Article ; Online: Capsaicin-sensitive cutaneous primary afferents convey electrically induced itch in humans.
2018 Volume 666, Page(s) 186–189
Abstract: Specially designed transcutaneous electrical stimulation paradigms can be used to provoke experimental itch. However, it is unclear which primary afferent fibers are activated and whether they represent pathophysiologically relevant, C-fiber mediated ... ...
Abstract | Specially designed transcutaneous electrical stimulation paradigms can be used to provoke experimental itch. However, it is unclear which primary afferent fibers are activated and whether they represent pathophysiologically relevant, C-fiber mediated itch. Since low-threshold mechano-receptors have recently been implicated in pruriception we aimed to characterize the peripheral primary afferent subpopulation conveying electrically evoked itch in humans (50Hz stimulation, 100μs square pulses, stimulus-response function to graded stimulus intensity). In 10 healthy male volunteers a placebo-controlled, 24-h 8% topical capsaicin-induced defunctionalization of capsaicin-sensitive (transient receptor potential V1-positive, 'TRPV1' |
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MeSH term(s) | Administration, Cutaneous ; Adult ; Capsaicin/pharmacology ; Electric Stimulation/methods ; Histamine/pharmacology ; Humans ; Male ; Nociceptors/physiology ; Pain Threshold/drug effects ; Pruritus/chemically induced ; Skin/physiopathology ; Young Adult |
Chemical Substances | Histamine (820484N8I3) ; Capsaicin (S07O44R1ZM) |
Language | English |
Publishing date | 2018-02-08 |
Publishing country | Ireland |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 194929-9 |
ISSN | 1872-7972 ; 0304-3940 |
ISSN (online) | 1872-7972 |
ISSN | 0304-3940 |
DOI | 10.1016/j.neulet.2017.11.061 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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