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Article: Predictors of Revascularization in Patients with Unstable Angina.

Budzianowski, Jan / Faron, Wojciech / Rzeźniczak, Janusz / Słomczyński, Marek / Hiczkiewicz, Dariusz / Olejniczak, Jacek / Hiczkiewicz, Jarosław / Burchardt, Paweł

Journal of clinical medicine

2024 Volume 13, Issue 4

Abstract: Background: The factors that determine the necessity of coronary artery revascularization in patients with unstable angina (UA) have been supported by limited data. Therefore, this study aimed to identify the predictors of revascularization in patients ... ...

Abstract	Background: The factors that determine the necessity of coronary artery revascularization in patients with unstable angina (UA) have been supported by limited data. Therefore, this study aimed to identify the predictors of revascularization in patients with UA. Methods: The study included the recorded data of 3668 patients with UA who underwent cardiac catheterization (age 66 ± 9.2, men 70%); 2615 of them (71%) underwent revascularization (percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass graft (CABG), or hybrid revascularization. The remaining 1053 patients (29%) had no significant coronary stenosis and were regarded as controls. Multivariable logistic regression analysis was performed to separate the predictors of revascularization. Results: It was found that severe angina (OR 2.7, 95%CI 1.9-3.7), male gender (OR 1.4, 95%CI 1.1-1.7), and hyperlipidemia were the predictors of revascularization. It was also noted that intraventricular conduction disorders including left and right bundle branch blocks and a history of previous revascularization and myocardial infarction were associated with lower odds of revascularization. Conclusion: Overall, however, the predictive value of the studied factors proved to be poor and may still point to the multifactorial nature of significant coronary artery stenosis and the need for revascularization in patients with UA.
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13041096
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Article ; Online: Treatment of acute coronary syndromes during the COVID‑19 pandemic: a designated COVID‑19 hospital perspective.

Słomczyński, Marek / Rzeźniczak, Janusz / Kasprzak, Dominika / Bugajski, Paweł / Bolewski, Andrzej / Burchardt, Paweł

Polish archives of internal medicine

2022 Volume 132, Issue 7-8

MeSH term(s)	Acute Coronary Syndrome/therapy ; COVID-19 ; Hospitals ; Humans ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2022-07-13
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16298
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Article: TAKOTSUBO SYNDROME AND CORONARY ARTERY FISTULA: CASE REPORT AND LITERATURE REVIEW.

Elikowski, Waldemar / Angerer, Dariusz / Fertała, Natalia / Zawodna-Marszałek, Magdalena / Greberska, Weronika / Ganowicz-Kaatz, Teresa / Słomczyński, Marek

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

2023 Volume 51, Issue 1, Page(s) 88–94

Abstract: Takotsubo syndrome (TTS) has been reported in various clinical conditions. Coronary artery fistula (CAF) is diagnosed in 0.2- 0.4% of patients undergoing coronary angiography. Pathologic communication between coronary artery (e.g., left anterior ... ...

Abstract	Takotsubo syndrome (TTS) has been reported in various clinical conditions. Coronary artery fistula (CAF) is diagnosed in 0.2- 0.4% of patients undergoing coronary angiography. Pathologic communication between coronary artery (e.g., left anterior descending coronary artery - LAD) and cardiac chambers (e.g., left ventricle - LV) is cameral type of CAF which particularly predispose to myocardial ischemia due to a steal syndrome. Eight cases of coexistent TTS and CAF have been reported so far; in 6 of them LAD cameral fistulas drained LV, in 2 others communications between coronary arteries and pulmonary artery were found. The authors describe a case of a 75-year-old female, admitted due to chest pain and dyspnea. Her clinical picture with ST-segment elevation in ECG, moderately increased troponin I and apical ballooning in echocardiography, was more typical for TTS than for myocardial infarction; besides that, color doppler imaging was suggestive of multiple CAF to LV. Coronary angiography showed communication between all (normal) coronary arteries and LV. Throughout the conservative therapy, first, an improvement and then normalization of LV function were observed after 2 and 6 days, respectively. Chest x-ray and computed tomography revealed mediastinal tumor (eventually diagnosed as lung cancer). Cardiac magnetic resonance performed after one month did not show late gadolinium enhancement. During the course of 24 months follow-up, she was taking bisoprolol and ramipril and her cardiologic state remained stable, even during chemotherapy and radiotherapy. The authors collected the clinical data of all 9 cases with concomitant TTS and CAF. Specific TTS triggering factors/predisposing conditions were present in all patients, which has indicated that coexistence of TTS and CAF is rather coincidental.
MeSH term(s)	Humans ; Female ; Aged ; Takotsubo Cardiomyopathy/diagnosis ; Takotsubo Cardiomyopathy/diagnostic imaging ; Contrast Media ; Gadolinium ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnostic imaging ; Fistula/complications
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2023-03-24
Publishing country	Poland
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	1388406-2
ISSN	1426-9686
ISSN	1426-9686
DOI	10.36740/Merkur202301112
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Article ; Online: A Review of Acute Coronary Syndrome and its Potential Impact on Cognitive Function.

