LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: Therapeutic approaches for Type 1 Diabetes: Promising cell-based approaches to achieve ultimate success.

    Sepyani, Sahar / Momenzadeh, Sedigheh / Safabakhsh, Saied / Nedaeinia, Reza / Salehi, Rasoul

    SLAS discovery : advancing life sciences R & D

    2023  Volume 29, Issue 1, Page(s) 23–33

    Abstract: Type 1 Diabetes mellitus (T1DM) is a chronic metabolic disorder characterized by pancreatic β-cells destruction. Despite substantial advances in T1DM treatment, lifelong exogenous insulin administration is the mainstay of treatments, and constant control ...

    Abstract Type 1 Diabetes mellitus (T1DM) is a chronic metabolic disorder characterized by pancreatic β-cells destruction. Despite substantial advances in T1DM treatment, lifelong exogenous insulin administration is the mainstay of treatments, and constant control of glucose levels is still a challenge. Endogenous insulin production by replacing insulin-producing cells is an alternative, but the lack of suitable donors is accounted as one of the main obstacles to its widespread application. The research and trials overview demonstrates that endogenous production of insulin has started to go beyond the deceased-derived to stem cells-derived insulin-producing cells. Several protocols have been developed over the past couple of years for generating insulin-producing cells (IPCs) from various stem cell types and reprogramming fully differentiated cells. A straightforward and quick method for achieving this goal is to investigate and apply the β-cell specific transcription factors as a direct strategy for IPCs generation. In this review, we emphasize the significance of transcription factors in IPCs development from different non-beta cell sources, and pertinent research underlies the marked progress in the methods for generating insulin-producing cells and application for Type 1 Diabetes treatment.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 1/therapy ; Diabetes Mellitus, Type 1/metabolism ; Mesenchymal Stem Cells/metabolism ; Insulin/metabolism ; Cell Differentiation ; Transcription Factors/metabolism
    Chemical Substances Insulin ; Transcription Factors
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2885123-7
    ISSN 2472-5560 ; 2472-5552
    ISSN (online) 2472-5560
    ISSN 2472-5552
    DOI 10.1016/j.slasd.2023.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4911: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Immunoglobulin-Negative DNAJB9-Associated Fibrillary Glomerulonephritis: A Report of 9 Cases.

    Said, Samar M / Rocha, Alejandro Best / Royal, Virginie / Valeri, Anthony M / Larsen, Christopher P / Theis, Jason D / Vrana, Julie A / McPhail, Ellen D / Bandi, Lalitha / Safabakhsh, Saied / Barnes, Chadwick / Cornell, Lynn D / Fidler, Mary E / Alexander, Mariam Priya / Leung, Nelson / Nasr, Samih H

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2020  Volume 77, Issue 3, Page(s) 454–458

    Abstract: Fibrillary glomerulonephritis (FGN) was previously defined by glomerular deposition of haphazardly oriented fibrils that stain with antisera to immunoglobulins but do not stain with Congo red. We report what is to our knowledge the first series of ... ...

