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Article ; Online: A facile synthesis of silver nanowires and their evaluation in the mitochondrial membrane potential.

Villalpando, M / Saavedra-Molina, Alfredo / Rosas, G

Materials science & engineering. C, Materials for biological applications

2020 Volume 114, Page(s) 110973

Abstract: Silver nanowires (AgNWs) with a high-aspect-ratio were successfully synthesized by a green method using Lavandula angustifolia plant extract. The morphology of the AgNWs was evaluated as a function of the concentration of precursor salt and nucleating ... ...

Abstract	Silver nanowires (AgNWs) with a high-aspect-ratio were successfully synthesized by a green method using Lavandula angustifolia plant extract. The morphology of the AgNWs was evaluated as a function of the concentration of precursor salt and nucleating agent. Furthermore, AgNWs were analyzed in a biological model using rat liver mitochondria by measuring their effect on membrane potential. The scanning electron microscopy (SEM), X-ray diffraction (XRD), and transmission electron microscopy (TEM) techniques structurally characterized the nanowires obtained. Also, ultraviolet-visible spectroscopy (UV-Vis) investigated the optical properties of AgNWs. Structural studies show AgNWs fcc with lengths up to 100 μm and diameters ranging from 60 to 130 nm growing in the [110] orientation. Both the CuSO
MeSH term(s)	Animals ; Membrane Potential, Mitochondrial ; Microscopy, Electron, Scanning ; Nanowires ; Rats ; Silver ; X-Ray Diffraction
Chemical Substances	Silver (3M4G523W1G)
Language	English
Publishing date	2020-05-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012160-X
ISSN	1873-0191 ; 0928-4931
ISSN (online)	1873-0191
ISSN	0928-4931
DOI	10.1016/j.msec.2020.110973
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Article ; Online: Diazoxide and moderate-intensity exercise improve skeletal muscle function by decreasing oxidants and enhancing antioxidant defenses in hypertensive male rats.

Bravo Sánchez, Estefanía / Nolasco Ruíz, César J / Gómez-Barroso, Mariana / Cortés Rojo, Christian / Rodríguez Orozco, Alain R / Saavedra Molina, Alfredo / Manzo Ávalos, Salvador / Montoya Pérez, Rocío

Physiological reports

2024 Volume 12, Issue 8, Page(s) e16026

Abstract: High sodium intake is decisive in the incidence increase and prevalence of hypertension, which has an impact on skeletal muscle functionality. Diazoxide is an antihypertensive agent that inhibits insulin secretion and is an opener of ... ...

Abstract	High sodium intake is decisive in the incidence increase and prevalence of hypertension, which has an impact on skeletal muscle functionality. Diazoxide is an antihypertensive agent that inhibits insulin secretion and is an opener of K
MeSH term(s)	Animals ; Diazoxide/pharmacology ; Male ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/drug effects ; Rats, Wistar ; Hypertension/metabolism ; Hypertension/physiopathology ; Physical Conditioning, Animal/physiology ; Rats ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Oxidative Stress/drug effects ; Oxidants/metabolism
Chemical Substances	Diazoxide (O5CB12L4FN) ; Antioxidants ; Oxidants
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.16026
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Article ; Online: Antioxidant effects of silver nanoparticles obtained by green synthesis from the aqueous extract of Eryngium carlinae on the brain mitochondria of streptozotocin-induced diabetic rats.

Lemus-de la Cruz, Jenaro / Trejo-Hurtado, Mitchell / Landa-Moreno, Cinthia / Peña-Montes, Donovan / Landeros-Páramo, José Luis / Cortés-Rojo, Christian / Montoya-Pérez, Rocío / Rosas, Gerardo / Saavedra-Molina, Alfredo

Journal of bioenergetics and biomembranes

2023 Volume 55, Issue 2, Page(s) 123–135

Abstract: Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia that affects practically all tissues and organs, being the brain one of most susceptible, due to overproduction of reactive oxygen species induced by diabetes. Eryngium ... ...

