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  1. AU="Saeed, Maria"
  2. AU="Benmeziane, Keltouma"
  3. AU="Barik, Saroj K."
  4. AU="Madhurima Basu" AU="Madhurima Basu"
  5. AU="Polanska, Nikola"
  6. AU="Stephane Cullati"
  7. AU="Held, Noelle A"
  8. AU="Zhu, Simeng"
  9. AU="Hantour, Naima"
  10. AU="Bo Shopsin"
  11. AU="Reese, Samario"
  12. AU="Retamal, Catalina"
  13. AU="Lee-Wing, Matthew"
  14. AU="Dostálová, I"
  15. AU=McCloskey Kayleigh A
  16. AU="Dharmarajan, Arun"
  17. AU="Stebel, Luigi"
  18. AU=Amico Patrizia
  19. AU="Kojev, Aslan"
  20. AU="Zhiyu Wang"
  21. AU="Shannon C Peyton"
  22. AU="Shiltsev, V."
  23. AU="Edward S. Debnam"
  24. AU="Freeston, Sarah L"
  25. AU="Bertolucci, S."
  26. AU="de Barros, Rosires M B"
  27. AU="Carr, Crystal C"
  28. AU="Davies, Mark Lloyd"
  29. AU=St Gelais Corine
  30. AU=Engstrom Malitta
  31. AU="Hongo, Akane"
  32. AU="Krykorková, I"
  33. AU=Yan Bing
  34. AU="Nakos, Konstantinos"
  35. AU="Schreiner, Ryan"
  36. AU=Pltz T
  37. AU="Akhmanova, Anna" AU="Akhmanova, Anna"
  38. AU="Goretsky, Anton"
  39. AU="Cordoza, Makayla L"
  40. AU=Midoux Patrick AU=Midoux Patrick
  41. AU="Mundt, H M"
  42. AU=Tsivitse Susan

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Treffer 1 - 10 von insgesamt 31

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  1. Artikel ; Online: Navigating the terrain of neutrophil extracellular traps in severe malaria pathogenesis.

    Saeed, Maria / Aitken, Elizabeth H / Rogerson, Stephen J

    Trends in parasitology

    2024  Band 40, Heft 4, Seite(n) 278–279

    Abstract: Du, Ren, et al. recently showed in a Plasmodium berghei ANKA (PbA) experimental malaria model that phosphatase of regenerating liver 2 (PRL2) regulates neutrophil extracellular traps (NETs) in severe malaria (SM)-related acute lung injury (ALI). PRL2 ... ...

    Abstract Du, Ren, et al. recently showed in a Plasmodium berghei ANKA (PbA) experimental malaria model that phosphatase of regenerating liver 2 (PRL2) regulates neutrophil extracellular traps (NETs) in severe malaria (SM)-related acute lung injury (ALI). PRL2 deficiency caused SM with ALI in a mouse model by increasing NETs in pulmonary tissue; hydroxychloroquine (HCQ) may ameliorate this.
    Mesh-Begriff(e) Animals ; Mice ; Extracellular Traps ; Neutrophils ; Lung/pathology ; Malaria/complications ; Acute Lung Injury/etiology ; Acute Lung Injury/pathology
    Sprache Englisch
    Erscheinungsdatum 2024-03-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2024.03.001
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  2. Artikel ; Online: Hartmann's procedure in rectal cancer surgery is often an intraoperative decision: a retrospective multicenter study.

    Mariusdottir, Elin / Jörgren, Fredrik / Saeed, Maria / Wikström, Jens / Lydrup, Marie-Louise / Buchwald, Pamela

    Langenbeck's archives of surgery

    2024  Band 409, Heft 1, Seite(n) 55

    Abstract: Purpose: This study aimed to investigate patient-related factors predicting the selection of rectal cancer patients to Hartmann's procedure as well as to investigate how often, and on what grounds, anterior resection is intraoperatively changed to ... ...

