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Article ; Online: The prevalence of hepatic and thyroid toxicity associated with imatinib treatment of chronic myeloid leukaemia: a systematic review.

Tobaiqy, Mansour / Helmi, Nawal / MacLure, Katie / Saade, Sylvia

International journal of clinical pharmacy

2023 Volume 46, Issue 2, Page(s) 368–381

Abstract: Background: Imatinib, a potent inhibitor of targeted protein tyrosine kinases, treats chronic myeloid leukaemia (CML). Data on imatinib-associated changes in hepatic and thyroid functions are limited and conflicting.: Aim: To report the prevalence of ...

Abstract	Background: Imatinib, a potent inhibitor of targeted protein tyrosine kinases, treats chronic myeloid leukaemia (CML). Data on imatinib-associated changes in hepatic and thyroid functions are limited and conflicting. Aim: To report the prevalence of hepatic and thyroid toxicity associated with the use of imatinib in CML patients. Method: Articles for the systematic review were selected from electronic databases (PubMed, CINALH, Web of Science). Readily accessible peer-reviewed full articles in English published 1st January 2000 to 18th July 2023 were included. The search terms included combinations of: imatinib, CML, liver toxicity, hepatic toxicity, thyroid toxicity. Screening of titles, abstracts, full text articles was conducted independently by two reviewers. Inclusions and exclusions were recorded following PRISMA guidelines. Detailed reasons for exclusion were recorded. Included articles were critically appraised. Results: Ten thousand one hundred and twenty-three CML patients were reported in the 82 included studies corresponding to 21 case reports, 2 case series, 39 clinical trials and 20 observational studies were selected. Excluding case studies/reports, 1268 (12.6%; n = 1268/10046) hepatotoxicity adverse events were reported, of which 64.7% were rated as mild grade I & II adverse events, 363 (28.6%) as severe, grade III and IV adverse events; some led to treatment discontinuation, liver transplantation and fatal consequences. Twenty (35.1%) studies reported discontinuation of imatinib treatment due to the severity of hepatic toxicity. Fourteen (8.4%, n = 14/167) thyroid dysfunction adverse events were reported. Conclusion: High frequency of mild and severe hepatotoxicity, associated with imatinib in CML patients, was reported in the published literature. Low numbers of mild and manageable thyroid toxicity events were reported.
MeSH term(s)	Humans ; Imatinib Mesylate/adverse effects ; Thyroid Gland ; Prevalence ; Pyrimidines/adverse effects ; Piperazines/adverse effects ; Benzamides/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/epidemiology ; Chemical and Drug Induced Liver Injury/etiology ; Antineoplastic Agents/adverse effects ; Protein Kinase Inhibitors/adverse effects
Chemical Substances	Imatinib Mesylate (8A1O1M485B) ; Pyrimidines ; Piperazines ; Benzamides ; Antineoplastic Agents ; Protein Kinase Inhibitors
Language	English
Publishing date	2023-12-26
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2601204-2
ISSN	2210-7711 ; 2210-7703 ; 0928-1231
ISSN (online)	2210-7711
ISSN	2210-7703 ; 0928-1231
DOI	10.1007/s11096-023-01671-0
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Article ; Online: Knowledge and Response to Stroke Among Lebanese Adults: A Population-Based Survey.

Saade, Sylvia / Hallit, Souheil / Salameh, Pascale / Hosseini, Hassan

Frontiers in public health

2022 Volume 10, Page(s) 891073

Abstract: Objectives: To date, research on public awareness of stroke warning symptoms, risk factors and practice in the general adult population in Lebanon is scarce. The aim of our study is to identify the level of stroke awareness in order to develop and ... ...

