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Article ; Online: Setting the global research agenda for community-based HIV service delivery through the faith sector

Martha T. Ndlovu-Teijema / Maarten O. Kok / Sabine L. van Elsland / Hilleen Smeets / David Barstow / Lyn van Rooyen / A. M. van Furth

Health Research Policy and Systems, Vol 19, Iss 1, Pp 1-

2021 Volume 10

Abstract: Abstract Background While leading AIDS organizations expect faith and health collaborations to play a crucial role in organizing and scaling up community-based HIV services, it is unclear how this can be realized. Little primary research has been ... ...

Abstract	Abstract Background While leading AIDS organizations expect faith and health collaborations to play a crucial role in organizing and scaling up community-based HIV services, it is unclear how this can be realized. Little primary research has been conducted into which strategies for collaboration and service provision are most effective, efficient, scalable and sustainable. Seeking to align research with urgent needs, enhance coordination and increase the likelihood that results are used, this study aimed to set an inclusive global research agenda that reflects priority research questions from key stakeholders at the intersection of HIV healthcare and faith. Methods In order to develop this global research agenda, we drew from document analyses, focus group discussions, interviews with purposively selected key informants from all continents (policy-makers, healthcare providers, faith leaders, academics and HIV activists), an online questionnaire, and expert meetings at several global conferences. We carried out focus group discussions and interviews with faith leaders in South Africa. Other stakeholder focus groups and interviews were carried out online or in person in France, Switzerland, the Netherlands and South Africa, and virtual questionnaires were distributed to stakeholders worldwide. Respondents were purposively sampled. Results We interviewed 53 participants, and 110 stakeholders responded to the online questionnaire. The participants worked in 54 countries, with the majority having research experience (84%), experience with policy processes (73%) and/or experience as a healthcare provider (60%) and identifying as religious (79%). From interviews (N = 53) and questionnaires (N = 110), we identified 10 research themes: addressing sexuality, stigma, supporting specific populations, counselling and disclosure, agenda-setting, mobilizing and organizing funding, evaluating faith-health collaborations, advantage of faith initiatives, gender roles, and education. Respondents emphasized the need for more ...
Keywords	HIV ; Health systems ; Agenda-setting ; Faith ; Religion ; Healthcare ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Disclosure of human immunodeficiency virus status to children in South Africa

Sabine L. van Elsland / Remco P.H. Peters / Cornelis Grobbelaar / Patiswa Ketelo / Maarten O. Kok / Mark F. Cotton / A. Marceline van Furth

Southern African Journal of HIV Medicine, Vol 20, Iss 1, Pp e1-e

A comprehensive analysis

2019 Volume 10

Abstract: Background: The extent of disclosure of HIV status to children and adolescents and the context facilitating their disclosure process have received little attention. Objectives: To assess disclosure and provide a comprehensive analysis of characteristics ... ...

Abstract	Background: The extent of disclosure of HIV status to children and adolescents and the context facilitating their disclosure process have received little attention. Objectives: To assess disclosure and provide a comprehensive analysis of characteristics associated with disclosure to children (3–14 years) receiving antiretroviral treatment in a South African semi-urban clinic. Methods: This cross-sectional study used structured interview administered questionnaires which were supplemented with medical record data. Predictors included child, caregiver, clinical and socio-economic characteristics, viral suppression, immune response, adherence, health-related quality of life and family functioning. Results: We included 190 children of whom 45 (23.7%) received disclosure about their HIV status, of whom 28 (14.7%) were partially disclosed and 17 (8.9%) were fully disclosed. Older age of the child and higher education of the caregiver were strongly associated with disclosure. Female caregivers, detectable viral load, syrup formulation, protease inhibitor (PI) regimens with stavudine and didanosine, and self-reported non-adherence were strongly associated with non-disclosure. Conclusion: When children do well on treatment, caregivers feel less stringent need to disclose. Well-functioning families, higher educated caregivers and better socio-economic status enabled and promoted disclosure. Non-disclosure can indicate a sub-optimal social structure which could negatively affect adherence and viral suppression. There is an urgent need to address disclosure thoughtfully and proactively in the long-term disease management. For the disclosure process to be beneficial, an enabling supportive context is important, which will provide a great opportunity for future interventions.
Keywords	Disclosure ; Child ; Paediatric ; HIV ; Quality of life ; South Africa ; Public aspects of medicine ; RA1-1270 ; Infectious and parasitic diseases ; RC109-216
Subject code	360
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: State of affairs of tuberculosis in prison facilities

Natalie V S Vinkeles Melchers / Sabine L van Elsland / Joep M A Lange / Martien W Borgdorff / Jan van den Hombergh

PLoS ONE, Vol 8, Iss 1, p e

a systematic review of screening practices and recommendations for best TB control.

