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Article: A PRISMA-IPD systematic review and meta-analysis: does age and follow-up improve active range of motion of the wrist and forearm following pediatric upper extremity cerebral palsy surgery?

Song, Amy X / Saad, Anthony / Hutnik, Lauren / Chandra, Onrina / McGrath, Aleksandra / Chu, Alice

2024 Volume 11, Page(s) 1150797

Abstract: Purpose: Surgical treatments such as tendon transfers and muscle lengthening play a significant role in cerebral palsy management,but timing of upper extremity cerebral palsy surgery remains controversial. This study systematically reviews the current ... ...

Abstract	Purpose: Surgical treatments such as tendon transfers and muscle lengthening play a significant role in cerebral palsy management,but timing of upper extremity cerebral palsy surgery remains controversial. This study systematically reviews the current literature and investigates the correlation between age at surgery and follow-up time with surgical outcomes in pediatric upper extremity cerebral palsy patients. Methods: A comprehensive search of PubMed, Cochrane, Web of Science, and CINAHL databases was performed from inception to July 2020 and articles were screened using PRISMA guidelines to include full-text, English papers. Data analysis was performed using itemized data points for age at surgery, follow-up length, and surgery outcomes, reported as changes in active forearm and wrist motion. A 3D linear model was performed, to analyze the relationship between age, follow-up length, and surgery outcomes. Results: A total of 3,855 papers were identified using the search terms and a total of 8 studies with itemized patient data ( Conclusion: These results suggest that there is significant correlation between the age and follow up after surgery with range of motion gains. Most notably, increased age at surgery had a significant negative correlation with select active range of motion postoperative outcomes. Future research should focus on identifying other factors that could affect results of surgical treatment in upper extremity.
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2024.1150797
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unveiling the unseen toll: exploring the impact of the Lebanese economic crisis on the health-seeking behaviors in a sample of patients with diabetes and hypertension.

Cherfane, Michelle / Boueri, Myriam / Issa, Elio / Abdallah, Racha / Hamam, Ali / Sbeity, Kassem / Saad, Anthony / Abi-Gerges, Aniella

BMC public health

2024 Volume 24, Issue 1, Page(s) 628

Abstract: Background: Against the backdrop of Lebanon's escalating multifaceted crisis which resulted in medication shortages for chronic diseases and unaffordable healthcare services, the current study endeavors to shed light on a critical yet overlooked facet ... ...

Abstract	Background: Against the backdrop of Lebanon's escalating multifaceted crisis which resulted in medication shortages for chronic diseases and unaffordable healthcare services, the current study endeavors to shed light on a critical yet overlooked facet of the Lebanese economic crisis- its profound impact on the health-seeking behaviors of patients with hypertension and diabetes mellitus. Methods: An exploratory cross-sectional study based on an online questionnaire was conducted on 156 adult Lebanese citizens diagnosed medically with either hypertension or diabetes. We gathered sociodemographic characteristics and healthcare-related challenges faced during the economic crisis. We also assessed stress levels using the Depression Anxiety Stress Scale (DASS-21). Descriptive and bivariate analyses were done using SPSS version 26. Results: The mean age of the population was 49.8 ± 17.7 years old, 51.6% were females and 48.4% were males, 29.7% had diabetes, 51.3% had hypertension and 19.0% had both diseases. Among all, 84.2% reported dissatisfaction with the current healthcare system, 31.6% reported changing their physician mainly because of unaffordable consultation fees (66%) or immigration of the physician (32%). Of those with hypertension and/or diabetes, less than 20% reported finding all their prescribed medications and 47% either modified or discontinued their treatment without seeking medical advice. In case of drug shortage, patients relied on stocked reserves (26%), alternative/generic medications (10%) and external sources for medication procurement such as relatives living abroad (41.7%), outsourcing suppliers (19.9%), dispensaries (19.6%) and NGOs (20.3%). All participants reported a high stress level (5.03/7) with a mean total DASS-21 score of 38.7 ± 35.8 that were attributed to August 4 Conclusion: Our findings explore how the economic crisis has taken its toll on almost all aspects of healthcare in a sample of patients with diabetes and hypertension in Lebanon. The drug shortage as well as disruptions in affordable healthcare access imposed several barriers to adequate adherence to treatment regimens and acted as important mental health stressors.
MeSH term(s)	Male ; Adult ; Female ; Humans ; Middle Aged ; Aged ; Economic Recession ; Cross-Sectional Studies ; Diabetes Mellitus/epidemiology ; Hypertension/epidemiology ; Patient Acceptance of Health Care
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-18116-6
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Article ; Online: Forearm and elbow secondary surgical procedures in neonatal brachial plexus palsy: a systematic scoping review.

