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Article ; Online: Carboxylic acid derivatives suppress the growth of

Hima, Sree / Remya, Chandran / Sadasivan, C / Dileep, K V

Journal of biomolecular structure & dynamics

2023 Volume 42, Issue 7, Page(s) 3563–3567

Abstract: Aspergillus ... ...

Abstract	Aspergillus favus
MeSH term(s)	Aspergillus flavus/metabolism ; Molecular Docking Simulation ; alpha-Amylases ; Aflatoxins ; Monosaccharides/metabolism ; Monosaccharides/pharmacology ; Carboxylic Acids/metabolism ; Carboxylic Acids/pharmacology ; 2,4-Dichlorophenoxyacetic Acid/metabolism ; 2,4-Dichlorophenoxyacetic Acid/pharmacology
Chemical Substances	alpha-Amylases (EC 3.2.1.1) ; Aflatoxins ; Monosaccharides ; Carboxylic Acids ; 2,4-Dichlorophenoxyacetic Acid (2577AQ9262)
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2214235
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Zs.A 2093: Show issues

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Article ; Online: In vitro comparison of middle meningeal artery embolization with Squid liquid embolic agent and Contour polyvinyl alcohol particles.

Sadasivan, Chander / Dashti, Nakisa / Marfoglio, Samantha / Fiorella, David

Journal of neurointerventional surgery

2024 Volume 16, Issue 3, Page(s) 280–284

Abstract: Background: Liquid embolic agents and polyvinyl alcohol (PVA) particles have been used for the embolization of the middle meningeal artery (MMA) for the treatment of chronic subdural hematomas. However, the vascular penetration and distribution of these ...

Abstract	Background: Liquid embolic agents and polyvinyl alcohol (PVA) particles have been used for the embolization of the middle meningeal artery (MMA) for the treatment of chronic subdural hematomas. However, the vascular penetration and distribution of these embolic agents have not yet been compared. The current study compares distribution of a liquid embolic agent (Squid) to PVA particles (Contour) in an in vitro model of the MMA. Methods: MMA models were embolized with Contour PVA particles 45-150 µm, Contour PVA particles 150-250 µm, and Squid-18 liquid embolic agent (n=5 each). The models were scanned and every vascular segment with embolic agent was manually marked on the images. Embolized vascular length as a percentage of control, average embolized vascular diameter, and embolization time were compared between the groups. Results: The 150-250 µm Contour particles primarily accumulated close to the microcatheter tip, yielding proximal branch occlusions. The 45-150 µm Contour particles achieved a more distal distribution, but in a patchy segmental pattern. However, the models embolized with Squid-18 had a consistently distal, near-complete and homogenous distribution. Embolized vascular length was significantly higher (76±13% vs 5±3%, P=0.0007) and average embolized vessel diameter was significantly smaller (405±25 µm vs 775±225 µm, P=0.0006) with Squid than with Contour. Embolization time with Squid was also lower (2.8±2.4 min vs 6.4±2.7 min, P=0.09). Conclusions: Squid-18 liquid results in a considerably more consistent, distal and homogeneous pattern of embolysate distribution than Contour PVA particles in an anatomical model of the MMA tree.
MeSH term(s)	Humans ; Polyvinyl Alcohol ; Meningeal Arteries/diagnostic imaging ; Embolization, Therapeutic/methods ; Polyvinyls
Chemical Substances	Polyvinyl Alcohol (9002-89-5) ; Polyvinyls
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/jnis-2023-020132
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Zs.A 6845: Show issues

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Article ; Online: Unveiling the molecular basis of lobeline's allosteric regulation of NMDAR: insights from molecular modeling.

Remya, Chandran / Variyar, E J / Omkumar, R V / Sadasivan, C / Dileep, K V

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22418

Abstract: Neurological and psychiatric disorders contribute significantly to the global disease burden, adversely affecting the quality of life for both patients and their families. Impaired glutamatergic signaling is considered to be a major cause for most of the ...