Abstract	Objectives: To date, research on public awareness of stroke warning symptoms, risk factors and practice in the general adult population in Lebanon is scarce. The aim of our study is to identify the level of stroke awareness in order to develop and implement preventive measures particularly in relationship to primary stroke prevention. Methods: It is a cross-sectional study conducted among 410 adult participants from the five main governorates of Lebanon. Stroke knowledge and practice were assessed using two validated questionnaires namely the Stroke Knowledge Test (SKT) and the Stroke Action Test (STAT). Multivariable linear regression models were conducted to examine socio-demographic, social habits, and clinical factors independently associated with the SKT and the STAT scores. Results: The mean SKT score of the participants was 9.16. 48.5% showed a poor stroke-related knowledge level and 51.5% a good knowledge level. Living in Mount Lebanon and occasional smokers showed statistically significant lower mean SKT scores; whereas, university degree and suffering from diabetes mellitus were associated with higher mean SKT scores. The mean overall STAT score was 41.3%. For 36.8% of the stroke symptoms, respondents selected call 112. The mean STAT scores of participants who get their information from the internet was statistically significantly lower. However, no association was found between the SKT score and the STAT score. Conclusion: Knowledge of stroke risk factors was low, as was awareness of the need to call 112 in response to stroke symptoms. Hence, it is essential to develop health education programs in order to decrease stroke morbidity and mortality.
MeSH term(s)	Adult ; Cross-Sectional Studies ; Health Knowledge, Attitudes, Practice ; Humans ; Lebanon/epidemiology ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/prevention & control ; Surveys and Questionnaires
Language	English
Publishing date	2022-06-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.891073
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Article: Attitudes towards continuous professional development: a study of pharmacists in Lebanon.

Saade, Sylvia / Ghazala, Fatima / Farhat, Ali / Hallit, Souheil

Pharmacy practice

2018 Volume 16, Issue 1, Page(s) 1103

Abstract: Objective: To investigate the views and assess motivation, attitudes of pharmacists in Lebanon towards mandatory continuous education (CE), its transition to Continuous Professional Development (CPD), and identify barriers to participation in CPD.: ... ...

Abstract	Objective: To investigate the views and assess motivation, attitudes of pharmacists in Lebanon towards mandatory continuous education (CE), its transition to Continuous Professional Development (CPD), and identify barriers to participation in CPD. Methods: A cross-sectional observational study, conducted between February and May 2017, enrolled 591 pharmacists. The questionnaire used in this study was developed after an extensive literature review and based on previous similar studies in different countries. Results: Half of the pharmacists who completed the questionnaire agreed that all the factors that were mentioned in the questionnaire motivated completing CPD, whereas 55.4% felt confident that CPD meets their needs. 78.4% felt confident in their abilities to assess what they have learned. 71.6% felt confident in their abilities to assess what additional CPD activity may be necessary. The majority of the pharmacists agreed that accessibility of group learning activities (location/distance) (69.6%), job restrictions (76.3%) and lack of time (80.6%) were the most essential barriers against participation in CPD. Motivation was significantly and positively correlated with attitude (r= 0.718), but negatively correlated with barriers (r= -0.243). Attitude was significantly and negatively correlated with barriers (r= -0.120). Conclusion: Our findings contribute to informing the forward pathway for the profession. Attitude and motivation to CPD were positive in this study. Accessibility of group learning activities due to distance and location, job restrictions and lack of time were the major barriers to participation in CPD. Potential solutions can be sought to address these issues.
Language	English
Publishing date	2018-03-17
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2414565-8
ISSN	1886-3655 ; 1885-642X
ISSN (online)	1886-3655
ISSN	1885-642X
DOI	10.18549/PharmPract.2018.01.1103
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Article ; Online: Assessment of post discharge medication prescription among Lebanese patients with cerebral infarction: Results of a cross-sectional study.

Malaeb, Diana / Cherri, Sarah / Hallit, Souheil / Saade, Sylvia / Hosseini, Hassan / Salameh, Pascale

Clinical neurology and neurosurgery

2020 Volume 191, Page(s) 105674

Abstract: Objectives: The study objective was to investigate the degree of physician adherence with the international guidelines for post-stroke discharge medications among Lebanese hospitals.: Patient and methods: This retrospective observational study was ... ...