2013 Volume 53644

Abstract: BACKGROUND: Prisoners are at high risk of developing tuberculosis (TB), causing morbidity and mortality. Prison facilities encounter many challenges in TB screening procedures and TB control. This review explores screening practices for detection of TB ... ...

Abstract	BACKGROUND: Prisoners are at high risk of developing tuberculosis (TB), causing morbidity and mortality. Prison facilities encounter many challenges in TB screening procedures and TB control. This review explores screening practices for detection of TB and describes limitations of TB control in prison facilities worldwide. METHODS: A systematic search of online databases (e.g., PubMed and Embase) and conference abstracts was carried out. Research papers describing screening and diagnostic practices among prisoners were included. A total of 52 articles met the inclusion criteria. A meta-analysis of TB prevalence in prison facilities by screening and diagnostic tools was performed. RESULTS: The most common screening tool was symptom questionnaires (63·5%), mostly reporting presence of cough. Microscopy of sputum with Ziehl-Neelsen staining and solid culture were the most frequently combined diagnostic methods (21·2%). Chest X-ray and tuberculin skin tests were used by 73·1% and 50%, respectively, as either a screening and/or diagnostic tool. Median TB prevalence among prisoners of all included studies was 1,913 cases of TB per 100,000 prisoners (interquartile range [IQR]: 332-3,517). The overall annual median TB incidence was 7·0 cases per 1000 person-years (IQR: 2·7-30·0). Major limitations for successful TB control were inaccuracy of diagnostic algorithms and the lack of adequate laboratory facilities reported by 61·5% of studies. The most frequent recommendation for improving TB control and case detection was to increase screening frequency (73·1%). DISCUSSION: TB screening algorithms differ by income area and should be adapted to local contexts. In order to control TB, prison facilities must improve laboratory capacity and frequent use of effective screening and diagnostic tools. Sustainable political will and funding are critical to achieve this.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment [version 2; peer review

Kylie E. C. Ainslie / Caroline E. Walters / Han Fu / Sangeeta Bhatia / Haowei Wang / Xiaoyue Xi / Marc Baguelin / Samir Bhatt / Adhiratha Boonyasiri / Olivia Boyd / Lorenzo Cattarino / Constanze Ciavarella / Zulma Cucunuba / Gina Cuomo-Dannenburg / Amy Dighe / Ilaria Dorigatti / Sabine L van Elsland / Rich FitzJohn / Katy Gaythorpe /

Wellcome Open Research, Vol

2 approved]

2020 Volume 5

Abstract: Background: The COVID-19 epidemic was declared a Global Pandemic by WHO on 11 March 2020. By 24 March 2020, over 440,000 cases and almost 20,000 deaths had been reported worldwide. In response to the fast-growing epidemic, which began in the Chinese city ...

Abstract	Background: The COVID-19 epidemic was declared a Global Pandemic by WHO on 11 March 2020. By 24 March 2020, over 440,000 cases and almost 20,000 deaths had been reported worldwide. In response to the fast-growing epidemic, which began in the Chinese city of Wuhan, Hubei, China imposed strict social distancing in Wuhan on 23 January 2020 followed closely by similar measures in other provinces. These interventions have impacted economic productivity in China, and the ability of the Chinese economy to resume without restarting the epidemic was not clear. Methods: Using daily reported cases from mainland China and Hong Kong SAR, we estimated transmissibility over time and compared it to daily within-city movement, as a proxy for economic activity. Results: Initially, within-city movement and transmission were very strongly correlated in the five mainland provinces most affected by the epidemic and Beijing. However, that correlation decreased rapidly after the initial sharp fall in transmissibility. In general, towards the end of the study period, the correlation was no longer apparent, despite substantial increases in within-city movement. A similar analysis for Hong Kong shows that intermediate levels of local activity were maintained while avoiding a large outbreak. At the very end of the study period, when China began to experience the re-introduction of a small number of cases from Europe and the United States, there is an apparent up-tick in transmission. Conclusions: Although these results do not preclude future substantial increases in incidence, they suggest that after very intense social distancing (which resulted in containment), China successfully exited its lockdown to some degree. Elsewhere, movement data are being used as proxies for economic activity to assess the impact of interventions. The results presented here illustrate how the eventual decorrelation between transmission and movement is likely a key feature of successful COVID-19 exit strategies.
Keywords	Medicine ; R ; Science ; Q ; covid19
Subject code	950
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Wellcome
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment [version 1; peer review

