LIVIVO - Search results -

Search results

Result 1 - 10 of total 11

Search options

Article: STIMULATION OF B3-RECEPTOR-INDUCED CENTRAL NEUROGENIC EDEMA AND VITIATED ELECTROLYTE HOMEOSTASIS IN EXPERIMENTAL RODENT MODEL.

Yahya, S / Tawfiq, H / Saber, Y

2023 , Issue 339, Page(s) 67–70

Abstract: Mirabegron is one of the recently introduced treatments for overactive bladder which avoids the undue effects of antimuscarinics such as constipation, headache, and dry mouth. This study investigated chronic relatively high doses of beta3 adrenergic ... ...

Abstract	Mirabegron is one of the recently introduced treatments for overactive bladder which avoids the undue effects of antimuscarinics such as constipation, headache, and dry mouth. This study investigated chronic relatively high doses of beta3 adrenergic receptor activation effect on electrolyte hemostasis and possible consequence on the central nervous system viability. In the present study, serum sodium, potassium, chloride, and calcium ion levels using flame photometry had been measured and eosin and hematoxylin staining for cerebral vasculature in the brain striatum. Results showed that chronic administration of mirabegron has a modest decrease in sodium, chloride, and potassium levels while increasing calcium serum levels. Moreover, edema and neuronal degeneration have been observed in Wistar rats. In summary, a chronic high dose of beta 3 adrenergic agonist Mirabegron might have a deleterious effect on electrolytes in question homeostasis due to loss of selectivity to beta 3 adrenoceptor when administered in a high dose.
Language	English
Publishing date	2023-07-31
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: ACUTE TOXICITY OF COUMACINES: AN IN VIVO STUDY.

Al-Shakarchi, W / Saber, Y / Merkhan, M / Mustafa, Y

Georgian medical news

2023 , Issue 338, Page(s) 126–131

Abstract: The design and synthesis of new drugs are increasingly challenging in chemistry settings. The synthesis is itself lured by the properties of the product after synthesis, including solubility, hygroscopicity, intensive adverse effects, and biological ... ...

Abstract	The design and synthesis of new drugs are increasingly challenging in chemistry settings. The synthesis is itself lured by the properties of the product after synthesis, including solubility, hygroscopicity, intensive adverse effects, and biological inefficacy; hence, the creation of a new drug should be considered in light of the avoidance of these downside features, if any. The present study is designed to investigate the acute toxicity of newly discovered heterocyclic frameworks derived from the coumarin backbone, namely coumacine I and coumacine II. To do so, a mouse model of 25 mice was subclassified into 5 groups (5 mice control, 5 mice coumacine I 1000 mg/kg, 5 mice coumacine II 1000 mg/kg, 5 mice coumacine I 2000 mg/kg, and 5 mice coumacine II 2000 mg/kg), a single dose was given, and mice were sacrificed after 4 hours post-dose. The blood sample and tissue were collected for biochemical and histopathological studies. Serums were analyzed for the measurement of renal function and liver enzyme activity using classical biochemical methods. A high dose of either compound caused deleterious changes, as evidenced by a significant (p<0.05) increase in creatinine, urea, GOT, and GPT, as well as disrupting tissue quasi-equilibrium at the cellular level in both kidney and liver. To sum up, coumacine I and coumacine II are relatively safe unless otherwise used in high doses, knowing that either dose in the present study is remarkably higher than the therapeutic dose of coumarins currently in use in clinical settings.
MeSH term(s)	Mice ; Animals ; Kidney/pathology ; Liver/pathology
Language	English
Publishing date	2023-06-27
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Reconceptualizing the Archetypal Trickster in Audre Lorde's Zami: A New Spelling of My Name.

Saber, Yomna

Journal of lesbian studies

2015 Volume 19, Issue 4, Page(s) 484–500

Abstract: Carl Jung categorizes the trickster as a psychological archetype and sets certain parameters for it. This article examines Audre Lorde's trickster Afrekete in Zami: A New Spelling of My Name (1982) and poses the question of how typically archetypal a ... ...