Abstract	Objectives: The study objective was to investigate the degree of physician adherence with the international guidelines for post-stroke discharge medications among Lebanese hospitals. Patient and methods: This retrospective observational study was conducted in three Lebanese hospitals between January 2016 and December 2017. Results: Out of 200 patients with stroke, 64.7 % were males. The difference of systolic blood pressure from baseline, 2 h, and after 24 h showed significant decrease by mean value 25.18 ± 33.45 (P < 0.001), and 6.44 ± 22.11 (P = 0.019) respectively. Also diastolic blood pressure showed significant decrease between baseline and after 24 h by a mean value 12.17 ± 13.63 (P value <0.001). Concerning post discharge medications adherence, antithrombotic drugs showed the highest percentage (73 %) followed by antihypertensive and lipid lowering agents by comparable results (47.5 % and 40.7 % respectively). The physician adherence for the three medications together showed (30.4 %). Conclusion: Secondary prevention for critical diseases such as stroke appears to be inadequate in the study area.
MeSH term(s)	Aged ; Antihypertensive Agents/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Cerebral Infarction/drug therapy ; Coronary Artery Bypass ; Cross-Sectional Studies ; Female ; Fibrinolytic Agents/therapeutic use ; Guideline Adherence ; Humans ; Hyperlipidemias/complications ; Hyperlipidemias/drug therapy ; Hypertension/complications ; Hypertension/drug therapy ; Hypolipidemic Agents/therapeutic use ; Lebanon ; Male ; Middle Aged ; Patient Discharge ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Secondary Prevention
Chemical Substances	Antihypertensive Agents ; Fibrinolytic Agents ; Hypolipidemic Agents
Language	English
Publishing date	2020-01-13
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2020.105674
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Article ; Online: Selfie addiction: The impact of personality traits? A cross-sectional study among the Lebanese population.

El Khoueiry, Christel / Sacre, Hala / Haddad, Chadia / Akel, Marwan / Saade, Sylvia / Hallit, Souheil / Obeid, Sahar

Perspectives in psychiatric care

2020 Volume 57, Issue 1, Page(s) 167–178

Abstract: Objectives: To examine the relationship between personality traits (Neuroticism, Openness, Consciousness, Agreeableness, and Extraversion) and selfie addiction among Lebanese adults.: Design/methods: A cross-sectional study, carried out between ... ...

Abstract	Objectives: To examine the relationship between personality traits (Neuroticism, Openness, Consciousness, Agreeableness, and Extraversion) and selfie addiction among Lebanese adults. Design/methods: A cross-sectional study, carried out between August 2017 and April 2018, enrolled 1206 community-dwelling participants. Results: Female gender (ORa = 2.79) and higher neuroticism (adjusted odds ratio [ORa] = 1.01) were significantly associated with moderate vs low selfie-taking. Higher openness (ORa = 0.96) was significantly associated with low selfie-taking. Female gender (ORa = 3.42) was significantly associated with intense vs low selfie-taking, whereas higher age (ORa = 0.93) and higher conscientiousness (ORa = 0.99) were significantly associated with lower intense selfie-taking. Practice implications: This relationship can serve as a basis for other studies to better understand this new phenomenon and, later, to draw attention to a "selfie" practice that can deviate from the norm.
MeSH term(s)	Adult ; Behavior, Addictive ; Cell Phone ; Cross-Sectional Studies ; Female ; Humans ; Lebanon ; Personality ; Personality Inventory ; Photography ; Self Concept
Language	English
Publishing date	2020-06-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	391097-0
ISSN	1744-6163 ; 0031-5990
ISSN (online)	1744-6163
ISSN	0031-5990
DOI	10.1111/ppc.12539
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Article: Factors associated with restrained eating and validation of the Arabic version of the restrained eating scale among an adult representative sample of the Lebanese population: a cross-sectional study.

