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Article ; Online: In situ chemoimmunotherapy hydrogel elicits immunogenic cell death and evokes efficient antitumor immune response.

Liu, Qin / Xu, Rui / Shen, Jingwen / Tao, Yaping / Shao, Jingyi / Ke, Yaohua / Liu, Baorui

2024 Volume 22, Issue 1, Page(s) 341

Abstract: Background: Chemoimmunotherapy has shown promising advantages of eliciting immunogenic cell death and activating anti-tumor immune responses. However, the systemic toxicity of chemotherapy and tumor immunosuppressive microenvironment limit the clinical ... ...

Abstract	Background: Chemoimmunotherapy has shown promising advantages of eliciting immunogenic cell death and activating anti-tumor immune responses. However, the systemic toxicity of chemotherapy and tumor immunosuppressive microenvironment limit the clinical application. Methods: Here, an injectable sodium alginate hydrogel (ALG) loaded with nanoparticle albumin-bound-paclitaxel (Nab-PTX) and an immunostimulating agent R837 was developed for local administration. Two murine hepatocellular carcinoma and breast cancer models were established. The tumor-bearing mice received the peritumoral injection of R837/Nab-PTX/ALG once a week for two weeks. The antitumor efficacy, the immune response, and the tumor microenvironment were investigated. Results: This chemoimmunotherapy hydrogel with sustained-release character was proven to have significant effects on killing tumor cells and inhibiting tumor growth. Peritumoral injection of our hydrogel caused little harm to normal organs and triggered a potent antitumor immune response against both hepatocellular carcinoma and breast cancer. In the tumor microenvironment, enhanced immunogenic cell death induced by the combination of Nab-PTX and R837 resulted in 3.30-fold infiltration of effector memory T cells and upregulation of 20 biological processes related to immune responses. Conclusions: Our strategy provides a novel insight into the combination of chemotherapy and immunotherapy and has the potential for clinical translation.
MeSH term(s)	Mice ; Animals ; Hydrogels/pharmacology ; Hydrogels/therapeutic use ; Imiquimod/pharmacology ; Imiquimod/therapeutic use ; Carcinoma, Hepatocellular ; Immunogenic Cell Death ; Cell Line, Tumor ; Liver Neoplasms/drug therapy ; Immunotherapy/methods ; Immunity ; Tumor Microenvironment ; Nanoparticles
Chemical Substances	Hydrogels ; Imiquimod (P1QW714R7M)
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-024-05102-0
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Article ; Online: Epidemiological characteristics of varicella in Songjiang District， Shanghai from 2013 to 2021

ZHU Qi / QIAN Jingxian / SHEN Jinhua / CHEN Wenhua / SHEN Jingwen / LU Hongmei

Shanghai yufang yixue, Vol 35, Iss 7, Pp 639-

2023 Volume 643

Abstract: ObjectiveTo evaluate the effectiveness of the varicella vaccine immunization strategy in Shanghai， and to provide evidence for enhancing prevention and control measures by analyzing the incidence and trends of varicella in Songjiang District， Shanghai ... ...

Abstract	ObjectiveTo evaluate the effectiveness of the varicella vaccine immunization strategy in Shanghai， and to provide evidence for enhancing prevention and control measures by analyzing the incidence and trends of varicella in Songjiang District， Shanghai from 2013 to 2021.MethodsA descriptive analysis was conducted on 12 417 varicella cases reported in Songjiang District between 2013 and 2021. The epidemiological distribution of varicella cases was described， and the incidence rates were compared among different demographic variables， including registered residence， gender， age， and occupation.ResultsA total of 12 417 varicella cases were reported in Songjiang District from 2013 to 2021，with an average annual incidence of 77.03/105. The incidence of varicella showed an increasing trend from 2013 to 2017 （χ2trend=19.39， P<0.001）， followed by a subsequent decrease from 2017 to 2021（χ2trend=758.62， P<0.001）. Varicella cases demonstrated significant seasonal variation， with peak incidences occurring in April to May and November to January of the following year. The incidence rate among local residents was higher than that among non-local residents （χ2=2 935.58， P<0.001）. Most （38.59%） of the cases were students aged between 5 and 9 years old， accounting for 23.45% of the total cases. However， the age distribution of cases varied over the years （χ2=615.57， P<0.001）， and the incidence among children aged 5 to 9 years showed a declining trend since 2017.ConclusionThe overall incidence of varicella in Songjiang District exhibites a declining trend in recent years. Although varicella primarily affects children， there have notable changes in the age distribution. Adjustment of the immunization strategy for varicella vaccines in Shanghai effectively reduces the proportion of school-age subjects.
Keywords	varicella ; epidemiology ; analysis ; Medicine ; R
Language	Chinese
Publishing date	2023-07-01T00:00:00Z
Publisher	Shanghai Preventive Medicine Association
Document type	Article ; Online
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Article ; Online: Inhibition of PI3K p110δ rebalanced Th17/Treg and reduced macrophages pyroptosis in LPS-induced sepsis.

