Abstract: Blackground: The COVID-19 pandemic has over-burdened the Spanish health service and, as a result, affected the treatment and management of oncological patients. The aim of this study is to make a descriptive analysis of the management of oncological ... ...

Title translation	The impact of the first wave of the COVID-19 pandemic on oncological patients in a tertiary hospital.
Abstract	Blackground: The COVID-19 pandemic has over-burdened the Spanish health service and, as a result, affected the treatment and management of oncological patients. The aim of this study is to make a descriptive analysis of the management of oncological patients and the functioning of the tumour committees in the University Hospital La Paz (Madrid) during the first wave of the pandemic. Materials and methods: A descriptive analysis was made, based on the results of a questionnaire given to all 18 adult tumour committees and 3 paediatric tumour committees in the University Hospital La Paz. Further information was obtained from all the hospital services involved in the diagnosis and treatment of oncological patients. Results: During the first wave of the pandemic, there was a significant decrease in diagnostic tests. For many weeks, the majority of oncological surgical procedures were delayed or referred to other hospitals. Highly beneficial systemic and radiotherapeutic treatments were maintained and preoperative treatment was increased. The diagnosis and treatment of paediatric tumours was unaltered. Tumour committees were affected but each one adjusted in a different way. All the departments involved in the diagnosis and treatment of oncological patients made contingency plans to minimalize the effect on patients. Conclusion: This study shows how the management of oncological patients and the functioning of tumour committees was affected during the COVID-19 pandemic.
MeSH term(s)	Adult ; COVID-19 ; Child ; Humans ; Neoplasms/epidemiology ; Neoplasms/therapy ; Pandemics ; Surveys and Questionnaires ; Tertiary Care Centers
Language	Spanish
Publishing date	2022-01-19
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2463888-2
ISSN	1988-561X ; 1988-561X
ISSN (online)	1988-561X
ISSN	1988-561X
DOI	10.1016/j.patol.2021.12.001
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Article ; Online: The Clinical Impact of Neoadjuvant Endocrine Treatment on Luminal-like Breast Cancers and Its Prognostic Significance: Results from a Single-Institution Prospective Cohort Study.

Martí, Covadonga / Yébenes, Laura / Oliver, José María / Moreno, Elisa / Frías, Laura / Berjón, Alberto / Loayza, Adolfo / Meléndez, Marcos / Roca, María José / Córdoba, Vicenta / Hardisson, David / Rodríguez, María Ángeles / Sánchez-Méndez, José Ignacio

Current oncology (Toronto, Ont.)

2022 Volume 29, Issue 4, Page(s) 2199–2210

Abstract: Purpose: Neoadjuvant endocrine treatment (NET) has become a useful tool for the downstaging of luminal-like breast cancers in postmenopausal patients. It enables us to increase breast- conserving surgery (BCS) rates, provides an opportunity for us to ... ...

Abstract	Purpose: Neoadjuvant endocrine treatment (NET) has become a useful tool for the downstaging of luminal-like breast cancers in postmenopausal patients. It enables us to increase breast- conserving surgery (BCS) rates, provides an opportunity for us to assess in vivo NET effectiveness, and allows us to study any biological changes that may act as valid biomarkers. The purpose of this study was to evaluate the safety and effectiveness of NET, and to assess the role of Ki67 proliferation rate changes as an indicator of endocrine responsiveness. Methods: From 2016 to 2020, a single-institution cohort of patients, treated with NET and further surgery, was evaluated. In patients with Ki67 ≥ 10%, a second core biopsy was performed after four weeks. Information regarding histopathological and clinical changes was gathered. Results: A total of 115 estrogen receptor-positive (ER+)/HER2-negative patients were included. The median treatment duration was 5.0 months (IQR: 2.0−6.0). The median maximum size in the surgical sample was 40% smaller than the pretreatment size measured by ultrasound (p < 0.0001). The median pretreatment Ki67 expression was 20.0% (IQR: 12.0−30.0), and was reduced to 5.0% (IQR: 1.8−10.0) after four weeks, and to 2.0% (IQR: 1.0−8.0) in the surgical sample (p < 0.0001). BCS was performed on 98 patients (85.2%). No pathological complete responses were recorded. A larger Ki67 fold change after four weeks was significantly related to a PEPI score of zero (p < 0.002). No differences were observed between luminal A- and B-like tumors, with regard to fold change and PEPI score. Conclusions: In our cohort, NET was proven to be effective for tumor size and Ki67 downstaging. This resulted in a higher rate of conservative surgery, aided in therapeutic decision making, provided prognostic information, and constituted a safe and well-tolerated approach.
MeSH term(s)	Breast Neoplasms/pathology ; Female ; Humans ; Ki-67 Antigen ; Neoadjuvant Therapy ; Prognosis ; Prospective Studies
Chemical Substances	Ki-67 Antigen
Language	English
Publishing date	2022-03-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29040179
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Article ; Online: EMD-based data augmentation method applied to handwriting data for the diagnosis of Essential Tremor using LSTM networks.

