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  1. Book ; Online: The developing testis

    Söder, Olle

    physiology and pathophysiology ; current knowledge on human testicular development

    2003  

    Author's details vol. ed.: Olle Söder
    Language English
    Size X + 160 S.
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    HBZ-ID TT050388099
    ISBN 978-3-318-00912-5 ; 3-318-00912-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: The developing testis

    Söder, Olle

    physiology and pathophysiology ; 2 tables

    (Endocrine development ; 5)

    2003  

    Author's details vol. ed. Olle Söder
    Series title Endocrine development ; 5
    Collection
    Keywords Hoden ; Entwicklung ; Physiologie ; Hodenkrankheit ; Pathophysiologie
    Subject Humanphysiologie ; Mensch ; Körperfunktion ; Männliche Geschlechtsdrüse ; Orchis ; Testis ; Didymus ; Testikel ; Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Ursprung ; Entwicklungsstadium
    Language English
    Size X, 160 S. : Ill., graph. Darst., 25 cm
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT013593843
    ISBN 3-8055-7495-9 ; 978-3-8055-7495-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 A 696 order for loan Magazin

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  3. Article ; Online: Endocrine disruptors and the male reproductive system.

    Stukenborg, Jan-Bernd / Mitchell, Rod T / Söder, Olle

    Best practice & research. Clinical endocrinology & metabolism

    2021  Volume 35, Issue 5, Page(s) 101567

    Abstract: In recent years, there has been an increased incidence in several of the most common reproductive disorders, including hypospadias and cryptorchidism in newborns, and testicular cancer and lower sperm quality in young adult males. In addition, the timing ...

    Abstract In recent years, there has been an increased incidence in several of the most common reproductive disorders, including hypospadias and cryptorchidism in newborns, and testicular cancer and lower sperm quality in young adult males. In addition, the timing of puberty has also changed over time. Although the cause of these reproductive effects is a matter of intense debate, a link with the presence of ubiquitous compounds in the environment, or the exposure to specific groups of medications during foetal life, has been suggested. Results from epidemiological and experimental studies, as well as clinical observations in humans indicate that endocrine-disrupting chemicals may be associated with those disorders. In this review, we will summarize the results of epidemiological studies and experimental studies utilising human testicular cells or tissue. Due to increasing public interest and the recently published data, the main focus will be on the effects of prenatal exposure to mild analgesics.
    MeSH term(s) Cryptorchidism/chemically induced ; Cryptorchidism/epidemiology ; Endocrine Disruptors/adverse effects ; Endocrine Disruptors/toxicity ; Female ; Genitalia, Male ; Humans ; Infant, Newborn ; Male ; Neoplasms, Germ Cell and Embryonal ; Pregnancy ; Testicular Neoplasms/chemically induced ; Testicular Neoplasms/epidemiology
    Chemical Substances Endocrine Disruptors
    Language English
    Publishing date 2021-08-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2052339-7
    ISSN 1878-1594 ; 1532-1908 ; 1521-690X
    ISSN (online) 1878-1594 ; 1532-1908
    ISSN 1521-690X
    DOI 10.1016/j.beem.2021.101567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Medium- and time-related effects on hypothermic storage of rat testicular cells.

    Elfageih, Rageia / Reda, Ahmed / Kjartansdottir, Kristin Ros / Pampanini, Valentina / Soder, Olle / Stukenborg, Jan-Bernd

    Reproduction & fertility

    2023  

    Abstract: Objective: Testicular samples obtained for fertility preservation often need to be transported between clinics. This study aimed to mimic this short-term hypothermic storage (4-8 °C) and explore the impact of these conditions and the transport medium ... ...

    Abstract Objective: Testicular samples obtained for fertility preservation often need to be transported between clinics. This study aimed to mimic this short-term hypothermic storage (4-8 °C) and explore the impact of these conditions and the transport medium composition on prepubertal rat testicular tissue samples.
    Methods: Testicular tissue samples obtained from seven days post-partum rats were transferred to six compositionally different basal culture media and a balanced salt solution, which had been kept at 4-8 °C prior to transfer. The samples were preserved for either 12 or 24 hours in these hypothermic conditions. The potential effects of the short-term storage were evaluated by assessing the morphology, measuring the testosterone levels by radioimmunoassay and analysing 96 genes with TaqMan Low-Density Arrays. Summarizing results: Levels of gene expression related to energy, apoptosis and angiogenesis pathways were altered after hypothermic storage for 12 and especially 24 hours. We observed only minor differences in gene expression profiles for germ and testicular somatic cells, and no differences in tissue morphology and testosterone production levels.
    Conclusions: Short-term hypothermic storage of testicular tissue with a maximum duration of 24 hours does not affect the overall expression profile of testicular cell-specific genes; however, in a minor way, it affects the expression of specific cellular genes.
    Language English
    Publishing date 2023-05-01
    Publishing country England
    Document type Journal Article
    ISSN 2633-8386
    ISSN (online) 2633-8386
    DOI 10.1530/RAF-22-0050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Conference proceedings: Diabetes Mellitus Typ 1 kann eine Hodenatrophie mit Leydig-Zell-Hyperplasie und Keimzelldepletion induzieren und beeinflusst somit negativ die Hodenfunktion und Fertilität in männlichen Ratten

