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  1. Article ; Online: ESBL – risikofaktorer og behandling.

    Søraas, Arne Vasli Lund

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2015  Volume 135, Issue 20, Page(s) 1880

    Title translation ESBL – risk factors and treatment.
    Language Norwegian
    Publishing date 2015-11-03
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.15.0798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 422: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 546: Show issues

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  2. Article ; Online: DNase analysed by a novel competitive assay in patients with complications after ChAdOx1 nCoV-19 vaccination and in normal unvaccinated blood donors.

    Fagerhol, Magne Kristoffer / Schultz, Nina Haagenrud / Mirlashari, Mohammad Reza / Wiedmann, Markus Karl Hermann / Nissen-Meyer, Lise Sofie Haug / Søraas, Arne Vasli Lund / Hetland, Geir

    Scandinavian journal of immunology

    2023  Volume 98, Issue 1, Page(s) e13274

    Abstract: Increased levels of neutrophil extracellular traps (NETs) have been detected in individuals with vaccine complications after the ChAdOx1 nCov vaccine with a correlation between the severity of vaccine side effects and the level of NETosis. DNases may ... ...

    Abstract Increased levels of neutrophil extracellular traps (NETs) have been detected in individuals with vaccine complications after the ChAdOx1 nCov vaccine with a correlation between the severity of vaccine side effects and the level of NETosis. DNases may disrupt NETs by degrading their content of DNA, and a balance has been reported between NETs and DNases. Because of this and since the inflammatory marker NETs may be used as a confirmatory test in diagnosing VITT, it is of interest to monitor levels of DNase in patients with increased NETs levels. The current novel rapid DNase ELISA was tested in blood samples of patients with known increased levels of NETs with or without VITT after ChAdOx1 nCoV-19 vaccination. DNase levels in VITT patients were significantly increased compared with normal unvaccinated blood donors and compared with patients with post-vaccination symptoms but not VITT. However, since EDTA was found to inhibit DNase, serum and not EDTA-plasma samples should be applied for DNase testing. The novel DNase assay may serve as a supplementary test to the NETs test when analysing samples from patients with suspected increased NETs levels.
    MeSH term(s) Humans ; Deoxyribonucleases ; ChAdOx1 nCoV-19 ; Blood Donors ; Vaccination/adverse effects ; Drug-Related Side Effects and Adverse Reactions
    Chemical Substances Deoxyribonucleases (EC 3.1.-) ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 120476-2
    ISSN 1365-3083 ; 0300-9475
    ISSN (online) 1365-3083
    ISSN 0300-9475
    DOI 10.1111/sji.13274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 806: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Elevated NETs and Calprotectin Levels after ChAdOx1 nCoV-19 Vaccination Correlate with the Severity of Side Effects.

    Hetland, Geir / Fagerhol, Magne Kristoffer / Wiedmann, Markus Karl Hermann / Søraas, Arne Vasli Lund / Mirlashari, Mohammad Reza / Nissen-Meyer, Lise Sofie Haug / Istre, Mette Stausland / Holme, Pål Andre / Schultz, Nina Haagenrud

    Vaccines

    2022  Volume 10, Issue 8

    Abstract: ChAdOx1 nCoV-19 vaccination has been associated with the rare side effect; vaccine-induced immune thrombotic thrombocytopenia (VITT). The mechanism of thrombosis in VITT is associated with high levels of neutrophil extracellular traps (NETs). The present ...

    Abstract ChAdOx1 nCoV-19 vaccination has been associated with the rare side effect; vaccine-induced immune thrombotic thrombocytopenia (VITT). The mechanism of thrombosis in VITT is associated with high levels of neutrophil extracellular traps (NETs). The present study examines whether key markers for NETosis, such as H3-NETs and calprotectin, as well as syndecan-1 for endotheliopathy, can be used as prognostic factors to predict the severity of complications associated with ChAdOx1 vaccination. Five patients with VITT, 10 with prolonged symptoms and cutaneous hemorrhages but without VITT, and 15 with only brief and mild symptoms after the vaccination were examined. Levels of H3-NETs and calprotectin in the vaccinated individuals were markedly increased in VITT patients compared to vaccinees with milder vaccination-associated symptoms, and a strong correlation (r ≥ 0.745, p < 0.001) was found with severity of vaccination side effects. Syndecan-1 levels were also positively correlated (r = 0.590, p < 0.001) in vaccinees to side effects after ChAdOx1 nCoV-19 vaccination. We hypothesize that the inflammatory markers NETs and calprotectin may be used as confirmatory tests in diagnosing VITT.
    Language English
    Publishing date 2022-08-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10081267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Inflammatory markers calprotectin, NETs, syndecan-1 and neopterin in COVID-19 convalescent blood donors.

