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  1. AU="Sadrozinski, H-F W."
  2. AU="Allan, Rachel"
  3. AU="Ma, Jiele"
  4. AU="Bizjak, Isabella"
  5. AU="Pelucchi, Paride"
  6. AU="Krug, Anne Barbara"
  7. AU="Pikridas, M"
  8. AU="Adams, Jonathan D"
  9. AU="Esquivel-Muelbert, A."
  10. AU="Khan, Meraj Alam"
  11. AU="Bullard, Stevan"
  12. AU="Wang, Peter H"
  13. AU="Preto, Jordane"
  14. AU="Pierce, Shaketha"
  15. AU="Sankar, Jishnu"
  16. AU="Yahagi, Naohisa"
  17. AU=Pinho Juliana
  18. AU="Brennan, Anna"
  19. AU="Lee, Theresa M"
  20. AU="Chunqing Ou"
  21. AU="Gwynn, Simon"
  22. AU="Holper, Sarah"
  23. AU="Haider, Farag Ibrahim"
  24. AU="Rice, Jordin L"
  25. AU="Gong, Xingguo"
  26. AU=Rother Magdalena B.
  27. AU="Petrov, Ksenia"
  28. AU="Rijneveld, R"
  29. AU=Lopez-Martinez Briceida
  30. AU=Astone Pia
  31. AU="Amaral, V"

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  1. Artikel: Overview of the LLUMC/UCSC/CSUSB Phase 2 Proton CT Project.

    Schulte, R W / Bashkirov, V / Johnson, R / Sadrozinski, H F-W / Schubert, K E

    Transactions of the American Nuclear Society

    2014  Band 106, Seite(n) 59–62

    Sprache Englisch
    Erscheinungsdatum 2014-04-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 0003-018X
    ISSN 0003-018X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Novel scintillation detector design and performance for proton radiography and computed tomography.

    Bashkirov, V A / Schulte, R W / Hurley, R F / Johnson, R P / Sadrozinski, H F-W / Zatserklyaniy, A / Plautz, T / Giacometti, V

    Medical physics

    2016  Band 43, Heft 2, Seite(n) 664–674

    Abstract: Purpose: Proton computed tomography (pCT) will enable accurate prediction of proton and ion range in a patient while providing the benefit of lower radiation exposure than in x-ray CT. The accuracy of the range prediction is essential for treatment ... ...

    Abstract Purpose: Proton computed tomography (pCT) will enable accurate prediction of proton and ion range in a patient while providing the benefit of lower radiation exposure than in x-ray CT. The accuracy of the range prediction is essential for treatment planning in proton or ion therapy and depends upon the detector used to evaluate the water-equivalent path length (WEPL) of a proton passing through the object. A novel approach is presented for an inexpensive WEPL detector for pCT and proton radiography.
    Methods: A novel multistage detector with an aperture of 10 × 37.5 cm was designed to optimize the accuracy of the WEPL measurements while simplifying detector construction and the performance requirements of its components. The design of the five-stage detector was optimized through simulations based on the geant4 detector simulation toolkit, and the fabricated prototype was calibrated in water-equivalent millimeters with 200 MeV protons in the research beam line of the clinical proton synchrotron at Loma Linda University Medical Center. A special polystyrene step phantom was designed and built to speed up and simplify the calibration procedure. The calibrated five-stage detector was tested in the 200 MeV proton beam as part of the pCT head scanner, using a water phantom and polystyrene slabs to verify the WEPL reconstruction accuracy.
    Results: The beam-test results demonstrated excellent performance of the new detector, in good agreement with the simulation results. The WEPL measurement accuracy is about 3.0 mm per proton in the 0-260 mm WEPL range required for a pCT head scan with a 200 MeV proton beam.
    Conclusions: The new multistage design approach to WEPL measurements for proton CT and radiography has been prototyped and tested. The test results show that the design is competitive with much more expensive calorimeter and range-counter designs.
    Mesh-Begriff(e) Calibration ; Equipment Design ; Protons ; Scintillation Counting/instrumentation ; Tomography, X-Ray Computed/instrumentation ; Uncertainty
    Chemische Substanzen Protons
    Sprache Englisch
    Erscheinungsdatum 2016-02-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1118/1.4939255
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Buch ; Online: High-Precision 4D Tracking with Large Pixels using Thin Resistive Silicon Detectors

    Arcidiacono, R. / Borghi, G. / Boscardin, M. / Cartiglia, N. / Vignali, M. Centis / Costa, M. / Betta, G-F. Dalla / Ferrero, M. / Ficorella, F. / Gioachin, G. / Lanteri, L. / Mandurrino, M. / Menzio, L. / Mulargia, R. / Pancheri, L. / Paternoster, G. / Rojas, A. / Sadrozinski, H-F W. / Seiden, A. /
    Siviero, F. / Sola, V. / Tornago, M.

