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  1. Article ; Online: Future perspectives of radiation therapy for Hodgkin Lymphoma: Risk-adapted, response-adapted, and safer than before.

    Saddi, Jessica / Barcellini, Amelia / Gotti, Manuel / Mazzacane, Alessandro / Tolva, Alessandra / Lazic, Tanja / Arcaini, Luca / Zecca, Marco / Orlandi, Ester / Filippi, Andrea Riccardo

    Hematological oncology

    2024  Volume 42, Issue 3, Page(s) e3269

    Abstract: Classical Hodgkin lymphoma is a lymphoproliferative disease with a good prognosis mainly seen in young people. Nevertheless secondary malignancy, cardiac disease and infertility may affect the long survivors with significant impact on quality of life, ... ...

    Abstract Classical Hodgkin lymphoma is a lymphoproliferative disease with a good prognosis mainly seen in young people. Nevertheless secondary malignancy, cardiac disease and infertility may affect the long survivors with significant impact on quality of life, morbidity and overall survival. In the last decades several treatment strategies were evaluated to reduce the toxicity of first line treatment such as avoiding radiotherapy or its reduction in terms of dosage and extension. Many trials including interim Positron Emission Tomography evaluation fail to compare efficacy between combined modality treatment versus chemotherapy alone in particular in early stage disease. In this review we analyze which subset of patients could take advantage from proton therapy in terms of toxicity and cost effectiveness.
    MeSH term(s) Humans ; Hodgkin Disease/radiotherapy ; Proton Therapy/adverse effects ; Proton Therapy/methods
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.3269
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  2. Article: Pragmatic Expectancy on Microbiota and Non-Small Cell Lung Cancer: A Narrative Review.

    Stella, Giulia Maria / Scialò, Filippo / Bortolotto, Chandra / Agustoni, Francesco / Sanci, Vincenzo / Saddi, Jessica / Casali, Lucio / Corsico, Angelo Guido / Bianco, Andrea

    Cancers

    2022  Volume 14, Issue 13

    Abstract: It is well known that lung cancer relies on a number of genes aberrantly expressed because of somatic lesions. Indeed, the lungs, based on their anatomical features, are organs at a high risk of development of extremely heterogeneous tumors due to the ... ...

    Abstract It is well known that lung cancer relies on a number of genes aberrantly expressed because of somatic lesions. Indeed, the lungs, based on their anatomical features, are organs at a high risk of development of extremely heterogeneous tumors due to the exposure to several environmental toxic agents. In this context, the microbiome identifies the whole assemblage of microorganisms present in the lungs, as well as in distant organs, together with their structural elements and metabolites, which actively interact with normal and transformed cells. A relevant amount of data suggest that the microbiota plays a role not only in cancer disease predisposition and risk but also in its initiation and progression, with an impact on patients' prognosis. Here, we discuss the mechanistic insights of the complex interaction between lung cancer and microbiota as a relevant component of the microenvironment, mainly focusing on novel diagnostic and therapeutic objectives.
    Language English
    Publishing date 2022-06-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14133131
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  3. Article ; Online: CT Scan-Guided Fine Needle Aspiration Cytology for Lung Cancer Diagnosis through the COVID-19 Pandemic: What We Have Learned.

    Stella, Giulia Maria / Chino, Vittorio / Putignano, Paola / Bertuccio, Francesco / Agustoni, Francesco / Saracino, Laura / Tomaselli, Stefano / Saddi, Jessica / Piloni, Davide / Bortolotto, Chandra

    Tomography (Ann Arbor, Mich.)

    2023  Volume 9, Issue 2, Page(s) 759–767

    Abstract: Background and rationale: Novel coronavirus-related disease (COVID-19) has profoundly influenced hospital organization and structures worldwide. In Italy, the Lombardy Region, with almost 17% of the Italian population, rapidly became the most severely ... ...