Kasprzak, Dominika / Rzeźniczak, Janusz / Ganowicz, Teresa / Łuczak, Tomasz / Słomczyński, Marek / Hiczkiewicz, Jarosław / Burchardt, Paweł

Global heart

2021 Volume 16, Issue 1, Page(s) 53

Abstract: According to the World Health Organization (WHO) forecasts, in 2030, the number of people suffering from dementia will reach 82 million people worldwide, representing a huge burden on health and social care systems. Epidemiological data indicates a ... ...

Abstract	According to the World Health Organization (WHO) forecasts, in 2030, the number of people suffering from dementia will reach 82 million people worldwide, representing a huge burden on health and social care systems. Epidemiological data indicates a relationship between coronary heart disease (CHD) and the occurrence of cognitive impairment (CI) and dementia. It is known that both diseases have common risk factors. However, the impact of myocardial infarction (MI) on cognitive function remains controversial and largely unknown. The main goal of this study is to attempt to summarize and discuss selected scientific reports on the causes, mechanisms and effects of CI in patients after acute coronary syndrome (ACS), especially after MI. The risk of CI can increase in patients after ACS, and can therefore also adversely affect the further course of treatment. A late diagnosis of CI can lead to serious clinical implications, such as an increase in the number of hospitalizations and mortality.
MeSH term(s)	Acute Coronary Syndrome/epidemiology ; Cognition ; Coronary Disease ; Humans ; Myocardial Infarction ; Risk Factors
Language	English
Publishing date	2021-08-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2629633-0
ISSN	2211-8179 ; 2211-8160
ISSN (online)	2211-8179
ISSN	2211-8160
DOI	10.5334/gh.934
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Article ; Online: Machine learning model for predicting late recurrence of atrial fibrillation after catheter ablation.

Budzianowski, Jan / Kaczmarek-Majer, Katarzyna / Rzeźniczak, Janusz / Słomczyński, Marek / Wichrowski, Filip / Hiczkiewicz, Dariusz / Musielak, Bogdan / Grydz, Łukasz / Hiczkiewicz, Jarosław / Burchardt, Paweł

Scientific reports

2023 Volume 13, Issue 1, Page(s) 15213

Abstract: Late recurrence of atrial fibrillation (LRAF) in the first year following catheter ablation is a common and significant clinical problem. Our study aimed to create a machine-learning model for predicting arrhythmic recurrence within the first year since ... ...

Abstract	Late recurrence of atrial fibrillation (LRAF) in the first year following catheter ablation is a common and significant clinical problem. Our study aimed to create a machine-learning model for predicting arrhythmic recurrence within the first year since catheter ablation. The study comprised 201 consecutive patients (age: 61.8 ± 8.1; women 36%) with paroxysmal, persistent, and long-standing persistent atrial fibrillation (AF) who underwent cryoballoon (61%) and radiofrequency ablation (39%). Five different supervised machine-learning models (decision tree, logistic regression, random forest, XGBoost, support vector machines) were developed for predicting AF recurrence. Further, SHapley Additive exPlanations were derived to explain the predictions using 82 parameters based on clinical, laboratory, and procedural variables collected from each patient. The models were trained and validated using a stratified fivefold cross-validation, and a feature selection was performed with permutation importance. The XGBoost model with 12 variables showed the best performance on the testing cohort, with the highest AUC of 0.75 [95% confidence interval 0.7395, 0.7653]. The machine-learned model, based on the easily available 12 clinical and laboratory variables, predicted LRAF with good performance, which may provide a valuable tool in clinical practice for better patient selection and personalized AF strategy following the procedure.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Machine Learning ; Radiofrequency Ablation ; Supervised Machine Learning
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-42542-y
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Article: Cognitive Impairment in Cardiovascular Patients after Myocardial Infarction: Prospective Clinical Study.