    2022  

    Abstract: The basic principle of operation of silicon sensors with resistive read-out is built-in charge sharing. Resistive Silicon Detectors (RSD, also known as AC-LGAD), exploiting the signals seen on the electrodes surrounding the impact point, achieve ... ...

    Abstract The basic principle of operation of silicon sensors with resistive read-out is built-in charge sharing. Resistive Silicon Detectors (RSD, also known as AC-LGAD), exploiting the signals seen on the electrodes surrounding the impact point, achieve excellent space and time resolutions even with very large pixels. In this paper, a TCT system using a 1064 nm picosecond laser is used to characterize sensors from the second RSD production at the Fondazione Bruno Kessler. The paper first introduces the parametrization of the errors in the determination of the position and time coordinates in RSD, then outlines the reconstruction method, and finally presents the results. Three different pixel sizes are used in the analysis: 200 x 340, 450 x 450, and 1300 x 1300 microns^2. At gain = 30, the 450 x 450 microns^2 pixel achieves a time jitter of 20 ps and a spatial resolution of 15 microns concurrently, while the 1300 x 1300 microns^2 pixel achieves 30 ps and 30 micron, respectively. The implementation of cross-shaped electrodes improves considerably the response uniformity over the pixel surface.

    Comment: 28 pages, 23 figures submitted to NIMA
    Schlagwörter Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
    Thema/Rubrik (Code) 621
    Erscheinungsdatum 2022-11-24
    Erscheinungsland us
    Dokumenttyp Buch ; Online
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  4. Artikel: The Phase I Proton CT Scanner and Test Beam Results at LLUMC, invited.

    Hurley, R F / Schulte, R W / Bashkirov, V A / Coutrakon, G / Sadrozinski, H F-W / Patyal, B

    Transactions of the American Nuclear Society

    2014  Band 106, Seite(n) 63–66

    Sprache Englisch
    Erscheinungsdatum 2014-03-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 0003-018X
    ISSN 0003-018X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Buch ; Online: Silicon Sensors for Future Particle Trackers

    Cartiglia, N. / Arcidiacono, R. / Borghi, G. / Boscardin, M. / Costa, M. / Galloway, Z. / Fausti, F. / Ferrero, M. / Ficorella, F. / Mandurrino, M. / Mazza, S. / Olave, E. J. / Paternoster, G. / Siviero, F. / Sadrozinski, H. F-W. / Sola, V. / Staiano, A. / Seiden, A. / Tornago, M. /
    Zhao, Y.

    2020  

    Abstract: Several future high-energy physics facilities are currently being planned. The proposed projects include high energy $e^+ e^-$ circular and linear colliders, hadron colliders and muon colliders, while the Electron-Ion Collider (EIC) has already been ... ...

    Abstract Several future high-energy physics facilities are currently being planned. The proposed projects include high energy $e^+ e^-$ circular and linear colliders, hadron colliders and muon colliders, while the Electron-Ion Collider (EIC) has already been approved for construction at the Brookhaven National Laboratory. Each proposal has its own advantages and disadvantages in term of readiness, cost, schedule and physics reach, and each proposal requires the design and production of specific new detectors. This paper first presents the performances required to the future silicon tracking systems at the various new facilities, and then it illustrates a few possibilities for the realization of such silicon trackers. The challenges posed by the future facilities require a new family of silicon detectors, where features such as impact ionization, radiation damage saturation, charge sharing, and analog readout are exploited to meet these new demands.
    Schlagwörter Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
    Thema/Rubrik (Code) 621
    Erscheinungsdatum 2020-03-31
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: An evaluation of spatial resolution of a prototype proton CT scanner.

    Plautz, Tia E / Bashkirov, V / Giacometti, V / Hurley, R F / Johnson, R P / Piersimoni, P / Sadrozinski, H F-W / Schulte, R W / Zatserklyaniy, A

    Medical physics

    2016  Band 43, Heft 12, Seite(n) 6291

    Abstract: Purpose: To evaluate the spatial resolution of proton CT using both a prototype proton CT scanner and Monte Carlo simulations.: Methods: A custom cylindrical edge phantom containing twelve tissue-equivalent inserts with four different compositions at ...