    Abstract Fibrillary glomerulonephritis (FGN) was previously defined by glomerular deposition of haphazardly oriented fibrils that stain with antisera to immunoglobulins but do not stain with Congo red. We report what is to our knowledge the first series of immunoglobulin-negative FGN, consisting of 9 adults (7 women and 2 men) with a mean age at diagnosis of 66 years. Patients presented with proteinuria (100%; mean protein excretion, 3g/d), hematuria (100%), and elevated serum creatinine level (100%). Comorbid conditions included carcinoma in 3 and hepatitis C virus infection in 2; no patient had hypocomplementemia or monoclonal gammopathy. Histologically, glomeruli were positive for DNAJB9, showed mostly mild mesangial hypercellularity and/or sclerosis, and were negative for immunoglobulins by immunofluorescence on frozen and paraffin tissue. Ultrastructurally, randomly oriented fibrils measuring 13 to 20nm in diameter were seen intermingling with mesangial matrix in all and infiltrating glomerular basement membranes in 5. On follow-up (mean duration, 21 months), 2 had disease remission, 4 had persistently elevated serum creatinine levels and proteinuria, and 3 required kidney replacement therapy. Thus, rare cases of FGN are not associated with glomerular immunoglobulin deposition, and the diagnosis of FGN in these cases can be confirmed by DNAJB9 immunostaining. Pathogenesis remains to be elucidated.
    MeSH term(s) Aged ; Aged, 80 and over ; Comorbidity ; Creatinine/metabolism ; Female ; Glomerular Basement Membrane/ultrastructure ; Glomerular Mesangium/ultrastructure ; Glomerulonephritis/epidemiology ; Glomerulonephritis/metabolism ; Glomerulonephritis/pathology ; Glomerulonephritis/therapy ; HSP40 Heat-Shock Proteins/metabolism ; Hematuria/metabolism ; Humans ; Immunoglobulin G/metabolism ; Immunosuppressive Agents/therapeutic use ; Liver Cirrhosis/epidemiology ; Male ; Membrane Proteins/metabolism ; Microscopy, Electron ; Middle Aged ; Molecular Chaperones/metabolism ; Neoplasms/epidemiology ; Proteinuria/metabolism ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Renal Replacement Therapy ; Sclerosis
    Chemical Substances DNAJB9 protein, human ; HSP40 Heat-Shock Proteins ; Immunoglobulin G ; Immunosuppressive Agents ; Membrane Proteins ; Molecular Chaperones ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2020.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 468: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Association of CREBRF variants with obesity and diabetes in Pacific Islanders from Guam and Saipan.

    Hanson, Robert L / Safabakhsh, Saied / Curtis, Jeffrey M / Hsueh, Wen-Chi / Jones, Lois I / Aflague, Tanisha F / Duenas Sarmiento, Jenny / Kumar, Satish / Blackburn, Nicholas B / Curran, Joanne E / Mahkee, Darin / Baier, Leslie J / Knowler, William C / Nelson, Robert G

    Diabetologia

    2019  Volume 62, Issue 9, Page(s) 1647–1652

    Abstract: Aims/hypothesis: Variants in CREBRF (rs12513649 and rs373863828) have been strongly associated with increased BMI and decreased risk of type 2 diabetes in Polynesian populations; the A allele at rs373863828 is common in Polynesians but rare in most ... ...

    Abstract Aims/hypothesis: Variants in CREBRF (rs12513649 and rs373863828) have been strongly associated with increased BMI and decreased risk of type 2 diabetes in Polynesian populations; the A allele at rs373863828 is common in Polynesians but rare in most other global populations. The aim of the present study was to assess the association of CREBRF variants with obesity and diabetes in Pacific Islander (largely Marianas and Micronesian) populations from Guam and Saipan.
    Methods: CREBRF rs12513649 and rs373863828 were genotyped in 2022 participants in a community-based cross-sectional study designed to identify determinants of diabetes and end-stage renal disease (ESRD). Associations were analysed with adjustment for age, sex, ESRD and the first four genetic principal components from a genome-wide association study (to account for population stratification); a genomic control procedure was used to account for residual stratification.
    Results: The G allele at rs12513649 had an overall frequency of 7.7%, which varied from 2.2% to 20.7% across different Marianas and Micronesian populations; overall frequency of the A allele at rs373863828 was 4.2% (range: 1.1-5.4%). The G allele at rs12513649 was associated with higher BMI (β = 1.55 kg/m
    Conclusions/interpretation: These results confirm the associations of CREBRF variants with higher BMI and lower risk of diabetes and, importantly, they suggest that these variants contribute to the risk of obesity and diabetes in Oceanic populations.
    MeSH term(s) Female ; Humans ; Male ; Alleles ; Body Mass Index ; Cross-Sectional Studies ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Genotype ; Guam ; Haplotypes ; Kidney Failure, Chronic/genetics ; Obesity/genetics ; Polymorphism, Single Nucleotide/genetics ; Tumor Suppressor Proteins/genetics ; Micronesia/ethnology ; Pacific Island People/genetics
    Chemical Substances CREB3 regulatory factor, human ; Tumor Suppressor Proteins
    Language English
    Publishing date 2019-07-06
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-019-4932-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 279: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top