    Abstract Purpose: This study aimed to investigate patient-related factors predicting the selection of rectal cancer patients to Hartmann's procedure as well as to investigate how often, and on what grounds, anterior resection is intraoperatively changed to Hartmann's procedure.
    Methods: Prospectively collected data from the Swedish Colorectal Cancer Registry regarding patients with rectal cancer operated upon from January 1 2007 to June 30 2017 in the county of Skåne were retrospectively reviewed. Data were expanded with further details from medical charts. A univariable analysis was performed to investigate variables associated with unplanned HP and significant variables included in a multivariable logistic regression analysis.
    Results: Altogether, 1141 patients who underwent Hartmann's procedure (275 patients, 24%), anterior resection (491 patients, 43%), or abdominoperineal resection (375 patients, 33%) were included. Patients undergoing Hartmann's procedure were significantly older and had more frequently comorbidity. The decision to perform Hartmann's procedure was made preoperatively in 209 (76%) patients, most commonly because of a comorbidity (27%) or oncological reasons (25%). Patient preference was noted in 8% of cases. In 64 cases (23%), the decision was made intraoperatively, most often due to anastomotic difficulties (60%) and oncological reasons (22%). Anastomotic difficulties were most often reported due to technical difficulties, a low tumor or neoadjuvant radiotherapy. Male gender was a significant risk factor for undergoing unplanned Hartmann's procedure.
    Conclusions: The decision to perform Hartmann's procedure was frequently made intraoperatively. Hartmann's procedure should be considered and discussed preoperatively in old and frail patients, especially in the presence of mid-rectal cancer and/or male gender, since these factors increase the risk of intraoperative anastomotic difficulties.
    Mesh-Begriff(e) Humans ; Male ; Retrospective Studies ; Rectal Neoplasms/surgery ; Rectum/surgery ; Proctocolectomy, Restorative/adverse effects ; Anastomosis, Surgical/methods ; Colostomy/methods ; Postoperative Complications/etiology ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2024-02-07
    Erscheinungsland Germany
    Dokumenttyp Multicenter Study ; Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-024-03237-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Evaluation of sodium citrate anticoagulant for the Resolution of edta-dependent pseudo Thrombocytopenia.

    Sharif, Fatima / Junaid, Ayesha / Ashraf, Khadija / Ijaz, Maira / Saeed, Maria / Farhat, Tuba / Rehman, Noor / Rehman, Mujeeb Ur

    Journal of Ayub Medical College, Abbottabad : JAMC

    2024  Band 35, Heft 4, Seite(n) 544–548

    Abstract: Background: EDTA-dependent pseudo thrombocytopenia (EDTA-PTCP) refers to a falsely low platelet count occurring in the presence of ethylene diamine tetra-acetic acid (EDTA) anticoagulant during blood sample collection, which results in the formation of ... ...

    Abstract Background: EDTA-dependent pseudo thrombocytopenia (EDTA-PTCP) refers to a falsely low platelet count occurring in the presence of ethylene diamine tetra-acetic acid (EDTA) anticoagulant during blood sample collection, which results in the formation of platelet clumps in vitro. This phenomenon has significant clinical implications, including unnecessary administration of platelets. Our study aims to evaluate the efficacy of sodium citrate anticoagulant for the resolution of EDTAPTCP.
    Methods: This retrospective study was conducted in the haematology laboratory of Shifa International Hospital (SIH), Pakistan. Patients with pseudo thrombocytopenia (i.e. platelet count less than 150,000/ul with platelet clumps seen on peripheral smear) were included in this study if they had blood samples drawn in both EDTA and sodium citrate tubes less than 48 hours apart. Data was analyzed using IBM® SPSS Software Version 22.
    Results: A total of 151 study participants were included in this study. The mean age was 48.95±20.69 years and the majority were female (52.3%). Wilcoxon signed-rank test showed that there was a statistically significant difference in platelet count measured in both tubes (Z = -3.223, p=0.001). Overall, blood samples processed in sodium citrate tubes showed lower platelet count than EDTA samples. Sodium citrate anticoagulant was able to correct EDTA-PTCP in 47 (31.1%) of the cases.
    Conclusions: Sodium citrate anticoagulant was only able to resolve one-third of our EDTA-PTCP cases. Our findings do not support the use of sodium citrate as a suitable alternative for correction of EDTA-PTCP.
    Mesh-Begriff(e) Humans ; Female ; Male ; Adult ; Middle Aged ; Aged ; Anticoagulants/adverse effects ; Edetic Acid/therapeutic use ; Edetic Acid/pharmacology ; Sodium Citrate/pharmacology ; Retrospective Studies ; Platelet Aggregation ; Thrombocytopenia/chemically induced ; Acetic Acid/pharmacology
    Chemische Substanzen Anticoagulants ; Edetic Acid (9G34HU7RV0) ; Sodium Citrate (1Q73Q2JULR) ; Acetic Acid (Q40Q9N063P)
    Sprache Englisch
    Erscheinungsdatum 2024-02-26
    Erscheinungsland Pakistan
    Dokumenttyp Journal Article
    ZDB-ID 2192473-9
    ISSN 1819-2718 ; 1025-9589
    ISSN (online) 1819-2718
    ISSN 1025-9589
    DOI 10.55519/JAMC-04-12300
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  4. Artikel: A Case of Systemic Lupus Erythematosus Presenting as Pure Red Cell Aplasia.

