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Article: [The economic burden of depression – study for cost of depression].

Sado, Mitsuhiro

Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica

2014 Volume 116, Issue 2, Page(s) 107–115

MeSH term(s)	Adult ; Age Distribution ; Aged ; Cost-Benefit Analysis ; Depression/economics ; Female ; Humans ; Male ; Middle Aged ; Sex Factors ; Young Adult
Language	Japanese
Publishing date	2014
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604306-9
ISSN	0033-2658
ISSN	0033-2658
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Article ; Online: Effectiveness of mindfulness-based interventions for people with dementia and mild cognitive impairment: A meta-analysis and implications for future research.

Nagaoka, Maki / Hashimoto, Zenta / Takeuchi, Hiroyoshi / Sado, Mitsuhiro

PloS one

2021 Volume 16, Issue 8, Page(s) e0255128

Abstract: Objective: To assess the effectiveness of mindfulness-based interventions on people with dementia and mild cognitive impairment.: Methods: We searched several electronic databases, namely Cochrane Library, EMBASE, and MEDLINE with no limitations for ... ...

Abstract	Objective: To assess the effectiveness of mindfulness-based interventions on people with dementia and mild cognitive impairment. Methods: We searched several electronic databases, namely Cochrane Library, EMBASE, and MEDLINE with no limitations for language or document type (last search: 1 February 2020). Randomized controlled trials of mindfulness-based interventions for people with dementia and mild cognitive impairment compared to active-control interventions, waiting lists, or treatment as usual were included. Predefined outcomes were anxiety symptoms, depressive symptoms, cognitive function, quality of life, mindfulness, ADL and attrition. We used the random effects model (DerSimonian-Laird method) for meta-analysis, reporting effect sizes as Standardized Mean Difference. Heterogeneity was assessed with the I2 statistics. Results: Eight randomized controlled trials, involving 276 patients, met the eligibility criteria and were included in the meta-analysis. We found no significant effects for mindfulness-based interventions in either the short-term or the medium- to long-term on any outcomes, when compared with control conditions. The number of included studies and sample sizes were too small. Additionally, the quality of evidence was low for each randomized controlled trial included in the analysis. This is primarily due to lack of intent-to-treat analysis, high risk of bias, and imprecise study results. The limited statistical power and weak body of evidence prevented us from reaching firm conclusions. Conclusions: We found no significant effects of mindfulness-based interventions on any of the outcomes when compared with control conditions. The evidence concerning the efficacy of mindfulness-based interventions in this population is scarce in terms of both quality and quantity. More well-designed, rigorous, and large-scale randomized controlled trials are needed.
MeSH term(s)	Activities of Daily Living ; Aged ; Aged, 80 and over ; Anxiety/psychology ; Cognition ; Cognitive Dysfunction/physiopathology ; Cognitive Dysfunction/therapy ; Dementia/physiopathology ; Humans ; Mindfulness ; Publication Bias ; Quality of Life ; Research ; Risk
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0255128
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Article: Formulation of a Mapping Formula to Estimate Well-Being Utility from Clinical Subjective Well-Being Scales.

Koreki, Akihiro / Nagaoka, Maki / Ninomiya, Akira / Mimura, Masaru / Sado, Mitsuhiro

Psychology research and behavior management

2022 Volume 15, Page(s) 3233–3241

Abstract: Purpose: Cost-effective analysis is one of the most useful analyses for political decision-making in medicine under a limited budget. Although the data of the ICEpop CAPability measure for Adults (ICECAP-A) is sometimes essential for the measurement of ... ...

