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  1. Book ; Online ; E-Book: Sinonasal and skull base malignancies

    Saba, Nabil F. / Lin, Derrick T.

    2022  

    Author's details edited by Nabil F. Saba and Derrick T. Lin
    Keywords Skull base/Cancer ; Nose/Tumors
    Subject code 616.99491
    Language English
    Size 1 online resource (282 pages)
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-97618-1 ; 9783030976170 ; 978-3-030-97618-7 ; 3030976173
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Sinonasal and Skull Base Malignancies

    Lin, Derrick T. / Saba, Nabil F.

    2022  

    Author's details ¿Nabil F. Saba Professor and Vice Chair Department of Hematology and Medical Oncology Lynne and Howard Halpern Chair in Head and Neck Cancer Research Co-Director, Head and Neck Cancers Multi-Disciplinary Program Winship Cancer Institute of Emory University Emory University School of Medicine 1365 Clifton Rd Building C Atlanta, GA 30322 USA § Derrick T. Lin, MD, FACS Daniel Miller Professor and Associate Chair Department of Otolaryngology, Head and Neck Surgery Harvard Medical School Massachusetts Eye and Ear Infirmary/ Massachusetts General Hospital 243 Charles Street Boston, MA 02114 §
    Keywords Sinonasal Malignancies ; skull base tumors ; Tumors ; Endoscopic Resections of Sinonals Tumors ; Radiation Therapy ; Surgical Management of Skull Base ; Surgical Management of Sinonasal Malignancies ; Rare Sinonasal Tumors ; Otorhinolaryngology ; Paranasal Sinus Tumors ; Skull Base Tumors
    Language English
    Size 296 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_15
    Format 160 x 241 x 21
    ISBN 9783030976170 ; 3030976173
    Database PDA

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  3. Book ; Online ; E-Book: Esophageal cancer

    Saba, Nabil F. / El-Rayes, Bassel

    prevention, diagnosis and therapy

    2020  

    Author's details Nabil F. Saba, Bassel F. El-Rayes editors
    Keywords Esophageal Neoplasms ; Oncology   ; Pathology ; Radiotherapy ; Surgery
    Subject code 616.994
    Language English
    Size 1 Online-Ressource (xii, 336 Seiten), Illustrationen, Diagramme
    Edition second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020330238
    ISBN 978-3-030-29832-6 ; 9783030298319 ; 3-030-29832-9 ; 3030298310
    DOI 10.1007/978-3-030-29832-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Preoperative chemotherapy for sinonasal squamous cell carcinoma (SNSCC): Time to move closer to a definitive answer.

    Saba, Nabil F

    Cancer

    2021  Volume 127, Issue 11, Page(s) 1734–1735

    MeSH term(s) Humans ; Paranasal Sinus Neoplasms/drug therapy ; Paranasal Sinus Neoplasms/surgery ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/surgery
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.33450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.146: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Immune check point inhibitors in advanced cutaneous squamous cell carcinomas: "Repeat and replicate".

    Steuer, Conor E / Saba, Nabil F

    Cancer

    2022  Volume 128, Issue 24, Page(s) 4177–4178

    Abstract: Recent evidence confirmed the significant clinical benefit from using immune check point inhibitors, namely PD-1 inhibitors, in patients with advanced cutaneous squamous cell carcinomas. The activity of these different agents seems to be strikingly ... ...

    Abstract Recent evidence confirmed the significant clinical benefit from using immune check point inhibitors, namely PD-1 inhibitors, in patients with advanced cutaneous squamous cell carcinomas. The activity of these different agents seems to be strikingly equivalent. This phase 2 trial confirms a similar clinical benefit to single agent nivolumab in treating this disease. The replication of these findings raises the question of whether substitution of these immunotherapeutic agents can be justified based on smaller confirmatory trials.
    MeSH term(s) Humans ; Carcinoma, Squamous Cell/drug therapy ; Nivolumab/therapeutic use ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Clinical Trials, Phase II as Topic
    Chemical Substances Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2022-10-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.34465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.146: Show issues Location:
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  6. Article: Cancer metabolism and carcinogenesis.

    Yang, Jianqiang / Shay, Chloe / Saba, Nabil F / Teng, Yong

    Experimental hematology & oncology

    2024  Volume 13, Issue 1, Page(s) 10

    Abstract: Metabolic reprogramming is an emerging hallmark of cancer cells, enabling them to meet increased nutrient and energy demands while withstanding the challenging microenvironment. Cancer cells can switch their metabolic pathways, allowing them to adapt to ... ...

