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Article ; Online: In silico identification of novel pre-microRNA genes in Rift valley fever virus suggest new pathomechanisms for embryo-fetal dysgenesis.

Sadeghi, Balal / Groschup, Martin H / Eiden, Martin

2024 Volume 15, Issue 1, Page(s) 2329447

Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that regulate the post-transcriptional expression of target genes. Virus-encoded miRNAs play an important role in the replication of viruses, modulate gene expression in both the virus and host, and affect ... ...

Abstract	MicroRNAs (miRNAs) are small non-coding RNAs that regulate the post-transcriptional expression of target genes. Virus-encoded miRNAs play an important role in the replication of viruses, modulate gene expression in both the virus and host, and affect their persistence and immune evasion in hosts. This renders viral miRNAs as potential targets for therapeutic applications, especially against pathogenic viruses that infect humans and animals. Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic RNA virus that causes severe disease in both humans and livestock. High mortality among newborn lambs and abortion storms are key characteristics of an RVF outbreak. To date, limited information is available on RVFV-derived miRNAs. In this study, computational methods were used to analyse the RVFV genome for putative pre-miRNA genes, which were then analysed for the presence of mature miRNAs. We detected 19 RVFV-encoded miRNAs and identified their potential mRNAs targets in sheep (
MeSH term(s)	Humans ; Pregnancy ; Female ; Animals ; Sheep/genetics ; Rift Valley fever virus/genetics ; Rift Valley Fever/genetics ; Rift Valley Fever/epidemiology ; Culicidae/genetics ; Disease Outbreaks ; MicroRNAs/genetics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2657572-3
ISSN	2150-5608 ; 2150-5594
ISSN (online)	2150-5608
ISSN	2150-5594
DOI	10.1080/21505594.2024.2329447
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In silico identification of novel pre-microRNA genes in Rift valley fever virus suggest new pathomechanisms for embryo-fetal dysgenesis

Sadeghi, Balal / Groschup, Martin H. / Eiden, Martin

2024

Abstract	MicroRNAs (miRNAs) are small non-coding RNAs that regulate the post-transcriptional expression of target genes. Virus-encoded miRNAs play an important role in the replication of viruses, modulate gene expression in both the virus and host, and affect their persistence and immune evasion in hosts. This renders viral miRNAs as potential targets for therapeutic applications, especially against pathogenic viruses that infect humans and animals. Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic RNA virus that causes severe disease in both humans and livestock. High mortality among newborn lambs and abortion storms are key characteristics of an RVF outbreak. To date, limited information is available on RVFV-derived miRNAs. In this study, computational methods were used to analyse the RVFV genome for putative pre-miRNA genes, which were then analysed for the presence of mature miRNAs. We detected 19 RVFV-encoded miRNAs and identified their potential mRNAs targets in sheep (Ovis aries), the most susceptible host. The identification of significantly enriched O. aries genes in association with RVFV miRNAs will help elucidate the molecular mechanisms underlying RVFV pathogenesis and potentially uncover novel drug targets for RVFV.
Keywords	article ; Text ; ddc:570 ; Animals ; Sheep ; Humans ; Culicidae ; Rift Valley fever virus ; Rift Valley Fever ; MicroRNAs ; Disease Outbreaks ; Pregnancy ; Female ; MicroRNA ; Computational Data Analysis
Subject code	570
Language	English
Publishing date	2024-03-28
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Audio / Video ; Online: Analyzing Usutu virus evolution and recent common ancestors in Germany using efficient surveillance strategies and next generation sequencing

Bergmann, Felicitas* / Holicki, Cora / Groschup, Martin H. / Ziegler, Ute / Sadeghi, Balal

[Poster]

2024

Keywords	Text ; ddc:570
Language	English
Publishing date	2024-03-25
Publishing country	de
Document type	Book ; Audio / Video ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Computational study of zebrafish immune-targeted microarray data for prediction of preventive drug candidates.

Ebrahimpour Gorji, Abdolvahab / Roudbari, Zahra / Ebrahimpour Gorji, Fatemeh / Sadeghi, Balal

Veterinary research forum : an international quarterly journal

2021 Volume 12, Issue 1, Page(s) 87–93

Abstract: Viral hemorrhagic septicemia virus (VHSV) is a rhabdovirus reported to cause economic loss in fish farms. Because of the lack of adequate preventative treatments, the identification of multipath genes involved in VHS infection might be an alternative to ... ...

