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Book ; Online: Polymer-Based Biomaterials and Tissue Engineering

Sabater i Serra, Roser / Serrano-Aroca, Ángel

2023

Keywords	Medicine ; bioactive glass ; copper ; polyhydroxyalkanoates ; tissue engineering ; scaffolds ; parastomal hernia ; surgical mesh ; hernia repair ; prevention ; biocompatibility ; n/a ; polylactic acid ; copolymers ; catalysts ; polymer synthesis ; ring-opening polymerization ; medical application ; electrospun nanofibres ; nanocomposites ; polylactic acid (PLA) ; poly(ε-caprolactone) (PCL) ; halloysite nanotubes (HNTs) ; drug release ; release kinetic modelling ; nanoparticles ; rivastigmine ; intranasal application ; optimization ; quality by design ; polymer-ceramic composites ; hydroxyapatite ; collagen ; swelling capacity ; surface roughness ; wettability ; surface free energy ; nonwoven ; cardiovascular stent ; human endothelial cells ; CD31 ; polysaccharide ; carrageenan ; nanoparticle ; pulmonary drug delivery ; carbon-based nanocomposite ; conductive cell substrate ; semi-IPN hydrogel ; graphene nanosheets ; poly(3-hydroxybutyrate-co-3-hydroxyvalerate) ; polyvinyl alcohol
Language	English
Size	1 electronic resource (190 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030382182
ISBN	9783036582368 ; 3036582363
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Special Issue: "Polymer-Based Biomaterials and Tissue Engineering".

Sabater I Serra, Roser / Serrano-Aroca, Ángel

Materials (Basel, Switzerland)

2023 Volume 16, Issue 14

Abstract: Polymers in the form of films, fibers, nano- and microspheres, composites, and porous supports are promising biomaterials for a wide range of advanced biomedical applications: wound healing, controlling drug delivery, anti-cancer therapy, biosensors, ... ...

Abstract	Polymers in the form of films, fibers, nano- and microspheres, composites, and porous supports are promising biomaterials for a wide range of advanced biomedical applications: wound healing, controlling drug delivery, anti-cancer therapy, biosensors, stem cell therapy, and tissue engineering [...].
Language	English
Publishing date	2023-07-10
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16144923
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Zinc Chloride: Time-Dependent Cytotoxicity, Proliferation and Promotion of Glycoprotein Synthesis and Antioxidant Gene Expression in Human Keratinocytes.

Salesa, Beatriz / Sabater I Serra, Roser / Serrano-Aroca, Ángel

Biology

2021 Volume 10, Issue 11

Abstract: The use of ionic metals such as zinc ( ... ...

Abstract	The use of ionic metals such as zinc (Zn
Language	English
Publishing date	2021-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology10111072
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biocompatible Alginate Film Crosslinked with Ca

Cano-Vicent, Alba / Tuñón-Molina, Alberto / Bakshi, Hamid / Sabater I Serra, Roser / Alfagih, Iman M / Tambuwala, Murtaza M / Serrano-Aroca, Ángel

ACS omega

2023 Volume 8, Issue 27, Page(s) 24396–24405

Abstract: Alginate is a highly promising biopolymer due to its non-toxic and biodegradable properties. Alginate hydrogels are often fabricated by cross-linking sodium alginate with calcium cations and can be engineered with highly desirable enhanced physical and ... ...

Abstract	Alginate is a highly promising biopolymer due to its non-toxic and biodegradable properties. Alginate hydrogels are often fabricated by cross-linking sodium alginate with calcium cations and can be engineered with highly desirable enhanced physical and biological properties for biomedical applications. This study reports on the anticancer, antiviral, antibacterial, in vitro, and in vivo toxicity, water absorption, and compound release properties of an alginate hydrogel crosslinked with calcium and different amounts of zinc cations. The results showed that the calcium alginate hydrogel film crosslinked with the highest amount of zinc showed similar water sorption properties to those of calcium alginate and released a suitable amount of zinc to provide anticancer activity against melanoma and colon cancer cells and has antibacterial properties against methicillin-resistant
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c01935
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Zinc Chloride: Time-Dependent Cytotoxicity, Proliferation and Promotion of Glycoprotein Synthesis and Antioxidant Gene Expression in Human Keratinocytes

Salesa, Beatriz / Sabater i Serra, Roser / Serrano-Aroca, Ángel

Biology. 2021 Oct. 20, v. 10, no. 11

2021

Abstract: The use of ionic metals such as zinc (Zn²⁺) is providing promising results in regenerative medicine. In this study, human keratinocytes (HaCaT cells) were treated with different concentrations of zinc chloride (ZnCl₂), ranging from 1 to 800 µg/mL, for 3, ...

