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  1. AU="SAREER, Ovais"
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  1. Artikel: Genetic, Developmental and Temporal Variability in Nitrate Accumulation and Nitrate Reductase Activity in Medicinal Herb Andrographis paniculata

    SAREER, Ovais / Nirit BERNSTEIN / Sayeed AHMAD / Shahid UMAR

    Soil Science Society of China Pedosphere. 2016 Dec., v. 26, no. 6

    2016  

    Abstract: There is a growing concern over the presence of high concentrations of nitrate in orally consumed herbal remedies. Since nitrate accumulation in the plant body can vary with spatial location in plant and plant development and temporally with photoperiod, ...

    Abstract There is a growing concern over the presence of high concentrations of nitrate in orally consumed herbal remedies. Since nitrate accumulation in the plant body can vary with spatial location in plant and plant development and temporally with photoperiod, understanding the relations between these factors and nitrate contents in the consumed herbs are vital for the development of agrotechnical strategies for nitrate avoidance. Therefore, the distribution profiles of nitrate content and nitrate reductase (NR) activity were analyzed in 14 accessions of Andrographis paniculata (Burm.f.) Wall. ex Nees., a medicinal plant widely used as a component of many herbal teas and medicinal infusions. Significant variation in nitrate accumulation in the plant was observed between the accessions, and most contained nitrate levels beyond the safety limit recommended according to the European Commission's Scientific Committee on Food. Nitrate content increased with plant development and leaf age, and that in leaf segment was higher in the middle of the leaf than at its tip or base; the nitrate concentration in plant organ followed the order of petiole < leaf < stem, and it was lower at mid-day than in the early morning or evening. Gradients of NR activity were negatively correlated with nitrate content in all studied temporal and spatial profiles. Identification of the characteristic spatial and developmental profiles of nitrate accumulation and NR activity in A. paniculata can guide the development of harvest strategies, aiming at minimizing nitrate contents in the consumed herbal tissue.
    Schlagwörter Andrographis paniculata ; enzyme activity ; herbal tea ; herbs ; medicinal plants ; nitrate reductase ; nitrates ; petioles ; photoperiod ; plant development ; temporal variation
    Sprache Englisch
    Erscheinungsverlauf 2016-12
    Umfang p. 839-847.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 1090441-4
    ISSN 1002-0160
    ISSN 1002-0160
    DOI 10.1016/S1002-0160(15)60089-3
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel: Andrographis paniculata: a critical appraisal of extraction, isolation and quantification of andrographolide and other active constituents

    Sareer, Ovais / Ahmad, Sayeed / Umar, Shahid

    Natural product research. 2014 Dec. 2, v. 28, no. 23

    2014  

    Abstract: Andrographis paniculata , referred to as ‘Kalmegh’ in ancient texts, is regarded as a nostrum of the modern world. Oral administration of the leaves of this plant is effective in the treatment of upper respiratory tract infections, liver toxicity and a ... ...

    Abstract Andrographis paniculata , referred to as ‘Kalmegh’ in ancient texts, is regarded as a nostrum of the modern world. Oral administration of the leaves of this plant is effective in the treatment of upper respiratory tract infections, liver toxicity and a variety of other ailments. The practices of adulteration in the original material of this drug have made it imperative to develop techniques to verify the authenticity of the products of this plant for quality assurance. Andrographolide, a bitter diterpenoid, is the major active principle present in the plant, and therefore its determination and quantification in the plant extracts are important. This article provides a detailed account of various extraction and chromatographic techniques used for the identification, isolation and quantification of the various active principles of A . paniculata. Pharmacological properties and phytochemistry of this plant and the physico-chemical properties of these bio-compounds have also been outlined.
    Schlagwörter Andrographis paniculata ; adulterated products ; chromatography ; diterpenoids ; drugs ; hepatotoxicity ; leaves ; oral administration ; physicochemical properties ; plant biochemistry ; plant extracts ; quality control ; respiratory tract diseases
    Sprache Englisch
    Erscheinungsverlauf 2014-1202
    Umfang p. 2081-2101.
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2014.924004
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Andrographis paniculata: a critical appraisal of extraction, isolation and quantification of andrographolide and other active constituents.

    Sareer, Ovais / Ahmad, Sayeed / Umar, Shahid

    Natural product research

    2014  Band 28, Heft 23, Seite(n) 2081–2101

    Abstract: Andrographispaniculata, referred to as 'Kalmegh' in ancient texts, is regarded as a nostrum of the modern world. Oral administration of the leaves of this plant is effective in the treatment of upper respiratory tract infections, liver toxicity and a ... ...

    Abstract Andrographispaniculata, referred to as 'Kalmegh' in ancient texts, is regarded as a nostrum of the modern world. Oral administration of the leaves of this plant is effective in the treatment of upper respiratory tract infections, liver toxicity and a variety of other ailments. The practices of adulteration in the original material of this drug have made it imperative to develop techniques to verify the authenticity of the products of this plant for quality assurance. Andrographolide, a bitter diterpenoid, is the major active principle present in the plant, and therefore its determination and quantification in the plant extracts are important. This article provides a detailed account of various extraction and chromatographic techniques used for the identification, isolation and quantification of the various active principles of A. paniculata. Pharmacological properties and phytochemistry of this plant and the physico-chemical properties of these bio-compounds have also been outlined.
    Mesh-Begriff(e) Andrographis/chemistry ; Diterpenes/analysis ; Diterpenes/chemistry ; Diterpenes/isolation & purification ; Diterpenes/pharmacology ; Molecular Structure ; Plant Extracts/chemistry ; Plants, Medicinal/chemistry
    Chemische Substanzen Diterpenes ; Plant Extracts ; andrographolide (410105JHGR)
    Sprache Englisch
    Erscheinungsdatum 2014
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2014.924004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Genetic, developmental and temporal variability in nitrate accumulation and nitrate reductase activity in medicinal herb Andrographis paniculata

    Sareer, Ovais / Bernstein, Nirit / Ahmad, Sayeed / Umar, Shahid

    Pedosphere

    2016  Band 26, Heft 6, Seite(n) 839

    Dokumenttyp Artikel
    ZDB-ID 1090441-4
    ISSN 1002-0160
    Datenquelle Current Contents Ernährung, Umwelt, Agrar

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