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  1. Article: Hemostatic spray as a therapy for pancreatic stump bleeding after cephalic duodenopancreatectomy.

    Falcão, Daniela / Ferreira, Daniela / Maia, Luís / Sadio, Ana / Pedroto, Isabel

    Revista espanola de enfermedades digestivas

    2022  Volume 115, Issue 8, Page(s) 456–457

    Abstract: A 70-year-old man with a cholangiocarcinoma underwent a cephalic duodenopancreatectomy. On the 2nd postoperative day, he had hematemesis without hemodynamic instability. Upper endoscopy (EGD) revealed a massive clot at the pancreatic stump, suspected as ... ...

    Abstract A 70-year-old man with a cholangiocarcinoma underwent a cephalic duodenopancreatectomy. On the 2nd postoperative day, he had hematemesis without hemodynamic instability. Upper endoscopy (EGD) revealed a massive clot at the pancreatic stump, suspected as the source of hemorrhage. After partial clot removal, no active bleeding was found and no therapy was performed. Pancreaticogastric and gastrojejunal anastomoses, as well as the efferent-limb, showed no suspicious lesions. Octreotide was initiated and heparin prophylaxis was temporarily stopped. Bleeding from pancreatic stump following pancreatoduodenectomy is a rare but a life-threatening condition. Conventional endoscopic therapies, including clip placement and cautery, are mostly ineffective and with high risk of pancreatitis. We report the second case of hemostatic powder as a safe and successful therapy in this scenario.
    MeSH term(s) Male ; Humans ; Aged ; Pancreaticoduodenectomy/adverse effects ; Hemostatics/therapeutic use ; Pancreas/surgery ; Hematemesis ; Pancreatitis ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy
    Chemical Substances Hemostatics
    Language English
    Publishing date 2022-11-03
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2022.9249/2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Small bowel obstruction: a hard diagnosis!

    Sadio, Ana / Peixoto, Paula / Pinho, Helena

    Gastroenterology

    2009  Volume 137, Issue 6, Page(s) e5–6

    MeSH term(s) Aged ; Colonoscopy ; Digestive System Surgical Procedures ; Duodenum/diagnostic imaging ; Duodenum/pathology ; Female ; Gallstones/complications ; Gallstones/diagnosis ; Gallstones/surgery ; Humans ; Ileum/diagnostic imaging ; Ileum/pathology ; Ileus/diagnosis ; Ileus/etiology ; Ileus/surgery ; Radiography ; Treatment Outcome
    Language English
    Publishing date 2009-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2009.04.065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution.

    Sadio, Ana / Amaral, Ana L / Nunes, Rute / Ricardo, Sara / Sarmento, Bruno / Almeida, Raquel / Tsukamoto, Hidekazu / das Neves, José

    Frontiers in physiology

    2016  Volume 7, Page(s) 579

    Abstract: The oral route is the most preferable one when it comes to drug administration. Different animal models have been used to characterize the fate of potential medicines upon oral delivery but fail to clarify specific events occurring at localized sites of ... ...

    Abstract The oral route is the most preferable one when it comes to drug administration. Different animal models have been used to characterize the fate of potential medicines upon oral delivery but fail to clarify specific events occurring at localized sites of the gastrointestinal tract, particularly at the small intestine. We developed a new mouse intra-intestinal infusion model that enabled the direct administration of substances (such as drugs or nanoparticle drug carriers) in the small intestine through an implanted catheter, which can be maintained for prolonged periods of time. The location of catheter insertion can be previously determined as more proximal or distal, allowing to test specific portions of the intestine. Since the model is presumably able to maintain normal physiological characteristics, namely the mucus coating of the intestinal wall, it allowed studying the distribution of different nanoparticles upon localized intra-intestinal administration. The hereby proposed mouse model has the potential to be useful in other types of studies, namely in clarifying localized processes occurring at specific sites of the intestine.
    Language English
    Publishing date 2016-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2016.00579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Modified-chitosan/siRNA nanoparticles downregulate cellular CDX2 expression and cross the gastric mucus barrier.

    Sadio, Ana / Gustafsson, Jenny K / Pereira, Bruno / Gomes, Carla Pereira / Hansson, Gunnar C / David, Leonor / Pêgo, Ana Paula / Almeida, Raquel

    PloS one

    2014  Volume 9, Issue 6, Page(s) e99449

    Abstract: Development of effective non-viral vectors is of crucial importance in the implementation of RNA interference in clinical routine. The localized delivery of siRNAs to the gastrointestinal mucosa is highly desired but faces specific problems such as the ... ...

    Abstract Development of effective non-viral vectors is of crucial importance in the implementation of RNA interference in clinical routine. The localized delivery of siRNAs to the gastrointestinal mucosa is highly desired but faces specific problems such as the stability in gastric acidity conditions and the presence of the mucus barrier. CDX2 is a transcription factor critical for intestinal differentiation being involved in the initiation and maintenance of gastrointestinal diseases. Specifically, it is the trigger of gastric intestinal metaplasia which is a precursor lesion of gastric cancer. Its expression is also altered in colorectal cancer, where it may constitute a lineage-survival oncogene. Our main objective was to develop a nanoparticle-delivery system of siRNA targeting CDX2 using modified chitosan as a vector. CDX2 expression was assessed in gastric carcinoma cell lines and nanoparticles behaviour in gastrointestinal mucus was tested in mouse explants. We show that imidazole-modified chitosan and trimethylchitosan/siRNA nanoparticles are able to downregulate CDX2 expression and overpass the gastric mucus layer but not colonic mucus. This system might constitute a potential therapeutic approach to treat CDX2-dependent gastric lesions.
    MeSH term(s) Animals ; CDX2 Transcription Factor ; Cell Line, Tumor ; Chitosan/chemistry ; Colon/metabolism ; Down-Regulation ; Gastric Mucosa/metabolism ; Homeodomain Proteins/metabolism ; Humans ; Imidazoles/chemistry ; Mice ; Mucus/metabolism ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; RNA, Small Interfering/metabolism ; Transfection
    Chemical Substances CDX2 Transcription Factor ; CDX2 protein, human ; Homeodomain Proteins ; Imidazoles ; RNA, Small Interfering ; imidazole (7GBN705NH1) ; Chitosan (9012-76-4)
    Language English
    Publishing date 2014-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0099449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Esophageal tuberculosis: an unusual cause of dysphagia.

    Peixoto, Paula C / Ministro, Paula S / Sadio, Ana D / Cancela, Eugénia M / Araújo, Ricardo N / Machado, Joana L / Castanheira, António H / Silva, Américo T / Nunes, Rui D / Carvalho, Maria T / Caldas, António F

    Gastrointestinal endoscopy

    2009  Volume 69, Issue 6, Page(s) 1173–1176

    MeSH term(s) Aged ; Bacteriological Techniques ; Bronchoscopy ; DNA, Bacterial/genetics ; Deglutition Disorders/etiology ; Diagnosis, Differential ; Esophageal Diseases/diagnosis ; Esophagoscopy ; Humans ; Male ; Mycobacterium tuberculosis/genetics ; Polymerase Chain Reaction ; Tuberculosis, Gastrointestinal/diagnosis ; Tuberculosis, Pulmonary/diagnosis
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2009-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2008.06.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 519: Show issues

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