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  1. Article ; Online: Cytokines, reverse genetics and anti-cytokine therapy

    M. S. Drutskaya / E. O. Gubernatorova / E. A. Gorshkova / K.-S. N. Athertkhany / M. A. Nosenko / V. S. Gogoleva / O. A. Namakanova / R. V. Zvartsev / A. A. Kruglov / S. A. Nedospasov

    Бюллетень сибирской медицины, Vol 18, Iss 1, Pp 38-

    2019  Volume 48

    Abstract: Cytokines comprise the molecular language of communication between the cells, which is needed to maintain the homeostatic functions of the body (including the immune system) and mediate various diseases. Many aspects of inflammation, autoimmune diseases ... ...

    Abstract Cytokines comprise the molecular language of communication between the cells, which is needed to maintain the homeostatic functions of the body (including the immune system) and mediate various diseases. Many aspects of inflammation, autoimmune diseases and neoplasia are associated with cytokine signaling through specific receptors. The establishment of new physiological functions of “old” cytokines and understanding the molecular and cellular mechanisms of their involvement in disease pathogenesis, as well as the search for new therapeutic targets and development of innovative approaches to anti-cytokine therapy, present a fundamental problem. When assessing the tremendous success of anti-cytokine therapy in treatment of certain autoimmune diseases, we should not forget that (a) this treatment does not eliminate the causes of the disease:autoreactive T-cell clones; and that (b) less than half of the patients respond to this therapy; and that (c) anti-cytokine therapy has serious side effects.
    Keywords tnf ; il-6 ; мышиные модели ; биспецифические антитела ; коллаген-индуцированный артрит ; экспериментальный аутоиммунный энцефаломиелит ; астма ; гуманизированные мыши ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Siberian State Medical University (Tomsk)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: TNFα is responsible for the canonical offspring number-size trade-off

    S. O. Maslennikova / L. A. Gerlinskaya / G. V. Kontsevaya / M. V. Anisimova / S. A. Nedospasov / N. A. Feofanova / M. P. Moshkin / Y. M. Moshkin

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 8

    Abstract: Abstract There is a canonical life-history trade-off between quantity and quality of offspring, but molecular determinants for this are unknown. Here, we show that knockout of tumor necrosis factor (TNF-KO) in mice switched a relation between the number ... ...

    Abstract Abstract There is a canonical life-history trade-off between quantity and quality of offspring, but molecular determinants for this are unknown. Here, we show that knockout of tumor necrosis factor (TNF-KO) in mice switched a relation between the number and size of developing embryos from expectedly negative to unexpectedly positive. Depletion of TNFα imbalanced humoral and trophic maintenance of embryo growth during gestation with respect to the litter size. The levels of embryotrophic GM-CSF cytokine and placental efficiency attained positive correlations with the number and size of embryos in TNF-KO females. Thus, TNFα oversees mother’s resource allocations to balance embryo growth with the number of offspring. Consequently, this suggests an intricate link between the number-size trade-off and immunity given a pivotal role of TNFα in immune homeostasis.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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