    Abstract Purpose: To evaluate the spatial resolution of proton CT using both a prototype proton CT scanner and Monte Carlo simulations.
    Methods: A custom cylindrical edge phantom containing twelve tissue-equivalent inserts with four different compositions at varying radial displacements from the axis of rotation was developed for measuring the modulation transfer function (MTF) of a prototype proton CT scanner. Two scans of the phantom, centered on the axis of rotation, were obtained with a 200 MeV, low-intensity proton beam: one scan with steps of 4°, and one scan with the phantom continuously rotating. In addition, Monte Carlo simulations of the phantom scan were performed using scanners idealized to various degrees. The data were reconstructed using an iterative projection method with added total variation superiorization based on individual proton histories. Edge spread functions in the radial and azimuthal directions were obtained using the oversampling technique. These were then used to obtain the modulation transfer functions. The spatial resolution was defined by the 10% value of the modulation transfer function (MTF
    Results: The radial spatial resolution of the prototype proton CT scanner depends on the total path length, W, of the proton in the phantom, whereas the azimuthal spatial resolution depends both on W and the position, u
    Conclusions: Multiple Coulomb scattering in the phantom is the limiting physical factor of the achievable spatial resolution of proton CT; additional loss of spatial resolution in the prototype system is associated with scattering in the proton tracking system and inadequacies of the proton path estimate used in the iterative reconstruction algorithm. Improvement in spatial resolution may be achievable by improving the most likely path estimate by incorporating information about high and low density materials, and by minimizing multiple Coulomb scattering in the proton tracking system.
    Mesh-Begriff(e) Monte Carlo Method ; Phantoms, Imaging ; Protons ; Signal-To-Noise Ratio ; Tomography Scanners, X-Ray Computed
    Chemische Substanzen Protons
    Sprache Englisch
    Erscheinungsdatum 2016-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1118/1.4966028
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Operation of the Preclinical Head Scanner for Proton CT.

    Sadrozinski, H F-W / Geoghegan, T / Harvey, E / Johnson, R P / Plautz, T E / Zatserklyaniy, A / Bashkirov, V / Hurley, R F / Piersimoni, P / Schulte, R W / Karbasi, P / Schubert, K E / Schultze, B / Giacometti, V

    Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment

    2016  Band 831, Seite(n) 394–399

    Abstract: We report on the operation and performance tests of a preclinical head scanner developed for proton computed tomography (pCT). After extensive preclinical testing, pCT is intended to be employed in support of proton therapy treatment planning and pre- ... ...

    Abstract We report on the operation and performance tests of a preclinical head scanner developed for proton computed tomography (pCT). After extensive preclinical testing, pCT is intended to be employed in support of proton therapy treatment planning and pre-treatment verification in patients undergoing particle-beam therapy. In order to assess the performance of the scanner, we have performed CT scans with 200 MeV protons from both the synchrotron of the Loma Linda University Medical Center (LLUMC) and the cyclotron of the Northwestern Medicine Chicago Proton Center (NMCPC). The very high sustained rate of data acquisition, exceeding one million protons per second, allowed a full 360° scan to be completed in less than 7 minutes. The reconstruction of various phantoms verified accurate reconstruction of the proton relative stopping power (RSP) and the spatial resolution in a variety of materials. The dose for an image with better than 1% uncertainty in the RSP is found to be close to 1 mGy.
    Sprache Englisch
    Erscheinungsdatum 2016-09-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 0168-9002
    ISSN 0168-9002
    DOI 10.1016/j.nima.2016.02.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Development of a Head Scanner for Proton CT.

    Sadrozinski, H F-W / Johnson, R P / Macafee, S / Plumb, A / Steinberg, D / Zatserklyaniy, A / Hurley, V Bashkirov F / Schulte, R

    Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment

    2012  Band 699, Seite(n) 205–210

    Abstract: We describe a new head scanner developed for Proton Computed Tomography (pCT) in support of proton therapy treatment planning, aiming at reconstructing an accurate map of the stopping power (S.P.) in a phantom and, in the future, in patients. The system ... ...

    Abstract We describe a new head scanner developed for Proton Computed Tomography (pCT) in support of proton therapy treatment planning, aiming at reconstructing an accurate map of the stopping power (S.P.) in a phantom and, in the future, in patients. The system consists of two silicon telescopes which track the proton before and after the phantom/patient, and an energy detector which measures the residual energy or range of the proton to reconstruct the Water Equivalent Path Length (WEPL) in the phantom. Based on the experience of the existing prototype and extensive Geant4 simulations and CT reconstructions, the new pCT scanner will support clinically useful proton fluxes.
    Sprache Englisch
    Erscheinungsdatum 2012-04-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 0168-9002
    ISSN 0168-9002
    DOI 10.1016/j.nima.2012.04.029
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  9. Artikel: Water-equivalent path length calibration of a prototype proton CT scanner.

