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  1. Article ; Online: Recommended Duration of Antibiotic Treatment for Immunocompetent Children With Salmonella Osteomyelitis.

    Højagergaard, Mathias Alexander / Thønnings, Sara / Søes, Lillian Marie / Smith, Birgitte

    The Pediatric infectious disease journal

    2023  Volume 42, Issue 11, Page(s) e429

    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000004050
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  2. Article ; Online: Performance of PCR-based syndromic testing compared to bacterial culture in patients with suspected pneumonia applying microscopy for quality assessment.

    Andrews, Vigith / Pinholt, Mette / Schneider, Uffe Vest / Schønning, Kristian / Søes, Lillian Marie / Lisby, Gorm

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2022  Volume 130, Issue 7, Page(s) 417–426

    Abstract: Syndromic testing for lower respiratory tract infections with BioFire® FilmArray® Pneumonia Panel Plus (BF) detects 27 pathogens with a turn-around-time of one hour. We compared the performance of BF with culture. Samples from 298 hospitalized patients ... ...

    Abstract Syndromic testing for lower respiratory tract infections with BioFire® FilmArray® Pneumonia Panel Plus (BF) detects 27 pathogens with a turn-around-time of one hour. We compared the performance of BF with culture. Samples from 298 hospitalized patients with suspected pneumonia routinely sent for culture were also analyzed using BF. Retrospectively, patients were clinically categorized as having "pneumonia" or "no pneumonia." BF and culture were compared by analytical performance, which was evaluated by pathogen concordance, and by clinical performance by comparing pathogen detections in patients with and without pneumonia. The BF results for viruses and atypical bacteria were not included in the performance analysis. In 298 patient samples, BF and culture detected 285 and 142 potential pathogens, respectively. Positive percent agreement (PPA) was 88% (125/142). In patients with community-acquired pneumonia (CAP), clinical sensitivity was 70% and 51%, and specificity was 43% and 71% for BF and culture, respectively. In patients with hospital-acquired pneumonia, the corresponding numbers were 55% and 23%, and 47% and 68%. There was no significant improvement of performance, when only high-quality sputum samples were considered. Efficacy of both BF and culture was low. Both tests are best used in CAP patients for whom the diagnosis has already been clinically established. Indiscriminate use may be clinically misleading and a cause of improper use of antibiotics.
    MeSH term(s) Community-Acquired Infections/diagnosis ; Humans ; Microscopy ; Molecular Diagnostic Techniques/methods ; Multiplex Polymerase Chain Reaction/methods ; Pneumonia/diagnosis ; Polymerase Chain Reaction ; Retrospective Studies
    Language English
    Publishing date 2022-05-22
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Response to letter in response to 'saliva is inferior to nose and throat swabs for SARS-CoV-2 detection in children'.

    von Linstow, Marie-Louise / Kruse, Alexandra / Kirkby, Nikolai / Søes, Lillian Marie / Nygaard, Ulrikka / Poulsen, Anja

    Acta paediatrica (Oslo, Norway : 1992)

    2021  Volume 110, Issue 12, Page(s) 3388

    MeSH term(s) COVID-19 ; Child ; Humans ; Pharynx ; SARS-CoV-2 ; Saliva ; Specimen Handling
    Language English
    Publishing date 2021-09-23
    Publishing country Norway
    Document type Letter ; Comment
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Non-toxigenic tox gene-bearing Corynebacterium ulcerans in a traumatic ulcer from a human case and his asymptomatic dog.

    Fuursted, Kurt / Søes, Lillian Marie / Crewe, Bjørn Thomas / Stegger, Marc / Andersen, Paal Skytt / Christensen, Jens Jørgen

    Microbes and infection

    2015  Volume 17, Issue 10, Page(s) 717–719

    Abstract: A non-toxigenic tox gene-bearing (NTTB) Corynebacterium ulcerans was grown from the wound of a 61-year-old gardener and in a nasal specimen from the patient's asymptomatic dog. The two isolates were similar in terms of antibiogram, multilocus sequence ... ...