Abstract	Neurological and psychiatric disorders contribute significantly to the global disease burden, adversely affecting the quality of life for both patients and their families. Impaired glutamatergic signaling is considered to be a major cause for most of the neurological and psychiatric disorders. Glutamate receptors are over activated in excitotoxic conditions, leading to dysregulation of Ca
MeSH term(s)	Humans ; Lobeline ; Molecular Docking Simulation ; Allosteric Regulation ; Quality of Life ; Receptors, N-Methyl-D-Aspartate/metabolism ; Models, Molecular
Chemical Substances	Lobeline (D0P25S3P81) ; Receptors, N-Methyl-D-Aspartate
Language	English
Publishing date	2023-12-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-49835-2
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Article ; Online: Trypsin is inhibited by phytocompounds liquiritin and terpinen-4-ol from the herb

Abhithaj, J / Sharanya, C S / Arun, K G / Jayadevi Variyar, E / Sadasivan, C

Journal of biomolecular structure & dynamics

2023 Volume 42, Issue 6, Page(s) 2957–2964

Abstract: Serine proteases are a class of hydrolytic enzymes involved in various physiological functions like digestion, coagulation, fibrinolysis and immunity. The present study evaluates the serine protease inhibitory potential of phytochemicals liquiritin and ... ...

Abstract	Serine proteases are a class of hydrolytic enzymes involved in various physiological functions like digestion, coagulation, fibrinolysis and immunity. The present study evaluates the serine protease inhibitory potential of phytochemicals liquiritin and terpinen-4-ol present in the herb
MeSH term(s)	Trypsin ; Serine Proteases ; Serine Endopeptidases ; Glycyrrhiza ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Glucosides ; Terpenes ; Flavanones
Chemical Substances	Trypsin (EC 3.4.21.4) ; liquiritin (T0O79T74CD) ; terpinenol-4 (562-74-3) ; Serine Proteases (EC 3.4.-) ; Serine Endopeptidases (EC 3.4.21.-) ; Glucosides ; Terpenes ; Flavanones
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2212784
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Zs.A 2093: Show issues

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Article ; Online: Acute-onset dysphonia secondary to a ruptured mycotic aortic arch aneurysm: a rare case of Ortner syndrome.

Sadasivan, Chandu / Kubinec, Chelsea / Ao, Peter / Captan, Vasile

Internal medicine journal

2023 Volume 53, Issue 10, Page(s) 1929–1930

MeSH term(s)	Humans ; Aneurysm, Aortic Arch ; Dysphonia/etiology ; Aortic Rupture/complications ; Aortic Rupture/diagnostic imaging
Language	English
Publishing date	2023-10-20
Publishing country	Australia
Document type	Case Reports ; Letter
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.16240
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 424: Show issues

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Article ; Online: Virtual screening-based identification of novel fatty acid synthase inhibitor and evaluation of its antiproliferative activity in breast cancer cells.

Amrutha Nisthul, A / Archana, P R / Anto, Ruby John / Sadasivan, C

Journal of molecular graphics & modelling

2021 Volume 105, Page(s) 107903

Abstract: Cancer cells activate de novo lipogenesis by overexpressing the lipogenic enzymes ACLY, ACC and FASN to support rapid cell division. FASN, previously known as oncogenic antigen-519 (OA-519) catalyzes seven sequential reactions to synthesize palmitic acid ...

Abstract	Cancer cells activate de novo lipogenesis by overexpressing the lipogenic enzymes ACLY, ACC and FASN to support rapid cell division. FASN, previously known as oncogenic antigen-519 (OA-519) catalyzes seven sequential reactions to synthesize palmitic acid (C16) from substrates acetyl CoA, and malonyl CoA. The dependence of cancer cells on FASN-derived lipids and the differential expression of FASN in cancer cells compared to their normal counterparts make it an attractive metabolic drug target in cancer therapy. In the present study, an attempt has been made to identify potent FASN inhibitors from Asinex-Synergy compound database using structure-based virtual screening. The serial docking protocols of increasing precisions identified LEG-17649942, with glide score -10.34 kcal/mol as a promising compound which can directly interact with active site residues H293 and H331. LEG-17649942 possesses drug-like pharmacokinetic properties as predicted by Qikprop. LEG-17649942 exhibited cytotoxicity in breast cancer cell lines SK-BR-3, MCF-7 and MDA-MB-231 with maximum activity against MDA-MB-231 cells with IC50 of 50 μM. The study put forward LEG-17649942 as a novel drug-lead compound against triple negative breast cancer with an exquisite binding pattern to FASN-KS domain.
MeSH term(s)	Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Fatty Acid Synthases/antagonists & inhibitors ; Female ; Humans
Chemical Substances	Fatty Acid Synthases (EC 2.3.1.85)
Language	English
Publishing date	2021-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1396450-1
ISSN	1873-4243 ; 1093-3263
ISSN (online)	1873-4243
ISSN	1093-3263
DOI	10.1016/j.jmgm.2021.107903
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Zs.A 3491: Show issues

