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  1. AU="Sadler, Eleanor D"
  2. AU="Thirunavu, Vineeth"
  3. AU="Saługa, Agnieszka"
  4. AU="Liang, Zhen Hua"
  5. AU="Malliaras, Peter"
  6. AU="Juan Prieto-Villalobos"
  7. AU="Blot, Guillaume"
  8. AU="Sanchez, Gabriela"
  9. AU=Mitton Julian A
  10. AU="Han, Hyunho"
  11. AU="Shama, Noura M Abo"
  12. AU=Uehara Akira
  13. AU=Fransen Justin H AU=Fransen Justin H
  14. AU="Memon, Roha Saeed"
  15. AU="Lipworth, Samuel"
  16. AU="Killian, Michael O"
  17. AU=Smaldino Paul E.
  18. AU=Bi Hai
  19. AU="Pintore, Giorgio"
  20. AU="Signorini C."
  21. AU="Mameli, Maria Sabrina"
  22. AU="Yong-ming GAO"
  23. AU="Paquette, Kimberly"
  24. AU="Sharawat, Indar Kumar"
  25. AU="Alexandre Alanio"
  26. AU="Caron, Jeffrey G"
  27. AU="Lubisi, Baratang A"
  28. AU="Edelman, Robert R."
  29. AU="van der Werf, Steffie"
  30. AU="Sam, Andrew"

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  1. Artikel ; Online: An 11-Year Review of Lactobacillus Bacteremia at a Pediatric Tertiary Care Center.

    Hefter, Yosefa / Powell, Lauren / Tabulov, Christine E / Sadler, Eleanor D / Campos, Joseph / Hanisch, Benjamin

    Hospital pediatrics

    2023  Band 13, Heft 6, Seite(n) e140–e143

    Abstract: Objectives: To inform clinical decisions on the use of probiotics in a pediatric inpatient setting, we sought to determine the number of cases of Lactobacillus bacteremia as well as associated patient characteristics in a tertiary-care pediatric ... ...

    Abstract Objectives: To inform clinical decisions on the use of probiotics in a pediatric inpatient setting, we sought to determine the number of cases of Lactobacillus bacteremia as well as associated patient characteristics in a tertiary-care pediatric hospital over an 11-year period.
    Methods: Cases of Lactobacillus bacteremia among admitted patients were identified through positive blood culture reports. The clinical chart for each case was reviewed for presenting symptoms and risk factors such as probiotic use, presence of a central venous catheter, immunocompromised state, impaired intestinal function, and age below 3 months. Concurrent total inpatient probiotic administration was assessed.
    Results: Over an 11-year period, 8 cases of Lactobacillus bacteremia were identified among 127 845 hospital admissions. All cases were associated with systemic signs of infection. Lactobacillus bacteremia patients most frequently had underlying impaired intestinal function and a central venous catheter. Three cases had a history of probiotic use. The peak number of annual cases did not coincide with the peak number of inpatients who received probiotics.
    Conclusions: Lactobacillus bacteremia is uncommon and did not correlate with doses of probiotics-administered in the hospital. However, certain populations may be at higher risk and require extra consideration in clinical decision-making regarding use of probiotics.
    Mesh-Begriff(e) Humans ; Child ; Infant ; Lactobacillus ; Tertiary Care Centers ; Probiotics/therapeutic use ; Risk Factors ; Bacteremia/diagnosis ; Bacteremia/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2023-03-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2154-1671
    ISSN (online) 2154-1671
    DOI 10.1542/hpeds.2022-006892
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Sustained viral suppression with dolutegravir monotherapy in a treatment-experienced adult with perinatally acquired HIV.

    Koay, Wei Li Adeline / Sadler, Eleanor D / Ferrer, Kathleen / Rakhmanina, Natella Y

    BMJ case reports

    2021  Band 14, Heft 11

    Abstract: We report a case of sustained viral suppression with dolutegravir monotherapy in a treatment-experienced adult with perinatally acquired HIV. The patient had recurrent pancreatitis with multiple antiretroviral drugs, leading to discontinuation of ... ...

    Abstract We report a case of sustained viral suppression with dolutegravir monotherapy in a treatment-experienced adult with perinatally acquired HIV. The patient had recurrent pancreatitis with multiple antiretroviral drugs, leading to discontinuation of antiretroviral therapy for several years. She was ultimately initiated on dolutegravir monotherapy two times per day via a gastrostomy tube. She did not develop any integrase strand transfer inhibitor mutations during the first 2 years on dolutegravir monotherapy. The patient has successfully maintained prolonged viral suppression for over 3 years with intermittent blips secondary only to intermittent medical issues. This case is unique in describing a highly treatment-experienced young adult with perinatal HIV infection who has been virally suppressed on dolutegravir monotherapy for a prolonged follow-up of 156 weeks.
    Mesh-Begriff(e) Female ; HIV Infections/drug therapy ; HIV Integrase Inhibitors/therapeutic use ; Heterocyclic Compounds, 3-Ring ; Humans ; Oxazines/therapeutic use ; Piperazines/therapeutic use ; Pyridones/therapeutic use ; Sustained Virologic Response ; Viral Load
    Chemische Substanzen HIV Integrase Inhibitors ; Heterocyclic Compounds, 3-Ring ; Oxazines ; Piperazines ; Pyridones ; dolutegravir (DKO1W9H7M1)
    Sprache Englisch
    Erscheinungsdatum 2021-11-02
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-243685
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Failure modes and effects analysis to improve transitions of care in patients discharged on outpatient parenteral antimicrobial therapy.

