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  1. Article ; Online: A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice.

    Sadler, Daniel G / Treas, Lillie / Sikes, James D / Porter, Craig

    American journal of physiology. Endocrinology and metabolism

    2022  Volume 323, Issue 6, Page(s) E517–E528

    Abstract: Typical vivarium temperatures (20-26°C) induce facultative thermogenesis in mice, a process attributable in part to uncoupling protein-1 (UCP1). The impact of modest changes in housing temperature on whole body and adipose tissue energetics in mice ... ...

    Abstract Typical vivarium temperatures (20-26°C) induce facultative thermogenesis in mice, a process attributable in part to uncoupling protein-1 (UCP1). The impact of modest changes in housing temperature on whole body and adipose tissue energetics in mice remains unclear. Here, we determined the effects of transitioning mice from 24°C to 30°C on total energy expenditure and adipose tissue protein signatures. C57BL/6J mice were housed at 24°C for 2 wk and then either remained at 24°C (
    MeSH term(s) Humans ; Male ; Female ; Mice ; Animals ; Uncoupling Protein 1/metabolism ; Proteomics ; Mice, Inbred C57BL ; Thermogenesis ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/metabolism ; Energy Metabolism
    Chemical Substances Uncoupling Protein 1
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00079.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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  2. Article ; Online: (-)-Epicatechin Alters Reactive Oxygen and Nitrogen Species Production Independent of Mitochondrial Respiration in Human Vascular Endothelial Cells.

    Sadler, Daniel G / Barlow, Jonathan / Draijer, Richard / Jones, Helen / Thijssen, Dick H J / Stewart, Claire E

    Oxidative medicine and cellular longevity

    2022  Volume 2022, Page(s) 4413191

    Abstract: Introduction: Vascular endothelial dysfunction is characterised by lowered nitric oxide (NO) bioavailability, which may be explained by increased production of reactive oxygen species (ROS), mitochondrial dysfunction, and altered cell signalling. (-)- ... ...

    Abstract Introduction: Vascular endothelial dysfunction is characterised by lowered nitric oxide (NO) bioavailability, which may be explained by increased production of reactive oxygen species (ROS), mitochondrial dysfunction, and altered cell signalling. (-)-Epicatechin (EPI) has proven effective in the context of vascular endothelial dysfunction, but the underlying mechanisms associated with EPI's effects remain unclear.
    Methods: HUVECs were treated with EPI (0-20 
    Results: Mitochondrial superoxide production without AA was increased 32% and decreased 53% after 5 and 10
    MeSH term(s) Cardiovascular Diseases/physiopathology ; Catechin/metabolism ; Endothelial Cells/metabolism ; Humans ; Mitochondria/metabolism ; Nitrogen/chemistry ; Oxygen/chemistry ; Risk Factors
    Chemical Substances Catechin (8R1V1STN48) ; Nitrogen (N762921K75) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2022/4413191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cocoa-flavanols enhance moderate-intensity pulmonary [Formula: see text] kinetics but not exercise tolerance in sedentary middle-aged adults.

    Sadler, Daniel G / Draijer, Richard / Stewart, Claire E / Jones, Helen / Marwood, Simon / Thijssen, Dick H J

    European journal of applied physiology

    2021  Volume 121, Issue 8, Page(s) 2285–2294

    Abstract: Introduction: Cocoa flavanols (CF) may exert health benefits through their potent vasodilatory effects, which are perpetuated by elevations in nitric oxide (NO) bioavailability. These vasodilatory effects may contribute to improved delivery of blood and ...