Abstract	Purpose: Cost-effective analysis is one of the most useful analyses for political decision-making in medicine under a limited budget. Although the data of the ICEpop CAPability measure for Adults (ICECAP-A) is sometimes essential for the measurement of cost effectiveness, such data are often lacking in most clinical trials. Therefore, a conversion formula (ie mapping) derived from the values of clinical assessment scales into utility is required. Patients and methods: We used an internet survey where 500 general residents were asked to fill in four kinds of self-reported questionnaires [ICECAP-A, the Satisfaction with Life Scale (SWLS), Flourishing Scale (FS), and the Scale of Positive and Negative Experience (SPANE)]. A beta regression was conducted with the utility assessed by ICECAP-A as a dependent variable. Results: We developed several mapping formulae depending on available questionnaires. These mapping formulae were well-validated in our validation sample. The models using a greater number of questionnaires tended to show better mapping. Conclusion: The mapping function of our formula was within the range of other reported mapping studies. We believe this formula is useful for cost effective analyses of several trials where utility data are lacking.
Language	English
Publishing date	2022-11-04
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495093-2
ISSN	1179-1578
ISSN	1179-1578
DOI	10.2147/PRBM.S383266
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Article: Economic Evaluation Alongside a Randomized Controlled Trial of Mindfulness-Based Cognitive Therapy in Healthy Adults.

Nagaoka, Maki / Koreki, Akihiro / Kosugi, Teppei / Ninomiya, Akira / Mimura, Masaru / Sado, Mitsuhiro

Psychology research and behavior management

2023 Volume 16, Page(s) 2767–2785

Abstract: Purpose: This study aimed to conduct an economic evaluation of mindfulness-based cognitive therapy (MBCT) in healthy participants by performing cost-utility analysis (CUA) and cost-benefit analysis (CBA).: Patients and methods: CUA was carried out ... ...

Abstract	Purpose: This study aimed to conduct an economic evaluation of mindfulness-based cognitive therapy (MBCT) in healthy participants by performing cost-utility analysis (CUA) and cost-benefit analysis (CBA). Patients and methods: CUA was carried out from a healthcare sector perspective and CBA was from the employer's perspective in parallel with a randomized controlled trial. Of the 90 healthy participants, 50 met the inclusion criteria and were randomized to the MBCT group (n = 25) or wait-list control group (n = 25). In the CUA, intervention costs and healthcare costs were included, while the mean difference in the change in quality-adjusted life years (QALYs) between the baseline and 16-week follow-up was used as an indicator of effect. Incremental cost-effectiveness ratio (ICER) was produced, and uncertainty was addressed using non-parametric bootstrapping with 5000 replications. In the CBA, the change in productivity losses was reflected as a benefit, while the costs included intervention and healthcare costs. The net monetary benefit was calculated, and uncertainty was handled with 5000 bootstrapping. Healthcare costs were measured with the self-report Health Service Use Inventory. The purchasing power parity in 2019 was used for currency conversion. Results: In the CUA, incremental costs and QALYs were estimated at JPY 19,700 (USD 189) and 0.011, respectively. The ICER then became JPY 1,799,435 (USD 17,252). The probability of MBCT being cost-effective was 92.2% at the threshold of 30,000 UK pounds per QALY. The CBA revealed that MBCT resulted in increased costs (JPY 24,180) and improved work productivity (JPY 130,640), with a net monetary benefit of JPY 106,460 (USD 1021). The probability of the net monetary benefit being positive was 69.6%. Conclusion: The results suggested that MBCT may be more cost-effective from a healthcare sector perspective and may be cost-beneficial from the employer's perspective.
Language	English
Publishing date	2023-07-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495093-2
ISSN	1179-1578
ISSN	1179-1578
DOI	10.2147/PRBM.S406347
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Article ; Online: Is 'dementia-friendly design' cost effective? The results of a preliminary literature review.

Koreki, Akihiro / Sado, Mitsuhiro / Katayama, Nariko / Rutherford, Alasdair / Bowes, Alison

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

2021 Volume 21, Issue 4, Page(s) 691–692

MeSH term(s)	Cost-Benefit Analysis ; Dementia ; Humans
Language	English
Publishing date	2021-04-20
Publishing country	England
Document type	Letter
ZDB-ID	2213105-X
ISSN	1479-8301 ; 1346-3500
ISSN (online)	1479-8301
ISSN	1346-3500
DOI	10.1111/psyg.12698
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Article: Emotional Exhaustion of Burnout Among Medical Staff and Its Association With Mindfulness and Social Support: A Single Center Study During the COVID-19 Pandemic in Japan.