    Saeed, Maria / Sharif, Fatima / Ijaz, Maira / Kamran, Shawana

    International journal of hematology-oncology and stem cell research

    2021  Band 15, Heft 2, Seite(n) 135–138

    Abstract: Pure red cell aplasia (PRCA) is an uncommon condition, which is rarely associated with Systemic Lupus Erythematosus (SLE). Prompt identification and management of the underlying SLE results in correction of anemia. We report the case of a young female ... ...

    Abstract Pure red cell aplasia (PRCA) is an uncommon condition, which is rarely associated with Systemic Lupus Erythematosus (SLE). Prompt identification and management of the underlying SLE results in correction of anemia. We report the case of a young female who presented due to severe anemia since the last two years. The cause of her anemia on initial investigations was not elicited in these two years, during which response to hematinics was poor and she remained transfusion dependent. Bone marrow biopsy showed PRCA after which autoimmune workup revealed SLE. Subsequently, treatment of SLE with steroids led to normalization of hemoglobin levels within a follow-up period of three months.
    Sprache Englisch
    Erscheinungsdatum 2021-08-27
    Erscheinungsland Iran
    Dokumenttyp Case Reports
    ZDB-ID 2652853-8
    ISSN 2008-2207 ; 2008-3009
    ISSN (online) 2008-2207
    ISSN 2008-3009
    DOI 10.18502/ijhoscr.v15i2.6045
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  5. Artikel ; Online: Does inclusive leadership influence task performance of hospitality industry employees? Role of psychological empowerment and trust in leader

    Siyal, Saeed / Liu, Jin / Ma, Long / Kumari, Kalpina / Saeed, Maria / Xin, Chunlin / Hussain, Sonia Najam

    Heliyon. 2023 May, v. 9, no. 5 p.e15507-

    2023  

    Abstract: Drawing on the social exchange theory, this research advances the understanding of leadership and task performance in the hospitality industry in China by exploring the impact of inclusive leadership on the task performance of subordinates working in ... ...

    Abstract Drawing on the social exchange theory, this research advances the understanding of leadership and task performance in the hospitality industry in China by exploring the impact of inclusive leadership on the task performance of subordinates working in dyadic forms. The current literature is scarce on the role of leadership in increasing the task performance of employees working in teams in dyadic forms. Multi-level sample of 410 leaders-subordinates in the hospitality industry was used to derive the research findings using PLS-SEM. The results indicated a positive influence of inclusive leadership on the task performance of subordinates. Psychological empowerment mediated this direct relationship. In addition, trust in leaders strengthened the direct link of inclusive leadership with task performance and psychological empowerment. The findings demonstrate that leaders in the hospitality industry should adopt an inclusive leadership style as it contributes to employee task performance, which improves the industry's performance.
    Schlagwörter hospitality industry ; leadership ; China ; Inclusive leadership ; Task performance ; Psychological empowerment ; Trust in leader ; COVID-19
    Sprache Englisch
    Erscheinungsverlauf 2023-05
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15507
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel: Does inclusive leadership influence task performance of hospitality industry employees? Role of psychological empowerment and trust in leader.

    Siyal, Saeed / Liu, Jin / Ma, Long / Kumari, Kalpina / Saeed, Maria / Xin, Chunlin / Hussain, Sonia Najam

    Heliyon

    2023  Band 9, Heft 5, Seite(n) e15507

    Abstract: Drawing on the social exchange theory, this research advances the understanding of leadership and task performance in the hospitality industry in China by exploring the impact of inclusive leadership on the task performance of subordinates working in ... ...