    Hetland, Geir / Fagerhol, Magne Kristoffer / Dimova-Svetoslavova, Veselka Petrova / Mirlashari, Mohammad Reza / Nguyen, Nhan Trung / Lind, Andreas / Kolset, Svein Olav / Søraas, Arne Vasli Lund / Nissen-Meyer, Lise Sofie Haug

    Scandinavian journal of clinical and laboratory investigation

    2022  Volume 82, Issue 6, Page(s) 481–485

    Abstract: Persisting inflammation has been discovered in lungs and other parenchymatous organs of some COVID-19 convalescents. Calprotectin, neutrophil extracellular traps (NETs), syndecan-1 and neopterin are general key inflammatory markers, and systemically ... ...

    Abstract Persisting inflammation has been discovered in lungs and other parenchymatous organs of some COVID-19 convalescents. Calprotectin, neutrophil extracellular traps (NETs), syndecan-1 and neopterin are general key inflammatory markers, and systemically enhanced levels of them may remain after the COVID-19 infection. These inflammatory markers were therefore measured in serum samples of 129 COVID-19 convalescent and 27 healthy blood donors or employees at Oslo Blood bank, Norway. Also antibodies against SARS-CoV-2 nucleocapsid antigen were measured, and timing of sampling and severity of infection noted. Whereas neopterin and NETs values remained low and those for syndecan-1 were not raised to statistically significant level, concentrations for calprotectin, as measured by a novel mixed monoclonal assay, were significantly increased in the convalescents. Antibodies against SARS-CoV-2 nucleocapsid antigen were elevated, but did not correlate with levels of inflammatory markers. Difference between the groups in only one biomarker makes evaluation of ongoing or residual inflammation in the convalescents difficult. If there is a low-grade inflammation, it would in that case involve neutrophils.
    MeSH term(s) Biomarkers ; Blood Donors ; COVID-19/diagnosis ; Extracellular Traps ; Humans ; Inflammation/diagnosis ; Leukocyte L1 Antigen Complex ; Neopterin ; SARS-CoV-2 ; Syndecan-1
    Chemical Substances Biomarkers ; Leukocyte L1 Antigen Complex ; Syndecan-1 ; Neopterin (670-65-5)
    Language English
    Publishing date 2022-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 3150-1
    ISSN 1502-7686 ; 0036-5513
    ISSN (online) 1502-7686
    ISSN 0036-5513
    DOI 10.1080/00365513.2022.2123387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Vaccine associated benign headache and cutaneous hemorrhage after ChAdOx1 nCoV-19 vaccine: A cohort study.

    Schultz, Nina Haagenrud / Søraas, Arne Vasli Lund / Sørvoll, Ingvild Hausberg / Akkök, Çigdem Akalin / Vetlesen, Annette / Bhamra, Jagjit Singh / Ahlen, Maria Therese / Holme, Pål Andre / Aamodt, Anne-Hege / Skagen, Karolina / Skattør, Thor Håkon / Skjelland, Mona / Wiedmann, Markus Kh

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2022  Volume 32, Issue 1, Page(s) 106860

    Abstract: Objectives: Fatal complications have occurred after vaccination with ChAdOx1 nCoV-19, a vaccine against Covid-19. Vaccine-induced immune thrombotic thrombocytopenia (VITT) with severe outcome is characterized by venous thrombosis, predominantly in ... ...