    Abstract A non-toxigenic tox gene-bearing (NTTB) Corynebacterium ulcerans was grown from the wound of a 61-year-old gardener and in a nasal specimen from the patient's asymptomatic dog. The two isolates were similar in terms of antibiogram, multilocus sequence typing (ST341), virulence genes, and only three SNPs were found to differentiate the two NTTB C. ulcerans isolates supporting a zoonotic transmission to or between the patient and his dog. Of interest, we found that the two C. ulcerans isolates, although not expressing the diphtheria toxin tox, possessed 13 out of 14 recently described virulence candidate genes.
    MeSH term(s) Animals ; Bacterial Toxins/genetics ; Carrier State/microbiology ; Carrier State/veterinary ; Corynebacterium/classification ; Corynebacterium/drug effects ; Corynebacterium/genetics ; Corynebacterium/isolation & purification ; Corynebacterium Infections/microbiology ; Corynebacterium Infections/pathology ; Corynebacterium Infections/veterinary ; Diphtheria Toxin/genetics ; Dogs ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Multilocus Sequence Typing ; Polymorphism, Single Nucleotide ; Ulcer/microbiology ; Ulcer/pathology ; Virulence Factors/genetics ; Wound Infection/microbiology ; Wound Infection/pathology ; Wounds and Injuries/complications ; Zoonoses/microbiology ; Zoonoses/transmission
    Chemical Substances Bacterial Toxins ; Diphtheria Toxin ; Virulence Factors
    Language English
    Publishing date 2015-10
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2015.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Two anthrax cases with soft tissue infection, severe oedema and sepsis in Danish heroin users.

    Russell, Lene / Pedersen, Michael / Jensen, Andreas V / Søes, Lillian Marie / Hansen, Ann-Brit Eg

    BMC infectious diseases

    2013  Volume 13, Page(s) 408

    Abstract: Background: Anthrax had become extremely rare in Europe, but in 2010 an outbreak of anthrax among heroin users in Scotland increased awareness of contaminated heroin as a source of anthrax. We present the first two Danish cases of injectional anthrax ... ...

    Abstract Background: Anthrax had become extremely rare in Europe, but in 2010 an outbreak of anthrax among heroin users in Scotland increased awareness of contaminated heroin as a source of anthrax. We present the first two Danish cases of injectional anthrax and discuss the clinical presentations, which included both typical and more unusual manifestations.
    Case presentations: The first patient, a 55-year old man with HIV and hepatitis C virus co-infection, presented with severe pain in the right thigh and lower abdomen after injecting heroin into the right groin. Computed tomography and ultrasonographic examination of the abdomen and right thigh showed oedematous thickened peritoneum, distended oedematous mesentery and subcutaneous oedema of the right thigh. At admission the patient was afebrile but within 24 hours he progressed to severe septic shock and abdominal compartment syndrome. Cultures of blood and intraperitoneal fluid grew Bacillus anthracis. The patient was treated with meropenem, clindamycin, ciprofloxacin and metronidazole. Despite maximum supportive care including mechanical ventilation, vasopressor treatment and continuous veno-venous hemodiafiltration the patient died on day four.The second patient, a 39-year old man with chronic hepatitis C virus infection, presented with fever and a swollen right arm after injecting heroin into his right arm. The arm was swollen from the axilla to the wrist with tense and discoloured skin. He was initially septic with low blood pressure but responded to crystalloids. During the first week, swelling progressed and the patient developed massive generalised oedema with a weight gain of 40 kg. When blood cultures grew Bacillus anthracis antibiotic treatment was changed to meropenem, moxifloxacin and metronidazole, and on day 7 hydroxycloroquin was added. The patient responded to treatment and was discharged after 29 days.
    Conclusions: These two heroin-associated anthrax cases from Denmark corroborate that heroin contaminated with anthrax spores may be a continuous source of injectional anthrax across Europe. Clinicians and clinical microbiologists need to stay vigilant and suspect anthrax in patients with a history of heroin use who present with soft tissue or generalised infection. Marked swelling of affected soft tissue or unusual intra-abdominal oedema should strengthen clinical suspicion.
    MeSH term(s) Adult ; Anthrax ; Bacillus anthracis/growth & development ; Bacillus anthracis/isolation & purification ; Denmark ; Drug Contamination ; Edema/microbiology ; Heroin/adverse effects ; Humans ; Male ; Middle Aged ; Sepsis/microbiology ; Soft Tissue Infections/microbiology ; Substance Abuse, Intravenous/complications
    Chemical Substances Heroin (70D95007SX)
    Language English
    Publishing date 2013-09-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/1471-2334-13-408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Emergence of a vancomycin-variable Enterococcus faecium ST1421 strain containing a deletion in vanX.

