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  1. Article ; Online: 50 years ago in the Journal of Pediatrics: Pleural effusion in the neonatal period. Perry RE, Hodgman J, Cass AB. J Pediatr 1963;62:838-43.

    Sadiq, Farouk H

    The Journal of pediatrics

    2013  Volume 162, Issue 6, Page(s) 1180

    MeSH term(s) Chylothorax/etiology ; Chylothorax/history ; Chylothorax/surgery ; History, 20th Century ; Humans ; Infant, Newborn ; Pleural Effusion/etiology ; Pleural Effusion/history ; Pleural Effusion/surgery
    Language English
    Publishing date 2013-06
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2012.12.081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of Discontinuation of Weekly Surveillance Testing on Methicillin-Resistant Staphylococcus aureus in the NICU.

    Petersen, Rebecca Y / Hillman, Noah H / Sadiq, Farouk H / Brownsworth, Christopher A / Williams, Howard L / Josephsen, Justin B

    American journal of perinatology

    2023  

    Abstract: Objective:  Methicillin-resistant : Study design:  This is a retrospective cohort study of infants admitted to two affiliated NICUs. The ADI cohort infants received weekly nasal MRSA cultures and were placed in contact isolation if MRSA colonized for ...

    Abstract Objective:  Methicillin-resistant
    Study design:  This is a retrospective cohort study of infants admitted to two affiliated NICUs. The ADI cohort infants received weekly nasal MRSA cultures and were placed in contact isolation if MRSA colonized for the duration of their hospitalization. The No Surveillance cohort infants were only placed in isolation if there was active MRSA infection or if MRSA colonization was identified incidentally. The rates of infection were determined between the cohorts.
    Results:  There were 8,406 neonates representing 193,684 NICU days in the comparison period. In the ADI cohort, MRSA colonization occurred in 3.4% of infants and infection occurred in 29 infants (0.4%). There were no differences between cohorts in the percent of infants with a MRSA infection at any site (0.5 vs. 0.5%,
    Conclusion:  The rates of MRSA infection did not change when weekly ADI was discontinued and was associated with a decrease in cost and resource utilization.
    Key points: · Placing MRSA-colonized infants in contact isolation is a common practice.. · Data are limited with respect to efficacy in the NICU.. · This study provides evidence that active detection and contact isolation for MRSA colonization may not be beneficial..
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0043-1763481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effects of Discontinuation of Weekly Surveillance Testing on Methicillin-Resistant Staphylococcus aureus in the NICU

    Petersen, Rebecca Y. / Hillman, Noah H. / Sadiq, Farouk H. / Brownsworth, Christopher A. / Williams, Howard L. / Josephsen, Justin B.

    American Journal of Perinatology

    2023  

    Abstract: Objective: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a major cause of serious morbidity and mortality in the neonatal intensive care unit (NICU). There is no clear consensus on infection control measures. Some approaches to MRSA ... ...

    Abstract Objective: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a major cause of serious morbidity and mortality in the neonatal intensive care unit (NICU). There is no clear consensus on infection control measures. Some approaches to MRSA colonization management may be burdensome with unclear benefits. The objective of this study was to determine if stopping weekly MRSA surveillance with active detection and contact isolation (ADI) was associated with a change in infection rate.
    Study Design: This is a retrospective cohort study of infants admitted to two affiliated NICUs. The ADI cohort infants received weekly nasal MRSA cultures and were placed in contact isolation if MRSA colonized for the duration of their hospitalization. The No Surveillance cohort infants were only placed in isolation if there was active MRSA infection or if MRSA colonization was identified incidentally. The rates of infection were determined between the cohorts.
    Results: There were 8,406 neonates representing 193,684 NICU days in the comparison period. In the ADI cohort, MRSA colonization occurred in 3.4% of infants and infection occurred in 29 infants (0.4%). There were no differences between cohorts in the percent of infants with a MRSA infection at any site (0.5 vs. 0.5%, p  = 0.89), rate of MRSA infections per 1,000 patient-days (0.197 vs. 0.201, p  = 0.92), rate of bloodstream infections (0.12 vs. 0.26%, p  = 0.18), or in the overall mortality rate (3.7 vs. 3.0% p  = 0.13). ADI represented an annual cost of $590,000.
    Conclusion: The rates of MRSA infection did not change when weekly ADI was discontinued and was associated with a decrease in cost and resource utilization.
    Key Points: Placing MRSA-colonized infants in contact isolation is a common practice. Data are limited with respect to efficacy in the NICU. This study provides evidence that active detection and contact isolation for MRSA colonization may not be beneficial.
    Keywords methicillin-resistant ; surveillance ; contact isolation
    Language English
    Publishing date 2023-02-27
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0043-1763481
    Database Thieme publisher's database

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  4. Article ; Online: Budesonide mixed with surfactant did not affect neurodevelopmental outcomes at 6 or 18 months corrected age in observational cohorts.