Otero, José Fernando Adrán / López-de-Ipina, Karmele / Caballer, Oscar Solans / Marti-Puig, Pere / Sánchez-Méndez, José Ignacio / Iradi, Jon / Bergareche, Alberto / Solé-Casals, Jordi

Scientific reports

2022 Volume 12, Issue 1, Page(s) 12819

Abstract: The increasing capacity of today's technology represents great advances in diagnosing diseases using standard procedures supported by computer science. Deep learning techniques are able to extract the characteristics of temporal signals to study their ... ...

Abstract	The increasing capacity of today's technology represents great advances in diagnosing diseases using standard procedures supported by computer science. Deep learning techniques are able to extract the characteristics of temporal signals to study their patterns and diagnose diseases such as essential tremor. However, these techniques require a large amount of data to train the neural network and achieve good results, and the more data the network has, the more accurate the final model implemented. In this work we propose the use of a data augmentation technique to improve the accuracy of a Long short-term memory system in the diagnosis of essential tremor. For this purpose, the multivariate Empirical Mode Decomposition method will be used to decompose the original temporal signals collected from control subjects and patients with essential tremor. The time series obtained from the decomposition, covering different frequency ranges, will be randomly shuffled and combined to generate new artificial samples for each group. Then, both the generated artificial samples and part of the real samples will be used to train the LSTM network, and the remaining original samples will be used to test the model. The experimental results demonstrate the capability of the proposed method, which is compared to a set of 10 different data augmentation methods, and in all cases outperforms all other methods. In the best case, the proposed method increases the accuracy of the classifier from 83.20% to almost 93% when artificial samples are generated, which is a promising result when only small databases are available.
MeSH term(s)	Databases, Factual ; Essential Tremor/diagnosis ; Handwriting ; Humans ; Neural Networks, Computer
Language	English
Publishing date	2022-07-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-16741-y
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Article: Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management.

Lopez-de-Ipina, Karmele / Solé-Casals, Jordi / Sánchez-Méndez, José Ignacio / Romero-Garcia, Rafael / Fernandez, Elsa / Requejo, Catalina / Poologaindran, Anujan / Faúndez-Zanuy, Marcos / Martí-Massó, José Félix / Bergareche, Alberto / Suckling, John

Frontiers in human neuroscience

2021 Volume 15, Page(s) 648573

Abstract: Essential tremor (ET) is a highly prevalent neurological disorder characterized by action-induced tremors involving the hand, voice, head, and/or face. Importantly, hand tremor is present in nearly all forms of ET, resulting in impaired fine motor skills ...

Abstract	Essential tremor (ET) is a highly prevalent neurological disorder characterized by action-induced tremors involving the hand, voice, head, and/or face. Importantly, hand tremor is present in nearly all forms of ET, resulting in impaired fine motor skills and diminished quality of life. To advance early diagnostic approaches for ET, automated handwriting tasks and magnetic resonance imaging (MRI) offer an opportunity to develop early essential clinical biomarkers. In this study, we present a novel approach for the early clinical diagnosis and monitoring of ET based on integrating handwriting and neuroimaging analysis. We demonstrate how the analysis of fine motor skills, as measured by an automated Archimedes' spiral task, is correlated with neuroimaging biomarkers for ET. Together, we present a novel modeling approach that can serve as a complementary and promising support tool for the clinical diagnosis of ET and a large range of tremors.
Language	English
Publishing date	2021-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2021.648573
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Article ; Online: External validation of a prognostic model based on total tumor load of sentinel lymph node for early breast cancer patients.

Piñero-Madrona, Antonio / Ripoll-Orts, Francisco / Sánchez-Méndez, José Ignacio / Chaves-Benito, Asunción / Gómez-de la Bárcena, Maximiliano Rodrigo / Calatrava-Fons, Ana / Menjón-Beltrán, Salomón / Peg-Cámara, Vicente

Breast cancer research and treatment

2020 Volume 181, Issue 2, Page(s) 339–345

Abstract: Background: A prognostic model based on the results of molecular analysis of sentinel lymph nodes (SLN) is needed to replace the information that staging the entire axilla provided. The aim of the study is to conduct an external validation of a ... ...

