Article ; Online: Comparison of the Efficacy of Cefazolin with and without Naproxen in Patients with Cellulitis Admitted to a Tertiary Hospital
Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol 11, Iss
2019-2020
2022 Volume 1
Abstract: Introduction: It is pertinent to carefully monitor the clinical course of patients with cellulitis. If not treated properly, there is a possibility of its extension to other skin surfaces, recurrent infection, risk of systemic spreading, and incidence of ...
| Abstract | Introduction: It is pertinent to carefully monitor the clinical course of patients with cellulitis. If not treated properly, there is a possibility of its extension to other skin surfaces, recurrent infection, risk of systemic spreading, and incidence of worse complications, such as sepsis and severe abscesses. Various antibiotic regimens with or without anti-inflammatory drugs have been administered as a treatment against cellulitis. However, there is no proposed standard and selective line of treatment against cellulitis. This study aimed to compare the efficacy and outcome of two medications, cefazolin alone and cefazolin combined with naproxen as a non-steroidal anti-inflammatory drug. Materials and Methods: This open-label randomized clinical trial was conducted on patients with cellulitis who were admitted to Labbafinejad Hospital (Tehran, Iran) from May 2019 to March 2020. The patients were randomly divided into group A (treated with 1-1.5 g of cefazolin alone intravenously every eight hours) and group B (treated with 1-1.5 g of cefazolin intravenously every eight hours combined with 500 mg of naproxen orally every 12 hours). The responses to these medications and the side effects were evaluated during hospitalizations. Results: The mean age of the 64 patients included in the study was 50.52±2.10 years and 51.56% of the patients were male. There were no significant differences between the control (n=33) and intervention (n=31) groups in terms of history of diabetes mellitus (p=0.666), antibiotic use (p=0.594), trauma (p=0.722), cellulitis (p=0.529), and smoking (p=0.705). The mean body temperatures of the two groups were not different in any of the first (p=0.762), third (p=0.789), and fifth (p=0.893) days. The improvement of clinical symptoms on the third day was significantly (p=0.045) more in group B (90.3%) than in group A (51.5%). Also, the clinical improvement on the fifth day was significantly (p=0.036) higher in group B (100%) than in group A (69.7%). In addition, the mean hospitalization periods ... |
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| Keywords | cellulitis ; treatment outcome ; cefazolin ; naproxen ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216 |
| Subject code | 616 |
| Language | Turkish |
| Publishing date | 2022-04-01T00:00:00Z |
| Publisher | Galenos Yayinevi |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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