Abstract	Carl Jung categorizes the trickster as a psychological archetype and sets certain parameters for it. This article examines Audre Lorde's trickster Afrekete in Zami: A New Spelling of My Name (1982) and poses the question of how typically archetypal a Black, female, lesbian trickster can be. Lorde occupies an idiosyncratic position in the canon in terms of race, gender, and sexual orientation. She bestows new qualities on her trickster coming from the peripheries she dwells in and challenges the Jungian model. Through Afrekete's linguistic dexterity and sexual identity, Lorde transforms the trickster from being seemingly innocuous into a figure of resistance grounded in lesbian erotica.
MeSH term(s)	Adult ; African Americans/psychology ; Female ; Homosexuality, Female/psychology ; Humans ; Jungian Theory ; Literature
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article
ZDB-ID	2221436-7
ISSN	1540-3548 ; 1089-4160
ISSN (online)	1540-3548
ISSN	1089-4160
DOI	10.1080/10894160.2015.993889
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6287: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Working horses welfare assessment and their owners perceive in middle and north Darfur states Sudan

Adam, Saber Y. / Fedail, Jaafar S. / Musa, Hassan H. / Musa, Taha H. / Ahmed, Abdelkareem A.

Applied Animal Behaviour Science. 2023 Feb., v. 259 p.105834-

2023

Abstract: Working horses in Low and Middle income countries have a significant impact on people's lives. In spite of their best, the well-being of Sudanese working horses are neglected. There is no information on Sudanese working horse’s welfare. The purpose of ... ...

Abstract	Working horses in Low and Middle income countries have a significant impact on people's lives. In spite of their best, the well-being of Sudanese working horses are neglected. There is no information on Sudanese working horse’s welfare. The purpose of this study was to investigate working horse welfare and owners' perceptions in two states. A methodology using owner interviews and direct parameters as well as body condition score and gait abnormality was applied. A total of 150 working horses and their owners were assessed (Middle Darfur =100, North Darfur =50). The results revealed that there was a significant difference between the body condition score of horses from the north and middle state, with 34% and 18% being thin, respectively. There was a significant difference (P = 0.040) in nasal discharge, with 24% and 18% of the horses from the north and middle, respectively. Moreover, there was a significant difference (P < 0.001) in dirty coat conditions, appeared in 62% and 33% of the horses from the north and middle, respectively. Horses that had external parasites differed significantly between both regions (P < 0.0001), with 70% and 23% having parasites in the north and middle, respectively. No significant differences were found between the horses from the north and middle state in terms of skin wounds and kicking behavior. We conclude that the northern state suffers from more direct welfare issues than the middle state. However, indirect parameter measures were worse in the middle state than in north. Owner awareness and additional research are required for both states.
Keywords	animal behavior ; body condition ; gait ; horses ; income ; nose ; welfare assessment ; Sudan ; Darfur ; Direct indicators ; Indirect indicators ; Parasite ; Welfare ; Working horse
Language	English
Dates of publication	2023-02
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	591645-8
ISSN	0168-1591
ISSN	0168-1591
DOI	10.1016/j.applanim.2023.105834
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 6191: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: A Comparison Between Working and Nonworking Donkeys Welfare Issues in Nyala City, South Darfur, Sudan.

Adam, Saber Y / Ahmed, Abdelkareem A / Musa, Hassan H / Fedail, Jaafar S / Musa, Taha H

Journal of equine veterinary science

2022 Volume 118, Page(s) 104110

Abstract: In impoverished nations, donkeys help people make a living. The welfare of donkeys in Sudan is neglected compared with developed countries. However, there is no information available about donkey welfare in Nyala. This study aimed to assess the welfare ... ...

Abstract	In impoverished nations, donkeys help people make a living. The welfare of donkeys in Sudan is neglected compared with developed countries. However, there is no information available about donkey welfare in Nyala. This study aimed to assess the welfare of donkeys in Nyala. Donkeys were divided into two groups (n = 50), working and nonworking. The donkeys' physical, emotional, and clinical parameters and an owner's interview were assessed. There were significant differences in body condition scores: 37% and 47% of working and nonworking donkeys, respectively, had ideal body condition scores, while 13% of working donkeys were emaciated. Of the working and nonworking 33% and 19% had hoof problems, respectively. Fifteen percent of working donkeys had ocular discharge, and 25% had wounds. In working donkeys, 7% and 5% depressive and aggressive behavioral responses, respectively, were observed. Furthermore, there were significant differences in tools used for hitting donkeys, with 33% and 17% of owners using a stick and whip, respectively, for hitting working donkeys. Eighty-two percent of owners feed their donkeys one to three times daily (50% working and 32% nonworking donkeys), and free access feeding was only observed in 18% of nonworking donkeys. There were no significant differences (P > .06) in emotional parameters. We conclude that working donkeys suffer from multiple welfare problems more than nonworking donkeys in Nyala. More awareness, veterinary services, and research are needed to improve donkey care in Nyala.
MeSH term(s)	Animals ; Equidae/physiology ; Animal Welfare ; Sudan
Language	English
Publishing date	2022-08-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2102631-2
ISSN	1542-7412 ; 0737-0806
ISSN (online)	1542-7412
ISSN	0737-0806
DOI	10.1016/j.jevs.2022.104110
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: A Comparison Between Working and Nonworking Donkeys Welfare Issues in Nyala City, South Darfur, Sudan