Zhang, Shiyun / Shan, Jiajia / Jie, Yiyang / Zhang, Xian / Zhu, Minyi / Shen, Jingwen / Mao, Kefan / Chen, Wenhao / Wang, Yong / Wen, Yanting

Molecular immunology

2024 Volume 170, Page(s) 110–118

Abstract: Sepsis is a systemic inflammatory response syndrome caused by trauma or infection, which can lead to multiple organ dysfunction. In severe cases, sepsis can also progress to septic shock and even death. Effective treatments for sepsis are still under ... ...

Abstract	Sepsis is a systemic inflammatory response syndrome caused by trauma or infection, which can lead to multiple organ dysfunction. In severe cases, sepsis can also progress to septic shock and even death. Effective treatments for sepsis are still under development. This study aimed to determine if targeting the PI3K/Akt signaling with CAL-101, a PI3K p110δ inhibitor, could alleviate lipopolysaccharide (LPS)-induced sepsis and contribute to immune tolerance. Our findings indicated that CAL-101 treatment improved survival rates and alleviated the progression of LPS-induced sepsis. Compared to antibiotics, CAL-101 not only restored the Th17/regulatory T cells (Treg) balance but also enhanced Treg cell function. Additionally, CAL-101 promoted type 2 macrophage (M2) polarization, inhibited TNF-α secretion, and increased IL-10 secretion. Moreover, CAL-101 treatment reduced pyroptosis in peritoneal macrophages by inhibiting caspase-1/gasdermin D (GSDMD) activation. This study provides a mechanistic basis for future clinical exploration of targeted therapeutics and immunomodulatory strategies in the treatment of sepsis.
MeSH term(s)	Animals ; Pyroptosis/drug effects ; Sepsis/immunology ; Sepsis/drug therapy ; Lipopolysaccharides/pharmacology ; Mice ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/drug effects ; Th17 Cells/immunology ; Th17 Cells/drug effects ; Mice, Inbred C57BL ; Class I Phosphatidylinositol 3-Kinases/antagonists & inhibitors ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Macrophages/immunology ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Macrophages, Peritoneal/immunology ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/metabolism ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Signal Transduction/drug effects
Chemical Substances	Lipopolysaccharides ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; Pik3cd protein, mouse (EC 2.7.1.137) ; Phosphoinositide-3 Kinase Inhibitors
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2024.04.008
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Article ; Online: A screen for regeneration-associated silencer regulatory elements in zebrafish.

Ando, Kazunori / Ou, Jianhong / Thompson, John D / Welsby, John / Bangru, Sushant / Shen, Jingwen / Wei, Xiaolin / Diao, Yarui / Poss, Kenneth D

Developmental cell

2024 Volume 59, Issue 5, Page(s) 676–691.e5

Abstract: Regeneration involves gene expression changes explained in part by context-dependent recruitment of transcriptional activators to distal enhancers. Silencers that engage repressive transcriptional complexes are less studied than enhancers and more ... ...

Abstract	Regeneration involves gene expression changes explained in part by context-dependent recruitment of transcriptional activators to distal enhancers. Silencers that engage repressive transcriptional complexes are less studied than enhancers and more technically challenging to validate, but they potentially have profound biological importance for regeneration. Here, we identified candidate silencers through a screening process that examined the ability of DNA sequences to limit injury-induced gene expression in larval zebrafish after fin amputation. A short sequence (s1) on chromosome 5 near several genes that reduce expression during adult fin regeneration could suppress promoter activity in stable transgenic lines and diminish nearby gene expression in knockin lines. High-resolution analysis of chromatin organization identified physical associations of s1 with gene promoters occurring preferentially during fin regeneration, and genomic deletion of s1 elevated the expression of these genes after fin amputation. Our study provides methods to identify "tissue regeneration silencer elements" (TRSEs) with the potential to reduce unnecessary or deleterious gene expression during regeneration.
MeSH term(s)	Animals ; Zebrafish/genetics ; Silencer Elements, Transcriptional ; Animals, Genetically Modified ; Promoter Regions, Genetic
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2024.01.004
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Client-Perpetrated Violence Experience Among Female Sex Worker in Guangdong, South China: Results from a Cross-Sectional Study.

Xie, Yewei / Xiong, Mingzhou / Qi, Zhidong / Shen, Jingwen / Xu, Xiaojuan / Luo, Xinyi / Wang, Cheng / Tang, Weiming

AIDS and behavior

2022 Volume 27, Issue 3, Page(s) 806–815

Abstract: Client-perpetrated violence (CPV) can lead to worse health consequences. However, little attention is paid to the CPV experience among Chinese female sex workers. Our study aimed to assess the association between CPV experience and health risk behaviors ... ...

Abstract	Client-perpetrated violence (CPV) can lead to worse health consequences. However, little attention is paid to the CPV experience among Chinese female sex workers. Our study aimed to assess the association between CPV experience and health risk behaviors among FSWs in China. Data used in this study was from the baseline interviewer-administered questionnaire of a cluster randomized controlled trial conducted in June-October 2020. The collected information included sociodemographic characteristics, HIV/STI symptoms, number of clients, quality of the workplace, and past CPV experience. The association between violence experience and potential HIV/STI risk factors was explored using multivariable regression. Among 480 FSWs who participated in this study, 13.5% experienced CPV in the past. Compared to those who had never experienced CPV, FSWs who experienced CPV were more likely to report previous STI-related symptoms (aOR 4.29, 95% CI 1.73-10.64), more than 15 clients in the past month (aOR 2.56, 95% CI 1.18-5.52), a history of HIV testing (aOR 2.99, 95% CI 1.64-5.46), and work at low-tier workplaces (aOR 2.09, 95% CI 1.18-3.70). Overall, CPV prevalence is not low among Chinese FSWs, and there are some associations with HIV/STI risk factors; a future intervention targeting CPV in HIV/STI prevention programs is needed.
MeSH term(s)	Female ; Humans ; Sex Workers ; HIV Infections/prevention & control ; Sexually Transmitted Diseases/epidemiology ; Cross-Sectional Studies ; Sex Work ; Violence ; China ; Risk Factors
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-022-03813-3
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Zs.A 6451: Show issues

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Article ; Online: Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation.

Liu, Xiaodan / Shen, Jingwen / Xie, Leiming / Wei, Zelin / Wong, Chouin / Li, Yiyao / Zheng, Xinhe / Li, Pilong / Song, Yan

Developmental cell

2019 Volume 52, Issue 3, Page(s) 277–293.e8

Abstract: Compacted heterochromatin blocks are prevalent in differentiated cells and present a barrier to cellular reprogramming. It remains obscure how heterochromatin remodeling is orchestrated during cell differentiation. Here we find that the evolutionarily ... ...

Abstract	Compacted heterochromatin blocks are prevalent in differentiated cells and present a barrier to cellular reprogramming. It remains obscure how heterochromatin remodeling is orchestrated during cell differentiation. Here we find that the evolutionarily conserved homeodomain transcription factor Prospero (Pros)/Prox1 ensures neuronal differentiation by driving heterochromatin domain condensation and expansion. Intriguingly, in mitotically dividing Drosophila neural precursors, Pros is retained at H3K9me3
MeSH term(s)	Animals ; Cell Differentiation ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/metabolism ; Female ; Gene Expression Regulation ; Heterochromatin/genetics ; Heterochromatin/metabolism ; Histones/genetics ; Histones/metabolism ; Liquid-Liquid Extraction ; Male ; Mitosis ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurons/cytology ; Neurons/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Nucleosomes ; Phase Transition ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Chromosomal Proteins, Non-Histone ; Drosophila Proteins ; Heterochromatin ; Histones ; Nerve Tissue Proteins ; Nuclear Proteins ; Nucleosomes ; Transcription Factors ; heterochromatin protein 1, Drosophila ; pros protein, Drosophila
Language	English
Publishing date	2019-12-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2019.11.019
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The Super Elongation Complex Drives Neural Stem Cell Fate Commitment.

Liu, Kun / Shen, Dan / Shen, Jingwen / Gao, Shihong M / Li, Bo / Wong, Chouin / Feng, Weidong / Song, Yan

Developmental cell

2017 Volume 40, Issue 6, Page(s) 537–551.e6

Abstract: Asymmetric stem cell division establishes an initial difference between a stem cell and its differentiating sibling, critical for maintaining homeostasis and preventing carcinogenesis. Yet the mechanisms that consolidate and lock in such initial fate ... ...

Abstract	Asymmetric stem cell division establishes an initial difference between a stem cell and its differentiating sibling, critical for maintaining homeostasis and preventing carcinogenesis. Yet the mechanisms that consolidate and lock in such initial fate bias remain obscure. Here, we use Drosophila neuroblasts to demonstrate that the super elongation complex (SEC) acts as an intrinsic amplifier to drive cell fate commitment. SEC is highly expressed in neuroblasts, where it promotes self-renewal by physically associating with Notch transcription activation complex and enhancing HES (hairy and E(spl)) transcription. HES in turn upregulates SEC activity, forming an unexpected self-reinforcing feedback loop with SEC. SEC inactivation leads to neuroblast loss, whereas its forced activation results in neural progenitor dedifferentiation and tumorigenesis. Our studies unveil an SEC-mediated intracellular amplifier mechanism in ensuring robustness and precision in stem cell fate commitment and provide mechanistic explanation for the highly frequent association of SEC overactivation with human cancers.
MeSH term(s)	Animals ; Cell Dedifferentiation ; Cell Lineage ; Cell Self Renewal ; Drosophila Proteins/metabolism ; Drosophila melanogaster/cytology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Female ; Genes, Insect ; Male ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Protein Binding ; Protein Subunits/metabolism ; Receptors, Notch/metabolism ; Signal Transduction ; Transcriptional Activation/genetics
Chemical Substances	Drosophila Proteins ; Protein Subunits ; Receptors, Notch
Language	English
Publishing date	2017-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2017.02.022
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Article ; Online: Integration of a (-Cu-S-)

Pathak, Abhishek / Shen, Jing-Wen / Usman, Muhammad / Wei, Ling-Fang / Mendiratta, Shruti / Chang, Yu-Shin / Sainbileg, Batjargal / Ngue, Chin-May / Chen, Ruei-San / Hayashi, Michitoshi / Luo, Tzuoo-Tsair / Chen, Fu-Rong / Chen, Kuei-Hsien / Tseng, Tien-Wen / Chen, Li-Chyong / Lu, Kuang-Lieh

Nature communications

2019 Volume 10, Issue 1, Page(s) 1721

Abstract: Designing highly conducting metal-organic frameworks (MOFs) is currently a subject of great interest for their potential applications in diverse areas encompassing energy storage and generation. Herein, a strategic design in which a metal-sulfur plane is ...

Abstract	Designing highly conducting metal-organic frameworks (MOFs) is currently a subject of great interest for their potential applications in diverse areas encompassing energy storage and generation. Herein, a strategic design in which a metal-sulfur plane is integrated within a MOF to achieve high electrical conductivity, is successfully demonstrated. The MOF {[Cu
Language	English
Publishing date	2019-04-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-019-09682-0
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