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Article ; Online: Effect of Preoperative Administration of Oral Melatonin on Pneumatic Tourniquet-Induced Ischemia-Reperfusion Injury in Orthopedic Surgery of Lower Extremities

Reza Jouybar / Saeed Khademi / Sima Razmjooie / Neda Bagheri

Iranian Journal of Medical Sciences, Vol 47, Iss 2, Pp 123-

A Randomized Clinical Trial

2022 Volume 130

Abstract: Background: Ischemic reperfusion injury (IRI) causes cellular damage and dysfunction. The present study aimed to evaluate the effect of melatonin on pneumatic tourniquet-induced IRI in orthopedic surgery of the lower extremities.Methods: A randomized ... ...

Abstract	Background: Ischemic reperfusion injury (IRI) causes cellular damage and dysfunction. The present study aimed to evaluate the effect of melatonin on pneumatic tourniquet-induced IRI in orthopedic surgery of the lower extremities.Methods: A randomized clinical trial was conducted at Chamran Hospital, Shiraz University of Medical Sciences (Shiraz, Iran), from September to November 2019. The target population was patients scheduled for elective orthopedic surgery of the lower extremities. A total of 67 patients were randomly divided into two groups, placebo (n=34) and melatonin (n=33). The groups received 10 mg melatonin or placebo the night before surgery and two hours before surgery. Primary outcome variables were the serum levels of superoxide dismutase (SOD) and malondialdehyde (MDA). Hemodynamic parameters, sedation score, and drug side effects were also evaluated. Data were analyzed using SPSS version 21.0 software. p Results: In the analysis phase, due to loss to follow-up (n=26), 41 patients divided into two groups of melatonin (n=20) and placebo (n=21) were evaluated. There was no significant difference in demographic data, duration of surgery (P=0.929), and tourniquet time (P=0.496) between the groups. The serum levels of SOD and MDA were not significantly different between the groups (P=0.866 and P=0.422, respectively), nor were the incidence of postoperative nausea (P=0.588) and patients’ satisfaction (P=0.088). However, the postoperative sedation score and vomiting between the groups were significantly different (p <0.001).Conclusion: Administration of 10 mg melatonin provided effective sedation, but had no significant effect on the serum levels of SOD and MDA, nor on pneumatic tourniquet-induced IRI in orthopedic surgery of the lower limbs.Trial registration number: IRCT20141009019470N87.
Keywords	melatonin ; superoxide dismutase ; malondialdehyde ; reperfusion injury ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy of Isoflurane-Remifentanil versus Propofol-Remifentanil on Controlled Hypotension and Surgeon Satisfaction in Rhinoplasty

Laleh Dehghanpisheh / Mohammad Ali Sahmeddini / Reza Kaboodkhani / Kazem Samadi / Saeed Khademi / Zahra Rafati / Sanaz Abbasi / Razieh Abbasi

Iranian Journal of Medical Sciences, Vol 48, Iss 4, Pp 379-

A Single-Blind Clinical Trial Study

2023 Volume 384

Abstract: Background: Rhinoplasty is a complex but popular surgery in Iran. The main complications of the surgery are post-operative bleeding and nasal septal hematoma due to poor intra-operative controlled hypertension. This study aimed to compare the efficacy of ...

Abstract	Background: Rhinoplasty is a complex but popular surgery in Iran. The main complications of the surgery are post-operative bleeding and nasal septal hematoma due to poor intra-operative controlled hypertension. This study aimed to compare the efficacy of isoflurane-remifentanil (I-R) versus propofol-remifentanil (P-R) to induce controlled hypotension and to assess surgeon satisfaction with each of these combinations during rhinoplasty. Methods: In 2020-2021, a single-blind clinical study was conducted on 98 patients aged 18-50 years undergoing rhinoplasty at Mother and Child Hospital (Shiraz, Iran). Patients were randomly divided into P-R (n=48) and I-R (n=50) groups. Changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR) were assessed during surgery and in the recovery room. A questionnaire was used to evaluate the level of surgeon satisfaction. Data were analyzed using independent samples t test, Chi-square test, and repeated measures ANOVA with SPSS software. P<0.05 was considered statistically significant.Results: Five minutes after anesthesia induction, the P-R combination had a greater effect on reducing SBP (P=0.010), DBP (P=0.007), MAP (P=0.003), and HR (P=0.026) than I-R. However, from the 40th minute to the end of surgery and after 30 minutes of recovery, the I-R combination had a slightly better effect on blood pressure reduction than P-R. There was no difference in surgeon satisfaction with either of the two drug combinations.Conclusion: Both P-R and I-R combinations are recommended to induce hypotension during rhinoplasty. However, I-R is more effective than P-R in inducing the desired controlled hypotension.
Keywords	hypotension ; propofol ; isoflurane ; rhinoplasty ; remifentanil ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
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Article ; Online: The effect of melatonin on cognitive functions following coronary artery bypass grafting