Kasprzak, Dominika / Kaczmarek-Majer, Katarzyna / Rzeźniczak, Janusz / Klamecka-Pohl, Katarzyna / Ganowicz-Kaatz, Teresa / Słomczyński, Marek / Budzianowski, Jan / Pieszko, Konrad / Hiczkiewicz, Jarosław / Tykarski, Andrzej / Burchardt, Paweł

Journal of clinical medicine

2023 Volume 12, Issue 15

Abstract: 1) Background: Assessment of cognitive function is not routine in cardiac patients, and knowledge on the subject remains limited. The aim of this study was to assess post-myocardial infarction (MI) cognitive functioning in order to determine the ... ...

Abstract	(1) Background: Assessment of cognitive function is not routine in cardiac patients, and knowledge on the subject remains limited. The aim of this study was to assess post-myocardial infarction (MI) cognitive functioning in order to determine the frequency of cognitive impairment (CI) and to identify factors that may influence it. (2) Methods: A prospective study included 468 patients hospitalized for MI. Participants were assessed twice: during the first hospitalization and 6 months later. The Mini-Mental State Examination was used to assess the occurrence of CI. (3) Results: Cognitive dysfunction based on the MMSE was found in 37% (N-174) of patients during the first hospitalization. After 6 months, the prevalence of deficits decreased significantly to 25% (N-91) (
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12154954
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Article ; Online: Cognitive impairment in patients after myocardial infarction.

Kasprzak, Dominika / Ganowicz-Kaatz, Teresa / Rzeźniczak, Janusz / Słomczyński, Marek / Kaczmarek-Majer, Katarzyna / Budzianowski, Jan / Pieszko, Konrad / Hiczkiewicz, Jarosław / Tykarski, Andrzej / Burchardt, Paweł

Kardiologia polska

2023 Volume 81, Issue 5, Page(s) 505–507

MeSH term(s)	Humans ; Cognitive Dysfunction/etiology ; Myocardial Infarction/complications
Language	English
Publishing date	2023-03-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.a2023.0056
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Article: Takotsubo syndrome in a patient with adrenal insufficiency, severe hyponatremia and coexistent coronary artery disease.

Elikowski, Waldemar / Małek-Elikowska, Małgorzata / Greberska, Weronika / Słomczyński, Marek / Marchlewska, Joanna / Korol, Luiza

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

2019 Volume 46, Issue 274, Page(s) 182–186

Abstract: Some endocrine disorders, including primary and secondary adrenal insufficiency (AI), predispose to takotsubo syndrome (TTS). Hyponatremia is a frequent feature seen in adrenal crisis; however, TTS cases preceded by low serum sodium associated with other ...

Abstract	Some endocrine disorders, including primary and secondary adrenal insufficiency (AI), predispose to takotsubo syndrome (TTS). Hyponatremia is a frequent feature seen in adrenal crisis; however, TTS cases preceded by low serum sodium associated with other diseases are also reported. A case report: The authors describe a case of a 72-year-old female with primary AI (Addison's disease) after adrenalectomy due to adrenal hypertrophy she underwent in childhood. Before admission, she missed a few doses of replacement therapy with prednisone and fludrocortisone. On admission, she presented with hypotension, severe heart failure (HF) and hyponatremia. Negative T-waves in ECG and left ventricular (LV) apical ballooning in echocardiography were suggestive of TTS. Restarted replacement therapy and symptomatic HF treatment resulted in gradual LV function normalization within 6 days. Cardiac magnetic resonance (CMR) performed after 4 weeks was normal and did not reveal any late gadolinium enhancement (LGE). However, elective coronary angiography made a month later showed critical stenosis of the left anterior descending coronary artery which was treated with coronary angioplasty. The authors suggest that each patient with adrenal crisis as well as with severe hyponatremia should be evaluated by echocardiography. The case presented confirms a possible coexistence of TTS and obstructive coronary artery disease.
MeSH term(s)	Adrenal Insufficiency ; Aged ; Contrast Media ; Coronary Artery Disease ; Female ; Gadolinium ; Humans ; Hyponatremia ; Takotsubo Cardiomyopathy
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2019-05-17
Publishing country	Poland
Document type	Case Reports ; Journal Article
ZDB-ID	1388406-2
ISSN	1426-9686
ISSN	1426-9686
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Article ; Online: Impact of genetic variants of selected cytochrome P450 isoenzymes on pharmacokinetics and pharmacodynamics of clopidogrel in patients co-treated with atorvastatin or rosuvastatin.

