Article ; Online: Structure-Based Drug Design of RdRp Inhibitors against SARS-CoV-2.
Topics in current chemistry (Cham)
2023 Volume 381, Issue 5, Page(s) 22
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic since 2019, spreading rapidly and posing a significant threat to human health and life. With over 6 billion confirmed cases of the virus, the need for ... ...
Abstract | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic since 2019, spreading rapidly and posing a significant threat to human health and life. With over 6 billion confirmed cases of the virus, the need for effective therapeutic drugs has become more urgent than ever before. RNA-dependent RNA polymerase (RdRp) is crucial in viral replication and transcription, catalysing viral RNA synthesis and serving as a promising therapeutic target for developing antiviral drugs. In this article, we explore the inhibition of RdRp as a potential treatment for viral diseases, analysing the structural information of RdRp in virus proliferation and summarizing the reported inhibitors' pharmacophore features and structure-activity relationship profiles. We hope that the information provided by this review will aid in structure-based drug design and aid in the global fight against SARS-CoV-2 infection. |
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MeSH term(s) | Humans ; SARS-CoV-2 ; COVID-19 ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; RNA-Dependent RNA Polymerase/chemistry ; RNA-Dependent RNA Polymerase/pharmacology ; Drug Design |
Chemical Substances | Antiviral Agents ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) |
Language | English |
Publishing date | 2023-06-15 |
Publishing country | Switzerland |
Document type | Journal Article ; Review |
ZDB-ID | 2848485-X |
ISSN | 2364-8961 ; 2365-0869 |
ISSN (online) | 2364-8961 |
ISSN | 2365-0869 |
DOI | 10.1007/s41061-023-00432-x |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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