    Abstract Background and rationale: Novel coronavirus-related disease (COVID-19) has profoundly influenced hospital organization and structures worldwide. In Italy, the Lombardy Region, with almost 17% of the Italian population, rapidly became the most severely affected area since the pandemic beginning. The first and the following COVID-19 surges significantly affected lung cancer diagnosis and subsequent management. Much data have been already published regarding the therapeutic repercussions whereas very few reports have focused on the consequences of the pandemic on diagnostic procedures.
    Methods: We, here, would like to analyze data of novel lung cancer diagnosis performed in our Institution in Norther Italy where we faced the earliest and largest outbreaks of COVID-19 in Italy.
    Results: We discuss, in detail, the strategies developed to perform biopsies and the safe pathways created in emergency settings to protect lung cancer patients in subsequent therapeutic phases. Quite unexpectedly, no significant differences emerged between cases enrolled during the pandemic and those before, and the two populations were homogeneous considering the composition and diagnostic and complication rates.
    Conclusions: By pointing out the role of multidisciplinarity in emergency contexts, these data will be of help in the future for designing tailored strategies to manage lung cancer in a real-life setting.
    MeSH term(s) Humans ; COVID-19 ; Biopsy, Fine-Needle/methods ; Pandemics ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Tomography, X-Ray Computed ; COVID-19 Testing
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography9020061
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  4. Article: Pleural Mesothelioma: Treatable Traits of a Heterogeneous Disease.

    Bertuccio, Francesco Rocco / Agustoni, Francesco / Galli, Giulia / Bortolotto, Chandra / Saddi, Jessica / Baietto, Guido / Baio, Nicola / Montini, Simone / Putignano, Paola / D'Ambrosio, Gioacchino / Corsico, Angelo G / Pedrazzoli, Paolo / Stella, Giulia Maria

    Cancers

    2023  Volume 15, Issue 24

    Abstract: Pleural mesothelioma is an aggressive disease with diffuse nature, low median survival, and prolonged latency presenting difficulty in prognosis, diagnosis, and treatment. Here, we review all these aspects to underline the progress being made in its ... ...

    Abstract Pleural mesothelioma is an aggressive disease with diffuse nature, low median survival, and prolonged latency presenting difficulty in prognosis, diagnosis, and treatment. Here, we review all these aspects to underline the progress being made in its investigation and to emphasize how much work remains to be carried out to improve prognosis and treatment.
    Language English
    Publishing date 2023-12-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245731
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  5. Article: Smoking Habit and Respiratory Function Predict Patients' Outcome after Surgery for Lung Cancer, Irrespective of Histotype and Disease Stage.

    Piloni, Davide / Bertuccio, Francesco R / Primiceri, Cristiano / Rinaldi, Pietro / Chino, Vittorio / Abbott, David Michael / Sottotetti, Federico / Bortolotto, Chandra / Agustoni, Francesco / Saddi, Jessica / Stella, Giulia M

    Journal of clinical medicine

    2023  Volume 12, Issue 4

    Abstract: Background: Growing evidence suggests that sublobar resections offer more favorable outcomes than lobectomy in early-stage lung cancer surgery. However, a percentage of cases that cannot be ignored develops disease recurrence irrespective of the surgery ...

    Abstract Background: Growing evidence suggests that sublobar resections offer more favorable outcomes than lobectomy in early-stage lung cancer surgery. However, a percentage of cases that cannot be ignored develops disease recurrence irrespective of the surgery performed with curative intent. The goal of this work is thus to compare different surgical approaches, namely, lobectomy and segmentectomy (typical and atypical) to derive prognostic and predictive markers.
    Patients and methods: Here we analyzed a cohort of 153 NSCLC patients in clinical stage TNM I who underwent pulmonary resection surgery with a mediastinal hilar lymphadenectomy from January 2017 to December 2021, with an average follow-up of 25.5 months. Partition analysis was also applied to the dataset to detect outcome predictors.
    Results: The results of this work showed similar OS between lobectomy and typical and atypical segmentectomy for patients with stage I NSCLC. In contrast, lobectomy was associated with a significant improvement in DFS compared with typical segmentectomy in stage IA, while in stage IB and overall, the two treatments were similar. Atypical segmentectomy showed the worst performance, especially in 3-year DFS. Quite unexpectedly, outcome predictor ranking analysis suggests a prominent role of smoking habits and respiratory function, irrespective of the tumor histotype and the patient's gender.
    Conclusions: Although the limited follow-up interval cannot allow conclusive remarks about prognosis, the results of this study suggest that both lung volumes and the degree of emphysema-related parenchymal damage are the strongest predictors of poor survival in lung cancer patients. Overall, these data point out that greater attention should be addressed to the therapeutic intervention for co-existing respiratory diseases to obtain optimal control of early lung cancer.
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12041561
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  6. Article ; Online: Rationale and Design of a Single-Arm, Phase 2, Multi-Center Study of Chemo-Immunotherapy Followed by Hypo-Fractionated RT and Maintenance Immunotherapy in Patients With Unresectable Stage III NSCLC: The DEDALUS Trial.