Sampei, Makiko / Okubo, Ryo / Sado, Mitsuhiro / Piedvache, Aurelie / Mizoue, Tetsuya / Yamaguchi, Koushi / Morisaki, Naho

Frontiers in psychiatry

2022 Volume 13, Page(s) 774919

Abstract: Background: Although higher rates of burnout have been reported during the COVID-19 pandemic, the contribution of the modifiable factors is lesser-known. We investigated how the risk of emotional exhaustion was associated with mindfulness skills and ... ...

Abstract	Background: Although higher rates of burnout have been reported during the COVID-19 pandemic, the contribution of the modifiable factors is lesser-known. We investigated how the risk of emotional exhaustion was associated with mindfulness skills and social support in a single medical center in Japan. Methods: We conducted a cross-sectional web survey on mental health for all staff of a national medical hospital from February to March 2021. We examined the association between self-rated emotional exhaustion and levels of mindfulness and social support using multivariate logistic regression. Results: Of the 830 participants, signs of emotional exhaustion were observed in 261 (31%) individuals. Among those highly exposed to the virus at work, individuals with low levels of mindfulness and social support had significantly higher odds of emotional exhaustion [OR 3.46 (95% CI; 1.48-8.09), OR; 3.08 (95% CI; 1.33-7.13), respectively] compared to those with high levels. However, among those not highly exposed to the virus, individuals with both low and moderate levels of mindfulness had significantly higher odds of emotional exhaustion. [OR 3.33 (95% CI; 2.22-5.00), OR; 2.61 (95% CI; 1.73-3.94), respectively]. Conclusion: We found that factors associated with emotional exhaustion differed by exposure to SARS-CoV-2. Building mindfulness skills can help reduce the high burden placed on the staff. Additionally, increasing social support may be useful especially for workers highly exposed to SARS-CoV-2.
Language	English
Publishing date	2022-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2022.774919
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Article ; Online: Does the Combination of the Cognitive Interventions Improve the Function of Daily Living and Save the Long-Term Care Cost? A Pilot Study of Effectiveness and Cost Saving Analysis of "Learning Therapy" for People with Dementia.

Sado, Mitsuhiro / Funaki, Kei / Ninomiya, Akira / Knapp, Martin / Mimura, Masaru

Journal of Alzheimer's disease : JAD

2020 Volume 74, Issue 3, Page(s) 775–784

Abstract: Background: Although the effects of various types of cognitive interventions have been evaluated, effectiveness and cost-saving effect of the combination of the different cognitive interventions is unknown.: Objective: This study aimed to evaluate ... ...

Abstract	Background: Although the effects of various types of cognitive interventions have been evaluated, effectiveness and cost-saving effect of the combination of the different cognitive interventions is unknown. Objective: This study aimed to evaluate the feasibility of conducting a definitive trial to assess the effectiveness of combined cognitive intervention. Methods: A matched controlled trial of learning therapy (LT), a combination of cognitive training and stimulation, was conducted. The samples were recruited from the nursing homes. Inclusion criteria were as follows: age 65 years or older, clinical diagnosis of dementia, level of activities of daily living at II or above, Mini-Mental State Examination score between 10 and 26, receiving long-term-care services without history of LT, and provision of written consent. The primary outcomes were safety, validity of eligibility, retention rate, and effect on the functions of daily living represented by Criterion Time for Certification of Needed Long-Term-Care (CT for CNLTC) at 12 months. Cost-benefit analysis was also conducted to assess the cost saving effect of LT. Results: No serious adverse events were detected. The exclusion rate at the screening phase was 5% and the retention rate was 77% at 12 months. LT demonstrated statistically significant improvement in CT for CNLTC at 12 months (Δ=18.8, almost equivalent to "one" degree of the care needed level) and saved the long-term-care cost by JPY 200,000 (USD 1,618). Conclusions: LT is effective for improving care recipients' level of care needed and has a cost saving effect. A randomized controlled trial is required to verify these findings. Clinical trial registration: This study was approved by the ethics committee at Keio University School of Medicine (ID: 20150061). This trial was registered at University hospital Medical Information Network Clinical Trial Registry (UMIN-CTR ID: UMIN000018223).
MeSH term(s)	Activities of Daily Living/psychology ; Aged ; Aged, 80 and over ; Cognitive Behavioral Therapy/methods ; Cost Savings ; Cost-Benefit Analysis ; Dementia/therapy ; Feasibility Studies ; Female ; Health Care Costs ; Humans ; Long-Term Care/economics ; Male ; Mental Status and Dementia Tests ; Nursing Homes ; Occupational Therapy/methods ; Pilot Projects ; Prospective Studies ; Treatment Outcome
Language	English
Publishing date	2020-03-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-190886
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Article: Are Analogue or Digital Clocks Friendlier for People Living with Dementia?