    Abstract Metabolic reprogramming is an emerging hallmark of cancer cells, enabling them to meet increased nutrient and energy demands while withstanding the challenging microenvironment. Cancer cells can switch their metabolic pathways, allowing them to adapt to different microenvironments and therapeutic interventions. This refers to metabolic heterogeneity, in which different cell populations use different metabolic pathways to sustain their survival and proliferation and impact their response to conventional cancer therapies. Thus, targeting cancer metabolic heterogeneity represents an innovative therapeutic avenue with the potential to overcome treatment resistance and improve therapeutic outcomes. This review discusses the metabolic patterns of different cancer cell populations and developmental stages, summarizes the molecular mechanisms involved in the intricate interactions within cancer metabolism, and highlights the clinical potential of targeting metabolic vulnerabilities as a promising therapeutic regimen. We aim to unravel the complex of metabolic characteristics and develop personalized treatment approaches to address distinct metabolic traits, ultimately enhancing patient outcomes.
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2669066-4
    ISSN 2162-3619
    ISSN 2162-3619
    DOI 10.1186/s40164-024-00482-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Time to Rethink Our Strategy With a Preoperative Intensification Approach.

    Saba, Nabil F

    International journal of radiation oncology, biology, physics

    2018  Volume 101, Issue 4, Page(s) 762

    Language English
    Publishing date 2018-06-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2018.03.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Cancer of the Paranasal Sinuses.

    Taylor, Melissa A / Saba, Nabil F

    Hematology/oncology clinics of North America

    2021  Volume 35, Issue 5, Page(s) 949–962

    Abstract: Sinonasal malignancies rare and pathologically diverse and make up <1% of all malignancies. Due to their anatomical location, they can cause significant morbidity with involvement of surrounding critical structures. They often present at a late stage ... ...

    Abstract Sinonasal malignancies rare and pathologically diverse and make up <1% of all malignancies. Due to their anatomical location, they can cause significant morbidity with involvement of surrounding critical structures. They often present at a late stage with insidious onset of symptoms. Treatment of sinonasal malignancies is challenging and they often require a multimodality approach with surgery, radiation, and chemotherapy. Outcomes are poor with 5-year overall survival around 32%, but this varies greatly depending on histologic subtype. There is an urgent need for more randomized controlled trials to better define the appropriate therapeutic regimens and to improve clinical outcomes.
    MeSH term(s) Humans ; Paranasal Sinus Neoplasms/diagnosis ; Paranasal Sinus Neoplasms/therapy ; Paranasal Sinuses/diagnostic imaging ; Paranasal Sinuses/surgery
    Language English
    Publishing date 2021-07-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2021.05.006
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    Se 1077: Show issues Location:
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  9. Article: Current Aspects and Future Considerations of EGFR Inhibition in Locally Advanced and Recurrent Metastatic Squamous Cell Carcinoma of the Head and Neck.

    Patel, Bhamini / Saba, Nabil F

    Cancers

    2021  Volume 13, Issue 14

    Abstract: Recurrent metastatic (RM) and locally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN) are devasting disease states with limited therapeutic options and poor overall survival. Targeting the epidermal growth factor receptor (EGFR) is one ...

    Abstract Recurrent metastatic (RM) and locally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN) are devasting disease states with limited therapeutic options and poor overall survival. Targeting the epidermal growth factor receptor (EGFR) is one area that has helped improve outcomes in this disease. Anti-EGFR based therapies have been shown to improve overall survival and mitigate the significant toxicities incurred from standard radiation, chemotherapy, and/or surgical options. Cetuximab, the most well-studied anti-EGFR monoclonal antibody, has demonstrated a positive impact on outcomes for RM and LA SCCHN. However, the development of early resistance to cetuximab highlights the need for a wider arsenal of therapy for RM and LA diseases. The use of immune checkpoint inhibitors has recently transformed the treatment of recurrent SCCHN. Drugs such as pembrolizumab and nivolumab have demonstrated success in recent clinical trials and have been approved for the treatment of advanced disease. Given the positive results of both EGFR targeted agents and immune checkpoint inhibitors, ongoing trials are studying their synergistic effects.
    Language English
    Publishing date 2021-07-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13143545
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  10. Article: Commentary: Randomized Phase II Study of Duligotuzumab (MEHD7945A) vs. Cetuximab in Squamous Cell Carcinoma of the Head and Neck (MEHGAN Study).

    Saba, Nabil F

    Frontiers in oncology

    2017  Volume 7, Page(s) 31

    Language English
    Publishing date 2017-03-13
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2017.00031
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