    Anderson, Connie D / Kothe, T Brett / Josephsen, Justin B / Sadiq, Farouk H / Burleyson, Nikki / Williams, Howard L / Hillman, Noah H

    Journal of perinatology : official journal of the California Perinatal Association

    2021  Volume 41, Issue 7, Page(s) 1681–1689

    Abstract: Background: The addition of budesonide to surfactant in very-low-birth-weight infants with less severe RDS decreased bronchopulmonary dysplasia (BPD) severity. Long-term neurodevelopmental follow-up was needed to monitor for systemic effects of ... ...

    Abstract Background: The addition of budesonide to surfactant in very-low-birth-weight infants with less severe RDS decreased bronchopulmonary dysplasia (BPD) severity. Long-term neurodevelopmental follow-up was needed to monitor for systemic effects of budesonide.
    Methods: Infants ≤1250 g who received intratracheal budesonide (0.25 mg/kg) with surfactant (n = 173) were compared to a historical cohort who received surfactant alone (n = 294). Peabody Developmental Motor Scales II at 4-6 months corrected age and Bayley Scales of Infant & Toddler Development III at 18-22 months corrected age were compared.
    Results: There were no differences in muscle tone or motor skills by Peabody exam. There were no differences in the cognitive, language, or motor domains between cohorts on Bayley III.
    Conclusions: In a cohort of infants treated with budesonide mixed with surfactant, there were no differences in developmental outcomes at 4-6 months or 18-22 months corrected age.
    MeSH term(s) Bronchopulmonary Dysplasia/drug therapy ; Budesonide/adverse effects ; Humans ; Infant ; Infant, Newborn ; Infant, Very Low Birth Weight ; Pulmonary Surfactants ; Surface-Active Agents
    Chemical Substances Pulmonary Surfactants ; Surface-Active Agents ; Budesonide (51333-22-3)
    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-021-01066-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Surfactant and budesonide for respiratory distress syndrome: an observational study.

    Kothe, T Brett / Sadiq, Farouk H / Burleyson, Nikki / Williams, Howard L / Anderson, Connie / Hillman, Noah H

    Pediatric research

    2019  Volume 87, Issue 5, Page(s) 940–945

    Abstract: Background: In preterm infants on moderately high ventilator support, the addition of budesonide to surfactant lowered bronchopulmonary dysplasia (BPD) rates by 20% without increased morbidity or mortality. The aim of this cohort comparison was to ... ...

    Abstract Background: In preterm infants on moderately high ventilator support, the addition of budesonide to surfactant lowered bronchopulmonary dysplasia (BPD) rates by 20% without increased morbidity or mortality. The aim of this cohort comparison was to determine the safety and efficacy of the combination in infants with milder respiratory distress syndrome (RDS).
    Methods: In August 2016 we began administering budesonide (0.25 mg/kg) mixed with surfactant (Survanta 4 mL/kg) to all infants ≤ 1250 g who failed CPAP and required intubation. Infants were compared to a historical cohort (2013-2016) who received surfactant alone.
    Results: BPD or death did not change between the historical surfactant cohort (71%, n = 294) and the budesonide cohort (69%, n = 173). Budesonide was associated with a decrease in the need for continued mechanical ventilation, severe BPD type II or death (19-12%), grade III BPD or death (31-21%), and the median gestational age at discharge was 1 week earlier. Histologic chorioamnionitis was associated with decreased budesonide effects. Secondary morbidities (NEC, IVH, ROP, Sepsis) were similar.
    Conclusion: Overall BPD rates remained unchanged with the addition of budesonide. Budesonide was associated with decreased severity of BPD, decreased mechanical ventilation use, earlier discharge, and similar short-term outcomes.
    MeSH term(s) Bronchopulmonary Dysplasia/drug therapy ; Budesonide/administration & dosage ; Chorioamnionitis ; Female ; Humans ; Infant, Newborn ; Male ; Patient Discharge ; Patient Safety ; Pregnancy ; Pulmonary Surfactants/therapeutic use ; Respiration, Artificial ; Respiratory Distress Syndrome, Newborn/drug therapy ; Respiratory Distress Syndrome, Newborn/metabolism ; Surface-Active Agents/administration & dosage ; Treatment Outcome
    Chemical Substances Pulmonary Surfactants ; Surface-Active Agents ; Budesonide (51333-22-3)
    Language English
    Publishing date 2019-11-12
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-019-0663-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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