Kylie E C Ainslie / Caroline E. Walters / Han Fu / Sangeeta Bhatia / Haowei Wang / Xiaoyue Xi / Marc Baguelin / Samir Bhatt / Adhiratha Boonyasiri / Olivia Boyd / Lorenzo Cattarino / Constanze Ciavarella / Zulma Cucunuba / Gina Cuomo-Dannenburg / Amy Dighe / Ilaria Dorigatti / Sabine L van Elsland / Rich FitzJohn / Katy Gaythorpe /

Wellcome Open Research, Vol

2 approved]

2020 Volume 5

Abstract	Background: The COVID-19 epidemic was declared a Global Pandemic by WHO on 11 March 2020. By 24 March 2020, over 440,000 cases and almost 20,000 deaths had been reported worldwide. In response to the fast-growing epidemic, which began in the Chinese city of Wuhan, Hubei, China imposed strict social distancing in Wuhan on 23 January 2020 followed closely by similar measures in other provinces. These interventions have impacted economic productivity in China, and the ability of the Chinese economy to resume without restarting the epidemic was not clear. Methods: Using daily reported cases from mainland China and Hong Kong SAR, we estimated transmissibility over time and compared it to daily within-city movement, as a proxy for economic activity. Results: Initially, within-city movement and transmission were very strongly correlated in the five mainland provinces most affected by the epidemic and Beijing. However, that correlation decreased rapidly after the initial sharp fall in transmissibility. In general, towards the end of the study period, the correlation was no longer apparent, despite substantial increases in within-city movement. A similar analysis for Hong Kong shows that intermediate levels of local activity were maintained while avoiding a large outbreak. At the very end of the study period, when China began to experience the re-introduction of a small number of cases from Europe and the United States, there is an apparent up-tick in transmission. Conclusions: Although these results do not preclude future substantial increases in incidence, they suggest that after very intense social distancing (which resulted in containment), China successfully exited its lockdown to some degree. Elsewhere, movement data are being used as proxies for economic activity to assess the impact of interventions. The results presented here illustrate how the eventual decorrelation between transmission and movement is likely a key feature of successful COVID-19 exit strategies.
Keywords	Medicine ; R ; Science ; Q
Subject code	950
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Wellcome
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Response to COVID-19 in South Korea and implications for lifting stringent interventions

Amy Dighe / Lorenzo Cattarino / Gina Cuomo-Dannenburg / Janetta Skarp / Natsuko Imai / Sangeeta Bhatia / Katy A. M. Gaythorpe / Kylie E. C. Ainslie / Marc Baguelin / Samir Bhatt / Adhiratha Boonyasiri / Nicholas F. Brazeau / Laura V. Cooper / Helen Coupland / Zulma Cucunuba / Ilaria Dorigatti / Oliver D. Eales / Sabine L. van Elsland / Richard G. FitzJohn /

BMC Medicine, Vol 18, Iss 1, Pp 1-

2020 Volume 12

Abstract: Abstract Background After experiencing a sharp growth in COVID-19 cases early in the pandemic, South Korea rapidly controlled transmission while implementing less stringent national social distancing measures than countries in Europe and the USA. This ... ...