Abstract	Viral hemorrhagic septicemia virus (VHSV) is a rhabdovirus reported to cause economic loss in fish farms. Because of the lack of adequate preventative treatments, the identification of multipath genes involved in VHS infection might be an alternative to explore the possibility of using drugs for the seasonal prevention of this fish disease. We propose labeling a category of drug molecules by further classification and interpretation of the Drug Gene Interaction Database using gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment scores. The study investigated disease networks of up-and down-regulated genes to find those with high interaction as substantial genes in pathways among the different disease networks. We prioritized these genes based on their relationship to those associated with VHS infection in the context of human protein-protein interaction networks and disease pathways. Among the 29 genes as potential drug targets, nine were selected as promising druggable genes (
Language	English
Publishing date	2021-03-15
Publishing country	Iran
Document type	Journal Article
ISSN	2008-8140
ISSN	2008-8140
DOI	10.30466/vrf.2019.94179.2270
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Article: Baseline of Physiological Body Temperature and Hematological Parameters in Captive

Rissmann, Melanie / Friedrichs, Virginia / Kley, Nils / Straube, Martin / Sadeghi, Balal / Balkema-Buschmann, Anne

Frontiers in physiology

2022 Volume 13, Page(s) 910157

Abstract: The discovery of bats as reservoir hosts for a number of highly pathogenic zoonotic agents has led to an increasing interest of infectious disease research in experimental studies with bats. Therefore, we established breeding colonies ... ...

Abstract	The discovery of bats as reservoir hosts for a number of highly pathogenic zoonotic agents has led to an increasing interest of infectious disease research in experimental studies with bats. Therefore, we established breeding colonies of
Language	English
Publishing date	2022-08-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.910157
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Article: Longitudinal Study of the Occurrence of Usutu Virus and West Nile Virus Infections in Birds in a Zoological Garden in Northern Germany.

Bergmann, Felicitas / Schmoock-Wellhausen, Martina / Fast, Christine / Holicki, Cora M / Michel, Friederike / Wysocki, Patrick / Sadeghi, Balal / Groschup, Martin H / Ziegler, Ute

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Usutu virus (USUV) and West Nile virus (WNV) are known to cause diseases and mortalities in bird populations. Since 2010/2011, USUV has circulated in Germany and spread nationwide, while WNV was only introduced into East Germany in 2018. The zoological ... ...

Abstract	Usutu virus (USUV) and West Nile virus (WNV) are known to cause diseases and mortalities in bird populations. Since 2010/2011, USUV has circulated in Germany and spread nationwide, while WNV was only introduced into East Germany in 2018. The zoological garden investigated is located in Northern Germany, where USUV infections in wild birds have been detected for several years. In this longitudinal study conducted over a four-year period, zoo birds were sampled biannually and screened for molecular and serological evidence of USUV and WNV. USUV genomes were detected in eight of the sampled birds and whole-genome sequences revealed the circulation of USUV lineages Europe 3 and Africa 3. Of the eight birds infected with USUV during the study period, four died after the infection, while four survived without displaying clinical signs. Furthermore, in a few of the birds, a USUV (re-)infection was confirmed on a serological level with three birds producing USUV-neutralizing antibodies (nAbs) over a period of four years. Nonetheless, in two birds sampled throughout this longitudinal study, neither a USUV nor a WNV infection was evident. In 2022, WNV nAbs were detected for the first time in a juvenile zoo bird, indicating the introduction of the virus into this region.
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12060753
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Article ; Online: Survey of Common Infectious Diseases in Urban Foxes (Vulpes spp.) in Southeastern Iran.

Akhtardanesh, Baharak / Khedri, Javad / Tokasi, Mahya / Tazerji, Sina Salajegheh / Shokrollahi, Nasim / Sadeghi, Balal / Poursina, Mansour / Malik, Yashpal Singh / Hajipour, Pouneh

Journal of wildlife diseases

2023 Volume 60, Issue 1, Page(s) 77–85

Abstract: The red fox (Vulpes vulpes) is one of the most common species of wild Canidae and is relatively abundant in Iran. Foxes (Vulpes spp.) transmit many zoonotic diseases, the most important of which are visceral leishmaniasis, rabies, hydatidosis, ... ...