Abstract	Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia that affects practically all tissues and organs, being the brain one of most susceptible, due to overproduction of reactive oxygen species induced by diabetes. Eryngium carlinae is a plant used in traditional Mexican medicine to treat diabetes, which has already been experimentally shown have hypoglycemic, antioxidant and hypolipidemic properties. The green synthesis of nanoparticles is a technique that combines plant extracts with metallic nanoparticles, so that the nanoparticles reduce the absorption and distribution time of drugs or compounds, increasing their effectiveness. In this work, the antioxidant effects and mitochondrial function in the brain were evaluated, as well as the hypoglycemic and hypolipidemic effect in serum of both the aqueous extract of the aerial part of E. carlinae, as well as its combination with silver nanoparticles of green synthesis. Administration with both, extract and the combination significantly decreased the production of reactive oxygen species, lipid peroxidation, and restored the activity of superoxide dismutase 2, glutathione peroxidase, and electron transport chain complexes in brain, while that the extract-nanoparticle combination decreased blood glucose and triglyceride levels. The results obtained suggest that both treatments have oxidative activity and restore mitochondrial function in the brain of diabetic rats.
MeSH term(s)	Rats ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Streptozocin/metabolism ; Streptozocin/pharmacology ; Streptozocin/therapeutic use ; Eryngium/metabolism ; Silver/pharmacology ; Silver/metabolism ; Silver/therapeutic use ; Reactive Oxygen Species/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Metal Nanoparticles ; Oxidative Stress ; Rats, Wistar ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Lipid Peroxidation ; Brain/metabolism ; Mitochondria/metabolism
Chemical Substances	Antioxidants ; Streptozocin (5W494URQ81) ; Silver (3M4G523W1G) ; Reactive Oxygen Species ; Hypoglycemic Agents ; Plant Extracts
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	198499-8
ISSN	1573-6881 ; 0145-479X ; 0449-5705
ISSN (online)	1573-6881
ISSN	0145-479X ; 0449-5705
DOI	10.1007/s10863-023-09963-w
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Article ; Online: Diazoxide improves muscle function in association with improved dyslipidemia and decreased muscle oxidative stress in streptozotocin-induced diabetic rats.

Vargas-Vargas, Manuel Alejandro / Saavedra-Molina, Alfredo / Gómez-Barroso, Mariana / Peña-Montes, Donovan / Cortés-Rojo, Christian / Rodríguez-Orozco, Alain R / Rocío, Montoya-Pérez

Journal of bioenergetics and biomembranes

2023 Volume 55, Issue 1, Page(s) 71–78

Abstract: Aim/introduction: Diabetes Mellitus is a chronic degenerative disease, and its main biochemical characteristic is hyperglycemia due to impaired insulin secretion, resistance to peripheral actions of insulin, or both. Hyperglycemia causes dyslipidemia ... ...