Abstract	Abstract Background After experiencing a sharp growth in COVID-19 cases early in the pandemic, South Korea rapidly controlled transmission while implementing less stringent national social distancing measures than countries in Europe and the USA. This has led to substantial interest in their “test, trace, isolate” strategy. However, it is important to understand the epidemiological peculiarities of South Korea’s outbreak and characterise their response before attempting to emulate these measures elsewhere. Methods We systematically extracted numbers of suspected cases tested, PCR-confirmed cases, deaths, isolated confirmed cases, and numbers of confirmed cases with an identified epidemiological link from publicly available data. We estimated the time-varying reproduction number, R t , using an established Bayesian framework, and reviewed the package of interventions implemented by South Korea using our extracted data, plus published literature and government sources. Results We estimated that after the initial rapid growth in cases, R t dropped below one in early April before increasing to a maximum of 1.94 (95%CrI, 1.64–2.27) in May following outbreaks in Seoul Metropolitan Region. By mid-June, R t was back below one where it remained until the end of our study (July 13th). Despite less stringent “lockdown” measures, strong social distancing measures were implemented in high-incidence areas and studies measured a considerable national decrease in movement in late February. Testing the capacity was swiftly increased, and protocols were in place to isolate suspected and confirmed cases quickly; however, we could not estimate the delay to isolation using our data. Accounting for just 10% of cases, individual case-based contact tracing picked up a relatively minor proportion of total cases, with cluster investigations accounting for 66%. Conclusions Whilst early adoption of testing and contact tracing is likely to be important for South Korea’s successful outbreak control, other factors including regional ...
Keywords	COVID-19 ; South Korea ; Public health interventions ; Reproduction number ; Contact tracing ; Medicine ; R ; covid19
Subject code	306
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reduction in mobility and COVID-19 transmission

Pierre Nouvellet / Sangeeta Bhatia / Anne Cori / Kylie E. C. Ainslie / Marc Baguelin / Samir Bhatt / Adhiratha Boonyasiri / Nicholas F. Brazeau / Lorenzo Cattarino / Laura V. Cooper / Helen Coupland / Zulma M. Cucunuba / Gina Cuomo-Dannenburg / Amy Dighe / Bimandra A. Djaafara / Ilaria Dorigatti / Oliver D. Eales / Sabine L. van Elsland / Fabricia F. Nascimento /

Richard G. FitzJohn / Katy A. M. Gaythorpe / Lily Geidelberg / William D. Green / Arran Hamlet / Katharina Hauck / Wes Hinsley / Natsuko Imai / Benjamin Jeffrey / Edward Knock / Daniel J. Laydon / John A. Lees / Tara Mangal / Thomas A. Mellan / Gemma Nedjati-Gilani / Kris V. Parag / Margarita Pons-Salort / Manon Ragonnet-Cronin / Steven Riley / H. Juliette T. Unwin / Robert Verity / Michaela A. C. Vollmer / Erik Volz / Patrick G. T. Walker / Caroline E. Walters / Haowei Wang / Oliver J. Watson / Charles Whittaker / Lilith K. Whittles / Xiaoyue Xi / Neil M. Ferguson

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 9

Abstract: Social distancing policies aiming to reduce COVID-19 transmission have been reflected in reductions in human mobility. Here, the authors show that reduced mobility is correlated with decreased transmission, but that this relationship weakened over time ... ...

Abstract	Social distancing policies aiming to reduce COVID-19 transmission have been reflected in reductions in human mobility. Here, the authors show that reduced mobility is correlated with decreased transmission, but that this relationship weakened over time as social distancing measures were relaxed.
Keywords	Science ; Q
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: State-level tracking of COVID-19 in the United States

H. Juliette T. Unwin / Swapnil Mishra / Valerie C. Bradley / Axel Gandy / Thomas A. Mellan / Helen Coupland / Jonathan Ish-Horowicz / Michaela A. C. Vollmer / Charles Whittaker / Sarah L. Filippi / Xiaoyue Xi / Mélodie Monod / Oliver Ratmann / Michael Hutchinson / Fabian Valka / Harrison Zhu / Iwona Hawryluk / Philip Milton / Kylie E. C. Ainslie /

Marc Baguelin / Adhiratha Boonyasiri / Nick F. Brazeau / Lorenzo Cattarino / Zulma Cucunuba / Gina Cuomo-Dannenburg / Ilaria Dorigatti / Oliver D. Eales / Jeffrey W. Eaton / Sabine L. van Elsland / Richard G. FitzJohn / Katy A. M. Gaythorpe / William Green / Wes Hinsley / Benjamin Jeffrey / Edward Knock / Daniel J. Laydon / John Lees / Gemma Nedjati-Gilani / Pierre Nouvellet / Lucy Okell / Kris V. Parag / Igor Siveroni / Hayley A. Thompson / Patrick Walker / Caroline E. Walters / Oliver J. Watson / Lilith K. Whittles / Azra C. Ghani / Neil M. Ferguson / Steven Riley / Christl A. Donnelly / Samir Bhatt / Seth Flaxman

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 9

Abstract: High numbers of COVID-19-related deaths have been reported in the United States, but estimation of the true numbers of infections is challenging. Here, the authors estimate that on 1 June 2020, 3.7% of the US population was infected with SARS-CoV-2, and ... ...