Karaźniewicz-Łada, Marta / Krzyżańska, Dagmara / Danielak, Dorota / Rzeźniczak, Janusz / Główka, Franciszek / Słomczyński, Marek / Burchardt, Paweł

European journal of clinical pharmacology

2020 Volume 76, Issue 3, Page(s) 419–430

Abstract: Purpose: Impaired antiplatelet effect of clopidogrel (CLP) can result from drug-drug interactions and genetic polymorphisms of drug-metabolizing enzymes. The aim of the study was to evaluate the effect of genetic polymorphisms of ABCB1 and the selected ... ...

Abstract	Purpose: Impaired antiplatelet effect of clopidogrel (CLP) can result from drug-drug interactions and genetic polymorphisms of drug-metabolizing enzymes. The aim of the study was to evaluate the effect of genetic polymorphisms of ABCB1 and the selected cytochrome P450 isoenzymes on the pharmacodynamics and pharmacokinetics of CLP and its metabolites in patients co-treated with atorvastatin or rosuvastatin. Methods: The study involved 50 patients after coronary angiography/angioplasty treated with CLP and atorvastatin (n = 25) or rosuvastatin (n = 25) for at least 6 months. Plasma concentrations of CLP, diastereoisomers of thiol metabolite (inactive H3 and active H4), and inactive CLP carboxylic acid metabolite were measured by UPLC-MS/MS method. Identification of the CYP2C192, CYP2C1917, CYP3A41G, CYP1A21F, and ABCB1 C3435T genetic polymorphisms was performed by PCR-RFLP, while platelet reactivity units (PRU) were tested using the VerifyNow P2Y12 assay. Results: There were significant differences in the pharmacokinetic parameters of the H4 active metabolite of CLP in the atorvastatin and rosuvastatin group divided according to their CYP2C19 genotype. There were no significant associations between CYP3A4, CYP1A2, and ABCB1 genotypes and pharmacokinetic parameters in either statin groups. In the multivariate analysis, CYP2C192 genotype and non-genetic factors including BMI, age, and diabetes significantly affected platelet reactivity in the studied groups of patients (P < 0.01). In the atorvastatin group, CYP2C192, CYP3A41G, and ABCB1 C3435T TT genotypes were independent determinants of PRU values (P < 0.01). Conclusion:* The CYP2C19*2 allele is the primary determinant of the exposition to the H4 active metabolite of clopidogrel and platelet reactivity in patients co-treated with atorvastatin or rosuvastatin.
MeSH term(s)	Alleles ; Anticholesteremic Agents/therapeutic use ; Atorvastatin/therapeutic use ; Blood Platelets/drug effects ; Clopidogrel/pharmacokinetics ; Clopidogrel/therapeutic use ; Cytochrome P-450 Enzyme System/genetics ; Female ; Genotype ; Humans ; Isoenzymes/therapeutic use ; Male ; Middle Aged ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/pharmacokinetics ; Platelet Aggregation Inhibitors/therapeutic use ; Polymorphism, Genetic/genetics ; Rosuvastatin Calcium/therapeutic use
Chemical Substances	Anticholesteremic Agents ; Isoenzymes ; Platelet Aggregation Inhibitors ; Rosuvastatin Calcium (83MVU38M7Q) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Atorvastatin (A0JWA85V8F) ; Clopidogrel (A74586SNO7)
Language	English
Publishing date	2020-01-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-019-02822-x
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Article ; Online: Right ventricular thrombi treated with apixaban in a patient with arrhythmogenic right ventricular cardiomyopathy.

Elikowski, Waldemar / Małek-Elikowska, Małgorzata / Greberska, Weronika / Bolewski, Andrzej / Zawodna, Magdalena / Słomczyński, Marek

Polish archives of internal medicine

2018 Volume 129, Issue 2, Page(s) 127–129

MeSH term(s)	Adult ; Arrhythmogenic Right Ventricular Dysplasia/complications ; Factor Xa Inhibitors/therapeutic use ; Heart Ventricles ; Humans ; Male ; Pyrazoles/therapeutic use ; Pyridones/therapeutic use ; Thrombosis/drug therapy ; Thrombosis/etiology
Chemical Substances	Factor Xa Inhibitors ; Pyrazoles ; Pyridones ; apixaban (3Z9Y7UWC1J)
Language	English
Publishing date	2018-12-13
Publishing country	Poland
Document type	Case Reports ; Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.4396
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