Abstract	Aim/introduction: Diabetes Mellitus is a chronic degenerative disease, and its main biochemical characteristic is hyperglycemia due to impaired insulin secretion, resistance to peripheral actions of insulin, or both. Hyperglycemia causes dyslipidemia and stimulates oxidative damage, leading to the main symptoms, such as fatigue and culminates in diabetic complications. Previous studies have shown that ATP-sensitive potassium channels counteract muscle fatigue and metabolic stress in healthy mouse models. To determine the effect of diazoxide on muscle strength development during diabetes, we tested the effect of diazoxide in streptozotocin-diabetic rats in muscle function, lipid profile and oxidative stress biomarkers. Materials and methods: Wistar rats were divided into 4 groups of six animals each: (1) Control group, (2) diabetes group, (3) Control group + diazoxide, and (4) Diabetic + diazoxide (DB + DZX). 4 weeks after rats were sacrificed, soleus and extensor digitorum longus muscles (EDL) were extracted to prepare homogenates and serum was obtained for biochemical measurements. Oxidative damage was evaluated by the thiobarbituric acid method and the fluorescent for reactive oxygen species (ROS) probe 2,4-H Results: Diabetic rats with diazoxide administration showed an increase in the development of muscle strength in both muscles; in turn, the onset of fatigue was longer compared to the group of diabetic rats without treatment. Regarding the lipid profile, diazoxide decreased total cholesterol levels in the group of diabetic rats treated with diazoxide (x̅46.2 mg/dL) compared to the untreated diabetic group (x̅=104.4 mg/dL); secondly, diazoxide decreased triglyceride concentrations (x̅=105.3 mg/dL) compared to the untreated diabetic rats (x̅=412.2 mg/dL) as well as the levels of very low-density lipoproteins (x̅=20.4 mg/dL vs. x̅=82.44 mg/dL). Regarding the various markers of oxidative stress, the diabetic group treated with diazoxide was able to reduce the concentrations of TBARS and total reactive oxygen species as well as preserve the concentrations of reduced glutathione. Conclusion: Diazoxide administration in diabetic rats increases muscle strength development in EDL and soleus muscle, decreases fatigue, reduces cholesterol and triglyceride concentrations and improves oxidative stress parameters such as TBARS, ROS, and glutathione status.
MeSH term(s)	Mice ; Rats ; Animals ; Diazoxide/adverse effects ; Diazoxide/metabolism ; Streptozocin/adverse effects ; Streptozocin/metabolism ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Diabetes Mellitus, Experimental/complications ; Thiobarbituric Acid Reactive Substances/adverse effects ; Thiobarbituric Acid Reactive Substances/metabolism ; Oxidative Stress ; Hyperglycemia/complications ; Muscle, Skeletal/metabolism ; Lipids ; Triglycerides/adverse effects ; Triglycerides/metabolism ; Cholesterol/metabolism
Chemical Substances	Diazoxide (O5CB12L4FN) ; Streptozocin (5W494URQ81) ; Reactive Oxygen Species ; Thiobarbituric Acid Reactive Substances ; Lipids ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	198499-8
ISSN	1573-6881 ; 0145-479X ; 0449-5705
ISSN (online)	1573-6881
ISSN	0145-479X ; 0449-5705
DOI	10.1007/s10863-023-09958-7
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Article: Effects of Apocynin on Heart Muscle Oxidative Stress of Rats with Experimental Diabetes: Implications for Mitochondria.

Bravo-Sánchez, Estefanía / Peña-Montes, Donovan / Sánchez-Duarte, Sarai / Saavedra-Molina, Alfredo / Sánchez-Duarte, Elizabeth / Montoya-Pérez, Rocío

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 3

Abstract: Diabetes mellitus (DM) constitutes one of the public health problems today. It is characterized by hyperglycemia through a defect in the β-cells function and/or decreased insulin sensitivity. Apocynin has been tasted acting directly as an NADPH oxidase ... ...

Abstract	Diabetes mellitus (DM) constitutes one of the public health problems today. It is characterized by hyperglycemia through a defect in the β-cells function and/or decreased insulin sensitivity. Apocynin has been tasted acting directly as an NADPH oxidase inhibitor and reactive oxygen species (ROS) scavenger, exhibiting beneficial effects against diabetic complications. Hence, the present study's goal was to dissect the possible mechanisms by which apocynin could mediate its cardioprotective effect against DM-induced oxidative stress. Male Wistar rats were assigned into 4 groups: Control (C), control + apocynin (C+A), diabetes (D), diabetes + apocynin (D+A). DM was induced with streptozotocin. Apocynin treatment (3 mg/kg/day) was applied for 5 weeks. Treatment significantly decreased blood glucose levels and insulin resistance in diabetic rats. In cardiac tissue, ROS levels were higher, and catalase enzyme activity was reduced in the D group compared to the C group; the apocynin treatment significantly attenuated these responses. In heart mitochondria, Complexes I and II of the electron transport chain (ETC) were significantly enhanced in the D+A group. Total glutathione, the level of reduced glutathione (GSH) and the GSH/ oxidized glutathione (GSSG) ratio were increased in the D+A group. Superoxide dismutase (SOD) and the glutathione peroxidase (GSH-Px) activities were without change. Apocynin enhances glucose uptake and insulin sensitivity, preserving the antioxidant defense and mitochondrial function.
Language	English
Publishing date	2021-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10030335
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Article: Hypolipidemic and Antioxidant Effects of