Reza Jouybar / Kambiz Zohoori / Saeed Khademi / Seyed Hedayatallah Akhlagh / Arash Mani / Seyed Amir reza Akhlagh / Elham Asadpour

Journal of Research in Medical Sciences, Vol 28, Iss 1, Pp 14-

A triple-blind randomized-controlled trial

2023 Volume 14

Abstract: Background: Cognitive dysfunction presents one of the chief causes of postoperative morbidity. Melatonin as a neurohormone can improve neurocognitive functioning and sleep disorders. We evaluated the effect of melatonin on the postoperative cognitive ... ...

Abstract	Background: Cognitive dysfunction presents one of the chief causes of postoperative morbidity. Melatonin as a neurohormone can improve neurocognitive functioning and sleep disorders. We evaluated the effect of melatonin on the postoperative cognitive function of patients undergoing coronary artery bypass grafting (CABG). Materials and Methods: A triple-blind randomized-controlled trial was conducted on 66 CABG candidates in Namazee Hospital (Shiraz, Iran). Patients were assigned equally into two groups receiving melatonin 10 mg or a placebo daily for 4 weeks before surgery and 2 days after surgery in the intensive care unit. The Mini-Mental State Examination (MMSE), Tower of London (ToL), and Wechsler Adults Intelligence Scale-Revised (WAIS-R) cognitive function tests were performed in both groups 4 weeks before surgery (time point 1), 2 days after surgery (time point 2), and 6 weeks after initial administration of melatonin (time point 3). Results: The mean change score (time point 3-time point 1) differed significantly between the two groups in the MMSE (P ≤ 0.001), ToL total score (P = 0.001), and WAIS-R general IQ (P ≤ 0.001), picture completion (P ≤ 0.001), vocabulary (P = 0.024), and digit span (P = 0.01). On the other hand, no significant differences were detected in the WAIS-R block design, ToL total time delay, ToL total lab, and ToL total result scores. Conclusion: The MMSE and WAIS-R tests revealed that melatonin might have prophylactic effects against postoperative cognitive disturbance in patients undergoing elective CABG.
Keywords	cognitive function ; coronary artery bypass graft surgery ; melatonin ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A novel PFBHE (periodic fluidized bed heat exchanger): Introduction and preliminary performance evaluation

Shahhosseini, Shahrokh / Mohammad Amin Sobati / Seyed Saeed Khademi

Energy. 2016 July 15, v. 107

2016

Abstract: In the present study, a novel PFBHE (periodic fluidized bed heat exchanger) has been proposed, and tested. In this heat exchanger, hot liquid is introduced into the bed of the solid particles during the hot exchange mode so the heat is transferred to the ...

Abstract	In the present study, a novel PFBHE (periodic fluidized bed heat exchanger) has been proposed, and tested. In this heat exchanger, hot liquid is introduced into the bed of the solid particles during the hot exchange mode so the heat is transferred to the solid particles from the hot liquid. Then, the cold liquid passes through the heated bed during the cold exchange mode and the heat is transferred to the cold liquid from the solid particles. The influences of different operating parameters such as hot and cold fluid velocities in the range of minimum fluidization velocity to particle discharging velocity, duration time of the hot and cold exchange modes, and hot liquid inlet temperature on the performance of PFBHE have been experimentally investigated. A new performance parameter has been introduced in order to evaluate the performance of PFBHE. According to the experimental results, the best performance of PFBHE was achieved when both hot and cold liquid velocities were 0.187 m/s, hot exchange mode duration time was 20 s, the cold exchange mode duration time was 25 s, and the hot liquid inlet temperature was 60 °C.
Keywords	fluidized beds ; heat ; heat exchangers ; liquids ; temperature
Language	English
Dates of publication	2016-0715
Size	p. 443-452.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2016.04.013
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Cardioprotective Effect of Extended Remote Ischemic Preconditioning in Patients Coronary Artery Bypass Grafting Undergoing

Ali Karami / Mohamad Bagher Khosravi / Masih Shafa / Simin Azemati / Saeed Khademi / Seyed Hedayatalla Akhlagh / Behzad Maghsodi

Iranian Journal of Medical Sciences, Vol 41, Iss 4, Pp 265-

A Randomized Clinical Trial

2016 Volume 274

Abstract: Background: The cardioprotective effect of ischemic preconditioning has been known for many years. Since the temporary ischemia in the heart may cause lethal cardiac effects, the idea of creating ischemia in organs far from the heart such as limbs was ... ...