Azer, Amanda / Hanna, Aedan / Shihora, Dhvani / Saad, Anthony / Duan, Yajie / McGrath, Aleksandra / Chu, Alice

JSES reviews, reports, and techniques

2023 Volume 4, Issue 1, Page(s) 61–69

Abstract: Background: Neonatal Brachial plexus palsy is an injury during delivery that can lead to loss of motor function and limited range of motion in patients due to damage of nerves in the brachial plexus. This scoping review aims to explore types of ... ...

Abstract	Background: Neonatal Brachial plexus palsy is an injury during delivery that can lead to loss of motor function and limited range of motion in patients due to damage of nerves in the brachial plexus. This scoping review aims to explore types of procedures performed and assess outcomes of forearm and elbow secondary surgery in pediatric patients. Methods: Searches of PubMed, Cochrane, Cumulative Index to Nursing and Allied Health Literature, Web of Sciences, and Scopus were completed to obtain studies describing surgical treatment of elbow and forearm in pediatric patients with neonatal Brachial plexus palsy. 865 abstracts and titles were screened by two independent reviewers resulting in 295 full text papers; after applying of inclusion and exclusion criteria 18 articles were included. The level of evidence of this study is level IV. Results: Ten main procedures were performed to regain function of the forearm and elbow in neonatal brachial plexus birth palsy patients. Procedures had different aims, with supination contracture (6) and elbow flexion restoration (5) being the most prevalent. The variance between preoperative and postoperative soft tissue and bony procedures outcomes decreased and showed improvement with respect to the aim of each procedure category. For soft tissue procedures, a statistically significant increase was found between preoperative and postoperative values for active elbow flexion, passive supination, and active supination. For bony procedures, there was a statistically significant decrease between preoperative and postoperative values of passive and active supination. Conclusion: Overall, all procedures completed in the assessed articles of this study were successful in their aim. Bony procedures, specifically osteotomies, were found to have a wider range of results, whereas soft tissue procedures were found to be more consistent and reproducible with respect to their outcomes. Bony and soft tissue procedures were found vary in their aims and outcomes. This study indicates the need for further research to augment knowledge about indications and long-term benefits to each procedure.
Language	English
Publishing date	2023-11-15
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-6391
ISSN (online)	2666-6391
DOI	10.1016/j.xrrt.2023.10.003
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Article: Self-directed Technology-Based Therapeutic Methods for Adult Patients Receiving Mental Health Services: Systematic Review.

Saad, Anthony / Bruno, Deanna / Camara, Bettina / D'Agostino, Josephine / Bolea-Alamanac, Blanca

JMIR mental health

2021 Volume 8, Issue 11, Page(s) e27404

Abstract: Background: Technological interventions used to treat illnesses and promote health are grouped under the umbrella term of digital therapeutics. The use of digital therapeutics is becoming increasingly common in mental health. Although many technologies ... ...