Abstract	The use of ionic metals such as zinc (Zn²⁺) is providing promising results in regenerative medicine. In this study, human keratinocytes (HaCaT cells) were treated with different concentrations of zinc chloride (ZnCl₂), ranging from 1 to 800 µg/mL, for 3, 12 and 24 h. The results showed a time–concentration dependence with three non-cytotoxic concentrations (10, 5 and 1 µg/mL) and a median effective concentration value of 13.5 µg/mL at a cell exposure to ZnCl₂ of 24 h. However, the zinc treatment with 5 or 1 µg/mL had no effect on cell proliferation in HaCaT cells in relation to the control sample at 72 h. The effects of the Zn²⁺ treatment on the expression of several genes related to glycoprotein synthesis, oxidative stress, proliferation and differentiation were assessed at the two lowest non-cytotoxic concentrations after 24 h of treatment. Out of 13 analyzed genes (superoxide dismutase 1 (SOD1), catalase (CAT), matrix metallopeptidase 1 (MMP1), transforming growth factor beta 1 (TGFB1), glutathione peroxidase 1 (GPX1), fibronectin 1 (FN1), hyaluronan synthase 2 (HAS2), laminin subunit beta 1 (LAMB1), lumican (LUM), cadherin 1 (CDH1), collagen type IV alpha (COL4A1), fibrillin (FBN) and versican (VCAN)), Zn²⁺ was able to upregulate SOD1, CAT, TGFB1, GPX1, LUM, CDH1, FBN and VCAN, with relative expression levels of at least 1.9-fold with respect to controls. We found that ZnCl₂ promoted glycoprotein synthesis and antioxidant gene expression, thus confirming its great potential in biomedicine.
Keywords	antioxidant genes ; cadherins ; catalase ; cell proliferation ; collagen ; cytotoxicity ; fibrillins ; fibronectins ; gene expression ; glutathione peroxidase ; glycoproteins ; humans ; hyaluronan synthase ; keratinocytes ; laminin ; median effective concentration ; medicine ; oxidative stress ; superoxide dismutase ; zinc ; zinc chloride
Language	English
Dates of publication	2021-1020
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology10111072
Database	NAL-Catalogue (AGRICOLA)

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Article: Pro-Myogenic Environment Promoted by the Synergistic Effect of Conductive Polymer Nanocomposites Combined with Extracellular Zinc Ions.

Aparicio-Collado, José Luis / Molina-Mateo, José / Cabanilles, Constantino Torregrosa / Vidaurre, Ana / Salesa, Beatriz / Serrano-Aroca, Ángel / Sabater I Serra, Roser

Biology

2022 Volume 11, Issue 12

Abstract: A new strategy based on the combination of electrically conductive polymer nanocomposites and extracellular ... ...

Abstract	A new strategy based on the combination of electrically conductive polymer nanocomposites and extracellular Zn
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11121706
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pro-Myogenic Environment Promoted by the Synergistic Effect of Conductive Polymer Nanocomposites Combined with Extracellular Zinc Ions

Aparicio-Collado, José Luis / Molina-Mateo, José / Cabanilles, Constantino Torregrosa / Vidaurre, Ana / Salesa, Beatriz / Serrano-Aroca, Ángel / Sabater i Serra, Roser

Biology (Basel). 2022 Nov. 25, v. 11, no. 12

2022

Abstract: A new strategy based on the combination of electrically conductive polymer nanocomposites and extracellular Zn²⁺ ions as a myogenic factor was developed to assess its ability to synergically stimulate myogenic cell response. The conductive nanocomposite ... ...