    Abstract Drawing on the social exchange theory, this research advances the understanding of leadership and task performance in the hospitality industry in China by exploring the impact of inclusive leadership on the task performance of subordinates working in dyadic forms. The current literature is scarce on the role of leadership in increasing the task performance of employees working in teams in dyadic forms. Multi-level sample of 410 leaders-subordinates in the hospitality industry was used to derive the research findings using PLS-SEM. The results indicated a positive influence of inclusive leadership on the task performance of subordinates. Psychological empowerment mediated this direct relationship. In addition, trust in leaders strengthened the direct link of inclusive leadership with task performance and psychological empowerment. The findings demonstrate that leaders in the hospitality industry should adopt an inclusive leadership style as it contributes to employee task performance, which improves the industry's performance.
    Sprache Englisch
    Erscheinungsdatum 2023-04-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15507
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  7. Artikel: Efficacy and safety of glucose sensors for delivery of insulin: A Systematic Review

    Najmeddine, Ahmad Ali / Saeed, Maria / Beadham, Ian G. / ElShaer, Amr

    PharmaNutrition. 2021 Dec., v. 18

    2021  

    Abstract: Diabetes is a widely spread chronic disease affecting about 463 million people in 2019. It is defined as chronic hyperglycemia caused by either an impaired action or an abnormal secretion of insulin. New diabetes medications based on glucose-sensitive ... ...

    Abstract Diabetes is a widely spread chronic disease affecting about 463 million people in 2019. It is defined as chronic hyperglycemia caused by either an impaired action or an abnormal secretion of insulin. New diabetes medications based on glucose-sensitive delivery systems can offer better control of blood glucose levels without the need to worry about the patient diet control or the frequency of exercising. Such delivery systems are comprised of glucose-sensitive moieties such as glucose oxidase, Phenylboronic acid derivatives and Concanavalin A. These systems can be administered via different routes such as subcutaneous injections, implants, oral, transdermal and nasal. This systematic review discussed the most suitable insulin delivery system in terms of efficiency to maintain blood glucose levels in normal range, and safety in animals upon administration.The search was conducted using different databases such as Web of Knowledge, Pubmed, Europe PMC, Wiley Online Library, and Science direct.A total of 313 studies were collected and 64 studies were included after screening using inclusion and exclusion criteria based on PICOS model. The results indicated that subcutaneous implants incorporated with glucose oxidase are the most suitable and were able to maintain normal blood glucose for up to 1738 h with a single administration. This was followed by PBA intraperitoneal implant, then oral GOx. Toxicity studies were conducted for all these dosage forms indicating good biocompatibility.The GOx subcutaneous implant was found to be the most efficient and safe insulin delivery systems offering prolonged control of glucose in diabetic patients.
    Schlagwörter blood glucose ; chronic diseases ; concanavalin A ; diabetes ; diet ; glucose ; glucose oxidase ; hyperglycemia ; insulin ; models ; nose ; patients ; phenylboronic acids ; systematic review ; toxicity ; Europe
    Sprache Englisch
    Erscheinungsverlauf 2021-12
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ISSN 2213-4344
    DOI 10.1016/j.phanu.2021.100280
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  8. Artikel ; Online: Structural insight into TNF-α inhibitors through combining pharmacophore-based virtual screening and molecular dynamic simulation.

    Qaiser, Hina / Saeed, Maria / Nerukh, Dmitry / Ul-Haq, Zaheer

    Journal of biomolecular structure & dynamics

    2020  Band 39, Heft 16, Seite(n) 5920–5939

    Abstract: Tumor Necrosis Factor-alpha (TNF-α), a multifunctional cytokine responsible for providing resistance against infections, inflammation, and cancers. TNF-α has emerged as a promising drug target against several autoimmune and inflammatory disorders. ... ...

    Abstract Tumor Necrosis Factor-alpha (TNF-α), a multifunctional cytokine responsible for providing resistance against infections, inflammation, and cancers. TNF-α has emerged as a promising drug target against several autoimmune and inflammatory disorders. Several synthetic antibodies (Infliximab, Etanercept, and Adalimumab) are available, but their potential to cause severe side effects has prompted them to develop alternative small molecules-based therapies for inhibition of TNF-α. In the present study, combined in silico approaches based on pharmacophore modeling, virtual screening, molecular docking, and molecular dynamics studies were employed to understand significant direct interactions between TNF-α protein and small molecule inhibitors. Initially, four different small molecule libraries (∼17.5 million molecules) were virtually screened against the selected pharmacophore model. The identified hits were further subjected to molecular docking studies. The three potent lead compounds (
    Mesh-Begriff(e) Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Small Molecule Libraries/pharmacology ; Tumor Necrosis Factor-alpha
    Chemische Substanzen Ligands ; Small Molecule Libraries ; Tumor Necrosis Factor-alpha
    Sprache Englisch
    Erscheinungsdatum 2020-07-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1796794
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  9. Artikel ; Online: Protonation states at different pH, conformational changes and impact of glycosylation in synapsin Ia.