Koreki, Akihiro / Kusudo, Keisuke / Suzuki, Hisaomi / Nozaki, Shoko / Onaya, Mitsumoto / Bowes, Alison / Sado, Mitsuhiro

Dementia and geriatric cognitive disorders extra

2021 Volume 11, Issue 3, Page(s) 207–212

Abstract: Background: In ageing population, it is desirable to reduce the impact of cognitive decline on daily life. While various types of dementia-friendly environments have been proposed, the question still remains regarding whether analogue or digital clocks ... ...

Abstract	Background: In ageing population, it is desirable to reduce the impact of cognitive decline on daily life. While various types of dementia-friendly environments have been proposed, the question still remains regarding whether analogue or digital clocks are friendlier for people with dementia. Methods: In clinical practice, we normally use our original clock reading test (10 analogue and 10 digital clocks) to assess patients' ability to read a clock. In the present study, a retrospective medical record survey was conducted. Fifty-five participants who had done the test were identified. The result of the test was compared between analogue and digital clocks. Additionally, to assess specific ability to read analogue clocks, an "analogue-digital gap" was defined as the difference between patients' performance for analogue and digital clocks. Univariate and multivariate analyses were conducted to detect significant factors associated with reading ability specific to analogue clocks. Results: The analogue clock proved less readable than the digital clock, even after adjusting for MMSE total score ( Conclusions: In the present study, the digital clock was friendlier than the analogue clock for patients with dementia. Compared to the digital clock, reading analogue clocks might require more widespread cognition, such as working memory and visuospatial processing. While our finding was a general tendency, and individual assessment is necessary, it might help the development of personalized environmental adjustments.
Language	English
Publishing date	2021-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2621464-7
ISSN	1664-5464
ISSN	1664-5464
DOI	10.1159/000518350
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Article ; Online: Cancellation of outpatient appointments in patients with attention-deficit/hyperactivity disorder.

Nomura, Kensuke / Tarumi, Ryosuke / Yoshida, Kazunari / Sado, Mitsuhiro / Suzuki, Takefumi / Mimura, Masaru / Uchida, Hiroyuki

PloS one

2021 Volume 16, Issue 11, Page(s) e0260431

Abstract: Background: Regular visit to psychiatric clinic is essential for successful treatment of any psychiatric condition including attention-deficit/hyperactivity disorder (AD/HD). However, cancellation of outpatient appointments in patients with AD/HD, which ...