Abstract	A new strategy based on the combination of electrically conductive polymer nanocomposites and extracellular Zn²⁺ ions as a myogenic factor was developed to assess its ability to synergically stimulate myogenic cell response. The conductive nanocomposite was prepared with a polymeric matrix and a small amount of graphene (G) nanosheets (0.7% wt/wt) as conductive filler to produce an electrically conductive surface. The nanocomposites’ surface electrical conductivity presented values in the range of human skeletal muscle tissue. The biological evaluation of the cell environment created by the combination of the conductive surface and extracellular Zn²⁺ ions showed no cytotoxicity and good cell adhesion (murine C2C12 myoblasts). Amazingly, the combined strategy, cell–material interface with conductive properties and Zn bioactive ions, was found to have a pronounced synergistic effect on myoblast proliferation and the early stages of differentiation. The ratio of differentiated myoblasts cultured on the conductive nanocomposites with extracellular Zn²⁺ ions added in the differentiation medium (serum-deprived medium) was enhanced by more than 170% over that of non-conductive surfaces (only the polymeric matrix), and more than 120% over both conductive substrates (without extracellular Zn²⁺ ions) and non-conductive substrates with extracellular Zn²⁺. This synergistic effect was also found to increase myotube density, myotube area and diameter, and multinucleated myotube formation. MyoD-1 gene expression was also enhanced, indicating the positive effect in the early stages of myogenic differentiation. These results demonstrate the great potential of this combined strategy, which stands outs for its simplicity and robustness, for skeletal muscle tissue engineering applications.
Keywords	biological assessment ; cell adhesion ; cellular microenvironment ; cytotoxicity ; electrical conductivity ; gene expression ; graphene ; humans ; mice ; muscle development ; myoblasts ; myotubes ; nanosheets ; polymer nanocomposites ; polymers ; skeletal muscle ; synergism ; zinc
Language	English
Dates of publication	2022-1125
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11121706
Database	NAL-Catalogue (AGRICOLA)

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Article: Engineered Highly Porous Polyvinyl Alcohol Hydrogels with Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and Graphene Nanosheets for Musculoskeletal Tissue Engineering: Morphology, Water Sorption, Thermal, Mechanical, Electrical Properties, and Biocompatibility.

Aparicio-Collado, José Luis / Zheng, Qiqi / Molina-Mateo, José / Torregrosa Cabanilles, Constantino / Vidaurre, Ana / Serrano-Aroca, Ángel / Sabater I Serra, Roser

Materials (Basel, Switzerland)

2023 Volume 16, Issue 8

Abstract: Electroactive composite materials are very promising for musculoskeletal tissue engineering because they can be applied in combination with electrostimulation. In this context, novel graphene-based poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/polyvinyl ... ...

Abstract	Electroactive composite materials are very promising for musculoskeletal tissue engineering because they can be applied in combination with electrostimulation. In this context, novel graphene-based poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/polyvinyl alcohol (PHBV/PVA) semi-interpenetrated networks (semi-IPN) hydrogels were engineered with low amounts of graphene (G) nanosheets dispersed within the polymer matrix to endow them with electroactive properties. The nanohybrid hydrogels, obtained by applying a hybrid solvent casting-freeze-drying method, show an interconnected porous structure and a high water-absorption capacity (swelling degree > 1200%). The thermal characterization indicates that the structure presents microphase separation, with PHBV microdomains located between the PVA network. The PHBV chains located in the microdomains are able to crystallize; even more after the addition of G nanosheets, which act as a nucleating agent. Thermogravimetric analysis indicates that the degradation profile of the semi-IPN is located between those of the neat components, with an improved thermal stability at high temperatures (>450 °C) after the addition of G nanosheets. The mechanical (complex modulus) and electrical properties (surface conductivity) significantly increase in the nanohybrid hydrogels with 0.2% of G nanosheets. Nevertheless, when the amount of G nanoparticles increases fourfold (0.8%), the mechanical properties diminish and the electrical conductivity does not increase proportionally, suggesting the presence of G aggregates. The biological assessment (C2C12 murine myoblasts) indicates a good biocompatibility and proliferative behavior. These results reveal a new conductive and biocompatible semi-IPN with remarkable values of electrical conductivity and ability to induce myoblast proliferation, indicating its great potential for musculoskeletal tissue engineering.
Language	English
Publishing date	2023-04-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16083114
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Zinc Maintains Embryonic Stem Cell Pluripotency and Multilineage Differentiation Potential via AKT Activation.