Abstract	Background: Technological interventions used to treat illnesses and promote health are grouped under the umbrella term of digital therapeutics. The use of digital therapeutics is becoming increasingly common in mental health. Although many technologies are currently being implemented, research supporting their usability, efficacy, and risk requires further examination, especially for those interventions that can be used without support. Objective: This review aims to identify the evidence-based, self-directed, technology-based methods of care that can be used in adult patients after they are discharged from mental health services. The interventions reviewed are automated with no human input required (either at the patient's or at the technology's end), so the patients can implement them without any support. Methods: A systematic review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and PROSPERO (International Prospective Register of Systematic Reviews) guidelines in 3 databases: PubMed, Web of Science, and OVID. The inclusion criteria were self-directed, automated, and technology-based interventions related to mental health, primarily for adults, having a solid evaluation process. The interventions had to be self-directed, in that the participants could use the technology without any external guidance. Results: We identified 36 papers that met the inclusion criteria: 26 randomized controlled trials, 9 nonrandomized controlled trial quantitative studies, and 1 qualitative study. The technologies used included websites, automated text messaging, phone apps, videos, computer software, and integrated voice response. There were 22 studies focused on internet-based cognitive behavioral therapies as a therapeutic paradigm compared with the waitlist, web-based human-delivered therapy, and other interventions. Among these studies, 14 used paradigms other than the internet-based cognitive behavioral therapy. Of the 8 studies comparing guided and unguided digital care, 3 showed no differences, 3 favored guided interventions, and 2 favored unguided interventions. The research also showed that dropout rates were as high as 80%, citing potential problems with the acceptability of the suggested technologies. Conclusions: There is limited research on the efficacy and suitability of self-directed technology-based care options for mental health. Digital technologies have the potential to bridge the gap between ambulatory care and independent living. However, these interventions may need to be developed collaboratively with the users to encourage their acceptability and to avoid high dropout rates.
Language	English
Publishing date	2021-11-26
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	2798262-2
ISSN	2368-7959
ISSN	2368-7959
DOI	10.2196/27404
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Article: Thermoresponsive PNIPAm–PMMA-Functionalized PVDF Membranes with Reactive Fe–Pd Nanoparticles for PCB Degradation

Saad, Anthony / Mills, Rollie / Wan, Hongyi / Ormsbee, Lindell / Bhattacharyya, Dibakar

Industrial & engineering chemistry process design and development. 2020 Aug. 28, v. 59, no. 38

2020

Abstract: Fe–Pd nanoparticles are immobilized in stimuli-responsive poly-N-isopropylacrylamide (PNIPAm)- and poly-methyl methacrylate-functionalized polyvinylidene fluoride membranes using ion exchange for 2-chlorobiphenyl (PCB-1) degradation via the reductive ... ...

Abstract	Fe–Pd nanoparticles are immobilized in stimuli-responsive poly-N-isopropylacrylamide (PNIPAm)- and poly-methyl methacrylate-functionalized polyvinylidene fluoride membranes using ion exchange for 2-chlorobiphenyl (PCB-1) degradation via the reductive pathway. PNIPAm is introduced into the reactive membrane system, and its thermoresponsive behavior is leveraged to enhance PCB-1 diffusion and adsorption into the reactive domain. The surface area-normalized rate constant (kSA) values were determined in the convective flow mode to be 0.13, 0.28, 0.72, and 1.36 L/m²/g at 15, 25, 35, and 45 °C, respectively, with an activation energy of 60 kJ/mol (3 wt % Pd). The diffusion coefficients for PCB-1 were 6.6 × 10–¹¹ and 8.7 × 10–¹¹ m²/s at 25 and 35 °C, respectively. The adsorption of PCB-1 onto PNIPAm hydrogels also increased from 40 to 70% as the temperature was increased above its lower critical solution temperature of 32 °C. The batch-mode kSA values were 0.12 L/m²/h at 25 °C and 0.35 L/m²/h at 35 °C.
Keywords	activation energy ; adsorption ; hydrogels ; ion exchange ; process design ; temperature ; thermoplastics
Language	English
Dates of publication	2020-0828
Size	p. 16614-16625.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1484436-9
ISSN	1520-5045 ; 0888-5885
ISSN (online)	1520-5045
ISSN	0888-5885
DOI	10.1021/acs.iecr.0c03260
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Article: Outcomes of humeral osteotomies versus soft-tissue procedures in secondary surgical procedures for neonatal brachial plexus palsy: a meta-analysis.

Azer, Amanda / Mendiratta, Dhruv / Saad, Anthony / Duan, Yajie / Cedarstrand, Matthew / Chinta, Sree / Hanna, Aedan / Shihora, Dhvani / McGrath, Aleksandra / Chu, Alice

Frontiers in surgery

2023 Volume 10, Page(s) 1267064

Abstract: Secondary surgical procedures can be used in brachial plexus birth injury to correct shoulder movement imbalances. This study compares outcomes of the two secondary surgical procedure types: humeral osteotomies and soft tissue procedures. Outcome ... ...

