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  1. AU="Sadia, Aatika"
  2. AU="Kay, Emma Sophia"
  3. AU="Yin, Fanghao"
  4. AU="Alawneh, Firas"
  5. AU="Gonzalez-Rivas, Diego"
  6. AU="Mathapati, Basavaraj"
  7. AU="Ogiwara, Yamato"
  8. AU="Jardim, M."
  9. AU=Round J A
  10. AU=Zhang Huan AU=Zhang Huan
  11. AU="Khalilzad, Mohammad"
  12. AU="Safrida Safrida"
  13. AU="Sheridan, Krystal"
  14. AU="Spencer, Sandra"
  15. AU="Ikhapoh, Izuagie"
  16. AU="Jabeen, Nyla"
  17. AU="Elaine Mary Cowan"
  18. AU="Marcos Federico Pascuali"
  19. AU="Shi, Zhuqing"
  20. AU="Bernard Rosner"
  21. AU="van de Schoor, F."
  22. AU="Strzelecki, Antoine"
  23. AU=Cheung P Y
  24. AU="Arima, Tetsuhiko"
  25. AU="José Del Castillo Diego, Julio"
  26. AU="Han, Shujie"
  27. AU="Hernandez-Garcia, Elena"
  28. AU="Mansfield, Sara A"
  29. AU="Igarashi, Miyako"
  30. AU="Eloisa Romano"

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  1. Artikel ; Online: Therapeutic dilemma in the repression of severe acute respiratory syndrome coronavirus-2 proteome.

    Sadia, Aatika / Basra, Muhammad Asim Raza

    Drug development research

    2020  Band 81, Heft 8, Seite(n) 942–949

    Abstract: Currently, the pandemic coronavirus disease 2019 (COVID-19) has unprecedentedly captivated its human hosts by causing respiratory illnesses because of evolution of the genetic makeup of novel coronavirus (CoV) known as severe acute respiratory syndrome ... ...

    Abstract Currently, the pandemic coronavirus disease 2019 (COVID-19) has unprecedentedly captivated its human hosts by causing respiratory illnesses because of evolution of the genetic makeup of novel coronavirus (CoV) known as severe acute respiratory syndrome coronavirus-2 (SARS CoV-2). As much as the researchers are inundated for the quest of effective treatments from available drugs, the discovery and trials of new experimental drugs are also at a threshold for clinical trials. There has been much concern regarding the new and targeted drugs considering the comprehensive ambiguity regarding the mechanism and pathway of the drug action with respect to the new and unpredictable structural and nonstructural proteins (NSPs) of SARS CoV-2. This study was aimed to discuss functional pathways related to NSPs in CoVs with updated knowledge regarding SARS CoV-2, mechanisms of action of certain approved and investigational drugs for correct orientation regarding the treatment strategies, including nucleotide analog mechanism, receptor analog mechanism, and peptide-peptide interactions, along with the impact of COVID-19 on a global scale. Although there is a dire need for targeted drugs against SARS CoV-2, the practical achievement of its cure is possible by only using effective drugs with appropriate mechanisms to eliminate the disease.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/ddr.21710
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Therapeutic dilemma in the repression of severe acute respiratory syndrome coronavirus-2 proteome

    Sadia, Aatika / Basra, Muhammad Asim Raza

    Drug dev. res

    Abstract: Currently, the pandemic coronavirus disease 2019 (COVID-19) has unprecedentedly captivated its human hosts by causing respiratory illnesses because of evolution of the genetic makeup of novel coronavirus (CoV) known as severe acute respiratory syndrome ... ...

    Abstract Currently, the pandemic coronavirus disease 2019 (COVID-19) has unprecedentedly captivated its human hosts by causing respiratory illnesses because of evolution of the genetic makeup of novel coronavirus (CoV) known as severe acute respiratory syndrome coronavirus-2 (SARS CoV-2). As much as the researchers are inundated for the quest of effective treatments from available drugs, the discovery and trials of new experimental drugs are also at a threshold for clinical trials. There has been much concern regarding the new and targeted drugs considering the comprehensive ambiguity regarding the mechanism and pathway of the drug action with respect to the new and unpredictable structural and nonstructural proteins (NSPs) of SARS CoV-2. This study was aimed to discuss functional pathways related to NSPs in CoVs with updated knowledge regarding SARS CoV-2, mechanisms of action of certain approved and investigational drugs for correct orientation regarding the treatment strategies, including nucleotide analog mechanism, receptor analog mechanism, and peptide-peptide interactions, along with the impact of COVID-19 on a global scale. Although there is a dire need for targeted drugs against SARS CoV-2, the practical achievement of its cure is possible by only using effective drugs with appropriate mechanisms to eliminate the disease.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #654645
    Datenquelle COVID19

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  3. Artikel: Synthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor.