    Mir, Sonia / Ashraf, Sajda / Saeed, Maria / Rahman, Atta-Ur / Ul-Haq, Zaheer

    Physical chemistry chemical physics : PCCP

    2021  Band 23, Heft 31, Seite(n) 16718–16729

    Abstract: Synapsin I (SynI) is the most abundant brain phosphoprotein present at presynaptic terminals that regulates neurotransmitter release, clustering of synaptic vesicles (SVs) at active zones, and stimulates synaptogenesis and neurite outgrowth. Earlier ... ...

    Abstract Synapsin I (SynI) is the most abundant brain phosphoprotein present at presynaptic terminals that regulates neurotransmitter release, clustering of synaptic vesicles (SVs) at active zones, and stimulates synaptogenesis and neurite outgrowth. Earlier studies have established that SynI displays pH-dependent tethering of SVs to actin filaments and exhibits a maximum binding around neutral pH, however, the effect of pH shift from acidic to basic on the conformational stability of SynI has not been explored yet. Another important aspect of SynIa is its O-GlcNAcylation (O-GlcNac) at the Thr87 position, which is responsible for the positive regulation of synaptic plasticity linked to learning and memory in mice. Furthermore, reduced levels of O-GlcNAc have been observed in Alzheimer's disease, suggesting a possible link to deficits in synaptic plasticity. In this study, the effect of pH and glycosylation on the structure and functional stability of SynIa is determined through molecular dynamics (MD) simulation approach. The 3D structure of SynIa was established via threading-based homology modeling methods. It was observed that the structure of SynIa adopts extended conformational changes as the pH shifts from acidic to basic, resulting in a compact conformation at pH 8.0. Moreover, the results obtained by comparing the glycosylated and unglycosylated protein indicated that the glycan moiety imparts stability to the protein by forming intramolecular hydrogen bond interactions with the protein residues. The results indicate that although O-GlcNAc moieties do not induce a significant change in SynIa structure they minimize protein dynamics, likely leading to enhanced protein stability.
    Mesh-Begriff(e) Glycosylation ; Humans ; Hydrogen-Ion Concentration ; Models, Molecular ; Protein Conformation ; Protons ; Synapsins/chemistry ; Synapsins/metabolism
    Chemische Substanzen Protons ; SYN1 protein, human ; Synapsins
    Sprache Englisch
    Erscheinungsdatum 2021-07-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d1cp00531f
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  10. Artikel ; Online: Relative assessment of different statistical instruments and measures for the prediction of promising outcomes using docking, virtual screening and ADMET analysis against HIV-RT.

    Shamshad, Hina / Saeed, Maria / Ul-Haq, Zaheer / Halim, Sobia Ahsan / Gul, Sana / Mirza, Agha Zeeshan

    Journal of biomolecular structure & dynamics

    2021  Band 40, Heft 17, Seite(n) 7680–7692

    Abstract: Reverse transcriptase is the most therapeutic target for the discovery of novel, potent, and non-toxic new anti-retroviral drugs. In the present work, various docking software such as Sybyl Surflex-Dock, OpenEye FRED, and Hermes GOLD were evaluated for ... ...

    Abstract Reverse transcriptase is the most therapeutic target for the discovery of novel, potent, and non-toxic new anti-retroviral drugs. In the present work, various docking software such as Sybyl Surflex-Dock, OpenEye FRED, and Hermes GOLD were evaluated for their efficiency to reproduce known cognate inhibitors' conformations. Three metrics were used and compared to assess the performance of the applied scoring functions, i.e. enrichment factor, receiver operating characteristic (ROC) curves, and Bedroc analysis. Twelve different scoring functions of three softwares were used to assess their ability to rank the cognate ligand within the active site of its proteins. The extensive virtual screening task was performed on eight crystal structures, and the performance of docking and scoring was assessed by their ability to efficiently detect known active compounds enriched in the top-ranked of the list among a randomly selected dataset of the ten thousand compounds of the NCI database. The effectiveness of post-docking relaxation in Surflex was also evaluated. The top 20, 50, and 100 compounds were selected based on consensus scoring functions from all 48 proteins with different ligand complexes. Further, the shortlisted leads were subjected to ADMET
    Mesh-Begriff(e) Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Proteins/chemistry ; RNA-Directed DNA Polymerase ; Software
    Chemische Substanzen Ligands ; Proteins ; RNA-Directed DNA Polymerase (EC 2.7.7.49)
    Sprache Englisch
    Erscheinungsdatum 2021-03-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2021.1900915
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