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  1. Article ; Online: Visfatin Levels May be an Early Marker of Atherosclerosis in Patients with Acromegaly.

    Piskinpasa, Hamide / Okuturlar, Yildiz / Dogansen, Sema Ciftci / Akdeniz, Yasemin Sefika / Esen, Ayse / Sadri, Sogol / Pirhan, Osman / Gemici, Aysegul Akdogan / Serin, Sibel Ocak / Gedikbası, Asuman / Adas, Mine / Mert, Meral

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2019  Volume 51, Issue 10, Page(s) 649–654

    Abstract: The purpose of the study was to compare serum visfatin levels between patients with acromegaly and healthy controls and to evaluate the relationships between visfatin levels and epicardial fat thickness (EFT), carotid intima media thickness (cIMT), and ... ...

    Abstract The purpose of the study was to compare serum visfatin levels between patients with acromegaly and healthy controls and to evaluate the relationships between visfatin levels and epicardial fat thickness (EFT), carotid intima media thickness (cIMT), and ankle brachial index (ABI). We conducted a cross-sectional case-control study of 54 patients with acromegaly (37 females and 17 males) and 34 healthy controls (22 females and 12 males). Serum visfatin was measured by ELISA. Acromegalic and control participants and those with active or controlled acromegaly were compared with respect to their serum visfatin, clinical and metabolic parameters, EFT, cIMT, and ABI. Linear correlation was used to identify associations between these parameters and visfatin in all participants. Serum visfatin and glycated hemoglobin (HbA1c) were higher in the acromegaly group than in the control group (p
    MeSH term(s) Acromegaly/blood ; Acromegaly/complications ; Adult ; Atherosclerosis/blood ; Atherosclerosis/diagnosis ; Atherosclerosis/etiology ; Biomarkers/blood ; Blood Glucose/analysis ; Carotid Intima-Media Thickness ; Case-Control Studies ; Cross-Sectional Studies ; Cytokines/blood ; Female ; Follow-Up Studies ; Glycated Hemoglobin A/analysis ; Human Growth Hormone/blood ; Humans ; Insulin-Like Growth Factor I/analysis ; Male ; Middle Aged ; Nicotinamide Phosphoribosyltransferase/blood ; Prognosis
    Chemical Substances Biomarkers ; Blood Glucose ; Cytokines ; Glycated Hemoglobin A ; IGF1 protein, human ; hemoglobin A1c protein, human ; Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6) ; Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12) ; nicotinamide phosphoribosyltransferase, human (EC 2.4.2.12)
    Language English
    Publishing date 2019-09-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-0998-4079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 681: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Visfatin Levels May be an Early Marker of Atherosclerosis in Patients with Acromegaly

    Piskinpasa, Hamide / Okuturlar, Yildiz / Dogansen, Sema Ciftci / Akdeniz, Yasemin Sefika / Esen, Ayse / Sadri, Sogol / Pirhan, Osman / Gemici, Aysegul Akdogan / Serin, Sibel Ocak / Gedikbası, Asuman / Adas, Mine / Mert, Meral

    Hormone and Metabolic Research

    2019  Volume 51, Issue 10, Page(s) 649–654

    Abstract: The purpose of the study was to compare serum visfatin levels between patients with acromegaly and healthy controls and to evaluate the relationships between visfatin levels and epicardial fat thickness (EFT), carotid intima media thickness (cIMT), and ... ...

    Abstract The purpose of the study was to compare serum visfatin levels between patients with acromegaly and healthy controls and to evaluate the relationships between visfatin levels and epicardial fat thickness (EFT), carotid intima media thickness (cIMT), and ankle brachial index (ABI). We conducted a cross-sectional case-control study of 54 patients with acromegaly (37 females and 17 males) and 34 healthy controls (22 females and 12 males). Serum visfatin was measured by ELISA. Acromegalic and control participants and those with active or controlled acromegaly were compared with respect to their serum visfatin, clinical and metabolic parameters, EFT, cIMT, and ABI. Linear correlation was used to identify associations between these parameters and visfatin in all participants. Serum visfatin and glycated hemoglobin (HbA1c) were higher in the acromegaly group than in the control group (p 0.001 and p 0.007, respectively). There was no difference in visfatin between the active and controlled acromegaly groups, but HbA1c was higher in the active than the controlled acromegaly group (p<0.04). EFT, cIMT, and ABI were similar between the acromegaly and control groups and between the active and controlled acromegaly groups. Serum visfatin positively correlated with HbA1c, growth hormone (GH), and insulin-like growth factor-1 (IGF-1)/upper limit of normal ratio (r=0.245, p=0.024; r=0.259, p=0.017; and r=0.282, p=0.009, respectively). This study has revealed that a high visfatin level is associated with glycemic dysregulation and higher levels of GH and IGF-1 in acromegalic patients.
    Keywords visfatin ; acromegaly ; diabetes mellitus ; epicardial fat thickness ; carotid intima media thickness
    Language English
    Publishing date 2019-09-05
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-0998-4079
    Database Thieme publisher's database