Abstract	The red fox (Vulpes vulpes) is one of the most common species of wild Canidae and is relatively abundant in Iran. Foxes (Vulpes spp.) transmit many zoonotic diseases, the most important of which are visceral leishmaniasis, rabies, hydatidosis, toxocariasis, and trichinellosis. In this study, visceral leishmaniasis, rabies, ectoparasites, canine gastrointestinal helminths, dermatophytosis, distemper, parvovirus infection, and heartworm infections were evaluated among live-trapped and rescued foxes injured by traffic road accidents referred to the teaching hospital of Kerman, Iran, veterinary faculty. Skin scraping and direct microscopic examination were used to detect ectoparasites and dermatophytosis. Immunochromatography rapid kits were used to detect dirofilariasis, parvovirus infection, and distemper. Necropsy was used to check for gastrointestinal parasites. Rabies and visceral leishmaniosis were screened for with direct fluorescent antibody test and ELISA methods, respectively. Gastrointestinal helminth infections, including Toxocara canis, Taenia taeniaeformis, Dipylidium caninum, Joyeuxiella echinorhyncoids, Toxascaris leonina, Taenia hydatigena, Echinococcus granulosus, Rictolaria spp., Oxynema spp., Macracanthorhynchus hirudinaceus, and Physaloptera spp., were detected. Skin scrapings showed dermatophytosis and various ectoparasites, including Rhipicephalus sanguineus, Ctenocephalides canis and Ctenocephalides felis, and Sarcoptes scabiei, in foxes with dermal lesions. Distemper and parvovirus infection (26.66%) were the common viral diseases, and rabies infection rate was quite high (16.66%). Dirofilariasis and leishmaniasis were detected in 10% of the population. This study showed that urban foxes which often cohabit with humans and domestic animals are carriers of many different pathogens. This interaction may facilitate indirect cross-species transmission of zoonotic disease. Periodic health monitoring and multidisciplinary cooperation for the diagnosis, control, and prevention of these zoonoses is highly recommended.
MeSH term(s)	Humans ; Animals ; Dogs ; Foxes/parasitology ; Dirofilariasis ; Distemper ; Iran/epidemiology ; Leishmaniasis, Visceral/veterinary ; Rabies/veterinary ; Zoonoses ; Helminths ; Cestoda ; Parvoviridae Infections/veterinary ; Tinea/veterinary ; Prevalence ; Dog Diseases/epidemiology
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	410709-3
ISSN	1943-3700 ; 0090-3558
ISSN (online)	1943-3700
ISSN	0090-3558
DOI	10.7589/JWD-D-23-00028
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Article: Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysis

Adhami, Masoumeh / Sadeghi, Balal / Rezapour, Ali / Haghdoost, Ali Akbar / MotieGhader, Habib

BMC biotechnology. 2021 Dec., v. 21, no. 1

2021

Abstract: BACKGROUND: The coronavirus disease-19 (COVID-19) emerged in Wuhan, China and rapidly spread worldwide. Researchers are trying to find a way to treat this disease as soon as possible. The present study aimed to identify the genes involved in COVID-19 and ...