    Frielitz-Wagner, Isabel Viola / Kloeting, Nora / Kulle, Alexandra / Rieck, Karen / Söder, Olle / Hiort, Olaf

    Diabetologie und Stoffwechsel

    (Diabetes Kongress 2024 – 58. Jahrestagung der DDG)

    2024  Volume 19, Issue S 01

    Event/congress Diabetes. Umwelt. Leben. Perspektiven aus allen Blickwinkeln, CityCube Berlin, 2024-05-08
    Series title Diabetes Kongress 2024 – 58. Jahrestagung der DDG
    Language German
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2222993-0
    ISSN 1861-9010 ; 1861-9002
    ISSN (online) 1861-9010
    ISSN 1861-9002
    DOI 10.1055/s-0044-1785255
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6479: Show issues Location:
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  6. Article ; Online: Adverse effects of metabolic disorders in childhood on adult reproductive function and fertility in the male.

    Wagner, Isabel Viola / Oliver, Elizabeth / Dötsch, Jörg / Söder, Olle

    Journal of pediatric endocrinology & metabolism : JPEM

    2020  Volume 34, Issue 1, Page(s) 13–23

    Abstract: Over the last 50 years, there has been a steady decline in fertility rates in humans, which has occurred in parallel with an increasing incidence of obesity and metabolic disorders. The potential impact of these disorders and plausible mechanisms by ... ...

    Abstract Over the last 50 years, there has been a steady decline in fertility rates in humans, which has occurred in parallel with an increasing incidence of obesity and metabolic disorders. The potential impact of these disorders and plausible mechanisms by which they negatively influence male reproduction are only partly understood and published data are often controversial. Obesity is one of the most important health challenges worldwide and is becoming more prevalent in children and adolescents. Obesity, the metabolic syndrome and related co-morbidities can lead to impaired male reproductive function, including adverse effects on spermatogenesis and steroidogenesis as illustrated by reduced sperm number and quality, decreased testosterone levels and elevated inflammatory markers. The incidence of diabetes mellitus type I is also dramatically increasing and may negatively impact spermatogenesis and testicular function, resulting in decreased serum testosterone and epididymal weight. In this review, we summarize and discuss the effects of metabolic diseases that typically develop during childhood and adolescence on later reproductive function and fertility. While impact on reproductive health is likely observed in both sexes, we have chosen to focus on the male in the current review. Specifically, we illustrate adverse effects of obesity, type 1 diabetes, the metabolic syndrome and insulin resistance on sperm function and testosterone metabolism. Identification of pathophysiological mechanisms during childhood may open up new avenues for early prevention and treatment resulting in better reproductive outcomes and improved fertility rates during adulthood.
    MeSH term(s) Adolescent ; Child ; Humans ; Infertility, Male/etiology ; Infertility, Male/pathology ; Male ; Metabolic Syndrome/complications ; Reproduction
    Language English
    Publishing date 2020-11-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1231070-0
    ISSN 2191-0251 ; 0334-018X
    ISSN (online) 2191-0251
    ISSN 0334-018X
    DOI 10.1515/jpem-2020-0276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Endocrine Disruptors and Child Health: New Insights.

    Cianfarani, Stefano / Söder, Olle

    Hormone research in paediatrics

    2016  Volume 86, Issue 4, Page(s) 219–220

    Language English
    Publishing date 2016-09-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2537278-6
    ISSN 1663-2826 ; 1663-2818
    ISSN (online) 1663-2826
    ISSN 1663-2818
    DOI 10.1159/000449273
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 414: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Can Klinefelter patients be female?