    Hansen, Thomas Arn / Pedersen, Martin Schou / Nielsen, Lone Gilmor / Ma, Chih Man German / Søes, Lillian Marie / Worning, Peder / Østergaard, Christian / Westh, Henrik / Pinholt, Mette / Schønning, Kristian

    The Journal of antimicrobial chemotherapy

    2018  Volume 73, Issue 11, Page(s) 2936–2940

    Abstract: Background: Primary screening for VRE with PCR directed against vanA allowed identification of vanA+ samples from which VRE could not be isolated when selective culture methods were used. From such a sample a vancomycin-susceptible, vanA+ Enterococcus ... ...

    Abstract Background: Primary screening for VRE with PCR directed against vanA allowed identification of vanA+ samples from which VRE could not be isolated when selective culture methods were used. From such a sample a vancomycin-susceptible, vanA+ Enterococcus faecium, Efm-V1511, was isolated, when vancomycin selection was not used during culture. Similar isolates with variable susceptibility to vancomycin were obtained in the following months.
    Objectives: To characterize Efm-V1511 and investigate the causes of variable susceptibility to vancomycin.
    Methods: All strains were sequenced using Illumina technology. Plasmids containing vanA were reconstructed by scaffolding to known plasmids or plasmids were sequenced using Oxford Nanopore MinION. Derived structures were verified by PCR and sequencing. Furthermore, selected vanA+ vancomycin-susceptible isolates were passaged in the presence of vancomycin and vancomycin-resistant variants obtained were sequenced.
    Results: Efm-V1511 belonged to ST1421 and contained a 49 696 bp plasmid pHVH-V1511 carrying a Tn1546-derived genetic element. Within this element vanX was truncated by a 252 bp 3' deletion explaining the susceptibility of Efm-V1511. Between March 2016 and April 2017, 48 isolates containing pHVH-V1511 were identified. All were ST1421. In isolates resistant to vancomycin, resistance could be attributed to changes in ddl disrupting gene function sometimes accompanied by changes in vanS, increased pHVH-V1511 copy number or the existence of an additional vanA-containing plasmid encoding a functional vanX.
    Conclusions: E. faecium carrying pHVH-V1511 is capable of nosocomial transmission and may develop clinical resistance to vancomycin. Strains may not be detected using standard culture methods for VRE.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Cross Infection/microbiology ; Cross Infection/transmission ; Enterococcus faecium/drug effects ; Enterococcus faecium/genetics ; Gene Deletion ; Humans ; Microbial Sensitivity Tests ; Plasmids/genetics ; Polymerase Chain Reaction ; Sequence Analysis, DNA ; Serine-Type D-Ala-D-Ala Carboxypeptidase/genetics ; Vancomycin/pharmacology ; Vancomycin Resistance/genetics
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Vancomycin (6Q205EH1VU) ; Serine-Type D-Ala-D-Ala Carboxypeptidase (EC 3.4.16.4) ; VanX dipeptidase (EC 3.4.17.14)
    Language English
    Publishing date 2018-08-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dky308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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