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Article ; Online: Binding of rosmarinic acid curcumin and capsaicin with PLA2: A comparative study.

Aiswarya, N / Remya, Chandran / Remashree, A B / Sadasivan, C / Dileep, K V

Biochemical and biophysical research communications

2022 Volume 626, Page(s) 187–191

Abstract: Phospholipase A2 (PLA2) is a key enzyme involved in the formation of pro-inflammatory mediators like eicosanoids. Inhibition of PLA2 is regarded as one of the effective methods of controlling inflammation. The present study investigated the binding ... ...

Abstract	Phospholipase A2 (PLA2) is a key enzyme involved in the formation of pro-inflammatory mediators like eicosanoids. Inhibition of PLA2 is regarded as one of the effective methods of controlling inflammation. The present study investigated the binding potentials of three natural compounds, rosmarinic acid (RA), capsaicin (CAP), and curcumin (CUR) by means of in silico and in vitro methods. Our study revealed that RA has relatively better binding affinity and inhibition potentials when compared to the other two molecules. Our ITC experiments were also suggested a slightly better binding energy for the RA. The stoichiometry of the protein ligand complex obtained from one of the ITC experiments suggested the possibilities of binding of a small molecule MCW (degraded product of CUR) on PLA2. Overall study demonstrated that the anti-inflammatory activity of RA, CUR and CAP may be partly due to the inhibition of PLA2.
MeSH term(s)	Capsaicin ; Cinnamates ; Curcumin/chemistry ; Curcumin/pharmacology ; Depsides ; Phospholipases A2/metabolism ; Rosmarinic Acid
Chemical Substances	Cinnamates ; Depsides ; Phospholipases A2 (EC 3.1.1.4) ; Curcumin (IT942ZTH98) ; Capsaicin (S07O44R1ZM)
Language	English
Publishing date	2022-08-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.08.028
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Zs.A 116: Show issues

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Article ; Online: The effect of actuation frequency on clot integration with the Tigertriever device: A preliminary in vitro study.

Sadasivan, Chander / Dashti, Nakisa / Gopal, Megha / Serna, Rowan J / Fiorella, David

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2024 , Page(s) 15910199241247886

Abstract: Background: The Tigertriever stent retriever (Rapid Medical) can be actively expanded and contracted by the operator, which allows for several actuation-related parameters to be optimized to potentially improve device efficacy. These parameters have not ...

Abstract	Background: The Tigertriever stent retriever (Rapid Medical) can be actively expanded and contracted by the operator, which allows for several actuation-related parameters to be optimized to potentially improve device efficacy. These parameters have not yet been evaluated. We conducted a benchtop study to evaluate the effect of actuation frequency on clot integration within the stent. Methods: A Tigertriever 17 device was deployed within a biological clot analog placed in a straight tube. The device was actuated between the maximally contracted and maximally expanded states with three different frequencies: passive (one-time opening, Results: The clot integration factor was significantly higher (23% increase, Conclusions: Faster actuation frequencies may result in improved clot integration with the Tigertriever device. This effect needs to be validated by clinical data.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/15910199241247886
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Article ; Online: Asthma and youth soccer

Sadasivan C / Cave A

Open Access Journal of Sports Medicine, Vol Volume 10, Pp 17-

an investigation into the level of asthma awareness and training among youth soccer coaches

2019 Volume 31

Abstract: Chandu Sadasivan, Andrew Cave Department of Family Medicine, University of Alberta, Edmonton, AB, Canada Purpose: Asthma is the most common chronic disease among children. Exercise-induced bronchoconstriction which is common in asthmatic patients also ... ...