Abstract	Background: The cardioprotective effect of ischemic preconditioning has been known for many years. Since the temporary ischemia in the heart may cause lethal cardiac effects, the idea of creating ischemia in organs far from the heart such as limbs was raised as remote ischemic preconditioning (RIPC). We hypothesized that the extension of RIPC has more cardioprotective effect in patients undergoing coronary artery bypass graft (CABG) surgeries. Methods: In this triple-blind randomized clinical trial study, 96 patients were randomly divided into 3 groups and two blood pressure cuffs were placed on both upper and lower extremities. In group A, only upper extremity cuff and in group B upper limb and lower limb cuff was inflated intermittently and group C was the control group. RIPC was induced with three 5-min cycles of cuff inflation about 100 mmHg over the initial systolic blood pressure before starting cardiopulmonary bypass. The primary endpoints were troponin I and creatine phosphokinase-myoglobin isoenzyme (CK-MB). Results: Six hours after the termination of CPB, there was a peak release of the troponin I level in all groups (group A=4.90 ng/ml, group B=4.40 ng/ml, and group C=4.50 ng/ml). There was a rise in plasma CK-MB in all groups postoperatively and there were not any significant differences in troponin I and CK-MB release between the three groups. Conclusion: RIPC induced by upper and lower limb ischemia does not reduce postoperative myocardial enzyme elevation in adult patients undergoing CABG. Trial Registration Number: IRCT2012071710311N1
Keywords	Ischemic preconditioning ; Coronary artery bypass ; Troponin I ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2016-07-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Serum Lactate Is not Correlated with Mixed or Central Venous Oxygen Saturation for Detecting Tissue Hypo Perfusion During Coronary Artery Bypass Graft Surgery

Shahrbano Shahbazi / Saeed Khademi / Masih Shafa / Reza Joybar / MaryamHadibarhaghtalab / Mohammad Ali Sahmeddini

International Cardiovascular Research Journal, Vol 7, Iss 14, Pp 130-

A Prospective Observational Study

2013 Volume 134

Abstract: Objectives:: Effective assessment of tissue perfusion is highly important during Coronary Artery Bypass Graft (CABG). Mixed venous O2 saturation (Svo2) is one of the best and routinely used markers of tissue perfusion. However, this method is costly and ... ...

Abstract	Objectives:: Effective assessment of tissue perfusion is highly important during Coronary Artery Bypass Graft (CABG). Mixed venous O2 saturation (Svo2) is one of the best and routinely used markers of tissue perfusion. However, this method is costly and leads to considerable complications. Thus, the present study aimed to determine whether the Svo2 can be substituted with central venous saturation (Scvo2) and if there is any correlation between lactate level and Svo2. Methods:: This prospective observational study was conducted on 62 patients scheduled for CABG. After induction and maintenance of anesthesia, blood samples drawn from central venous, pulmonary artery, and radial artery were used to measure Scvo2, Svo2 and serum lactate level respectively before and after Cardio Pulmonary Bypass (CPB). Pearson’s correlation test was used to determine the correlation between Svo2 and Scvo2 as well as between Svo2 and serum lactate level. Besides, P < 0.05 was considered as statistically significant. Results:: Overall, 62 Patients, 33 males (53.2%) and 29 females (46.8%) were enrolled into the present study. The most common coexisting illness was hypertension detected in 33 patients (53.2%) followed by hypercholesterolemia in 28 ones (44.4%). In this study, Svo2 was positively correlated with Scvo2 (r = 0.63, P < 0.001). However, no correlation was found between Svo2 and lactate (r = 0.124, P = 0.348). Conclusions:: In summary, Scvo2 is considered as the best substitute of Svo2 for detecting tissue hypo perfusion during CPB. Although the lactate level had been considered as an appropriate marker of tissue perfusion and ischemia, it was not correlated to Svo2 during CABG.
Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2013-12-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of the Effect of a Preoperative Single Dose of Gabapentin on Emergence Agitation in Patients Undergoing Breast Cancer Surgery

Simin Azemati / Abbas Gholami Dokouhaki / Abdolrasoul Talei / Saeed Khademi / Nader Moin-Vaziri

Middle East Journal of Cancer , Vol 4, Iss 4, Pp 145-

2013 Volume 151

Abstract: Background: Emergence agitation is a transient confusional state that usuallyoccurs within 10 to 30 minutes of recovery from general anesthesia. It may lead to seriousconsequences and increasing hospital costs. This study evaluates the effect of ... ...