Adam, Saber Y. / Ahmed, Abdelkareem A. / Musa, Hassan H. / Feail, Jafaar S. / Musa, Taha H.

Journal of equine veterinary science. 2022 Aug. 22,

2022

Abstract	In impoverished nations, donkeys help people make a living. The welfare of donkeys in Sudan is neglected compared with developed countries. However, there is no information available about donkey welfare in Nyala. This study aimed to assess the welfare of donkeys in Nyala. Donkeys were divided into two groups (n=50), working and nonworking. The donkeys' physical, emotional, and clinial parameters and an owner's interview were assessed. There were significant differences in body condition scores: 37% and 47% of working and nonworking donkeys, respectively, had ideal body condition scores, while 13% of working donkeys were emaciated. Of the working and nonworking 33% and 19% had hoof problems, respectively. Fifteen percent of working donkeys had ocular discharge, and 25% had wounds. In working donkeys, 7% and 5% depressive and aggressive behavioral responses, respectively, were observed. Furthermore, there were significant differences in tools used for hitting donkeys, with 33% and 17% of owners using a stick and whip, respectively, for hitting working donkeys. 82% of owners feed their donkeys one to three times daily (50% working and 32% nonworking donkeys), and free access feeding was only observed in 18% of nonworking donkeys. There were no significant differences (P >0.06) in emotional parameters. We conclude that working donkeys suffer from multiple welfare problems more than nonworking donkeys in Nyala. More awareness, veterinary services, and research are needed to improve donkey care in Nyala.
Keywords	asses ; body condition ; hooves ; horses ; veterinary medicine ; Sudan
Language	English
Dates of publication	2022-0822
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ZDB-ID	2102631-2
ISSN	1542-7412 ; 0737-0806
ISSN (online)	1542-7412
ISSN	0737-0806
DOI	10.1016/j.jevs.2022.104110
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Book ; Thesis: Multimerisierung von Thyreoglobulin

Saber, Yasmin

Identifizierung einer Transglutaminase für die kovalente Quervernetzung von Thyreoglobulin

1997

Author's details	von Yasmin Saber
Language	German
Size	1 Mikrofiche
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Bonn, 1997
Database	Former special subject collection: coastal and deep sea fishing

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Book ; Thesis: Multimerisierung von Thyreoglobulin

Saber, Yasmin

Identifizierung einer Transglutaminase für die kovalente Quervernetzung von Thyreoglobulin

1997

Author's details	von Yasmin Saber
Language	German
Size	1 Mikrofiche
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Bonn, 1997
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Isolation of insoluble secretory product from bovine thyroid: extracellular storage of thyroglobulin in covalently cross-linked form.

Herzog, V / Berndorfer, U / Saber, Y

The Journal of cell biology

1992 Volume 118, Issue 5, Page(s) 1071–1083

Abstract: Extracellular storage of thyroglobulin (TG) is an important prerequisite for maintaining constant levels of thyroid hormones in vertebrates. Storage of large amounts is made possible by compactation of TG in the follicle lumen with concentrations of at ... ...