    Samra, Malka M / Sadia, Aatika / Azam, Muhammad / Imran, Muhammad / Ahmad, Irfan / Basra, Muhammad Asim Raza

    Arabian journal for science and engineering

    2022  Band 47, Heft 6, Seite(n) 7105–7122

    Abstract: Drug development on basis of coordination compounds provides versatile structural and functional properties as compared to other organic compounds. In the present study, a new Ca(II) complex of meloxicam was synthesized and characterized by elemental ... ...

    Abstract Drug development on basis of coordination compounds provides versatile structural and functional properties as compared to other organic compounds. In the present study, a new Ca(II) complex of meloxicam was synthesized and characterized by elemental analysis, FT-IR, UV-Vis,
    Sprache Englisch
    Erscheinungsdatum 2022-01-19
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ISSN 2193-567X
    ISSN 2193-567X
    DOI 10.1007/s13369-021-06521-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Teicoplanin is a potential inhibitor of SARS CoV-2 replication enzymes

    Basra, MuhammadAsim Raza / Sadia, Aatika / Azam, Muhammad

    Asian Pacific Journal of Tropical Biomedicine

    A docking study

    2020  Band 10, Heft 12, Seite(n) 563

    Schlagwörter Biochemistry, Genetics and Molecular Biology (miscellaneous) ; covid19
    Sprache Englisch
    Verlag Medknow
    Erscheinungsland in
    Dokumenttyp Artikel ; Online
    ISSN 2221-1691
    DOI 10.4103/2221-1691.294093
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Working memory span and receptive vocabulary assessment in Urdu speaking children with speech sound disorder.

    Yasmin, Tahira / Hafeez, Huma / Sadia, Aatika / Lubna, Mubarak / Tarar, Sharmeen Aslam / Raza, Muhammad Hashim / Basra, Muhammad Asim Raza

    Acta psychologica

    2022  Band 231, Seite(n) 103777

    Abstract: Emerging evidence suggests that impaired speech may be related to reduced working memory (WM). The current study aimed to validate and compare the influence of articulation, short-term memory (STM), WM, and receptive vocabulary abilities of Pakistani ... ...

    Abstract Emerging evidence suggests that impaired speech may be related to reduced working memory (WM). The current study aimed to validate and compare the influence of articulation, short-term memory (STM), WM, and receptive vocabulary abilities of Pakistani children with speech sound disorder (SSD; N = 50) versus typically developing (TD; N = 30) children aged 7-13 years. Assessments included the Test for Assessment of Articulation and Phonology in Urdu (TAAPU), Peabody Picture Vocabulary Test-4, translated to Urdu (U-PPVT-4), and Digit Memory Test (DMT) used to determine speech articulation, receptive vocabulary, and memory abilities respectively. The percentage correct consonants (PCC) score was used to divide the SSD group further into SSD severity groups. The TD and SSD groups significantly differed in performance on all tasks (p < 0.05). Moreover, the SSD severity groups showed significant differences (p < 0.0001) in performance on different components of TAAPU (total errors and substitution errors) and DMT tasks. However, the SSD severity groups did not show significant differences in performance on the U-PPVT-4. Correlational analyses indicate statistically significant correlations of PCC with STM, WM, and receptive vocabulary. Regression analyses suggested that both WM and STM contribute to speech intelligibility in children with SSD. Our findings in Urdu-speaking children support previous results in English-speaking children suggesting the articulation skills, receptive vocabulary, STM, and WM were less developed in children with SSD than in TD children.
    Sprache Englisch
    Erscheinungsdatum 2022-11-07
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1480049-4
    ISSN 1873-6297 ; 0001-6918
    ISSN (online) 1873-6297
    ISSN 0001-6918
    DOI 10.1016/j.actpsy.2022.103777
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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