Esquivel-Gutiérrez, Edgar R / Manzo-Avalos, Salvador / Peña-Montes, Donovan J / Saavedra-Molina, Alfredo / Morreeuw, Zoé P / Reyes, Ana G

Plants (Basel, Switzerland)

2021 Volume 10, Issue 11

Abstract: In the present study, we used a by-product ... ...

Abstract	In the present study, we used a by-product from
Language	English
Publishing date	2021-11-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10112492
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Article ; Online: Glutathione peroxidase 2 (Gpx2) preserves mitochondrial function and decreases ROS levels in chronologically aged yeast.

Canizal-García, Melina / Olmos-Orizaba, Berenice Eridani / Moreno-Jiménez, Mario / Calderón-Cortés, Elizabeth / Saavedra-Molina, Alfredo / Cortés-Rojo, Christian

Free radical research

2021 Volume 55, Issue 2, Page(s) 165–175

Abstract: Glutathione peroxidase 4 (Gpx4) counteracts mitochondrial lipid peroxidation in mammals. In yeast, Gpx2 is orthologous of Gpx4, is localized in mitochondria, and reduces both inorganic and organic peroxides. However, a phenotype of oxidative stress ... ...

Abstract	Glutathione peroxidase 4 (Gpx4) counteracts mitochondrial lipid peroxidation in mammals. In yeast, Gpx2 is orthologous of Gpx4, is localized in mitochondria, and reduces both inorganic and organic peroxides. However, a phenotype of oxidative stress hypersensitivity has not been observed with
MeSH term(s)	Glutathione Peroxidase/metabolism ; Reactive Oxygen Species/metabolism ; Saccharomyces cerevisiae ; Yeasts
Chemical Substances	Reactive Oxygen Species ; Glutathione Peroxidase (EC 1.11.1.9)
Language	English
Publishing date	2021-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1194130-3
ISSN	1029-2470 ; 1071-5762
ISSN (online)	1029-2470
ISSN	1071-5762
DOI	10.1080/10715762.2021.1882677
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Article: Hypolipidemic and Antioxidant Effects of Guishe Extract from Agave lechuguilla, a Mexican Plant with Biotechnological Potential, on Streptozotocin-Induced Diabetic Male Rats

Esquivel-Gutiérrez, Edgar R. / Manzo-Avalos, Salvador / Peña-Montes, Donovan J. / Saavedra-Molina, Alfredo / Morreeuw, Zoé P. / Reyes, Ana G.

Plants. 2021 Nov. 18, v. 10, no. 11

2021

Abstract: In the present study, we used a by-product from Agave lechuguilla (guishe) to test its antidiabetic effect, hypolipidemic activity, and capacity to mitigate the oxidative stress in kidney mitochondria from streptozotocin-induced diabetic rats. Orally, a ... ...

Abstract	In the present study, we used a by-product from Agave lechuguilla (guishe) to test its antidiabetic effect, hypolipidemic activity, and capacity to mitigate the oxidative stress in kidney mitochondria from streptozotocin-induced diabetic rats. Orally, a crude aqueous extract from lyophilized guishe was administered over 5 weeks at different doses. Blood glucose and body weight were monitored. Also, blood chemistry, bilirubin, and alanine aminotransferase were assayed. Furthermore, the activity of catalase, thiobarbituric acid reactive species, mitochondrial superoxide dismutase, glutathione and glutathione peroxidase were determined in isolated kidney mitochondria. Our results show that guishe extracts have no antidiabetic properties at any dose. Nevertheless, it was able to diminish serum triglyceride levels and regulate the oxidative stress observed in isolated kidney mitochondria. These observations indicate that the aqueous extract from guishe can be used to treat abnormalities in serum lipids, as a hypolipidemic, and mitigate the oxidative stress, as an antioxidant, occurring during diabetes.
Keywords	Agave lechuguilla ; alanine transaminase ; antioxidants ; bilirubin ; blood glucose ; blood serum ; body weight ; byproducts ; catalase ; diabetes ; freeze drying ; glutathione ; glutathione peroxidase ; glycemic effect ; kidneys ; males ; mitochondria ; oxidative stress ; superoxide dismutase ; thiobarbituric acid-reactive substances ; triacylglycerols
Language	English
Dates of publication	2021-1118
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10112492
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of Apocynin on Heart Muscle Oxidative Stress of Rats with Experimental Diabetes: Implications for Mitochondria