Abstract	Secondary surgical procedures can be used in brachial plexus birth injury to correct shoulder movement imbalances. This study compares outcomes of the two secondary surgical procedure types: humeral osteotomies and soft tissue procedures. Outcome measures assessed included active and passive internal and external rotation, active and passive abduction and adduction, active and passive flexion and extension, percentage of the humeral head anterior to the middle glenoid fossa, glenoid version, and Mallet Score. Nineteen full-text articles were included in the analysis. Humeral osteotomies resulted in a loss of internal rotation postoperatively (-15.94°). Active internal rotation was not evaluated for soft tissue procedures. All other assessed outcomes were improved postoperatively for bony and soft tissue procedures. Bony procedures exhibited a greater degree of active external rotation postoperatively when compared to soft tissue procedures (+67° vs. +40°). Both bony and soft tissue procedures Improve shoulder function in children with neonatal brachial plexus palsy, however, soft tissue procedures showed greater consistency in outcomes.
Language	English
Publishing date	2023-11-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2023.1267064
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Article: Thermo-responsive adsorption-desorption of perfluoroorganics from water using PNIPAm hydrogels and pore functionalized membranes.

Saad, Anthony / Mills, Rollie / Wan, Hongyi / Mottaleb, M Abdul / Ormsbee, Lindell / Bhattacharyya, Dibakar

Journal of membrane science

2020 Volume 599

Abstract: Perfluorochemicals (PFCs) are emerging contaminants in various water sources. Responsive polymers provide a new avenue for PFC adsorption/desorption from water. Poly-N-isopropylacrylamide's (PNIPAm's) temperature-responsive behavior and hydrophilic/ ... ...

Abstract	Perfluorochemicals (PFCs) are emerging contaminants in various water sources. Responsive polymers provide a new avenue for PFC adsorption/desorption from water. Poly-N-isopropylacrylamide's (PNIPAm's) temperature-responsive behavior and hydrophilic/hydrophobic transition is leveraged for reversible adsorption and desorption of PFCs. Adsorption of PFOA (perfluoro-octanoic acid) onto PNIPAm hydrogels yielded Freundlich distribution coefficients (K
Language	English
Publishing date	2020-01-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2020.117821
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Article: Pore Functionalized PVDF Membranes with In-Situ Synthesized Metal Nanoparticles: Material Characterization, and Toxic Organic Degradation.

Wan, Hongyi / Briot, Nicolas J / Saad, Anthony / Ormsbee, Lindell / Bhattacharyya, Dibakar

Journal of membrane science

2018 Volume 530, Page(s) 147–157

Abstract: Functionalized PVDF membrane platforms were developed for environmentally benign in-situ nanostructured Fe/Pd synthesis and remediation of chlorinated organic compounds. To prevent leaching and aggregation, nanoparticle catalysts were integrated into ... ...

Abstract	Functionalized PVDF membrane platforms were developed for environmentally benign in-situ nanostructured Fe/Pd synthesis and remediation of chlorinated organic compounds. To prevent leaching and aggregation, nanoparticle catalysts were integrated into membrane domains functionalized with poly (acrylic acid). Nanoparticles of 16-19 nm were observed inside the membrane pores by using focused ion beam (FIB). This technique prevents mechanical deformation of the membrane, compared to the normal SEM preparation methods, thus providing a clean, smooth surface for nanoparticles characterization. This allowed quantification of nanoparticle properties (size and distribution) versus depth underneath the membrane surface (0-20 µm). The results showed that nanoparticles were uniformly sized and evenly distributed inside the membrane pores. However, the size of nanoparticles inside the membrane pores was 13.9% smaller than those nanoparticles located on the membrane surface. Investigating nanoparticles inside membrane pores increases the accuracy of kinetic analysis and modeling aspects. Furthermore, the Fe/Pd immobilized membranes showed excellent performance in the degradation of chlorinated organics: Over 96% degradation of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) was achieved in less than 15 s residence time in convective flow mode. The regeneration and reuse of this catalytic membrane system were also studied. Particles were examined in XRD upon formation, after deliberate oxidation, and after regeneration. The regenerated sample showed the same crystalline pattern as the original sample. Repeated degradation experiments demonstrated successful PCB 126 dechlorination with nanoparticles regenerated for four cycles with only a small loss in reactivity. It demonstrated that Fe/Pd immobilized membranes have the potential for large-scale remediation applications.
Language	English
Publishing date	2018-01-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2017.02.021
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Article: Incidence of gastric dilatation-volvulus following a splenectomy in 238 dogs.

