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  1. Article: Die Kinder der dunklen Triade. Wenn die Entdeckung von vererbten Ähnlichkeiten zum Albtraum wird

    Sacco, Francesca

    Psychoscope

    2023  Volume 44, Issue 1, Page(s) 38–40

    Abstract: Unter Einbezug von zwei Fallbeispielen werden Grundzüge der psychotherapeutischen Begleitung von Kindern psychopathischer Elternteile werden erörtert. Als zentral werden beschrieben: Unterstützung der Patientin oder des Patienten beim schmerzhaften ... ...

    Title translation The children of the dark triad. When the discovery of inherited similarities becomes a nightmare
    Abstract Unter Einbezug von zwei Fallbeispielen werden Grundzüge der psychotherapeutischen Begleitung von Kindern psychopathischer Elternteile werden erörtert. Als zentral werden beschrieben: Unterstützung der Patientin oder des Patienten beim schmerzhaften Prozess der Bewusstwerdung, Vermittlung sachlicher Informationen über die Persönlichkeitsstruktur des Elternteils als "chronisch und unheilbar" und Förderung der Fähigkeit, emotionalen Abstand zu gewinnen.
    Keywords Antisocial Personality Disorder ; Antisoziale Persönlichkeitsstörung ; Dark Triad ; Dunkle Triade ; Kinder (Nachkommenschaft) ; Offspring ; Psychopathie ; Psychopathy ; Psychotherapeutic Processes ; Psychotherapeutische Prozesse ; Psychotherapie ; Psychotherapy
    Language German
    Document type Article
    ISSN 1420-620X
    ISSN 1420-620X
    Database PSYNDEX

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  2. Article: [No title information]

    Sacco, Francesca / Bünzli, Dominique

    Revue medicale suisse

    2022  Volume 18, Issue 807, Page(s) 2352

    Title translation Contre la pénurie de médecins, l’aide à la domiciliation.
    MeSH term(s) Humans ; Physicians
    Language French
    Publishing date 2022-12-07
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2022.18.807.2352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Noch viel Potenzial in der Gesundheitspolitik. Der Gesundheitspsychologie sollte in der Gesundheitsförderung mehr Bedeutung zukommen

    Sacco, Francesca

    Psychoscope

    2020  Volume 41, Issue 2, Page(s) 37–39

    Abstract: Es wird dafür plädiert, dass Psychologinnen und Psychologen in der Schweiz stärker bei der Ausarbeitung von Kampagnen zu Prävention und Gesundheitsförderung zu Rate gezogen werden und dieses Feld nicht Kommunikations- und Werbeagenturen zu überlassen. ...

    Title translation Still a lot of potential in health policy. Health psychology should be given more importance in health promotion
    Abstract Es wird dafür plädiert, dass Psychologinnen und Psychologen in der Schweiz stärker bei der Ausarbeitung von Kampagnen zu Prävention und Gesundheitsförderung zu Rate gezogen werden und dieses Feld nicht Kommunikations- und Werbeagenturen zu überlassen.
    Keywords Advertising ; Communication ; Gesundheitsförderung ; Health Promotion ; Kommunikation ; Prevention ; Prävention ; Psychologinnen und Psychologen ; Psychologists ; Werbung
    Language German
    Document type Article
    ISSN 1420-620X
    ISSN 1420-620X
    Database PSYNDEX

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  4. Article ; Online: The Cyclin-dependent kinase 1: more than a cell cycle regulator.

    Massacci, Giorgia / Perfetto, Livia / Sacco, Francesca

    British journal of cancer

    2023  Volume 129, Issue 11, Page(s) 1707–1716

    Abstract: The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry out versatile functions during the last decade. From cell cycle ... ...

    Abstract The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry out versatile functions during the last decade. From cell cycle control to gene expression regulation and apoptosis, CDK1 is intimately involved in many cellular events that are vital for cell survival. Here, we provide a comprehensive catalogue of the CDK1 upstream regulators and substrates, describing how this kinase is implicated in the control of key 'cell cycle-unrelated' biological processes. Finally, we describe how deregulation of CDK1 expression and activation has been closely associated with cancer progression and drug resistance.
    MeSH term(s) Humans ; CDC2 Protein Kinase/genetics ; CDC2 Protein Kinase/metabolism ; Protein Serine-Threonine Kinases/genetics ; Genes, cdc ; Cell Cycle ; Cell Division
    Chemical Substances CDC2 Protein Kinase (EC 2.7.11.22) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-10-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-023-02468-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Mutig oder verrückt? Wer eine Niere an eine unbekannte Person spendet, kann unter Verdacht geraten

    Sacco, Francesca

    Psychoscope

    2019  Volume 40, Issue 4, Page(s) 34–37

    Abstract: Es wird skizziert, wie das von psychologischem und psychiatrischem Fachpersonal durchgeführte Beurteilungsverfahren abläuft, denen "altruistische Organspenderinnen und -spender" unterzogen werden. Dadurch sollen unter den Personen, die eine ihrer Nieren ... ...