Abstract	Background: Emergence agitation is a transient confusional state that usuallyoccurs within 10 to 30 minutes of recovery from general anesthesia. It may lead to seriousconsequences and increasing hospital costs. This study evaluates the effect of gabapentinon emergence agitation in patients undergoing breast cancer surgery.Methods: This randomized, double blind controlled trial enrolled 100 femalepatients with American Society of Anesthesiologists' classifications I and II who werecandidates for breast cancer surgery. Patients were randomly assigned into two groups(n=50) that received either oral gabapentin 600 mg or placebo. Induction andmaintenance of anesthesia were similar in both groups. At the end of surgery, patient'sagitation score, pain score, and presence of nausea or vomiting were reported. In theward, the presence of headache or dizziness was checked during the first 8 h. Mann-Whitney test was used for comparison of agitation and pain scores between two groups.Chi-square test was used for comparing occurrence of nausea, vomiting and qualitative.The qualitative demographic variable and t-test compared quantitative demographicvariables.Results: There was a significantly lower incidence of emergence agitation in thegabapentin group before (P<0.001) and after (P=0.029) extubation. There weresignificantly lower mean agitation scores before (P<001) and after (P=0.006) extubationand in the pain score (P=0.005) in the gabapentin group. The need for remifentanilinfusion (P<0.05) during surgery was significantly lower in the gabapentin groupcompared with the placebo group. Occurrence of nausea and vomiting and gabapentinside effects that included headache or dizziness did not significantly differ between twogroups (P=0.126, P=1, P=0.629 respectively).Conclusion: Gabapentin not only decreased postoperative pain but also effectivelyreduced emergence agitation without any significant side effects in patients undergoingbreast cancer surgery.
Keywords	Gabapentin ; Emergence agitation ; Postoperative pain ; Nausea and vomiting ; Headache ; Dizziness ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	616
Language	English
Publishing date	2013-10-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The impact of music on postoperative pain and anxiety following cesarean section.

Reza, Nikandish / Ali, Sahmedini Mohammad / Saeed, Khademi / Abul-Qasim, Avand / Reza, Tabatabaee Hamid

Middle East journal of anaesthesiology

2007 Volume 19, Issue 3, Page(s) 573–586

Abstract: Background: The relief of post-cesarean delivery pain is important. Good pain relief improves mobility and reduces the risk of thromboembolic disease, which may have been increased during pregnancy. Pain may impair the mother's ability to optimally care ...

Abstract	Background: The relief of post-cesarean delivery pain is important. Good pain relief improves mobility and reduces the risk of thromboembolic disease, which may have been increased during pregnancy. Pain may impair the mother's ability to optimally care for her infant in the immediate postpartum period and may adversely affect early interactions between mother and infant. It is necessary, therefore that pain relief be safe and effective and results in no adverse neonatal effects during breast-feeding. Music may be considered as a potential method of post cesarean pain therapy due to its noninvasiveness and lack of side effects. In this study we evaluated the effect of intraoperative music under general anesthesia for reducing the postoperative morphine requirements after cesarean section. Methods: In a double blind placebo-controlled trial, 100 women (ASA I) scheduled for elective cesarean section under general anesthesia, were randomly allocated into two groups of fifty. After standardization of anesthesia, patients in the music group were exposed to a compact disk of Spanish guitar after induction of anesthesia up to the time of wound dressing. In the control group patients were exposed to white music. Post operative pain and anxiety were evaluated by visual analog scale (VAS) up to six hours after discharge from PACU. Morphine was given intravenously for reducing pain to VAS < or = 3 postoperatively. Results: There was not statistically significant difference in VAS for pain between two groups up to six hours postoperatively (P>0.05). In addition, morphine requirements were not different between two groups at different time intervals up to six hours postoperatively (P>0.05). There were not statistically significant difference between two groups regarding postoperative anxiety score and vomiting frequency (P>0.05). Conclusion: As per conditions of this study, intraoperative Spanish music was not effective in reducing postoperative pain after cesarean section. In addition postoperative morphine requirement, anxiety, and vomiting were not affected by the music during general anesthesia.
MeSH term(s)	Adult ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/therapeutic use ; Anesthesia, General ; Anti-Anxiety Agents/therapeutic use ; Antiemetics/administration & dosage ; Antiemetics/therapeutic use ; Anxiety/psychology ; Cesarean Section/adverse effects ; Cesarean Section/psychology ; Double-Blind Method ; Female ; Humans ; Metoclopramide/administration & dosage ; Metoclopramide/therapeutic use ; Midazolam/therapeutic use ; Morphine/administration & dosage ; Morphine/therapeutic use ; Music/psychology ; Pain Measurement ; Pain, Postoperative/drug therapy ; Pain, Postoperative/psychology ; Postoperative Period ; Pregnancy ; Prospective Studies
Chemical Substances	Analgesics, Opioid ; Anti-Anxiety Agents ; Antiemetics ; Morphine (76I7G6D29C) ; Metoclopramide (L4YEB44I46) ; Midazolam (R60L0SM5BC)
Language	English
Publishing date	2007-10
Publishing country	Lebanon
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	442030-5
ISSN	0544-0440
ISSN	0544-0440
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Perioperative Effect of Ascorbic Acid on Inflammatory Response in Coronary Artery Bypass Graft Surgery; A Randomized Controlled Trial Coronary Artery Bypass Graft Surgery