Abstract	Extracellular storage of thyroglobulin (TG) is an important prerequisite for maintaining constant levels of thyroid hormones in vertebrates. Storage of large amounts is made possible by compactation of TG in the follicle lumen with concentrations of at least 100-400 mg/ml. We recently observed that the luminal content from bovine thyroids can be isolated in an intact state and be separated from soluble TG. For this purpose, bovine thyroid tissue was homogenized and subjected to various steps of purification. This procedure resulted in a pellet of single globules measuring 20-120 microns in diameter. Scanning electron microscopy revealed a unique cobblestone-like surface pattern of isolated globules, showing in detail the impressions of the apical plasma membranes of thyrocytes which had formerly surrounded the luminal content before tissue homogenization. Isolated thyroid globules were rapidly digested by trypsin but extremely resistant to various protein solubilization procedures. Homogenization of isolated globules resulted in the release of approximately 3% of total protein, showing that only a minor proportion of TG was loosely incorporated in thyroid globules whereas approximately 22% appeared to be interconnected with the globule matrix by disulfide bridges. Analysis by SDS-gel electrophoresis and immunoblotting confirmed that the protein released by this procedure consisted of TG. The vast majority (approximately 75%) of the globule matrix protein was found to be covalently cross-linked by non-disulfide bonds. TG in isolated globules was highly iodinated (approximately 55 iodine atoms per 12-S TG subunit) suggesting that the covalent nondisulfide cross-linking occurs in part during the iodination of TG and that this process involves the formation of intermolecular dityrosine bridges. Mechanisms must exist which solubilize or disperse the insoluble luminal content prior to endocytosis of TG.
MeSH term(s)	Animals ; Cattle ; Immunohistochemistry ; Iodine/analysis ; Microscopy, Electron, Scanning ; Microscopy, Fluorescence ; Microscopy, Immunoelectron ; Solubility ; Thyroglobulin/chemistry ; Thyroglobulin/isolation & purification ; Thyroglobulin/ultrastructure ; Thyroid Gland/chemistry ; Thyroid Gland/ultrastructure
Chemical Substances	Thyroglobulin (9010-34-8) ; Iodine (9679TC07X4)
Language	English
Publishing date	1992-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.118.5.1071
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ub I Zs.190: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Azido derivatives of cellobiose: oxidation at C1 with cellobiose dehydrogenase from Sclerotium rolfsii.

Mulla, Dafina / Kracher, Daniel / Ludwig, Roland / Nagy, Gabor / Grandits, Melanie / Holzer, Wolfgang / Saber, Yasser / Gabra, Nermeen / Viernstein, Helmut / Unger, Frank M

Carbohydrate research

2013 Volume 382, Page(s) 86–94

Abstract: We report the chemo-enzymatic synthesis of three cellobiono-1,5-lactone azido derivatives, designed as building blocks for biomedical polymer scaffolds. The synthesis is based on regioselective protection of cellobiose or 1,6-O-anhydro-β-d-cellobiose ... ...

Abstract	We report the chemo-enzymatic synthesis of three cellobiono-1,5-lactone azido derivatives, designed as building blocks for biomedical polymer scaffolds. The synthesis is based on regioselective protection of cellobiose or 1,6-O-anhydro-β-d-cellobiose before azidation and subsequent deprotection. The oxidation to the corresponding cellobiono-1,5-lactones was investigated with 6'-azido-6'-deoxycellobiose (6'N3Clb, 5), 6-azido-6-deoxycellobiose (6N3Clb, 11) and 2-azido-2-deoxycellobiose (2N3Clb, 15) under the catalysis of cellobiose dehydrogenase (CDH) from the plant-pathogenic fungus Sclerotium rolfsii. Substrate binding characteristics and kinetics of CDH for the three cellobiose azido derivatives were studied employing computational docking, steady-state and presteady-state techniques. The process of enzymatic oxidation of the cellobiose azido intermediates was optimized by using the available kinetic information. Whereas the conversion of 15 by CDH is very slow, the conversion of 5 and 11 by a regenerated, bi-enzymatic process (CDH/redox mediator/laccase/O2) is fast, quantitative and produces azido derivatives of cellobiono-1,5-lactone in an environmentally friendly, oxygen-driven process.
MeSH term(s)	Ascomycota/enzymology ; Ascomycota/pathogenicity ; Azides/chemistry ; Carbohydrate Dehydrogenases/chemistry ; Carbohydrate Dehydrogenases/metabolism ; Cellobiose/chemical synthesis ; Cellobiose/chemistry ; Cellobiose/metabolism ; Chemistry Techniques, Synthetic/methods ; Kinetics ; Lactones/chemistry ; Molecular Docking Simulation ; Oxidation-Reduction ; Protein Conformation ; Substrate Specificity
Chemical Substances	Azides ; Lactones ; Cellobiose (16462-44-5) ; Carbohydrate Dehydrogenases (EC 1.1.-) ; cellobiose-quinone oxidoreductase (EC 1.1.99.18)
Language	English
Publishing date	2013-09-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1435-7
ISSN	1873-426X ; 0008-6215
ISSN (online)	1873-426X
ISSN	0008-6215
DOI	10.1016/j.carres.2013.09.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 2002/704: Show issues
Z 4.3: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED