Article ; Online: Progress of researches on inducing hepatic stellate cell ferroptosis for treatment of liver fibrosis
Jichu yixue yu linchuang, Vol 44, Iss 1, Pp 108-
2024 Volume 113
Abstract: Emerging evidence suggests that ferroptosis, an iron-dependent form of regulated cell death, plays a critical role in the genesis of liver fibrosis through inducing hepatic stellate cell (HSC) ferroptosis to inhibit liver fibrosis or inducing hepatic ... ...
| Abstract | Emerging evidence suggests that ferroptosis, an iron-dependent form of regulated cell death, plays a critical role in the genesis of liver fibrosis through inducing hepatic stellate cell (HSC) ferroptosis to inhibit liver fibrosis or inducing hepatic ferroptosis to potentiates liver fibrosis. Pharmacologically targeting at ferroptosis with its inducers can slow down the progression of liver fibrosis in vitro and in vivo model. This review suggests that pharmacological induction of HSC ferroptosis might be used as a potential novel targeted therapy for the treatment of liver fibrosis. |
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| Keywords | liver fibrosis|hepatic stellate cell|ferroptosis ; Medicine ; R |
| Language | Chinese |
| Publishing date | 2024-01-01T00:00:00Z |
| Publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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