Reza Jouybar / Hiva Kabgani / Hamid Kamalipour / Shahrbanoo Shahbazi / Elaheh Allahyary / Manoocher Rasouli / Seyd Hedayatallah Akhlagh / Masih Shafa / Mohammad Ghazinoor / Mohammad Taghi Moeinvaziri / Saeed Khademi

International Cardiovascular Research Journal, Vol 6, Iss 1, Pp 13-

2012 Volume 17

Abstract: Background: Different pharmacological agents may decrease the inflammatory response during cardiac surgery. The aim of this study was to evaluate the effect of ascorbic acid as an antioxidant on inflammatory markers (interleukins 6 and interleukin 8) ... ...

Abstract	Background: Different pharmacological agents may decrease the inflammatory response during cardiac surgery. The aim of this study was to evaluate the effect of ascorbic acid as an antioxidant on inflammatory markers (interleukins 6 and interleukin 8) released during cardiopulmonary bypass. Method: Forty patients scheduled for elective coronary artery bypass grafting surgery, were randomly assigned to two groups. The patients in the case group were given 3 grams ascorbic acid 12-18 hours before operation and 3 grams during CPB initiation. The patients in the control group were given the same amounts of normal saline at similar times. Blood samples were collected 6 hours preoperatively and postoperative serum interleukin 6 and 8 were measured using enzyme-linked immunosorbent assay (ELISA). Result: In both groups CPB caused an increase in IL6 and IL8 plasma concentrations compared with baseline levels, but the pattern of changes at such levels were similar in both groups after receiving ascorbic acid or placebo. Ascorbic acid did not reduce the inflammatory cytokines during CPB. Compared to the placebo, ascorbic acid had no significant effect on hemodynamic parameters such as systolic and diastolic blood pressure, heart rate, arterial blood gases, BUN, Creatinine and WBC and platelet counts. Conclusion: Ascorbic acid has no effect on the reduction of IL6 and IL8 during CPB. Also, it causes no improvement in hemodynamics, blood gas variables, and the outcomes of patients undergoing CABG.
Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2012-03-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chronic Incisional Pain after Open Appendectomy

Reza Nik Andish / Mohammad Ali Sahmoddini / Saeed Khademi / Fatemeh Ganji / Sara Soleiman Zadeh / Najmeh Habibi

مجله دانشکده پزشکی اصفهان, Vol 24, Iss 83, Pp 71-

2007 Volume 63

Abstract: Background: Although appendectomy is the most common emergency abdominal surgery, there is no epidemiologic study on chronic pain after open appendectomy. The aim of this study was to evaluate the incidence and possible risk factors of chronic pain ... ...

Abstract	Background: Although appendectomy is the most common emergency abdominal surgery, there is no epidemiologic study on chronic pain after open appendectomy. The aim of this study was to evaluate the incidence and possible risk factors of chronic pain following this common surgical procedure. Methods: In this cross-sectional survey, a questionnaire was completed regarding the pain at the surgical site by calling available patients who had undergone open appendectomy from 1999-2004 in a hospital in Fasa. The patients records were checked for the results of pathology. Findings: Out of 1130 patients operated by open appendectomy, 155 were available. The mean time left after appendectomy was 28 months. At the time of study, 41 (26%) patients still had pain at the site of operation and 9.85% of them had severe pain at rest and 22% suffered from severe pain during daily activities. Chronic pain was significantly more common among patients who had the memory of severe acute post-operative pain and there was no significant difference in the chronicity of pain according to age, sex and positive appendectomy. Conclusion: Chronic post-appendectomy pain is provalent. It is more common in patients with severe acute post-operative pain but it seems not to be related with age, sex, and positive appendectomy. Key words: Pain, chronic, postoperative, appendectomy
Keywords	Medicine ; R ; Medicine (General) ; R5-920
Subject code	616
Language	Persian
Publishing date	2007-08-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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