Abstract	Chandu Sadasivan, Andrew Cave Department of Family Medicine, University of Alberta, Edmonton, AB, Canada Purpose: Asthma is the most common chronic disease among children. Exercise-induced bronchoconstriction which is common in asthmatic patients also occurs in individuals with no prior asthma diagnosis. Despite this and the fact that soccer is a high ventilation sport, there are no validated asthma management protocols in place for soccer coaches. This study aims to address 1) soccer coaches’ current knowledge on asthma, 2) whether there is a need for asthma-related training, and 3) any barriers to administration of such training.Patients and methods: A total of 2,300 volunteer youth soccer coaches from the Edmonton Minor Soccer Association (EMSA) were invited to participate in completing a 22-question online survey. The survey was open for 1month from June 8, 2018, to July 8, 2018.Results: There was a response rate of 22% (513 of 2,300). Respondents were on average, inexperienced coaches, coached younger age groups, and approximately one-third of respondents had personal experience with asthma (either themselves or their child had asthma). 93% of respondents had not received any asthma-related training at any coaching level, whether it be from EMSA or the Alberta Soccer Association. Coaches had strong knowledge on how to treat asthma attacks, but mixed levels of knowledge on asthma attack prevention. Experienced coaches were better at identifying the number of players with asthma on their team and the number of asthma-related incidents they had encountered as coaches. Coaches demonstrated a receptive attitude toward receiving asthma-related training, with 91% of respondents saying training would be beneficial and 69% of respondents saying training should be mandatory.Conclusion: The results of this study indicate that soccer coaches have limited knowledge regarding asthma management, acknowledge a need for asthma-related training, and are willing to participate in and could benefit from educational interventions as it pertains to their roles as coaches. Keywords: coaching, exercise-induced bronchoconstriction, management, protocol
Keywords	coaching ; exercised-induced bronchoconstriction ; management ; protocol ; Sports medicine ; RC1200-1245
Subject code	796
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Repurposing of Streptomyces antibiotics as adenosine deaminase inhibitors by pharmacophore modeling, docking, molecular dynamics, and

Arun, K G / Sharanya, C S / Abhithaj, J / Sadasivan, C

Journal of receptor and signal transduction research

2020 Volume 40, Issue 1, Page(s) 77–88

Abstract: Adenosine deaminase (ADA) is an enzyme present in purine metabolic pathway. Its inhibitors are considered to be potent drug lead compounds against inflammatory and malignant diseases. This study aimed to test ADA inhibitory activity of some Streptomyces ... ...

Abstract	Adenosine deaminase (ADA) is an enzyme present in purine metabolic pathway. Its inhibitors are considered to be potent drug lead compounds against inflammatory and malignant diseases. This study aimed to test ADA inhibitory activity of some Streptomyces secondary metabolites by using computational and
MeSH term(s)	Adenosine Deaminase/metabolism ; Adenosine Deaminase Inhibitors/chemistry ; Adenosine Deaminase Inhibitors/pharmacology ; Aminoglycosides/chemistry ; Aminoglycosides/pharmacology ; Anti-Bacterial Agents/pharmacology ; Catalytic Domain ; Drug Evaluation, Preclinical ; Drug Repositioning ; Enzyme Assays ; Humans ; Least-Squares Analysis ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Novobiocin/chemistry ; Novobiocin/pharmacology ; Quantitative Structure-Activity Relationship ; Spectrometry, Fluorescence ; Streptomyces/chemistry
Chemical Substances	Adenosine Deaminase Inhibitors ; Aminoglycosides ; Anti-Bacterial Agents ; Ligands ; Novobiocin (17EC19951N) ; nikkomycin (9Z22C3QQCJ) ; Adenosine Deaminase (EC 3.5.4.4)
Language	English
Publishing date	2020-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1230969-2
ISSN	1532-4281 ; 1079-9893
ISSN (online)	1532-4281
ISSN	1079-9893
DOI	10.1080/10799893.2020.1715432
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Zs.A 1643: Show issues

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