    Title translation Brave or crazy? Anyone who donates a kidney to an unknown person may come under suspicion
    Abstract Es wird skizziert, wie das von psychologischem und psychiatrischem Fachpersonal durchgeführte Beurteilungsverfahren abläuft, denen "altruistische Organspenderinnen und -spender" unterzogen werden. Dadurch sollen unter den Personen, die eine ihrer Nieren zu Lebzeiten an ihnen unbekannte Personen spenden möchten ("ungerichtete Organspenden"), diejenigen identifiziert werden, die selbstaufopfernde Tendenzen zeigen, auf der Suche nach sozialer Anerkennung bzw. Selbstwertsteigerung sind oder andere, möglicherweise für sie selbst problematische Absichten mit dieser Spende verfolgen.
    Keywords Charitable Behavior ; Gewebespende ; Motivation ; Psychiatric Evaluation ; Psychiatrische Beurteilung ; Psychological Report ; Psychologisches Gutachten ; Self-Esteem ; Social Approval ; Soziale Anerkennung ; Tissue Donation ; Wertschätzung der eigenen Person ; Wohltätigkeit
    Language German
    Document type Article
    ISSN 1420-620X
    ISSN 1420-620X
    Database PSYNDEX

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  6. Article ; Online: Phosphoproteomics and Organelle Proteomics in Pancreatic Islets.

    Caliskan, Özüm Sehnaz / Massacci, Giorgia / Krahmer, Natalie / Sacco, Francesca

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2456, Page(s) 123–140

    Abstract: Over the recent years, mass spectrometry (MS)-based proteomics has undergone dramatic advances in sample preparation, instrumentation, and computational methods. Here, we describe in detail, how a workflow quantifies global protein phosphorylation in ... ...

    Abstract Over the recent years, mass spectrometry (MS)-based proteomics has undergone dramatic advances in sample preparation, instrumentation, and computational methods. Here, we describe in detail, how a workflow quantifies global protein phosphorylation in pancreatic islets and characterizes intracellular organelle composition on protein level by MS-based proteomics.
    MeSH term(s) Islets of Langerhans/metabolism ; Mass Spectrometry/methods ; Organelles/metabolism ; Phosphorylation ; Proteomics/methods
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2124-0_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Assembling Disease Networks From Causal Interaction Resources.

    Cesareni, Gianni / Sacco, Francesca / Perfetto, Livia

    Frontiers in genetics

    2021  Volume 12, Page(s) 694468

    Abstract: The development of high-throughput high-content technologies and the increased ease in their application in clinical settings has raised the expectation of an important impact of these technologies on diagnosis and personalized therapy. Patient genomic ... ...

    Abstract The development of high-throughput high-content technologies and the increased ease in their application in clinical settings has raised the expectation of an important impact of these technologies on diagnosis and personalized therapy. Patient genomic and expression profiles yield lists of genes that are mutated or whose expression is modulated in specific disease conditions. The challenge remains of extracting from these lists functional information that may help to shed light on the mechanisms that are perturbed in the disease, thus setting a rational framework that may help clinical decisions. Network approaches are playing an increasing role in the organization and interpretation of patients' data. Biological networks are generated by connecting genes or gene products according to experimental evidence that demonstrates their interactions. Till recently most approaches have relied on networks based on physical interactions between proteins. Such networks miss an important piece of information as they lack details on the functional consequences of the interactions. Over the past few years, a number of resources have started collecting causal information of the type protein A activates/inactivates protein B, in a structured format. This information may be represented as signed directed graphs where physiological and pathological signaling can be conveniently inspected. In this review we will (i) present and compare these resources and discuss the different scope in comparison with pathway resources; (ii) compare resources that explicitly capture causality in terms of data content and proteome coverage (iii) review how causal-graphs can be used to extract disease-specific Boolean networks.
    Language English
    Publishing date 2021-06-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.694468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Integration of NMR Spectroscopy in an Analytical Workflow to Evaluate the Effects of Oxidative Stress on Abituzumab: Beyond the Fingerprint of mAbs