    Filippi, Andrea Riccardo / Agustoni, Francesco / Arcangeli, Stefano / Cortinovis, Diego / Ferrari, Alessandra / Cicognini, Daniela / Saddi, Jessica / Klersy, Catherine / Pedrazzoli, Paolo / Malapelle, Umberto / Grossi, Francesco

    Clinical lung cancer

    2023  Volume 24, Issue 3, Page(s) e122–e125

    Abstract: Introduction/background: This single-arm, phase 2, multi-center, study aims to assess the safety and efficacy of a regimen of induction chemo-immunotherapy followed by de-intensified, hypo-fractionated thoracic radiotherapy (RT) given concurrently with ... ...

    Abstract Introduction/background: This single-arm, phase 2, multi-center, study aims to assess the safety and efficacy of a regimen of induction chemo-immunotherapy followed by de-intensified, hypo-fractionated thoracic radiotherapy (RT) given concurrently with durvalumab and maintenance durvalumab in patients with unresectable, stage III NSCLC.
    Material and methods: we will enroll 45 patients with unresectable stage III NSCLC, any PD-L1, deemed ineligible for concurrent CRT by a thoracic oncology multidisciplinary team, and candidate to sequential chemoradiation followed by durvalumab.
    Results: Primary endpoint is safety, defined by the incidence of grade 3 and 4 possibly related adverse events (PRAEs) within 6 months from the initiation of treatment. The secondary objectives are PFS and OS (median and 12 months). Ancillary endpoints are molecular response evaluated by cfDNA isolation baseline, after chemo-immuno RT and at progression, and radiomics analysis on CT scans at baseline and before maintenance.
    Conclusion: DEDALUS phase 2 trial explores the safety and efficacy of a novel sequence of chemo-radiation (with de-intensified RT) plus the anti-PD-L1 agent durvalumab in patients with stage III unresectable NSCLC who are candidates to sequential chemoradiation plus maintenance immunotherapy.
    MeSH term(s) Humans ; Lung Neoplasms/therapy ; Immunotherapy ; Chemoradiotherapy ; Induction Chemotherapy ; Carcinoma, Non-Small-Cell Lung/therapy
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Multicenter Study ; Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2145146-1
    ISSN 1938-0690 ; 1525-7304
    ISSN (online) 1938-0690
    ISSN 1525-7304
    DOI 10.1016/j.cllc.2022.12.015
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    Zs.A 5893: Show issues Location:
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    Zs.MO 440: Show issues

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  7. Article ; Online: Association between treatment-related lymphopenia and survival in glioblastoma patients following postoperative chemoradiotherapy.

    Mapelli, Roberto / Julita, Chiara / Bianchi, Sofia Paola / Gallina, Nicolò / Lucchini, Raffaella / Midulla, Martina / Puci, Flavia / Saddi, Jessica / Trivellato, Sara / Panizza, Denis / De Ponti, Elena / Arcangeli, Stefano

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2021  Volume 198, Issue 5, Page(s) 448–457

    Abstract: Purpose: Our study investigated the association between treatment-related lymphopenia and overall survival (OS) in a series of glioblastoma (GBM) patients. We also explored clinical and dosimetric predictors of lymphocytes depletion.: Methods: ... ...