    Soder, Olle

    Hormone research

    2007  Volume 68, Issue 3, Page(s) 156

    MeSH term(s) Disorders of Sex Development/classification ; Female ; Humans ; Klinefelter Syndrome/genetics ; Klinefelter Syndrome/pathology ; Male
    Language English
    Publishing date 2007
    Publishing country Switzerland
    Document type Comment ; Journal Article
    ZDB-ID 124442-5
    ISSN 1423-0046 ; 0301-0163
    ISSN (online) 1423-0046
    ISSN 0301-0163
    DOI 10.1159/000101523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 414: Show issues Location:
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  9. Article: Sexual dimorphism of gonadal development.

    Söder, Olle

    Best practice & research. Clinical endocrinology & metabolism

    2007  Volume 21, Issue 3, Page(s) 381–391

    Abstract: Sexual dimorphism is a term describing morphological differences between the sexes, but is often extended to include all differences observed between females and males. Sex differentiation in vertebrates is by definition sexually dimorphic and starts at ... ...

    Abstract Sexual dimorphism is a term describing morphological differences between the sexes, but is often extended to include all differences observed between females and males. Sex differentiation in vertebrates is by definition sexually dimorphic and starts at the level of the sex chromosomes. In this review the sexual dimorphism of gonadal differentiation is discussed, with a focus on human development. In the embryo, the indifferent gonadal anlagen harbours four different cell lineages with bipotential fates dependent on the sex of the individual. The different paths taken by these cell lineages in male and female development are reviewed, along with other sexually dimorphic features of gonadal development. These include sex-determining genes, timing of events, dependence on germ cells, spatial organization of stromal cells, steroidogenic cells types, and other aspects.
    MeSH term(s) Animals ; Cell Lineage/physiology ; Female ; Fetal Organ Maturity/genetics ; Gametogenesis/physiology ; Gene Expression Regulation, Developmental ; Genes, Homeobox ; Germ Cells/physiology ; Gonadal Steroid Hormones/biosynthesis ; Gonadal Steroid Hormones/pharmacology ; Humans ; Male ; Sex Characteristics ; Sex Determination Processes ; Sex Differentiation ; Urogenital System/cytology ; Urogenital System/embryology
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2007-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2052339-7
    ISSN 1532-1908 ; 1521-690X
    ISSN (online) 1532-1908
    ISSN 1521-690X
    DOI 10.1016/j.beem.2007.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Use of a three-layer gradient system of cells for rat testicular organoid generation.

    Alves-Lopes, João Pedro / Söder, Olle / Stukenborg, Jan-Bernd

    Nature protocols

    2018  Volume 13, Issue 2, Page(s) 248–259

    Abstract: We have recently developed a 3D culture system that allows the reorganization of rat primary testicular cells into organoids with a functional blood-testis barrier, as well as the establishment and maintenance of germ cells. The innovative aspect of our ... ...

    Abstract We have recently developed a 3D culture system that allows the reorganization of rat primary testicular cells into organoids with a functional blood-testis barrier, as well as the establishment and maintenance of germ cells. The innovative aspect of our model, the three-layer gradient system (3-LGS), comprises cells combined with Matrigel placed between two layers of Matrigel without cells, which creates a gradient of cells and allows the reorganization of testicular cells into organized structures after 5-7 d in culture. This reorganization is not observed when testicular cells are suspended in only one layer of Matrigel, the methodology used in the majority of the protocols for generating organoids. The model can be applied to follow and quantify cell migration during testicular organoid formation, and to explore the role of growth factors and the toxic effects of drugs and environmental contaminants on germ cell maintenance and blood-testis barrier integrity. The 3-LGS is a robust and reproducible method that requires a small volume of Matrigel and a low number of cells (16 μl and 132,000 cells, respectively), enabling and facilitating high-throughput analysis of germ-to-somatic cell associations in vitro.
    MeSH term(s) Animals ; Cell Culture Techniques/methods ; Cell Differentiation/physiology ; Cells, Cultured ; Collagen ; Drug Combinations ; Laminin ; Male ; Organoids/transplantation ; Proteoglycans ; Rats ; Spermatogenesis/physiology ; Spermatogonia/growth & development ; Spermatogonia/physiology ; Testis
    Chemical Substances Drug Combinations ; Laminin ; Proteoglycans ; matrigel (119978-18-6) ; Collagen (9007-34-5)
    Language English
    Publishing date 2018-01-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2244966-8
    ISSN 1750-2799 ; 1754-2189
    ISSN (online) 1750-2799
    ISSN 1754-2189
    DOI 10.1038/nprot.2017.140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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