Mnatsakanyan, Hayk / Sabater I Serra, Roser / Salmeron-Sanchez, Manuel / Rico, Patricia

Frontiers in cell and developmental biology

2019 Volume 7, Page(s) 180

Abstract: Embryonic stem cells (ESCs) possess remarkable abilities, as they can differentiate into all cell types (pluripotency) and be self-renewing, giving rise to two identical cells. These characteristics make ESCs a powerful research tool in fundamental ... ...

Abstract	Embryonic stem cells (ESCs) possess remarkable abilities, as they can differentiate into all cell types (pluripotency) and be self-renewing, giving rise to two identical cells. These characteristics make ESCs a powerful research tool in fundamental embryogenesis as well as candidates for use in regenerative medicine. Significant efforts have been devoted to developing protocols to control ESC fate, including soluble and complex cocktails of growth factors and small molecules seeking to activate/inhibit key signaling pathways for the maintenance of pluripotency states or activate differentiation. Here we describe a novel method for the effective maintenance of mouse ESCs, avoiding the supplementation of complex inhibitory cocktails or cytokines, e.g., LIF. We show that the addition of zinc to ESC cultures leads to a stable pluripotent state that shares biochemical, transcriptional and karyotypic features with the classical LIF treatment. We demonstrate for the first time that ESCs maintained in long-term cultures with added zinc, are capable of sustaining a stable ESCs pluripotent phenotype, as well as differentiating efficiently upon external stimulation. We show that zinc promotes long-term ESC self-renewal (>30 days) via activation of ZIP7 and AKT signaling pathways. Furthermore, the combination of zinc with LIF results in a synergistic effect that enhances LIF effects, increases AKT and STAT3 activity, promotes the expression of pluripotency regulators and avoids the expression of differentiation markers.
Language	English
Publishing date	2019-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2019.00180
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Active methods in electricity and magnetism courses: Influence of degree, academic level and gender on student performance.

Serrano, María-Antonia / Vidaurre, Ana / Meseguer-Dueñas, José M / Tort-Ausina, Isabel / Quiles, Susana / Sabater I Serra, Roser / García-Sanchez, Tania / Bernal-Pérez, Soledad / Gámiz-González, M Amparo / Molina-Mateo, José / Gómez-Tejedor, José Antonio / Riera, Jaime

Heliyon

2023 Volume 9, Issue 10, Page(s) e20490

Abstract: The performance of first-year students in electromagnetism (E&M) courses of different engineering degrees at a Spanish public university was measured using the Brief Electricity and Magnetism Assessment (BEMA), a standard research-based instrument to ... ...

Abstract	The performance of first-year students in electromagnetism (E&M) courses of different engineering degrees at a Spanish public university was measured using the Brief Electricity and Magnetism Assessment (BEMA), a standard research-based instrument to assess students' understanding after attending introductory courses in electricity and magnetism. In all cases, Flipped classroom (FC) built on information and communications technology was used. The objective of this paper is to analyse if the gain in the BEMA pre and post-test results is influenced by several factors such as the degree, the students' academic grade, and gender. Moreover, as some studies have shown that the students' retention of the concepts was significantly stronger in active learning than in traditional approaches, a third BEMA test was performed by the students to analyse the long-term retention gain dependence on the same factors. Students from different engineering degree programs were asked to complete two BEMA tests during the course and a third one after a few months. ANOVA tests were used to analyse the existence of significant differences in gain between student degree programs, student academic level and student gender. Results have shown no differences in the BEMA performance by degree program, but significant differences were found by academic level and gender. Retention did not depend on the degree course but on the academic level. Mean gain value by academic level, and gender was obtained and concluded that the best students presented the best gain results and that gain depends on the students' gender: males outperformed females in the BEMA tests, although there were no significant differences in the course grades. It is thus necessary to understand these differences and to implement measures in daily teaching work to improve women's performance.
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e20490
Database	MEDical Literature Analysis and Retrieval System OnLINE

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