    Abstract Purpose: Our study investigated the association between treatment-related lymphopenia and overall survival (OS) in a series of glioblastoma (GBM) patients. We also explored clinical and dosimetric predictors of lymphocytes depletion.
    Methods: Between 2015 and 2019, 64 patients were treated at the same institution with postoperative chemoradiotherapy. Peripheral lymphocyte count (PLC) data and dose-volume histogram parameters were collected. Radiotherapy (RT) schedule consisted in standard total dose of 60 Gy in 30 daily fractions, with concomitant and adjuvant temozolomide (TMZ). Posttreatment acute absolute lymphopenia (nadir AAL) was calculated as a PLC lower than 1.0 × 10
    Results: A total of 57 patients were eligible and included in the analyses. The median PLC was significantly decreased following chemoradiotherapy (2180/mm
    Conclusion: Although iatrogenic immunosuppression could be associated with inferior clinical outcomes, our data show that treatment-related lymphopenia does not adversely affect GBM survival. Prospective studies are required to confirm these findings.
    MeSH term(s) Brain Neoplasms/radiotherapy ; Chemoradiotherapy/adverse effects ; Glioblastoma/therapy ; Humans ; Lymphopenia/etiology ; Temozolomide/adverse effects
    Chemical Substances Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2021-10-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-021-01855-5
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  8. Article ; Online: Early 7-day supplemental parenteral nutrition improves body composition and muscle strength in hypophagic cancer patients at nutritional risk.

    Caccialanza, Riccardo / Cereda, Emanuele / Caraccia, Marilisa / Klersy, Catherine / Nardi, Mariateresa / Cappello, Silvia / Borioli, Valeria / Turri, Annalisa / Imarisio, Ilaria / Lasagna, Angioletta / Saddi, Jessica / Arcaini, Luca / Benazzo, Marco / Stragliotto, Silvia / Zagonel, Vittorina / Pedrazzoli, Paolo

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2018  Volume 27, Issue 7, Page(s) 2497–2506

    Abstract: Purpose: The international guidelines recommend the use of supplemental parenteral nutrition (SPN) in cancer patients when they are malnourished and hypophagic and where enteral nutrition is not feasible. However, there are limited data on the short- ... ...

    Abstract Purpose: The international guidelines recommend the use of supplemental parenteral nutrition (SPN) in cancer patients when they are malnourished and hypophagic and where enteral nutrition is not feasible. However, there are limited data on the short-term effects of SPN in this patient population.
    Methods: The aim of this bicentric single-arm clinical trial (NCT02828150) was to evaluate the effects of early 7-day SPN on bioimpedance vectorial analysis (BIVA)-derived body composition, handgrip strength (HG), and serum prealbumin (PAB) in 131 hypophagic, hospitalized cancer patients at nutritional risk, with contraindications for enteral nutrition.
    Results: One hundred eighteen patients (90.1%) completed the 7-day SPN support regimen and 102 of them (86.4%) were in advanced disease stage. SPN induced a significant improvement of phase angle (PhA, + 0.25 [95% CI 0.11, 0.39]; p = 0.001), standardized phase angle (SPA, + 0.33 [95% CI 0.13, 0.53]; p = 0.002), HG (+ 2.1 kg -95% CI 1.30, 2.81]; p < 0.001), and PAB (+ 3.8 mg/dL [95% CI 2.1, 5.6]; p < 0.001). In multivariable analysis, the effects on BIVA parameters were more pronounced in patients (N = 90, 76.3%) in whom estimated protein and calorie requirements were both satisfied (adjusted difference: PhA, + 0.39 [95% CI 0.04, 0.73]; p = 0.030; SPA, + 0.62 [95% CI 0.16, 1.09]; p = 0.009). No significant changes in hydration status were detected and no severe metabolic or other complications occurred.
    Conclusions: Early 7-day SPN resulted in improved body composition, HG and PAB levels in hypophagic, and hospitalized cancer patients at nutritional risk in the absence of any relevant clinical complications. Further trials, aimed at verifying the efficacy of this early nutritional intervention on mid- and long-term primary clinical endpoints in specific cancer types, are warranted.
    MeSH term(s) Aged ; Body Composition/physiology ; Dietary Supplements ; Female ; Humans ; Male ; Middle Aged ; Muscle Strength/physiology ; Neoplasms/diet therapy ; Neoplasms/pathology ; Nutritional Requirements ; Parenteral Nutrition/methods
    Language English
    Publishing date 2018-11-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-018-4527-0
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