    Hurley, R F / Schulte, R W / Bashkirov, V A / Wroe, A J / Ghebremedhin, A / Sadrozinski, H F-W / Rykalin, V / Coutrakon, G / Koss, P / Patyal, B

    Medical physics

    2011  Band 39, Heft 5, Seite(n) 2438–2446

    Abstract: Purpose: The authors present a calibration method for a prototype proton computed tomography (pCT) scanner. The accuracy of these measurements depends upon careful calibration of the energy detector used to measure the residual energy of the protons ... ...

    Abstract Purpose: The authors present a calibration method for a prototype proton computed tomography (pCT) scanner. The accuracy of these measurements depends upon careful calibration of the energy detector used to measure the residual energy of the protons that passed through the object.
    Methods: A prototype pCT scanner with a cesium iodide (CsI(Tl)) crystal calorimeter was calibrated by measuring the calorimeter response for protons of 200 and 100 MeV initial energies undergoing degradation in polystyrene plates of known thickness and relative stopping power (RSP) with respect to water. Calibration curves for the two proton energies were obtained by fitting a second-degree polynomial to the water-equivalent path length versus calorimeter response data. Using the 100 MeV calibration curve, the RSP values for a variety of tissue-equivalent materials were measured and compared to values obtained from a standard depth-dose range shift measurement using a water-tank. A cylindrical water phantom was scanned with 200 MeV protons and its RSP distribution was reconstructed using the 200 MeV calibration.
    Results: It is shown that this calibration method produces measured RSP values of various tissue-equivalent materials that agree to within 0.5% of values obtained using an established water-tank method. The mean RSP value of the water phantom reconstruction was found to be 0.995 ± 0.006.
    Conclusions: The method presented provides a simple and reliable procedure for calibration of a pCT scanner.
    Mesh-Begriff(e) Calibration ; Image Processing, Computer-Assisted ; Phantoms, Imaging ; Protons ; Tomography, X-Ray Computed/instrumentation ; Uncertainty ; Water
    Chemische Substanzen Protons ; Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2011-04-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 188780-4
    ISSN 0094-2405
    ISSN 0094-2405
    DOI 10.1118/1.3700173
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: 200 MeV proton radiography studies with a hand phantom using a prototype proton CT scanner.

    Plautz, Tia / Bashkirov, V / Feng, V / Hurley, F / Johnson, R P / Leary, C / Macafee, S / Plumb, A / Rykalin, V / Sadrozinski, H F-W / Schubert, K / Schulte, R / Schultze, B / Steinberg, D / Witt, M / Zatserklyaniy, A

    IEEE transactions on medical imaging

    2011  Band 33, Heft 4, Seite(n) 875–881

    Abstract: Proton radiography has applications in patient alignment and verification procedures for proton beam radiation therapy. In this paper, we report an experiment which used 200 MeV protons to generate proton energy-loss and scattering radiographs of a hand ... ...

    Abstract Proton radiography has applications in patient alignment and verification procedures for proton beam radiation therapy. In this paper, we report an experiment which used 200 MeV protons to generate proton energy-loss and scattering radiographs of a hand phantom. The experiment used the first-generation proton computed tomography (CT) scanner prototype, which was installed on the research beam line of the clinical proton synchrotron at Loma Linda University Medical Center. It was found that while both radiographs displayed anatomical details of the hand phantom, the energy-loss radiograph had a noticeably higher resolution. Nonetheless, scattering radiography may yield more contrast between soft and bone tissue than energy-loss radiography, however, this requires further study. This study contributes to the optimization of the performance of the next-generation of clinical proton CT scanners. Furthermore, it demonstrates the potential of proton imaging (proton radiography and CT), which is now within reach of becoming available as a new, potentially low-dose medical imaging modality.
    Mesh-Begriff(e) Algorithms ; Hand/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted/methods ; Phantoms, Imaging ; Protons ; Radiation Dosage ; Tomography, X-Ray Computed/instrumentation ; Tomography, X-Ray Computed/methods
    Chemische Substanzen Protons
    Sprache Englisch
    Erscheinungsdatum 2011-03-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 622531-7
    ISSN 1558-254X ; 0278-0062
    ISSN (online) 1558-254X
    ISSN 0278-0062
    DOI 10.1109/TMI.2013.2297278
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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