    Abstract Objectives: Fatal complications have occurred after vaccination with ChAdOx1 nCoV-19, a vaccine against Covid-19. Vaccine-induced immune thrombotic thrombocytopenia (VITT) with severe outcome is characterized by venous thrombosis, predominantly in cerebral veins, thrombocytopenia and anti-PF4/polyanion antibodies. Prolonged headaches and cutaneous hemorrhages, frequently observed after the ChAdOx1 nCoV-19 vaccine, have therefore caused anxiety among vaccinees. We investigated whether these symptoms represent a mild form of VITT, with a potential for aggravation, e.g. in case of a second vaccination dose, or a different entity of vaccine complications MATERIALS AND METHODS: We included previously healthy individuals who had a combination of headache and spontaneous severe cutaneous hemorrhages emerging after the 1
    Results: None of the symptomatic vaccinees had cerebral vein thrombosis, hemorrhage or other pathology on MRI. Platelet counts were within normal range and no anti-PF4/polyanion platelet activating antibodies were found. Moreover, vasculitis markers, platelet activation markers and thrombin generation were normal. Furthermore, almost all symptoms resolved, and none had recurrence of symptoms after further vaccination with mRNA vaccines against Covid-19.
    Conclusions: The combination of headaches and subcutaneous hemorrhage did not represent VITT and no other specific coagulation disorder or intracranial pathology was found. However, symptoms initially mimicking VITT demand vigilance and low threshold for a clinical evaluation combined with platelet counts and D-dimer.
    MeSH term(s) Humans ; ChAdOx1 nCoV-19 ; Cohort Studies ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Vaccines ; Purpura, Thrombocytopenic, Idiopathic ; Thrombocytopenia ; Antibodies
    Chemical Substances ChAdOx1 nCoV-19 (B5S3K2V0G8) ; polyanions ; COVID-19 Vaccines ; Vaccines ; Antibodies
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2022.106860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3519: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Dispersion of SARS-CoV-2 in air surrounding COVID-19-infected individuals with mild symptoms.

    Gohli, Jostein / Anderson, Ane Marie / Brantsaeter, Arne Broch / Bøifot, Kari Oline / Grub, Carola / Hadley, Cathrine Lund / Lind, Andreas / Pettersen, Ellen Susanne / Søraas, Arne Vasli Lund / Dybwad, Marius

    Indoor air

    2022  Volume 32, Issue 2, Page(s) e13001

    Abstract: Since the beginning of the pandemic, the transmission modes of SARS-CoV-2-particularly the role of aerosol transmission-have been much debated. Accumulating evidence suggests that SARS-CoV-2 can be transmitted by aerosols, and not only via larger ... ...

    Abstract Since the beginning of the pandemic, the transmission modes of SARS-CoV-2-particularly the role of aerosol transmission-have been much debated. Accumulating evidence suggests that SARS-CoV-2 can be transmitted by aerosols, and not only via larger respiratory droplets. In this study, we quantified SARS-CoV-2 in air surrounding 14 test subjects in a controlled setting. All subjects had SARS-CoV-2 infection confirmed by a recent positive PCR test and had mild symptoms when included in the study. RT-PCR and cell culture analyses were performed on air samples collected at distances of one, two, and four meters from test subjects. Oronasopharyngeal samples were taken from consenting test subjects and analyzed by RT-PCR. Additionally, total aerosol particles were quantified during air sampling trials. Air viral concentrations at one-meter distance were significantly correlated with both viral loads in the upper airways, mild coughing, and fever. One sample collected at four-meter distance was RT-PCR positive. No samples were successfully cultured. The results reported here have potential application for SARS-CoV-2 detection and monitoring schemes, and for increasing our understanding of SARS-CoV-2 transmission dynamics. Practical implications. In this study, quantification of SARS-CoV-2 in air was performed around infected persons with mild symptoms. Such persons may go longer before they are diagnosed and may thus be a disproportionately important epidemiological group. By correlating viral concentrations in air with behavior and symptoms, we identify potential risk factors for viral dissemination in indoor environments. We also show that quantification of total aerosol particles is not a useful strategy for monitoring SARS-CoV-2 in indoor environments.
    MeSH term(s) Aerosols ; Air Microbiology ; Air Pollution, Indoor ; COVID-19/virology ; Humans ; Pandemics ; SARS-CoV-2/isolation & purification
    Chemical Substances Aerosols
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1081722-0
    ISSN 1600-0668 ; 0905-6947
    ISSN (online) 1600-0668
    ISSN 0905-6947
    DOI 10.1111/ina.13001
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    In stock of ZB MED Bonn / Germany

    Z 7724: Show issues

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