Bravo-Sánchez, Estefanía / Peña-Montes, Donovan / Sánchez-Duarte, Sarai / Saavedra-Molina, Alfredo / Sánchez-Duarte, Elizabeth / Montoya-Pérez, Rocío

Antioxidants. 2021 Feb. 24, v. 10, no. 3

2021

Abstract	Diabetes mellitus (DM) constitutes one of the public health problems today. It is characterized by hyperglycemia through a defect in the β-cells function and/or decreased insulin sensitivity. Apocynin has been tasted acting directly as an NADPH oxidase inhibitor and reactive oxygen species (ROS) scavenger, exhibiting beneficial effects against diabetic complications. Hence, the present study’s goal was to dissect the possible mechanisms by which apocynin could mediate its cardioprotective effect against DM-induced oxidative stress. Male Wistar rats were assigned into 4 groups: Control (C), control + apocynin (C+A), diabetes (D), diabetes + apocynin (D+A). DM was induced with streptozotocin. Apocynin treatment (3 mg/kg/day) was applied for 5 weeks. Treatment significantly decreased blood glucose levels and insulin resistance in diabetic rats. In cardiac tissue, ROS levels were higher, and catalase enzyme activity was reduced in the D group compared to the C group; the apocynin treatment significantly attenuated these responses. In heart mitochondria, Complexes I and II of the electron transport chain (ETC) were significantly enhanced in the D+A group. Total glutathione, the level of reduced glutathione (GSH) and the GSH/ oxidized glutathione (GSSG) ratio were increased in the D+A group. Superoxide dismutase (SOD) and the glutathione peroxidase (GSH-Px) activities were without change. Apocynin enhances glucose uptake and insulin sensitivity, preserving the antioxidant defense and mitochondrial function.
Keywords	NAD(P)H oxidase (H2O2-forming) ; antioxidant activity ; blood glucose ; cardioprotective effect ; catalase ; electron transport chain ; enzyme activity ; glucose ; glutathione ; glutathione peroxidase ; hyperglycemia ; insulin resistance ; males ; mitochondria ; myocardium ; oxidative stress ; public health ; reactive oxygen species ; streptozotocin ; superoxide dismutase
Language	English
Dates of publication	2021-0224
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10030335
Database	NAL-Catalogue (AGRICOLA)

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Article: An Ethyl Acetate Extract of

Trejo-Hurtado, Cristian M / Landa-Moreno, Cinthia I / la Cruz, Jenaro Lemus-de / Peña-Montes, Donovan J / Montoya-Pérez, Rocío / Salgado-Garciglia, Rafael / Manzo-Avalos, Salvador / Cortés-Rojo, Christian / Monribot-Villanueva, Juan Luis / Guerrero-Analco, José Antonio / Saavedra-Molina, Alfredo

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Secondary metabolites such as flavonoids are promising in the treatment of non-alcoholic fatty liver disease (NAFLD), which is one of the complications of diabetes due to oxidative stress and inflammation. Some plants, such ... ...

Abstract	Secondary metabolites such as flavonoids are promising in the treatment of non-alcoholic fatty liver disease (NAFLD), which is one of the complications of diabetes due to oxidative stress and inflammation. Some plants, such as
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061235
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