Abstract	BACKGROUND: The coronavirus disease-19 (COVID-19) emerged in Wuhan, China and rapidly spread worldwide. Researchers are trying to find a way to treat this disease as soon as possible. The present study aimed to identify the genes involved in COVID-19 and find a new drug target therapy. Currently, there are no effective drugs targeting SARS-CoV-2, and meanwhile, drug discovery approaches are time-consuming and costly. To address this challenge, this study utilized a network-based drug repurposing strategy to rapidly identify potential drugs targeting SARS-CoV-2. To this end, seven potential drugs were proposed for COVID-19 treatment using protein-protein interaction (PPI) network analysis. First, 524 proteins in humans that have interaction with the SARS-CoV-2 virus were collected, and then the PPI network was reconstructed for these collected proteins. Next, the target miRNAs of the mentioned module genes were separately obtained from the miRWalk 2.0 database because of the important role of miRNAs in biological processes and were reported as an important clue for future analysis. Finally, the list of the drugs targeting module genes was obtained from the DGIDb database, and the drug-gene network was separately reconstructed for the obtained protein modules. RESULTS: Based on the network analysis of the PPI network, seven clusters of proteins were specified as the complexes of proteins which are more associated with the SARS-CoV-2 virus. Moreover, seven therapeutic candidate drugs were identified to control gene regulation in COVID-19. PACLITAXEL, as the most potent therapeutic candidate drug and previously mentioned as a therapy for COVID-19, had four gene targets in two different modules. The other six candidate drugs, namely, BORTEZOMIB, CARBOPLATIN, CRIZOTINIB, CYTARABINE, DAUNORUBICIN, and VORINOSTAT, some of which were previously discovered to be efficient against COVID-19, had three gene targets in different modules. Eventually, CARBOPLATIN, CRIZOTINIB, and CYTARABINE drugs were found as novel potential drugs to be investigated as a therapy for COVID-19. CONCLUSIONS: Our computational strategy for predicting repurposable candidate drugs against COVID-19 provides efficacious and rapid results for therapeutic purposes. However, further experimental analysis and testing such as clinical applicability, toxicity, and experimental validations are required to reach a more accurate and improved treatment. Our proposed complexes of proteins and associated miRNAs, along with discovered candidate drugs might be a starting point for further analysis by other researchers in this urgency of the COVID-19 pandemic.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antiviral agents ; daunorubicin ; drug development ; gene expression regulation ; gene targeting ; gene therapy ; microRNA ; new drugs ; paclitaxel ; pandemic ; protein-protein interactions ; toxicity
Language	English
Dates of publication	2021-12
Size	p. 22.
Publishing place	BioMed Central
Document type	Article
ISSN	1472-6750
DOI	10.1186/s12896-021-00680-z
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Impact of animal saliva on the performance of rapid antigen tests for detection of SARS-CoV-2 (wildtype and variants B.1.1.7 and B.1.351)

Hagag, Ibrahim T. / Weber, Saskia / Sadeghi, Balal / Groschup, Martin H. / Keller, Markus

[Manuscript Draft]

2023

Keywords	Text ; ddc:630 ; SARS-CoV-2 ; Real-time RT-PCR ; Rapid Antigen Assays ; Saliva ; Variants of Concern (VoC)
Language	English
Publishing date	2023-03-31
Publisher	Zenodo
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Impact of animal saliva on the performance of rapid antigen tests for detection of SARS-CoV-2 (wildtype and variants B.1.1.7 and B.1.351)

Hagag, Ibrahim T. / Weber, Saskia / Sadeghi, Balal / Groschup, Martin H. / Keller, Markus

Veterinary microbiology. 2021 Nov., v. 262

2021

Abstract: SARS-CoV-2 infects several animal species and SARS-CoV-2 variants of concern (VOCs) may even show (as in humans) enhanced inter- and intra-species transmission rates. We correlated sensitivity data of SARS-CoV-2 rapid antigen tests (RATs) to viral RNA ... ...

Abstract	SARS-CoV-2 infects several animal species and SARS-CoV-2 variants of concern (VOCs) may even show (as in humans) enhanced inter- and intra-species transmission rates. We correlated sensitivity data of SARS-CoV-2 rapid antigen tests (RATs) to viral RNA genome equivalents analyzed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Further, we checked their suitability for testing animals by assessing saliva and VOC effects. Viral loads up to 2 logs (RNA copy number) under the hypothetical SARS-CoV-2 infectivity threshold were detected by most analyzed RATs. However, while saliva from various animal species showed generally no adverse effects on the RATs’ analytical sensitivities, the detection of VOCs B.1.1.7 and B.1.351 was in some RATs inferior to non-VOC viruses.
Keywords	RNA ; Severe acute respiratory syndrome coronavirus 2 ; antigens ; genome ; pathogenicity ; reverse transcriptase polymerase chain reaction ; saliva
Language	English
Dates of publication	2021-11
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2021.109243
Database	NAL-Catalogue (AGRICOLA)

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