Saade, Sylvia / Hallit, Souheil / Haddad, Chadia / Hallit, Rabih / Akel, Marwan / Honein, Karl / Akiki, Maria / Kheir, Nelly / Obeid, Sahar

Journal of eating disorders

2019 Volume 7, Page(s) 24

Abstract: Background: Previous research suggests that restrained eating is problematic in Lebanon and is associated with the occurrence of clinically diagnosed eating disorders. Because of the alarming prevalence and severity of these disorders, the aim of this ... ...

Abstract	Background: Previous research suggests that restrained eating is problematic in Lebanon and is associated with the occurrence of clinically diagnosed eating disorders. Because of the alarming prevalence and severity of these disorders, the aim of this study is to investigate factors that may contribute to restrained eating in adults among a representative sample of the Lebanese population. Methods: This is a cross-sectional study conducted between January and May 2018; 811 adult participants were enrolled from all Lebanese districts. The Dutch Restrained Eating scale was used to measure body disturbance. The factors that were assessed in the questionnaire were body dissatisfaction, self-esteem, perceived stress, anxiety, depression, emotion regulation, emotional eating and adult attachment styles. Results: The mean age of the participants was 27.59 ± 11.76 years, and included 66.5% females. In the absence of a cutoff value for the Dutch Restrained Eating scale, we took the median (2.6) as the cutoff value. The results showed that 391 (48.3%) had restrained eating. The Dutch Restrained Eating scale items converged over a solution of one factor that had an Eigenvalue over 1, explaining a total of 60.69% of the variance (Cronbach's alpha was high =0.928). The linear regression results, taking the Dutch restrained eating scale as the dependent variable, showed that being a female (Beta = 0.31), increased age (Beta = 0.01), higher body mass index (Beta = 0.01), an intermediate monthly income (Beta = 0.25), higher body dissatisfaction scores (Beta = 0.03), higher adult anxiety attachment style (Beta = 0.008), higher emotion regulation cognitive reappraisal facet (Beta = 0.01), feeling pressure from TV/magazine to lose weight (Beta = 0.45) and practicing sport activities (Beta = 0.41) were associated with higher restrained eating scores. Conclusion: Our findings show that numerous factors are associated with restrained eating in the Lebanese community. They include body dissatisfaction, cognitive reappraisal, female gender, eating attitudes, social media pressure and adult attachment. Therefore, the development of prevention strategies directed at an improved body image perception and increasing knowledge about factors that might influence this body image and critical thinking regarding media images is warranted, with the ultimate goal of promoting healthier choices in the Lebanese population.
Language	English
Publishing date	2019-07-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2699357-0
ISSN	2050-2974
ISSN	2050-2974
DOI	10.1186/s40337-019-0254-2
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Article ; Online: Factors associated with undiagnosed type II diabetes mellitus, undiagnosed impaired fasting glucose and these patients' quality of life in Lebanon.

Hallit, Souheil / Saade, Sylvia / Zeidan, Rouba Karen / Iskandar, Katia / Kheir, Nelly / Youssef, Lara / Costantine, Rachelle / Hallit, Rabih / Salameh, Pascale

Journal of public health (Oxford, England)

2019 Volume 42, Issue 3, Page(s) 550–560

Abstract: Objective: To assess the association between undiagnosed impaired fasting glucose (UIFG) and diabetes (UD), their risk factors and the patients' knowledge about diabetes and their quality of life (QOL).: Methods: A cross-sectional study was conducted ...