Abstract	High numbers of COVID-19-related deaths have been reported in the United States, but estimation of the true numbers of infections is challenging. Here, the authors estimate that on 1 June 2020, 3.7% of the US population was infected with SARS-CoV-2, and 0.01% was infectious, with wide variation by state.
Keywords	Science ; Q
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries

Alexandra B Hogan, PhD / Britta L Jewell, PhD / Ellie Sherrard-Smith, PhD / Juan F Vesga, PhD / Oliver J Watson, PhD / Charles Whittaker, MSc / Arran Hamlet, PhD / Jennifer A Smith, DPhil / Peter Winskill, PhD / Robert Verity, PhD / Marc Baguelin, PhD / John A Lees, PhD / Lilith K Whittles, PhD / Kylie E C Ainslie, PhD / Samir Bhatt, DPhil / Adhiratha Boonyasiri, MD / Nicholas F Brazeau, PhD / Lorenzo Cattarino, PhD / Laura V Cooper, MPhil /

Helen Coupland, MRes / Gina Cuomo-Dannenburg, MMath / Amy Dighe, MRes / Bimandra A Djaafara, MRes / Christl A Donnelly, ProfScD / Jeff W Eaton, PhD / Sabine L van Elsland, PhD / Richard G FitzJohn, PhD / Han Fu, PhD / Katy A M Gaythorpe, PhD / William Green, MRes / David J Haw, PhD / Sarah Hayes, MSc / Wes Hinsley, PhD / Natsuko Imai, PhD / Daniel J Laydon, PhD / Tara D Mangal, PhD / Thomas A Mellan, PhD / Swapnil Mishra, PhD / Gemma Nedjati-Gilani, PhD / Kris V Parag, PhD / Hayley A Thompson, MPH / H Juliette T Unwin, PhD / Michaela A C Vollmer, PhD / Caroline E Walters, PhD / Haowei Wang, MSc / Yuanrong Wang / Xiaoyue Xi, MSc / Neil M Ferguson, ProfDPhil / Lucy C Okell, PhD / Thomas S Churcher, PhD

The Lancet Global Health, Vol 8, Iss 9, Pp e1132-e

a modelling study

2020 Volume 1141

Abstract: Summary: Background: COVID-19 has the potential to cause substantial disruptions to health services, due to cases overburdening the health system or response measures limiting usual programmatic activities. We aimed to quantify the extent to which ... ...

Abstract	Summary: Background: COVID-19 has the potential to cause substantial disruptions to health services, due to cases overburdening the health system or response measures limiting usual programmatic activities. We aimed to quantify the extent to which disruptions to services for HIV, tuberculosis, and malaria in low-income and middle-income countries with high burdens of these diseases could lead to additional loss of life over the next 5 years. Methods: Assuming a basic reproduction number of 3·0, we constructed four scenarios for possible responses to the COVID-19 pandemic: no action, mitigation for 6 months, suppression for 2 months, or suppression for 1 year. We used established transmission models of HIV, tuberculosis, and malaria to estimate the additional impact on health that could be caused in selected settings, either due to COVID-19 interventions limiting activities, or due to the high demand on the health system due to the COVID-19 pandemic. Findings: In high-burden settings, deaths due to HIV, tuberculosis, and malaria over 5 years could increase by up to 10%, 20%, and 36%, respectively, compared with if there was no COVID-19 pandemic. The greatest impact on HIV was estimated to be from interruption to antiretroviral therapy, which could occur during a period of high health system demand. For tuberculosis, the greatest impact would be from reductions in timely diagnosis and treatment of new cases, which could result from any prolonged period of COVID-19 suppression interventions. The greatest impact on malaria burden could be as a result of interruption of planned net campaigns. These disruptions could lead to a loss of life-years over 5 years that is of the same order of magnitude as the direct impact from COVID-19 in places with a high burden of malaria and large HIV and tuberculosis epidemics. Interpretation: Maintaining the most critical prevention activities and health-care services for HIV, tuberculosis, and malaria could substantially reduce the overall impact of the COVID-19 pandemic. Funding: ...
Keywords	Public aspects of medicine ; RA1-1270 ; covid19
Subject code	306
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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