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 681: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Clinical Characteristics and Outcomes of COVID-19 in Turkish Patients with Hematological Malignancies

    Civriz Bozdağ, Sinem / Cengiz Seval, Güldane / Yönal Hindilerden, İpek / Hindilerden, Fehmi / Andıç, Neslihan / Baydar, Mustafa / Aydın Kaynar, Lale / Toprak, Selami Koçak / Göksoy, Hasan Sami / Balık Aydın, Berrin / Demirci, Ufuk / Can, Ferda / Özkocaman, Vildan / Gündüz, Eren / Güven, Zeynep Tuğba / Özkurt, Zübeyde Nur / Demircioğlu, Sinan / Beksaç, Meral / İnce, İdris /
    Yılmaz, Umut / Eroğlu Küçükdiler, Hilal / Abishov, Elgün / Yavuz, Boran / Ataş, Ünal / Mutlu, Yaşa Gül / Baş, Volkan / Özkalemkaş, Fahir / Üsküdar Teke, Hava / Gürsoy, Vildan / Çelik, Serhat / Çiftçiler, Rafiye / Yağcı, Münci / Topçuoğlu, Pervin / Çeneli, Özcan / Abbasov, Hamza / Selim, Cem / Ar, Muhlis Cem / Yücel, Orhan Kemal / Sadri, Sevil / Albayrak, Canan / Demir, Ahmet Muzaffer / Güler, Nil / Keklik, Muzaffer / Terzi, Hatice / Doğan, Ali / Yegin, Zeynep Arzu / Kurt Yüksel, Meltem / Sadri, Soğol / Yavaşoğlu, İrfan / Beköz, Hüseyin Saffet / Aksu, Tekin / Maral, Senem / Erol, Veysel / Kaynar, Leylagül / İlhan, Osman / Bolaman, Ali Zahit / Sevindik, Ömür Gökmen / Akyay, Arzu / Özcan, Muhit / Gürman, Günhan / Ünal, Şule / Yavuz, Yasemin / Diz Küçükkaya, Reyhan / Özsan, Güner Hayri

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2021  Volume 39, Issue 1, Page(s) 43–54

    Abstract: Objective: Patients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 infection in highly immunosuppressed populations, such as in ...

    Abstract Objective: Patients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 infection in highly immunosuppressed populations, such as in patients with hematological malignancies, is a point of interest. We aimed to analyze the symptoms, complications, intensive care unit admissions, and mortality rates of patients with hematological malignancies infected with SARS-CoV-2 in Turkey.
    Materials and methods: In this multicenter study, we included 340 adult and pediatric patients diagnosed with SARS-CoV-2 from March to November 2020. Diagnosis and status of primary disease, treatment schedules for hematological malignancies, time from last treatment, life expectancy related to the hematological disease, and comorbidities were recorded, together with data regarding symptoms, treatment, and outcome of SARS-CoV-2 infection.
    Results: Forty four patients were asymptomatic at diagnosis of SARS-CoV- 2 infection. Among symptomatic patients, fever, cough, and dyspnea were observed in 62.6%, 48.8%, and 41.8%, respectively. Sixty-nine (20%) patients had mild SARS-CoV-2 disease, whereas moderate, severe, and critical disease was reported in 101 (29%), 71 (20%), and 55 (16%) patients, respectively. Of the entire cohort, 251 (73.8%) patients were hospitalized for SARS-CoV-2. Mortality related to SARS-CoV-2 infection was 26.5% in the entire cohort; this comprised 4.4% of those patients with mild disease, 12.4% of those with moderate disease, and 83% of those with severe or critical disease. Active hematological disease, lower life expectancy related to primary hematological disease, neutropenia at diagnosis of SARS-CoV-2, ICU admission, and first-line therapy used for coronavirus disease-2019 treatment were found to be related to higher mortality rates. Treatments with hydroxychloroquine alone or in combination with azithromycin were associated with a higher rate of mortality in comparison to favipiravir use.
    Conclusion: Patients with hematological malignancy infected with SARS-CoV-2 have an increased risk of severe disease and mortality.
    MeSH term(s) Adult ; Amides/administration & dosage ; Azithromycin/administration & dosage ; COVID-19/complications ; COVID-19/mortality ; Child ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/mortality ; Hematologic Neoplasms/therapy ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/adverse effects ; Pyrazines/administration & dosage ; SARS-CoV-2 ; Turkey/epidemiology
    Chemical Substances Amides ; Pyrazines ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5) ; favipiravir (EW5GL2X7E0)
    Language English
    Publishing date 2021-09-15
    Publishing country Turkey
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.4274/tjh.galenos.2021.2021.0287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6534: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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