Abstract	Background: Regular visit to psychiatric clinic is essential for successful treatment of any psychiatric condition including attention-deficit/hyperactivity disorder (AD/HD). However, cancellation of outpatient appointments in patients with AD/HD, which represents a significant medical loss, has not been systematically investigated to our knowledge. Methods: A systematic chart review was conducted for patients visiting the Shimada Ryoiku medical Center for Challenged Children in Japan at the age of ≤15 years from January to December 2013. The primary outcome measure was the cancellation rate, defined as the number of missed visits divided by the number of scheduled visits. The cancellation rates during 24 months after the first visit were compared between outpatients with AD/HD and other psychiatric disorders, including pervasive developmental disorders (PDD), and developmental coordination disorders and/or communication disorders (DCD-CD). A generalized linear model with binomial distribution was used to examine factors associated with cancellation rates exclusively in the AD/HD group. Results: We included 589 patients (mean ± SD age, 5.6 ± 3.4 years; 432 males) in the analysis. The cancellation rate in patients with AD/HD was 12.3% (95% confidence interval [CI]: 10.0-15.1), which was significantly higher than in those with PDD (5.6%, 95% CI: 3.8-8.3) and DCD-CD (5.3%, 95% CI: 3.6-7.8). Prescriptions of osmotic-release oral system-methylphenidate (OROS-MPH) and antipsychotics were associated with fewer cancellations in AD/HD patients (odds ratios: 0.61, 95% CI: 0.39-0.95 and 0.49, 95% CI: 0.25-0.95, respectively), although these significances did not find in the subgroup analysis including only patients with ≥ 6 years old. Conclusions: Patients with AD/HD were more likely to miss appointments compared to those with other psychiatric disorders. The impact of AD/HD medications as well as potential psychiatric symptoms of their parents or caregivers on appointment cancellations needs to be evaluated in more detail in future investigations.
MeSH term(s)	Ambulatory Care/psychology ; Ambulatory Care/statistics & numerical data ; Attention Deficit Disorder with Hyperactivity/psychology ; Female ; Humans ; Japan ; Male ; Outpatients/psychology ; Outpatients/statistics & numerical data
Language	English
Publishing date	2021-11-19
Publishing country	United States
Document type	Journal Article ; Systematic Review
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0260431
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Article: A Long-Term Pilot Study of Mindfulness-Based Cognitive Therapy for Subjective Well-Being Among Healthy Individuals in Comparison with Clinical Samples.

Sado, Mitsuhiro / Kosugi, Teppei / Ninomiya, Akira / Park, Sunre / Fujisawa, Daisuke / Nagaoka, Maki / Mimura, Masaru

Psychology research and behavior management

2021 Volume 14, Page(s) 1655–1664

Abstract: Purpose: Mindfulness-based cognitive therapy (MBCT) could be an intervention for improving subjective well-being among healthy individuals (HIs). However, MBCT studies for HIs to improve their subjective well-being are rare. The aim of this study was to ...

Abstract	Purpose: Mindfulness-based cognitive therapy (MBCT) could be an intervention for improving subjective well-being among healthy individuals (HIs). However, MBCT studies for HIs to improve their subjective well-being are rare. The aim of this study was to report the feasibility, safety and effectiveness of MBCT for HIs in comparison with clinical samples. Patients and methods: We conducted a single-arm, pre-post comparison pilot study offering MBCT to both HIs and people with common mental disorders. Twenty-four participants in total were included in the study. Eight weekly two-hour sessions with six monthly boosters were offered to all participants. Assessment was carried out at baseline, week 4, 8, and during follow-up. The 5-item World Health Organization Well-Being Index (WHO-5) was the primary clinical outcome measure. Results: The results showed the MBCT is sufficiently safe and would be more feasible in HIs compared to in clinical samples (attendance rate: 81.5% vs 61.3%, p=0.06). Although Satisfaction with Life Scale, the other scale of subjective well-being used, improved significantly at week 20 (p=0.01), no significant improvement was seen in WHO-5. The results of the sub-group analysis revealed WHO-5 improved significantly at week 8 and 32 among the subjects whose baseline scores began in the lower half. Conclusion: MBCT is sufficiently safe and would be more feasible with HIs compared to the clinical samples. In designing randomized controlled trials, selecting HIs with lower subjective well-being would be reasonable to minimize the "ceiling effect" on outcomes.
Language	English
Publishing date	2021-10-08
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495093-2
ISSN	1179-1578
ISSN	1179-1578
DOI	10.2147/PRBM.S318460
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