Maki, Lynn C / Males, Kristina N / Byrnes, Madeline J / El-Saad, Anthony A / Coronado, George S

The Canadian veterinary journal = La revue veterinaire canadienne

2017 Volume 58, Issue 12, Page(s) 1275–1280

Abstract: There is contradicting information in the veterinary literature regarding canine splenectomy and the increased risk for subsequent gastric dilatation-volvulus. The main purpose of this study was to determine the rate of occurrence of gastric dilatation- ... ...

Abstract	There is contradicting information in the veterinary literature regarding canine splenectomy and the increased risk for subsequent gastric dilatation-volvulus. The main purpose of this study was to determine the rate of occurrence of gastric dilatation-volvulus following splenectomy in medium to large breed dogs compared with a control group undergoing other abdominal procedures. Follow-up was performed by reviewing the medical records and conducting phone interviews. Weight, gender, and presence of a hemoabdomen at the time of surgery were not significantly associated with occurrence of gastric dilatation-volvulus, while increasing age was. Ten of 238 (4%) dogs in the splenectomy group and 3/209 (1.4%) dogs in the control group subsequently developed gastric dilatation-volvulus, which was not significantly different (
MeSH term(s)	Animals ; Case-Control Studies ; Dog Diseases/epidemiology ; Dog Diseases/etiology ; Dogs/surgery ; Female ; Gastric Dilatation/epidemiology ; Gastric Dilatation/etiology ; Gastric Dilatation/veterinary ; Incidence ; Male ; Retrospective Studies ; Risk Factors ; Splenectomy/adverse effects ; Splenectomy/veterinary ; Stomach Volvulus/epidemiology ; Stomach Volvulus/etiology ; Stomach Volvulus/veterinary
Language	English
Publishing date	2017-12
Publishing country	Canada
Document type	Journal Article
ZDB-ID	41603-4
ISSN	0008-5286
ISSN	0008-5286
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Article: Development of bench and full-scale temperature and pH responsive functionalized PVDF membranes with tunable properties

Xiao, Li / Isner, Austin / Waldrop, Krysta / Saad, Anthony / Takigawa, Doreen / Bhattacharyya, Dibakar

Journal of membrane science. 2014 May 01, v. 457

2014

Abstract: Temperature and pH responsive polymers (poly(N-isopropylacrylamide) (PNIPAAm), and polyacrylic acid, PAA) were synthesized in one common macrofiltration PVDF membrane platform by pore-filling method. The microstructure and morphology of the PNIPAAm–PVDF, ...

Abstract	Temperature and pH responsive polymers (poly(N-isopropylacrylamide) (PNIPAAm), and polyacrylic acid, PAA) were synthesized in one common macrofiltration PVDF membrane platform by pore-filling method. The microstructure and morphology of the PNIPAAm–PVDF, and PNIPAAm–FPAA–PVDF membranes were studied by attenuated total reflectance Fourier transform infrared (ATR-FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The membrane pore size was controlled by the swelling and shrinking of the PNIPAAm at the temperature around lower critical solution temperature (LCST). The composite membrane demonstrated a rapid and reversible swelling and deswelling change within a small temperature range. The controllable flux makes it possible to utilize this temperature responsive membrane as a valve to regulate filtration properties by temperature change. Dextran solution (Mw=2,000,000g/mol, 26nm diameter) was used to evaluate the separation performance of the temperature responsive membranes. The ranges of dextran rejection are from 4% to 95% depending on the temperature, monomer amount and pressure. The full-scale membrane was also developed to confirm the feasibility of our bench-scale experimental results. The full-scale membrane also exhibited both temperature and pH responsivity. This system was also used for controlled nanoparticles synthesis and for dechlorination reaction.
Keywords	Fourier transform infrared spectroscopy ; asymmetric membranes ; atomic force microscopy ; dechlorination ; dextran ; filtration ; microstructure ; nanoparticles ; pH ; polyacrylic acid ; porosity ; scanning electron microscopy ; temperature ; thermogravimetry
Language	English
Dates of publication	2014-0501
Size	p. 39-49.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2014.01.033
Database	NAL-Catalogue (AGRICOLA)

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