Abstract	Objective: To assess the association between undiagnosed impaired fasting glucose (UIFG) and diabetes (UD), their risk factors and the patients' knowledge about diabetes and their quality of life (QOL). Methods: A cross-sectional study was conducted between May and September 2017 in four laboratories enrolling 495 patients. We used the Diabetes Knowledge and SF-12 questionnaires to assess the patients' knowledge about diabetes and QOL. This study meets the Wilson and Jungner criteria for disease screening. Results: A higher knowledge score (ORa = 0.85) was significantly associated with the absence of diabetes compared to UPD, whereas an increased age (ORa = 1.2) and a positive family history of diabetes (ORa = 1.81) were significantly associated with higher odds of UPD. An increased knowledge score (ORa = 0.55) was significantly associated with an absence of diabetes compared to UD, whereas an increased BMI (ORa = 1.40) and an increased age (ORa = 1.07) were associated with increased odds of having UD.UD (Beta = -5.799) was significantly associated with decreased total physical component QOL score, whereas increased diabetes knowledge score (Beta = 0.415) was significantly associated with increased physical QOL. A higher diabetes knowledge score (Beta = 0.459) were associated with increased mental QOL. Conclusion: Seeing the relatively high percentage of UD and UIFG, we propose that screening should be considered and subject to proper assessment in the light of the findings of this study.
MeSH term(s)	Blood Glucose ; Cross-Sectional Studies ; Diabetes Mellitus ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Fasting ; Humans ; Lebanon/epidemiology ; Prevalence ; Quality of Life ; Risk Factors
Chemical Substances	Blood Glucose
Language	English
Publishing date	2019-05-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2142082-8
ISSN	1741-3850 ; 1741-3842
ISSN (online)	1741-3850
ISSN	1741-3842
DOI	10.1093/pubmed/fdz051
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Article ; Online: Association of problematic internet use with depression, impulsivity, anger, aggression, and social anxiety: Results of a national study among Lebanese adolescents.

Haddad, Chadia / Malaeb, Diana / Sacre, Hala / Bou Khalil, Jad / Khansa, Wael / Al Hajj, Roula / Kheir, Nelly / Saade, Sylvia / Obeid, Sahar / Hallit, Souheil

Pediatric investigation

2021 Volume 5, Issue 4, Page(s) 255–264

Abstract: Importance: Several studies conducted worldwide (mostly in Western countries) highlighted the negative effects of problematic internet use, particularly among adolescents aged 12 to 17, including depression, impulsivity, aggression, and social fear and ... ...

Abstract	Importance: Several studies conducted worldwide (mostly in Western countries) highlighted the negative effects of problematic internet use, particularly among adolescents aged 12 to 17, including depression, impulsivity, aggression, and social fear and avoidance. In Lebanon, literature on the prevalence and impact of problematic internet use among adolescents is limited. Objective: This study aim was to study the association between problematic internet use and depression, impulsivity, anger, aggression and social phobia among Lebanese adolescents. Methods: A cross-sectional study was performed on 1103 young adolescents (14-17 years), recruited from October 2017 till April 2018. The Internet Addiction Test (IAT) was used to evaluate the level of problematic internet use. Data were analyzed using the MANCOVA analysis. The main independent variable of interest was the IAT, while the dependent variables included the psychological scales. Results: The multivariate analysis taking the psychological scales as the dependent variables and the problematic internet use (IAT score) as an independent variable, showed that problematic internet use was associated with higher depression, impulsivity, aggression, anger, hostility and social anxiety. Interpretation: Problematic internet use has become an important health issue that should not be overlooked, particularly because of the increased use of the internet by adolescents. Educational programs on early exposure to the internet should be developed.
Language	English
Publishing date	2021-12-13
Publishing country	United States
Document type	Journal Article
ISSN	2574-2272
ISSN (online)	2574-2272
DOI	10.1002/ped4.12299
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Article ; Online: Internet Addiction Among Lebanese Adolescents: The Role of Self-Esteem, Anger, Depression, Anxiety, Social Anxiety and Fear, Impulsivity, and Aggression-A Cross-Sectional Study.

Obeid, Sahar / Saade, Sylvia / Haddad, Chadia / Sacre, Hala / Khansa, Wael / Al Hajj, Roula / Kheir, Nelly / Hallit, Souheil

The Journal of nervous and mental disease

2019 Volume 207, Issue 10, Page(s) 838–846

Abstract: The study objective was to evaluate the association between depression, anxiety, social anxiety and fear, impulsivity, and aggression and Internet addiction (IA) among Lebanese adolescents. This cross-sectional study, conducted between October 2017 and ... ...