    Abstract Introduction: Cocoa flavanols (CF) may exert health benefits through their potent vasodilatory effects, which are perpetuated by elevations in nitric oxide (NO) bioavailability. These vasodilatory effects may contribute to improved delivery of blood and oxygen (O
    Purpose: Therefore, the objective of this study was to examine how CF supplementation impacts pulmonary O
    Methods: We employed a double-blind cross-over, placebo-controlled design whereby 17 participants (11 male, 6 female; mean ± SD, 45 ± 6 years) randomly received either 7 days of daily CF (400 mg) or placebo (PL) supplementation. On day 7, participants completed a series of 'step' moderate- and severe-intensity exercise tests for the determination of [Formula: see text] kinetics.
    Results: During moderate-intensity exercise, the time constant of the phase II [Formula: see text] kinetics ([Formula: see text]) was decreased by 15% in CF as compared to PL (mean ± SD; PL 40 ± 12 s vs. CF 34 ± 9 s, P = 0.019), with no differences in the amplitude of [Formula: see text] (A[Formula: see text]; PL 0.77 ± 0.32 l min
    Conclusion: Our data show that acute CF supplementation enhanced [Formula: see text] kinetics during moderate-, but not severe-intensity exercise in middle-aged participants. These novel effects of CFs, in this demographic, may contribute to improved tolerance of moderate-activity physical activities, which appear commonly present in daily life.
    Trial registration: Registered under ClinicalTrials.gov Identifier no. NCT04370353, 30/04/20 retrospectively registered.
    MeSH term(s) Cacao/metabolism ; Cross-Over Studies ; Double-Blind Method ; Exercise Test ; Exercise Tolerance/physiology ; Female ; Flavanones/metabolism ; Humans ; Male ; Middle Aged ; Oxygen Consumption/drug effects ; Pulmonary Circulation/drug effects ; Sedentary Behavior ; Vasodilation/drug effects
    Chemical Substances Flavanones
    Language English
    Publishing date 2021-05-10
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-021-04682-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.195: Show issues Location:
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  4. Article ; Online: Parental cardiorespiratory fitness influences early life energetics and metabolic health.

    Sadler, Daniel G / Treas, Lillie / Ross, Taylor / Sikes, James D / Britton, Steven L / Koch, Lauren G / Piccolo, Brian D / Børsheim, Elisabet / Porter, Craig

    Physiological genomics

    2023  Volume 56, Issue 2, Page(s) 145–157

    Abstract: High cardiorespiratory fitness (CRF) is associated with a reduced risk of metabolic disease and is linked to superior mitochondrial respiratory function. This study investigated how intrinsic CRF affects bioenergetics and metabolic health in adulthood ... ...

    Abstract High cardiorespiratory fitness (CRF) is associated with a reduced risk of metabolic disease and is linked to superior mitochondrial respiratory function. This study investigated how intrinsic CRF affects bioenergetics and metabolic health in adulthood and early life. Adult rats selectively bred for low and high running capacity [low capacity runners (LCR) and high capacity runners (HCR), respectively] underwent metabolic phenotyping before mating. Weanlings were evaluated at 4-6 wk of age, and whole body energetics and behavior were assessed using metabolic cages. Mitochondrial respiratory function was assessed in permeabilized tissues through high-resolution respirometry. Proteomic signatures of adult and weanling tissues were determined using mass spectrometry. The adult HCR group exhibited lower body mass, improved glucose tolerance, and greater physical activity compared with the LCR group. The adult HCR group demonstrated higher mitochondrial respiratory capacities in the soleus and heart compared with the adult LCR group, which coincided with a greater abundance of proteins involved in lipid catabolism. HCR and LCR weanlings had similar body mass, but HCR weanlings displayed reduced adiposity. In addition, HCR weanlings exhibited better glucose tolerance and higher physical activity levels than LCR weanlings. Higher respiratory capacities were observed in the soleus, heart, and liver tissues of HCR weanlings compared with LCR weanlings, which were not owed to greater mitochondrial content. Proteomic analyses indicated a greater potential for lipid oxidation in the contractile muscles of HCR weanlings. In conclusion, offspring born to parents with high CRF possess an enhanced capacity for lipid catabolism and oxidative phosphorylation, thereby influencing metabolic health. These findings highlight that intrinsic CRF shapes the bioenergetic phenotype with implications for metabolic resilience in early life.
    MeSH term(s) Rats ; Animals ; Cardiorespiratory Fitness ; Proteomics ; Liver/metabolism ; Lipids ; Glucose/metabolism ; Physical Conditioning, Animal/physiology
    Chemical Substances Lipids ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2038823-8
    ISSN 1531-2267 ; 1094-8341
    ISSN (online) 1531-2267
    ISSN 1094-8341
    DOI 10.1152/physiolgenomics.00045.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5697: Show issues Location:
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