    Cerofolini, Linda / Ravera, Enrico / Fischer, Christian / Trovato, Andrea / Sacco, Francesca / Palinsky, Wolf / Angiuoni, Gabriella / Fragai, Marco / Baroni, Fabio

    Analytical Chemistry. 2023 June 06, v. 95, no. 24 p.9199-9206

    2023  

    Abstract: The assessment of the higher-order structure (HOS) by NMR is a powerful methodology to characterize the structural features of biologics. Forced oxidative stress studies are used to investigate the stability profile, to develop pharmaceutical ... ...

    Abstract The assessment of the higher-order structure (HOS) by NMR is a powerful methodology to characterize the structural features of biologics. Forced oxidative stress studies are used to investigate the stability profile, to develop pharmaceutical formulations and analytical methods. Here, the effects of forced oxidative stress by H₂O₂ on the monoclonal antibody Abituzumab have been characterized by a multianalytical approach combining NMR spectroscopy, mass spectrometry, differential scanning calorimetry, surface plasmon resonance, computational tools, and bioassays. This integrated strategy has provided qualitative and semiquantitative characterization of the samples and information at residue level of the effects that oxidation has on the HOS of Abituzumab, correlating them to the loss of the biological activity.
    Keywords analytical chemistry ; bioactive properties ; calorimetry ; mass spectrometry ; monoclonal antibodies ; nuclear magnetic resonance spectroscopy ; oxidation ; oxidative stress ; surface plasmon resonance
    Language English
    Dates of publication 2023-0606
    Size p. 9199-9206.
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c00317
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 52/94: Show issues
    Z 2.9: Show issues

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  9. Article ; Online: Integration of NMR Spectroscopy in an Analytical Workflow to Evaluate the Effects of Oxidative Stress on Abituzumab: Beyond the Fingerprint of mAbs.

    Cerofolini, Linda / Ravera, Enrico / Fischer, Christian / Trovato, Andrea / Sacco, Francesca / Palinsky, Wolf / Angiuoni, Gabriella / Fragai, Marco / Baroni, Fabio

    Analytical chemistry

    2023  Volume 95, Issue 24, Page(s) 9199–9206

    Abstract: The assessment of the higher-order structure (HOS) by NMR is a powerful methodology to characterize the structural features of biologics. Forced oxidative stress studies are used to investigate the stability profile, to develop pharmaceutical ... ...

    Abstract The assessment of the higher-order structure (HOS) by NMR is a powerful methodology to characterize the structural features of biologics. Forced oxidative stress studies are used to investigate the stability profile, to develop pharmaceutical formulations and analytical methods. Here, the effects of forced oxidative stress by H
    MeSH term(s) Hydrogen Peroxide ; Workflow ; Antibodies, Monoclonal/chemistry ; Magnetic Resonance Spectroscopy
    Chemical Substances Abituzumab (724QD330RD) ; Hydrogen Peroxide (BBX060AN9V) ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c00317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Combining Mass Spectrometry-Based Phosphoproteomics with a Network-Based Approach to Reveal FLT3-Dependent Mechanisms of Chemoresistance.

    Pugliese, Giusj Monia / Latini, Sara / Massacci, Giorgia / Perfetto, Livia / Sacco, Francesca

    Proteomes

    2021  Volume 9, Issue 2

    Abstract: FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor clinical outcome, relapse and chemotherapeutic resistance. Elucidating the molecular mechanisms underlying FLT3-dependent ... ...

    Abstract FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor clinical outcome, relapse and chemotherapeutic resistance. Elucidating the molecular mechanisms underlying FLT3-dependent pathogenesis and drug resistance is a crucial goal of biomedical research. Given the complexity and intricacy of protein signaling networks, deciphering the molecular basis of FLT3-driven drug resistance requires a systems approach. Here we discuss how the recent advances in mass spectrometry (MS)-based (phospho) proteomics and multiparametric analysis accompanied by emerging computational approaches offer a platform to obtain and systematically analyze cell-specific signaling networks and to identify new potential therapeutic targets.
    Language English
    Publishing date 2021-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720995-7
    ISSN 2227-7382
    ISSN 2227-7382
    DOI 10.3390/proteomes9020019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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