Abstract	The study objective was to evaluate the association between depression, anxiety, social anxiety and fear, impulsivity, and aggression and Internet addiction (IA) among Lebanese adolescents. This cross-sectional study, conducted between October 2017 and April 2018, enrolled 1103 young adolescents aged between 13 and 17 years. The Internet Addiction Test (IAT) was used to screen for IA. The results also showed that 56.4% of the participants were average Internet users (IAT score ≤49), 40.0% had occasional/frequent problems (IAT scores between 50 and 79), and 3.6% had significant problems (IAT scores ≥80) because of Internet use. The results of a stepwise regression showed that higher levels of aggression (β = 0.185), depression (Multiscore Depression Inventory for Children) (β = 0.219), impulsivity (β = 0.344), and social fear (β = 0.084) were associated with higher IA, whereas an increased number of siblings (β = -0.779) and a higher socioeconomic status (β = -1.707) were associated with lower IA. Uncontrolled use of the Internet can be associated with addiction and other psychological comorbidities.
MeSH term(s)	Adolescent ; Adolescent Behavior/psychology ; Aggression/physiology ; Aggression/psychology ; Anger/physiology ; Anxiety/diagnosis ; Anxiety/epidemiology ; Anxiety/psychology ; Behavior, Addictive/diagnosis ; Behavior, Addictive/epidemiology ; Behavior, Addictive/psychology ; Cross-Sectional Studies ; Depression/diagnosis ; Depression/epidemiology ; Depression/psychology ; Fear/physiology ; Fear/psychology ; Female ; Humans ; Impulsive Behavior/physiology ; Internet/trends ; Lebanon/epidemiology ; Male ; Self Concept ; Surveys and Questionnaires
Language	English
Publishing date	2019-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	3020-x
ISSN	1539-736X ; 0022-3018
ISSN (online)	1539-736X
ISSN	0022-3018
DOI	10.1097/NMD.0000000000001034
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Article ; Online: Knowledge, Attitude and Practice of Lebanese Community Pharmacists toward Chronic Obstructive Pulmonary Disease.

Hallit, Souheil / Zeidan, Rouba Karen / Saade, Sylvia / Hajj, Aline / Hallit, Rabih / Akel, Marwan / Yahchouchy, Charbel / Kheir, Nelly / Iskandar, Katia / Sacre, Hala / Salameh, Pascale

Journal of epidemiology and global health

2020 Volume 10, Issue 1, Page(s) 86–95

Abstract: Inclusion of a pharmacist showed that pharmacy-led patient education can positively impact treatment outcome, chronic obstructive pulmonary disease (COPD) knowledge, medication adherence, quality of life, significant reduction in hospital admission rates, ...

Abstract	Inclusion of a pharmacist showed that pharmacy-led patient education can positively impact treatment outcome, chronic obstructive pulmonary disease (COPD) knowledge, medication adherence, quality of life, significant reduction in hospital admission rates, and emergency department visits. The objectives were to assess the degree of COPD knowledge in Lebanese community pharmacists as well as their attitudes and practice toward disease management. Between January and May 2018, a cross-sectional survey enrolled 709 Lebanese community pharmacists. A committee was created to build up the questionnaire; it was composed of two physicians (one infectious disease specialist and one pulmonologist) and eight pharmacists, with long expertise in community and hospital pharmacy. It comprised 12 questions assessing knowledge, 12 questions for attitude, and 13 questions for practice. Higher attitude (
MeSH term(s)	Adult ; Attitude of Health Personnel ; Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Health Promotion/methods ; Humans ; Lebanon/epidemiology ; Male ; Middle Aged ; Patient Education as Topic/methods ; Pharmacists/psychology ; Pharmacists/statistics & numerical data ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/prevention & control ; Surveys and Questionnaires
Language	English
Publishing date	2020-01-25
Publishing country	France
Document type	Journal Article
ZDB-ID	2645324-1
ISSN	2210-6014 ; 2210-6014
ISSN (online)	2210-6014
ISSN	2210-6014
DOI	10.2991/jegh.k.191215.004
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