    Sadler, Eleanor D / Avdic, Edina / Cosgrove, Sara E / Hohl, Dawn / Grimes, Michael / Swarthout, Meghan / Dzintars, Kathryn / Lippincott, Christopher K / Keller, Sara C

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2021  Band 78, Heft 13, Seite(n) 1223–1232

    Abstract: Purpose: To identify barriers to safe and effective completion of outpatient parenteral antimicrobial therapy (OPAT) in patients discharged from an academic medical center and to develop targeted solutions to potentially resolve or improve the ... ...

    Abstract Purpose: To identify barriers to safe and effective completion of outpatient parenteral antimicrobial therapy (OPAT) in patients discharged from an academic medical center and to develop targeted solutions to potentially resolve or improve the identified barriers.
    Summary: A failure modes and effects analysis (FMEA) was conducted by a multidisciplinary OPAT task force to evaluate the processes for patients discharged on OPAT to 2 postdischarge dispositions: (1) home and (2) skilled nursing facility (SNF). The task force created 2 process maps and identified potential failure modes, or barriers, to the successful completion of each step. Thirteen and 10 barriers were identified in the home and SNF process maps, respectively. Task force members created 5 subgroups, each developing solutions for a group of related barriers. The 5 areas of focus included (1) the OPAT electronic order set, (2) critical tasks to be performed before patient discharge, (3) patient education, (4) patient follow-up and laboratory monitoring, and (5) SNF communication. Interventions involved working with information technology to update the electronic order set, bridging communication and ensuring completion of critical tasks by creating an inpatient electronic discharge checklist, developing patient education resources, planning a central OPAT outpatient database within the electronic medical record, and creating a pharmacist on-call pager for SNFs.
    Conclusion: The FMEA approach was helpful in identifying perceived barriers to successful transitions of care in patients discharged on OPAT and in developing targeted interventions. Healthcare organizations may reproduce this strategy when completing quality improvement planning for this high-risk process.
    Mesh-Begriff(e) Aftercare ; Ambulatory Care ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Healthcare Failure Mode and Effect Analysis ; Humans ; Infusions, Parenteral ; Outpatients ; Patient Discharge
    Chemische Substanzen Anti-Bacterial Agents ; Anti-Infective Agents
    Sprache Englisch
    Erscheinungsdatum 2021-05-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxab165
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Reducing Vancomycin Use in a Level IV NICU.

    Hamdy, Rana F / Bhattarai, Sopnil / Basu, Sudeepta K / Hahn, Andrea / Stone, Brian / Sadler, Eleanor D / Hammer, Benjamin M / Galiote, John / Slomkowski, Julie / Casto, Anne M / Korzuch, Katelyn P / Chase, Hannah / Nzegwu, Nneka / Greenberg, Isabella / Ortiz, Noelle / Blake, Carmen / Chang, Jaeho / Bost, James E / Payne, Asha S /
    Shah, Rahul K / Soghier, Lamia

    Pediatrics

    2020  Band 146, Heft 2

    Abstract: Background and objectives: Vancomycin remains one of the most commonly prescribed antibiotics in NICUs despite recommendations to limit its use for known resistant infections. Baseline data revealing substantially higher vancomycin use in our NICU ... ...

    Abstract Background and objectives: Vancomycin remains one of the most commonly prescribed antibiotics in NICUs despite recommendations to limit its use for known resistant infections. Baseline data revealing substantially higher vancomycin use in our NICU compared to peer institutions informed our quality improvement initiative. Our aim was to reduce the vancomycin prescribing rate in neonates hospitalized in our NICU by 50% within 1 year and sustain for 1 year.
    Methods: In the 60-bed level IV NICU of an academic referral center, we used a quality improvement framework to develop key drivers and interventions including (1) physician education with benchmarking antibiotic prescribing rates; (2) pharmacy-initiated 48-hour antibiotic time-outs on rounds; (3) development of clinical pathways to standardize empirical antibiotic choices for early-onset sepsis, late-onset sepsis, and necrotizing enterocolitis; coupled with (4) daily prospective audit with feedback from the antimicrobial stewardship program.
    Results: We used statistical process u-charts to show vancomycin use declined from 112 to 38 days of therapy per 1000 patient-days. After education, pharmacy-initiated 48-hour time-outs, and development of clinical pathways, vancomycin use declined by 29%, and by an additional 52% after implementation of prospective audit with feedback. Vancomycin-associated acute kidney injury also declined from 1.4 to 0.1 events per 1000 patient-days.
    Conclusions: Through a sequential implementation approach of education, standardization of care with clinical pathways, pharmacist-initiated 48-hour time-outs, and prospective audit with feedback, vancomycin days of therapy declined by 66% over a 1-year period and has been sustained for 1 year.
    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship/organization & administration ; Antimicrobial Stewardship/statistics & numerical data ; Brazil ; Critical Pathways ; Enterocolitis, Necrotizing/drug therapy ; Hospitals, Pediatric/statistics & numerical data ; Hospitals, Urban/statistics & numerical data ; Humans ; Inappropriate Prescribing/prevention & control ; Inappropriate Prescribing/statistics & numerical data ; Infant, Newborn ; Infant, Newborn, Diseases/drug therapy ; Intensive Care Units, Neonatal/statistics & numerical data ; Pharmacy Service, Hospital/organization & administration ; Prospective Studies ; Quality Improvement ; Sepsis/drug therapy ; Vancomycin/therapeutic use
    Chemische Substanzen Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Sprache Englisch
    Erscheinungsdatum 2020-07-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2019-2963
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Um IV Zs.131: Hefte anzeigen Standort:
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