Abstract	Background: A prognostic model based on the results of molecular analysis of sentinel lymph nodes (SLN) is needed to replace the information that staging the entire axilla provided. The aim of the study is to conduct an external validation of a previously developed model for the prediction of 5-year DFS in a group of breast cancer patients that had undergone SLN biopsy assessed by the One Step Nucleic Acid Amplification (OSNA) method. Methods: We collected retrospective data of 889 patients with breast cancer, who had not received systemic treatment before surgery, and who underwent SLN biopsy and evaluation of all SLN by OSNA. The discrimination ability of the model was assessed by the area under the ROC curve (AUC ROC), and its calibration by comparing 5-years DFS Kaplan-Meier estimates in quartile groups of model predicted probabilities (MPP). Results: The AUC ROC ranged from 0.78 (at 2 years) to 0.73 (at 5 years) in the training set, and from 0.78 to 0.71, respectively, in the validation set. The MPP allowed to distinguish four groups of patients with heterogeneous DFS (log-rank test p < 0.0001). In the highest risk group, the HR were 6.04 [95% CI 2.70, 13.48] in the training set and 4.79 [2.310, 9.93] in the validation set. Conclusions: The model for the prediction of 5-year DFS was successfully validated using the most stringent form of validation, in centers different from those involved in the development of the model. The external validation of the model confirms its utility for the prediction of 5-year DFS and the usefulness of the TTL value as a prognostic variable.
MeSH term(s)	Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Models, Statistical ; Prognosis ; Retrospective Studies ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node Biopsy ; Survival Rate ; Tumor Burden
Language	English
Publishing date	2020-04-06
Publishing country	Netherlands
Document type	Journal Article ; Validation Study
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-020-05623-4
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Article: Discrete Cosine Transform for the Analysis of Essential Tremor.

Solé-Casals, Jordi / Anchustegui-Echearte, Iker / Marti-Puig, Pere / Calvo, Pilar M / Bergareche, Alberto / Sánchez-Méndez, José Ignacio / Lopez-de-Ipina, Karmele

Frontiers in physiology

2019 Volume 9, Page(s) 1947

Abstract: Essential tremor (ET) is the most common movement disorder. In fact, its prevalence is about 20 times higher than that of Parkinson's disease. In addition, studies have shown that a high percentage of cases, between 50 and 70%, are estimated to be of ... ...

Abstract	Essential tremor (ET) is the most common movement disorder. In fact, its prevalence is about 20 times higher than that of Parkinson's disease. In addition, studies have shown that a high percentage of cases, between 50 and 70%, are estimated to be of genetic origin. The gold standard test for diagnosis, monitoring and to differentiate between both pathologies is based on the drawing of the Archimedes' spiral. Our major challenge is to develop the simplest system able to correctly classify Archimedes' spirals, therefore we will exclusively use the information of the
Language	English
Publishing date	2019-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2018.01947
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Article: Cancer de mama con Her-2-neu y receptores hormonales positivos. Quimioterapia neoadyuvante, biopsia de ganglio centinela y tratamiento hormonal.

López Carpintero, Nayara / Sánchez Méndez, José Ignacio / de Santiago García, José Ignacio

Ginecologia y obstetricia de Mexico

2012 Volume 80, Issue 11, Page(s) 720–724

Abstract: Neoadjuvant chemotherapy is an interesting option in the therapy of some breast cancer cases. Cases in which the timing for sentinel lymph node biopsy is controversial. Co-expression of estrogen receptors and Her2/neu (c-erbB-2) in breast cancer may ... ...

Title translation	Co-expression of estrogen receptors and Her2/neu in breast cancer. Neoadjuvant chemotherapy sentinel lymph node and hormonotherapy.
Abstract	Neoadjuvant chemotherapy is an interesting option in the therapy of some breast cancer cases. Cases in which the timing for sentinel lymph node biopsy is controversial. Co-expression of estrogen receptors and Her2/neu (c-erbB-2) in breast cancer may imply hormone resistance, especially to tamoxifen. We present a clinic case with co-expression of estrogen receptors and Her2/neu that was treated with neoadjuvant chemotherapy and previous sentinel lymph node biopsy followed by breasttumorectomy with axillar lymphadenectomy, radiotherapy and hormonotherapy with letrozol, geserelina and trastuzumab. A good treatment response was found.
MeSH term(s)	Adult ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Chemotherapy, Adjuvant ; Female ; Hormones/therapeutic use ; Humans ; Neoadjuvant Therapy ; Receptor, ErbB-2/biosynthesis ; Receptors, Estrogen/biosynthesis ; Sentinel Lymph Node Biopsy
Chemical Substances	Hormones ; Receptors, Estrogen ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	Spanish
Publishing date	2012-11
Publishing country	Mexico
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	731087-0
ISSN	0300-9041 ; 0072-453X
ISSN	0300-9041 ; 0072-453X
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